A Potential Role for Acrolein in Neutrophil-Mediated Chronic Inflammation

An Aberrant Leukotriene A4Hydrolase–Proline-Glycine-Proline Pathway in the Pathogenesis of Chronic Obstructive Pulmonary Disease

(2014) J. Michael Wells et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Novel Proteolytic Cascade Generates an Extracellular Matrix-Derived Chemoattractant in Chronic Neutrophilic Inflammation

(2014) A. Gaggar et al.   JOURNAL OF IMMUNOLOGY

Cigarette Smoke Induces Systemic Defects in Cystic Fibrosis Transmembrane Conductance Regulator Function

(2013) S. Vamsee Raju et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immunopathogenesis of chronic obstructive pulmonary disease

(2013) Rebecca A. Holloway et al.   CURRENT OPINION IN PULMONARY MEDICINE

The small airways in chronic obstructive pulmonary disease

(2013) Jeffrey I. Stewart et al.   CURRENT OPINION IN PULMONARY MEDICINE

Cigarette Smoke-Induced Collagen Destruction; Key to Chronic Neutrophilic Airway Inflammation?

(2013) Saskia A. Overbeek et al.   PLoS One

Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells

(2012) Nadia Moretto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Elevated neutrophil elastase and acrolein-protein adducts are associated with W256 regression

(2012) M. Jaganjac et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patients with cystic fibrosis

(2012) Richard B. Moss et al.   Journal of Cystic Fibrosis

Acrolein Induces Endoplasmic Reticulum Stress and Causes Airspace Enlargement

(2012) Yoshiaki Kitaguchi et al.   PLoS One

A CXCL8 receptor antagonist based on the structure of N-acetyl-proline-glycine-proline

(2011) Patricia L. Jackson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation

(2011) Christian D. Sadik et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Self-Propagating Matrix Metalloprotease-9 (MMP-9) Dependent Cycle of Chronic Neutrophilic Inflammation

(2011) Xin Xu et al.   PLoS One

Endothelial Dysfunction and Claudin 5 Regulation during Acrolein-Induced Lung Injury

(2010) An Soo Jang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A Critical Role for LTA4H in Limiting Chronic Pulmonary Neutrophilic Inflammation

(2010) R. J. Snelgrove et al.   SCIENCE

The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages

(2010) Gabriela Ambrozova et al.   TOXICOLOGY IN VITRO

The Presence of a Matrix-Derived Neutrophil Chemoattractant in Bronchiolitis Obliterans Syndrome after Lung Transplantation

(2009) M. T. Hardison et al.   JOURNAL OF IMMUNOLOGY

Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen

(2009) Philip J. O'Reilly et al.   JOURNAL OF NEUROIMMUNOLOGY

Acrolein activates matrix metalloproteinases by increasing reactive oxygen species in macrophages

(2009) Timothy E. O'Toole et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects of Acrolein on Leukotriene Biosynthesis in Human Neutrophils

(2008) Karin A. Zemski Berry et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease

(2008) Jan F. Stevens et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells

(2008) Charles R. Myers et al.   TOXICOLOGY

Acrolein-Activated Matrix Metalloproteinase 9 Contributes to Persistent Mucin Production

(2007) Hitesh S. Deshmukh et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY