Diet as a Source of Acrolein: Molecular Basis of Aldehyde Biological Activity in Diabetes and Digestive System Diseases

Mass Spectrometry Analysis of DNA and Protein Adducts as Biomarkers in Human Exposure to Cigarette Smoking: Acrolein as an Example

(2023) Hauh-Jyun Candy Chen   Chemical Research in Toxicology

Acrolein-inducing ferroptosis contributes to impaired peripheral neurogenesis in zebrafish

(2023) Haozhe Qi et al.   Frontiers in Neuroscience

Molecular Characteristics of Toxicity of Acrolein Produced from Spermine

(2023) Keiko Kashiwagi et al.   Biomolecules

A search for acrolein scavengers among food components

(2023) Takeshi Uemura et al.   AMINO ACIDS

Correlation of the presence of acrolein with higher alcohols, glycerol, and acidity in cachaças

(2023) Gabriela Fontes Alvarenga et al.   JOURNAL OF FOOD SCIENCE

Electronic Cigarette Solvents, JUUL E-Liquids, and Biomarkers of Exposure: In Vivo Evidence for Acrolein and Glycidol in E-Cig-Derived Aerosols

(2022) Pawel Lorkiewicz et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Increased acrolein–DNA adducts in buccal brushings of e-cigarette users

(2022) Guang Cheng et al.   CARCINOGENESIS

Heart Failure: An Underappreciated Complication of Diabetes. A Consensus Report of the American Diabetes Association

(2022) Rodica Pop-Busui et al.   DIABETES CARE

Formation, Mitigation, and Detection of Acrylamide in Foods

(2022) Nivine Bachir et al.   Food Analytical Methods

Cigarette Smoke Containing Acrolein Contributes to Cisplatin Resistance in Human Bladder Cancers through the Regulation of HER2 Pathway or FGFR3 Pathway

(2022) Jian-Hua Hong et al.   MOLECULAR CANCER THERAPEUTICS

Correlation of Ferroptosis and Other Types of Cell Death in Neurodegenerative Diseases

(2022) Xiaoting Dang et al.   Neuroscience Bulletin

Acrolein Promotes Aging and Oxidative Stress via the Stress Response Factor DAF-16/FOXO in Caenorhabditis elegans

(2022) Jiaqian Hong et al.   Foods

Increased Levels of the Acrolein Metabolite 3-Hydroxypropyl Mercapturic Acid in the Urine of e-Cigarette Users

(2022) Menglan Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Comparative study of oral versus parenteral crocin in mitigating acrolein-induced lung injury in albino rats

(2022) Walaa Abdelhaliem Rashad et al.   Scientific Reports

Origin and Fate of Acrolein in Foods

(2022) Kaiyu Jiang et al.   Foods

Up-Date on Diabetic Nephropathy

(2022) Maria Chiara Pelle et al.   Life-Basel

Acrolein Increases the Pulmonary Tumorigenic Activity of the Tobacco-Specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

(2022) Lisa A. Peterson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Quantitation of DNA Adducts Resulting from Acrolein Exposure and Lipid Peroxidation in Oral Cells of Cigarette Smokers from Three Racial/Ethnic Groups with Differing Risks for Lung Cancer

(2022) Sungshim L. Park et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Acrolein plays a culprit role in the pathogenesis of diabetic nephropathy in vitro and in vivo

(2022) Zhen-Jie Tong et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The Role of Acrolein in Neurodegenerative Diseases and Its Protective Strategy

(2022) Xinxin Chang et al.   Foods

Carcinogenicity and chronic toxicity of acrolein in rats and mice by two-year inhalation study.

