The Role of Acrolein in Neurodegenerative Diseases and Its Protective Strategy

Protective Effect of Ganoderma atrum Polysaccharide on Acrolein-Induced Apoptosis and Autophagic Flux in IEC-6 Cells

(2022) Yudan Wang et al.   Foods

Origin and Fate of Acrolein in Foods

(2022) Kaiyu Jiang et al.   Foods

Catechins in green tea powder (matcha) are heat-stable scavengers of acrolein, a lipid peroxide-derived reactive carbonyl species

(2021) Koichi Sugimoto et al.   FOOD CHEMISTRY

Neuroinflammation: An overview of neurodegenerative and metabolic diseases and of biotechnological studies

(2020) Ana Paula de Araújo Boleti et al.   NEUROCHEMISTRY INTERNATIONAL

Mechanistic studies of inhibition on acrolein by myricetin

(2020) Dingmin Zhang et al.   FOOD CHEMISTRY

Carcinogenicity of acrolein, crotonaldehyde, and arecoline

(2020) M Matilde Marques et al.   LANCET ONCOLOGY

Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases

(2020) Rosalba Leuci et al.   Foods

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

Mechanisms behind the atherothrombotic effects of acrolein, a review

(2019) Mohammad Reza Zirak et al.   FOOD AND CHEMICAL TOXICOLOGY

Acrolein-mediated alpha-synuclein pathology involvement in the early post-injury pathogenesis of mild blast-induced Parkinsonian neurodegeneration

(2019) Glen Acosta et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Formation of di-cysteine acrolein adduct decreases cytotoxicity of acrolein by ROS alleviation and apoptosis intervention

(2019) Zhao Yin et al.   JOURNAL OF HAZARDOUS MATERIALS

Acrolein is involved in ischemic stroke-induced neurotoxicity through spermidine/spermine-N1-acetyltransferase activation

(2019) Jin-Hui Liu et al.   EXPERIMENTAL NEUROLOGY

Involvement of ADAM10 in acrolein-induced astrocytic inflammation

(2019) Jung Hyun Park et al.   TOXICOLOGY LETTERS

Aldehyde levels in e-cigarette aerosol: Findings from a replication study and from use of a new-generation device

(2018) Konstantinos E. Farsalinos et al.   FOOD AND CHEMICAL TOXICOLOGY

Acrolein-mediated neuronal cell death and alpha-synuclein aggregation: Implications for Parkinson's disease

(2018) Abeje Ambaw et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Caloric restriction ameliorates acrolein-induced neurotoxicity in rats

(2018) Ying-Juan Huang et al.   NEUROTOXICOLOGY

Supplementation of Blackcurrant Anthocyanins Increased Cyclic Glycine-Proline in the Cerebrospinal Fluid of Parkinson Patients: Potential Treatment to Improve Insulin-Like Growth Factor-1 Function

(2018) Dawei Fan et al.   Nutrients

Systemic Acrolein Elevations in Mice With Experimental Autoimmune Encephalomyelitis and Patients With Multiple Sclerosis

(2018) Melissa Tully et al.   Frontiers in Neurology

Neuroprotective effects of Baicalein in animal models of Parkinson's disease: A Systematic review of experimental studies

(2018) Qi Zhu et al.   PHYTOMEDICINE

Dimercaprol is an acrolein scavenger that mitigates acrolein-mediated PC-12 cells toxicity and reduces acrolein in rat following spinal cord injury

(2017) Ran Tian et al.   JOURNAL OF NEUROCHEMISTRY

Neuroprotective Effects of Baicalein on Acrolein-induced Neurotoxicity in the Nigrostriatal Dopaminergic System of Rat Brain

(2017) Wei-Zhong Zhao et al.   MOLECULAR NEUROBIOLOGY

Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

(2017) Tahir Ali et al.   MOLECULAR NEUROBIOLOGY

Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death

(2017) Yi-Ting Wang et al.   Scientific Reports

Toxic acrolein production due to Ca2+ influx by the NMDA receptor during stroke

(2016) Mizuho Nakamura et al.   ATHEROSCLEROSIS

Aggravation of brain infarction through an increase in acrolein production and a decrease in glutathione with aging

