Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice

Targeting Polyamine Oxidase to Prevent Excitotoxicity-Induced Retinal Neurodegeneration

(2019) Prahalathan Pichavaram et al.   Frontiers in Neuroscience

NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy

(2019) Khalil Miloudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of Arginase 2 Ameliorates Retinal Neurodegeneration in a Mouse Model of Multiple Sclerosis

(2019) Chithra D. Palani et al.   MOLECULAR NEUROBIOLOGY

Spermine oxidase: A Promising Therapeutic Target for Neurodegeneration in Diabetic Retinopathy

(2019) S. Priya Narayanan et al.   PHARMACOLOGICAL RESEARCH

The role of inflammation in diabetic eye disease

(2019) Marina Mesquida et al.   Seminars in Immunopathology

Neurodegeneration in diabetic retinopathy: does it really matter?

(2018) Rafael Simó et al.   DIABETOLOGIA

Role of Inflammation in Diabetic Retinopathy

(2018) Anne Rübsam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diabetic Retinopathy: Pathophysiology and Treatments

(2018) Wei Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Müller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein-scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine

(2018) Rosemary E. McDowell et al.   DIABETOLOGIA

Polyamine catabolism and oxidative damage

(2018) Tracy Murray Stewart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequential phases of RGC axonal and somatic injury in EAE mice examined using DTI and OCT

(2018) Christopher Nishioka et al.   Multiple Sclerosis and Related Disorders

The pathology associated with diabetic retinopathy

(2017) Judith Lechner et al.   VISION RESEARCH

Müller cells and diabetic retinopathy

(2017) Brandon A. Coughlin et al.   VISION RESEARCH

Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy

(2016) C. Patel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Long Noncoding RNA-Sox2OT Knockdown Alleviates Diabetes Mellitus-Induced Retinal Ganglion Cell (RGC) injury

(2016) Chao-Peng Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Therapeutic targeting of diabetic retinal neuropathy as a strategy in preventing diabetic retinopathy

(2016) Gabriela de Moraes et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Localization of Acrolein-Lysine Adduct in Fibrovascular Tissues of Proliferative Diabetic Retinopathy

(2016) Yoko Dong et al.   CURRENT EYE RESEARCH

Global Estimates on the Number of People Blind or Visually Impaired by Diabetic Retinopathy: A Meta-analysis From 1990 to 2010

(2016) Janet L. Leasher et al.   DIABETES CARE

Nap Interferes with Hypoxia-Inducible Factors and VEGF Expression in Retina of Diabetic Rats

(2016) Agata Grazia D’Amico et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

p75NTR and Its Ligand ProNGF Activate Paracrine Mechanisms Etiological to the Vascular, Inflammatory, and Neurodegenerative Pathologies of Diabetic Retinopathy

(2016) P. F. Barcelona et al.   JOURNAL OF NEUROSCIENCE

Vascular Changes and Neurodegeneration in the Early Stages of Diabetic Retinopathy: Which Comes First?

(2016) Karoline Boegeberg Jonsson et al.   OPHTHALMIC RESEARCH

Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury

(2016) Esraa Shosha et al.   Cell Death & Disease

Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease

(2015) Akshata Moghe et al.   TOXICOLOGICAL SCIENCES

Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury

(2015) T Noro et al.   Cell Death & Disease

Neurodegeneration as a Primary Change and Role of Neuroprotection in Diabetic Retinopathy

(2014) Vishal Jindal   MOLECULAR NEUROBIOLOGY

Edaravone Protect against Retinal Damage in Streptozotocin-Induced Diabetic Mice

(2014) Dongqing Yuan et al.   PLoS One

Loss of Synaptic Connectivity, Particularly in Second Order Neurons Is a Key Feature of Diabetic Retinal Neuropathy in the Ins2Akita Mouse

(2014) Jose R. Hombrebueno et al.   PLoS One

Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism

(2014) S P Narayanan et al.   Cell Death & Disease

Interrelationships between the Retinal Neuroglia and Vasculature in Diabetes

(2014) Timothy S. Kern   Diabetes & Metabolism Journal

A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity

(2013) Caterina Capone et al.   FREE RADICAL BIOLOGY AND MEDICINE

A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury

(2013) Manuela Cervelli et al.   PLoS One

Requirement of NOX2 Expression in Both Retina and Bone Marrow for Diabetes-Induced Retinal Vascular Injury

(2013) Modesto Rojas et al.   PLoS One

Arginase as a mediator of diabetic retinopathy

(2013) Chintan Patel   Frontiers in Immunology

A Possible Role of Acrolein in Diabetic Retinopathy: Involvement of a VEGF/TGFβ Signaling Pathway of the Retinal Pigment Epithelium in Hyperglycemia

(2012) Jeffery Grigsby et al.   CURRENT EYE RESEARCH

Global Prevalence and Major Risk Factors of Diabetic Retinopathy

(2012) J. W. Y. Yau et al.   DIABETES CARE

Inhibition of acetylpolyamine and spermine oxidases by the polyamine analogue chlorhexidine

(2012) Manuela Cervelli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Exclusion of aldose reductase as a mediator of ERG deficits in a mouse model of diabetic eye disease

(2012) IVY S. SAMUELS et al.   VISUAL NEUROSCIENCE

Spermine oxidase: ten years after

(2011) Manuela Cervelli et al.   AMINO ACIDS

Inner retinal visual dysfunction is a sensitive marker of non-proliferative diabetic retinopathy

(2011) Gregory R Jackson et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Arginase 2 Deletion Reduces Neuro-Glial Injury and Improves Retinal Function in a Model of Retinopathy of Prematurity

(2011) Subhadra P. Narayanan et al.   PLoS One

Polyamine patterns in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy

(2010) Man-Jeong Paik et al.   CLINICA CHIMICA ACTA

Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy

(2010) Hille W. van Dijk et al.   VISION RESEARCH

Polyamine Catabolism Is Enhanced after Traumatic Brain Injury

(2009) Kamyar Zahedi et al.   JOURNAL OF NEUROTRAUMA

Mitochondria- and caspase-dependent cell death pathway involved in neuronal degeneration in diabetic retinopathy

(2008) T Oshitari et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Near complete loss of retinal ganglion cells in the math5/brn3b double knockout elicits severe reductions of other cell types during retinal development

(2008) Ala Moshiri et al.   DEVELOPMENTAL BIOLOGY

Evaluation of N ε-(3-formyl-3,4-dehydropiperidino)lysine as a novel biomarker for the severity of diabetic retinopathy

(2008) X. Zhang et al.   DIABETOLOGIA

Retinal ganglion cells in diabetes

(2008) Timothy S. Kern et al.   JOURNAL OF PHYSIOLOGY-LONDON

Vascular endothelial growth factor in eye disease

(2008) J.S. Penn et al.   PROGRESS IN RETINAL AND EYE RESEARCH