(2021) Michiharu Matsumoto et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Impact of e-Liquid Composition, Coil Temperature, and Puff Topography on the Aerosol Chemistry of Electronic Cigarettes

(2021) Yichen Li et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Low-Dose Acrolein, an Endogenous and Exogenous Toxic Molecule, Inhibits Glucose Transport via an Inhibition of Akt-Regulated GLUT4 Signaling in Skeletal Muscle Cells

(2021) Ching-Chia Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ferroptosis: A potential therapeutic target for neurodegenerative diseases

(2021) D. Vitalakumar et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

N‐acetylcysteine is more effective than ellagic acid in preventing acrolein induced dysfunction in mitochondria isolated from rat liver

(2021) Behnaz shafie et al.   JOURNAL OF FOOD BIOCHEMISTRY

Acrolein contributes to human colorectal tumorigenesis through the activation of RAS-MAPK pathway

(2021) Hong-Chieh Tsai et al.   Scientific Reports

Exposure to Heated Tobacco Products and Adverse Health Effects, a Systematic Review

(2021) Małgorzata Znyk et al.   International Journal of Environmental Research and Public Health

ROCK1 Mediates Retinal Glial Cell Migration Promoted by Acrolein

(2021) Kanae Fukutsu et al.   Frontiers in Medicine

Mechanisms of acrolein induces toxicity in human umbilical vein endothelial cells: Oxidative stress, DNA damage response, and apoptosis

(2021) Dan Liu et al.   ENVIRONMENTAL TOXICOLOGY

Toxicity mechanism of acrolein on DNA damage and apoptosis in BEAS-2B cells: Insights from cell biology and molecular docking analyses

(2021) Dan Liu et al.   TOXICOLOGY

Impact of protein carbonylation on the chemical characteristics of the hair surface

(2021) Hitoshi Masaki et al.   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice

(2020) Fang Liu et al.   Journal of Clinical Medicine

Understanding MAPK Signaling Pathways in Apoptosis

(2020) Jicheng Yue et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetics of diabetes mellitus and diabetes complications

(2020) Joanne B. Cole et al.   Nature Reviews Nephrology

Quantitative Liquid Chromatography–Nanoelectrospray Ionization–High-Resolution Tandem Mass Spectrometry Analysis of Acrolein-DNA Adducts and Etheno-DNA Adducts in Oral Cells from Cigarette Smokers and Nonsmokers

(2020) Viviana Paiano et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pathological Role of Unsaturated Aldehyde Acrolein in Diabetic Retinopathy

(2020) Miyuki Murata et al.   Frontiers in Immunology

Oxidative Stress Markers in Chronic Kidney Disease with Emphasis on Diabetic Nephropathy

(2020) Nina Vodošek Hojs et al.   Antioxidants

The cells involved in the pathological process of diabetic retinopathy

(2020) Songtao Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry

(2020) Kyohei Muguruma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Simultaneous generation of acrylamide, β-carboline heterocyclic amines and advanced glycation ends products in an aqueous Maillard reaction model system

(2020) Wei Quan et al.   FOOD CHEMISTRY

Carcinogenicity of acrolein, crotonaldehyde, and arecoline

(2020) M Matilde Marques et al.   LANCET ONCOLOGY

Morin decreases acrolein-induced cell injury in normal human hepatocyte cell line LO2

(2020) Zhao Yin et al.   Journal of Functional Foods

Acrolein is involved in the synergistic potential of cigarette smoking- and betel quid chewing-related human oral cancer.

(2019) Hsiang-Tsui Wang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Identification of acrolein metabolites in human buccal cells, blood, and urine after consumption of commercial fried food

(2019) Tse‐Wen Wang et al.   Food Science & Nutrition

The relationship between acrolein and oxidative stress in COPD: in systemic plasma and in local lung tissue

(2019) Masanori Yasuo et al.   International Journal of Chronic Obstructive Pulmonary Disease

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Apocynin ameliorates diabetic retinopathy in rats: Involvement of TLR4/NF-κB signaling pathway

(2019) Yixin Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Bitterness in alcoholic beverages: The profiles of perception, constituents, and contributors

(2019) Yi Luo et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Dihydroxyacetone levels in electronic cigarettes: Wick temperature and toxin formation

(2018) Shawna Vreeke et al.   AEROSOL SCIENCE AND TECHNOLOGY

Acrolein as a Major Volatile in the Early Stages of Fish Oil TAG Oxidation

(2018) Ako Shibata et al.   Journal of Oleo Science

Mitochondrial dysfunction in diabetic kidney disease

(2018) Josephine M. Forbes et al.   Nature Reviews Nephrology

Electronic cigarette-generated aldehydes: The contribution of e-liquid components to their formation and the use of urinary aldehyde metabolites as biomarkers of exposure