(2016) Takeshi Uemura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acrolein and Human Disease: Untangling the Knotty Exposure Scenarios Accompanying Several Diverse Disorders

(2016) Philip C. Burcham   CHEMICAL RESEARCH IN TOXICOLOGY

Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury

(2016) Zhe Chen et al.   JOURNAL OF NEUROCHEMISTRY

Structural Elucidation of a Carnosine-Acrolein Adduct and its Quantification in Human Urine Samples

(2016) Vanderson S. Bispo et al.   Scientific Reports

Molecular mechanisms of acrolein-mediated myelin destruction in CNS trauma and disease

(2015) R. Shi et al.   FREE RADICAL RESEARCH

Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease

(2015) Akshata Moghe et al.   TOXICOLOGICAL SCIENCES

Mechanisms of CDDO-imidazolide-mediated cytoprotection against acrolein-induced neurocytotoxicity in SH-SY5Y cells and primary human astrocytes

(2015) Adam Speen et al.   TOXICOLOGY LETTERS

Polyphenol Extract from Phellinus igniarius Protects against Acrolein Toxicity In Vitro and Provides Protection in a Mouse Stroke Model

(2015) Papawee Suabjakyong et al.   PLoS One

NMR investigation of acrolein stability in hydroalcoholic solution as a foundation for the valid HS-SPME/GC–MS quantification of the unsaturated aldehyde in beverages

(2014) Martin Kächele et al.   ANALYTICA CHIMICA ACTA

Acrolein detection: potential theranostic utility in multiple sclerosis and spinal cord injury

(2014) Melissa Tully et al.   Expert Review of Neurotherapeutics

Comparison of select analytes in aerosol from e-cigarettes with smoke from conventional cigarettes and with ambient air

(2014) Rana Tayyarah et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

New Insights in the Pathogenesis of Multiple Sclerosis—Role of Acrolein in Neuronal and Myelin Damage

(2013) Melissa Tully et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin analog 1, 5-bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibits enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE-19 cell toxicity

(2013) Yuan Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo

(2013) Ying-Juan Huang et al.   TOXICOLOGY LETTERS

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

α-Synuclein oligomers and clinical implications for Parkinson disease

(2012) Lorraine V. Kalia et al.   ANNALS OF NEUROLOGY

Augmented glutathione synthesis decreases acrolein toxicity

(2012) Hideyuki Tomitori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony

(2012) Rodrigo Medeiros et al.   EXPERIMENTAL NEUROLOGY

In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple

(2012) Qin Zhu et al.   FOOD CHEMISTRY

Head injury, alpha-synuclein Rep1, and Parkinson's disease

(2011) Samuel M. Goldman et al.   ANNALS OF NEUROLOGY

Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice

(2011) Sanjay Srivastava et al.   ATHEROSCLEROSIS

Acrolein scavengers: Reactivity, mechanism and impact on health

(2011) Qin Zhu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Toxicology and risk assessment of acrolein in food

(2011) Klaus Abraham et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Correlation between images of silent brain infarction, carotid atherosclerosis and white matter hyperintensity, and plasma levels of acrolein, IL-6 and CRP

(2010) Madoka Yoshida et al.   ATHEROSCLEROSIS

Brain infarction correlates more closely with acrolein than with reactive oxygen species

(2010) Ryotaro Saiki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune enchephalomyelitis mouse

(2010) G. Leung et al.   NEUROSCIENCE

Identification of acrolein-conjugated protein in plasma of patients with brain infarction

(2009) Madoka Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mammalian polyamine metabolism and function

(2009) Anthony E. Pegg   IUBMB LIFE

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Intense Correlation Between Brain Infarction and Protein-Conjugated Acrolein

(2009) Ryotaro Saiki et al.   STROKE

Acrolein, IL-6 and CRP as markers of silent brain infarction

(2008) Madoka Yoshida et al.   ATHEROSCLEROSIS

Acrolein toxicity: Comparison with reactive oxygen species

(2008) Madoka Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protective effect of Pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity

(2008) Mubeen A. Ansari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCε signaling and cardioprotection

(2008) Guang-Wu Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease

(2008) Jan F. Stevens et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

(2008) Claire Henchcliffe et al.   Nature clinical practice. Neurology