(2018) Daniel J. Conklin et al.   AEROSOL SCIENCE AND TECHNOLOGY

Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients

(2018) Vatsalya Vatsalya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Müller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein-scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine

(2018) Rosemary E. McDowell et al.   DIABETOLOGIA

Evaluating mode of action of acrolein toxicity in an in vitro human airway tissue model

(2018) Rui Xiong et al.   TOXICOLOGICAL SCIENCES

Alcoholic liver disease

(2018) Helmut K. Seitz et al.   Nature Reviews Disease Primers

Pathophysiology and Management of Alcoholic Liver Disease: Update 2016

(2017) Felix Stickel et al.   Gut and Liver

Sugar and Aldehyde Content in Flavored Electronic Cigarette Liquids

(2017) Pebbles Fagan et al.   NICOTINE & TOBACCO RESEARCH

ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy

(2017) Pierre-Raphaël Rothschild et al.   Scientific Reports

Acrolein and Human Disease: Untangling the Knotty Exposure Scenarios Accompanying Several Diverse Disorders

(2016) Philip C. Burcham   CHEMICAL RESEARCH IN TOXICOLOGY

Pathogenesis of Alcoholic Liver Disease

(2016) Winston Dunn et al.   Clinics in Liver Disease

Alcoholic Liver Disease

(2016) Stanley Martin Cohen   Clinics in Liver Disease

Localization of Acrolein-Lysine Adduct in Fibrovascular Tissues of Proliferative Diabetic Retinopathy

(2016) Yoko Dong et al.   CURRENT EYE RESEARCH

Acrolein metabolites, diabetes and insulin resistance

(2016) Aliya G. Feroe et al.   ENVIRONMENTAL RESEARCH

Retinal fibrosis in diabetic retinopathy

(2016) Sayon Roy et al.   EXPERIMENTAL EYE RESEARCH

The importance of glial cells in the homeostasis of the retinal microenvironment and their pivotal role in the course of diabetic retinopathy

(2016) Francesco Saverio Sorrentino et al.   LIFE SCIENCES

Oxidative stress, mitochondrial damage and diabetic retinopathy

(2015) Renu A. Kowluru et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Glycerol as feedstock in the synthesis of chemicals: a life cycle analysis for acrolein production

(2015) D. Cespi et al.   GREEN CHEMISTRY

Cooking-related PM2.5 and acrolein measured in grocery stores and comparison with other retail types

(2015) W. R. Chan et al.   INDOOR AIR

A Potential Role for Acrolein in Neutrophil-Mediated Chronic Inflammation

(2015) Brett D. Noerager et al.   INFLAMMATION

Mutual enhancement between high-mobility group box-1 and NADPH oxidase-derived reactive oxygen species mediates diabetes-induced upregulation of retinal apoptotic markers

(2015) Ghulam Mohammad et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Formation of Acrolein in the Autoxidation of Triacylglycerols with Different Fatty Acid Compositions

(2015) Ako Shibata et al.   JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY

Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease

(2015) Akshata Moghe et al.   TOXICOLOGICAL SCIENCES

Hydroxytyrosol protects against acrolein induced preosteoblast cell toxicity: Involvement of Nrf2/Keap1 pathway

(2015) Jing Gao et al.   Journal of Functional Foods

Cigarette side-stream smoke lung and bladder carcinogenesis: inducing mutagenic acrolein-DNA adducts, inhibiting DNA repair and enhancing anchorage-independent-growth cell transformation

(2015) Hyun-Wook Lee et al.   Oncotarget

Elevated Levels of Mercapturic Acids of Acrolein and Crotonaldehyde in the Urine of Chinese Women in Singapore Who Regularly Cook at Home

(2015) Stephen S. Hecht et al.   PLoS One

An Aberrant Leukotriene A4Hydrolase–Proline-Glycine-Proline Pathway in the Pathogenesis of Chronic Obstructive Pulmonary Disease

(2014) J. Michael Wells et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Protection of HepG2 cells against acrolein toxicity by 2-cyano-3,12-dioxooleana-1,9-dien-28-imidazolide via glutathione-mediated mechanism

(2014) Halley Shah et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Isotope-Labeling Studies on the Formation Pathway of Acrolein during Heat Processing of Oils

(2014) Alice Ewert et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chromatographic determination of low-molecular mass unsaturated aliphatic aldehydes with peroxyoxalate chemiluminescence detection after fluorescence labeling with 4-(N,N-dimethylaminosulfonyl)-7-hydrazino-2,1,3-benzoxadiazole

(2014) Marwa Fathy Bakr Ali et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Acrolein induced both pulmonary inflammation and the death of lung epithelial cells

(2014) Yang Sun et al.   TOXICOLOGY LETTERS

Inflammatory and cytotoxic effects of acrolein, nicotine, acetylaldehyde and cigarette smoke extract on human nasal epithelial cells

(2014) David M Comer et al.   BMC Pulmonary Medicine

VEGF Secreted by Hypoxic Muller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy

(2013) M. Rodrigues et al.   DIABETES

Linolenic Acid as the Main Source of Acrolein Formed During Heating of Vegetable Oils

(2013) Yasushi Endo et al.   JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY

Repair kinetics of acrolein- and (E)-4-hydroxy-2-nonenal-derived DNA adducts in human colon cell extracts

(2013) Sujata Choudhury et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Curcumin analog 1, 5-bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibits enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE-19 cell toxicity

(2013) Yuan Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells

(2012) Nadia Moretto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Protein Carbonylation and Aggregation Precede Neuronal Apoptosis Induced by Partial Glutathione Depletion

(2012) Anushka Dasgupta et al.   ASN Neuro

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Scientific assessment of the use of sugars as cigarette tobacco ingredients: A review of published and other publicly available studies

(2012) Ewald Roemer et al.   CRITICAL REVIEWS IN TOXICOLOGY

A Possible Role of Acrolein in Diabetic Retinopathy: Involvement of a VEGF/TGFβ Signaling Pathway of the Retinal Pigment Epithelium in Hyperglycemia

(2012) Jeffery Grigsby et al.   CURRENT EYE RESEARCH

Effect of Carcinogenic Acrolein on DNA Repair and Mutagenic Susceptibility

(2012) Hsiang-Tsui Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acrolein cytotoxicity in hepatocytes involves endoplasmic reticulum stress, mitochondrial dysfunction and oxidative stress

(2012) Mohammad K. Mohammad et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Intraocular Oxygen Distribution in Advanced Proliferative Diabetic Retinopathy

(2011) Clemens A.K. Lange et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Development of Two Stable Isotope Dilution Assays for the Quantitation of Acrolein in Heat-Processed Fats

(2011) Alice Ewert et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Proteomic profiling of acrolein adducts in human lung epithelial cells

(2011) Page C. Spiess et al.   Journal of Proteomics

The effects of acrolein on the thioredoxin system: Implications for redox-sensitive signaling

(2011) Charles R. Myers et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Toxicology and risk assessment of acrolein in food

(2011) Klaus Abraham et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Elevated Levels of Volatile Organic Carcinogen and Toxicant Biomarkers in Chinese Women Who Regularly Cook at Home

(2010) S. S. Hecht et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Investigation of Reactive α-Dicarbonyl Compounds Generated from the Maillard Reactions ofl-Methionine with Reducing Sugars via Their Stable Quinoxaline Derivatives

(2010) Yvonne V. Pfeifer et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells

(2010) Zhihui Feng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Indoor acrolein emission and decay rates resulting from domestic cooking events

(2009) Vincent Y. Seaman et al.   ATMOSPHERIC ENVIRONMENT

Protein Modification by Acrolein: Formation and Stability of Cysteine Adducts

(2009) Jian Cai et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Emissions of volatile aldehydes from heated cooking oils

(2009) Harinageswara Rao Katragadda et al.   FOOD CHEMISTRY

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease

(2008) Jan F. Stevens et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells

(2008) Charles R. Myers et al.   TOXICOLOGY

Carbohydrate pyrolysis mechanisms from isotopic labeling

(2007) John B. Paine et al.   JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS