Mechanisms of acrolein induces toxicity in human umbilical vein endothelial cells: Oxidative stress, DNA damage response, and apoptosis

Homoharringtonine inhibits melanoma cells proliferation in vitro and vivo by inducing DNA damage, apoptosis, and G2/M cell cycle arrest

(2021) Jia-feng Tang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Exploring the Potential Mechanism of Costunolide‐Induced MCF‐7 Cells Apoptosis by Multi‐Spectroscopy, Molecular Docking and Cell Experiments

(2021) Dan Liu et al.   CHEMISTRY & BIODIVERSITY

Zinc oxide nanoparticle-triggered oxidative stress and autophagy activation in human tenon fibroblasts

(2021) Dadong Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Micro- and nanoscale biophysical cues for cardiovascular disease therapy

(2021) Priya Mohindra et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK

(2020) Chunfeng Xie et al.   JOURNAL OF HAZARDOUS MATERIALS

The NADPH oxidase 4 protects vascular endothelial cells from copper oxide nanoparticles-induced oxidative stress and cell death

(2020) Hui He et al.   LIFE SCIENCES

Ablation of TMEM126B protects against oxygen-glucose deprivation/reoxygenation-induced injuries of PC12 cells via maintaining mitochondrial anti-apoptotic functions

(2020) Lihong Wei et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

New chalcone-tethered 1,3,5-triazines potentiate the anticancer effect of cisplatin against human lung adenocarcinoma A549 cells by enhancing DNA damage and cell apoptosis

(2020) Marwa H. El-Wakil et al.   BIOORGANIC CHEMISTRY

A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas/FasL pathway

(2020) Jiayue Gao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Oxidative stress, cell cycle arrest, DNA damage and apoptosis in the mud crab (Scylla paramamosain) induced by cadmium exposure

(2020) Chang-Hong Cheng et al.   CHEMOSPHERE

Morin decreases acrolein-induced cell injury in normal human hepatocyte cell line LO2

(2020) Zhao Yin et al.   Journal of Functional Foods

Tinospora cordifolia ameliorated titanium dioxide nanoparticle-induced toxicity via regulating oxidative stress-activated MAPK and NRF2/Keap1 signaling pathways in Nile tilapia (Oreochromis niloticus)

(2020) Vadavanath Prabhakaran Vineetha et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

In vitro dosimetry analyses for acrolein exposure in normal human lung epithelial cells and human lung cancer cells

(2020) Rui Xiong et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein

(2019) Menglan Chen et al.   PLoS One

Toxic effects of Cr(VI) on the bovine hemoglobin and human vascular endothelial cells: Molecular interaction and cell damage

(2019) Xiangyu Cao et al.   CHEMOSPHERE

Mechanisms behind the atherothrombotic effects of acrolein, a review

(2019) Mohammad Reza Zirak et al.   FOOD AND CHEMICAL TOXICOLOGY

Clock-Bmal1 mediates MMP9 induction in acrolein-promoted atherosclerosis associated with gut microbiota regulation

(2019) Xiaoyue Wu et al.   ENVIRONMENTAL POLLUTION

The protective effects of a novel polysaccharide from Lentinus edodes mycelia on islet β (INS-1) cells damaged by glucose and its transportation mechanism with human serum albumin

(2019) Xiang-yu Cao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Reactive Carbonyl Species: Diabetic Complication in the Heart and Lungs

(2019) Cheng-ju Tian et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Polyphenols: Major regulators of key components of DNA damage response in cancer

(2019) Maryam Majidinia et al.   DNA REPAIR

Poly(ADP-Ribose) Polymerase-1 inhibition potentiates cell death and phosphorylation of DNA damage response proteins in oxidative stressed retinal cells

(2019) Sandra M. Martín-Guerrero et al.   EXPERIMENTAL EYE RESEARCH

The active components derived from Penthorum chinense Pursh protect against oxidative-stress-induced vascular injury via autophagy induction

(2019) Xiaolei Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Scavenging activity and mechanism study of ferulic acid against reactive carbonyl species acrolein

(2019) Zhi-hao Tao et al.   Journal of Zhejiang University-SCIENCE B

Usnic acid induces apoptosis in human gastric cancer cells through ROS generation and DNA damage and causes up-regulation of DNA-PKcs and γ-H2A.X phosphorylation

(2019) Kunal Kumar et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway

(2019) Xiaoman Xie et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

BDE-209 induces male reproductive toxicity via cell cycle arrest and apoptosis mediated by DNA damage response signaling pathways

(2019) Xiangyang Li et al.   ENVIRONMENTAL POLLUTION

Acrolein-induced apoptosis of smooth muscle cells through NEAT1-Bmal1/Clock pathway and a protection from asparagus extract

(2019) Lijun Chen et al.   ENVIRONMENTAL POLLUTION

Sirt3 confers protection against acrolein-induced oxidative stress in cochlear nucleus neurons

(2018) Juan Qu et al.   NEUROCHEMISTRY INTERNATIONAL

Acrolein induces NLRP3 inflammasome-mediated pyroptosis and suppresses migration via ROS-dependent autophagy in vascular endothelial cells

(2018) Chunteng Jiang et al.   TOXICOLOGY

Endosulfan induces autophagy and endothelial dysfunction via the AMPK/mTOR signaling pathway triggered by oxidative stress

(2017) Lianshuang Zhang et al.   ENVIRONMENTAL POLLUTION

Assessment of genotoxicity of four volatile pollutants from cigarette smoke based on the in vitro γH2AX assay using high content screening

(2017) Sen Zhang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Melatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways

(2017) Maryam Majidinia et al.   JOURNAL OF PINEAL RESEARCH

Endosulfan induces cell dysfunction through cycle arrest resulting from DNA damage and DNA damage response signaling pathways

(2017) Jialiu Wei et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway

(2017) Peng Chu et al.   VASCULAR PHARMACOLOGY

Sodium fluoride causes hepatocellular S-phase arrest by activating ATM-p53-p21 and ATR-Chk1-Cdc25A pathways in mice

(2017) Huan Liu et al.   Oncotarget

Curcumin induces G2/M cell cycle arrest and apoptosis of head and neck squamous cell carcinoma in vitro and in vivo through ATM/Chk2/p53-dependent pathway

(2017) An Hu et al.   Oncotarget

Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies

(2017) Xinyu Yang et al.   Frontiers in Physiology

Resveratrol enhances the efficacy of sorafenib mediated apoptosis in human breast cancer MCF7 cells through ROS, cell cycle inhibition, caspase 3 and PARP cleavage

(2016) Arindam Mondal et al.   BIOMEDICINE & PHARMACOTHERAPY

c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease

(2016) Ramon Yarza et al.   Frontiers in Pharmacology

Gene networks and toxicity pathways induced by acute cadmium exposure in adult largemouth bass (Micropterus salmoides)

(2014) Alvine C. Mehinto et al.   AQUATIC TOXICOLOGY

Role of Flow-Sensitive microRNAs in Endothelial Dysfunction and Atherosclerosis

(2014) Sandeep Kumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells

(2014) Haifeng Hou et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

DNA Damage Response Genes and the Development of Cancer Metastasis

(2014) Constantinos G. Broustas et al.   RADIATION RESEARCH

Reactive Carbonyl SpeciesIn Vivo: Generation and Dual Biological Effects

(2014) Halyna M. Semchyshyn   TheScientificWorldJOURNAL

Airborne acrolein induces keratin-8 (Ser-73) hyperphosphorylation and intermediate filament ubiquitination in bronchiolar lung cell monolayers

(2014) Philip C. Burcham et al.   TOXICOLOGY

Aldose reductase regulates acrolein-induced cytotoxicity in human small airway epithelial cells

(2013) Umesh C.S. Yadav et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells

(2013) Yingjuan Huang et al.   NEUROSCIENCE LETTERS

Augmented glutathione synthesis decreases acrolein toxicity

(2012) Hideyuki Tomitori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reactive carbonyl species: Their production from lipid peroxides, action in environmental stress, and the detoxification mechanism

(2012) Jun’ichi Mano   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Acrolein cytotoxicity in hepatocytes involves endoplasmic reticulum stress, mitochondrial dysfunction and oxidative stress

(2012) Mohammad K. Mohammad et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Colony-forming assays reveal enhanced suppression of hepatitis C virus replication using combinations of direct-acting antivirals

(2011) Emily J.S. Graham et al.   JOURNAL OF VIROLOGICAL METHODS

Acrolein - a pulmonary hazard

(2011) Kiflai Bein et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Environmental Risk Factors for Heart Disease

(2011) T.E. O'Toole et al.   REVIEWS ON ENVIRONMENTAL HEALTH

Particulate Matter Air Pollution and Cardiovascular Disease

(2010) Robert D. Brook et al.   CIRCULATION

Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells

(2009) Julie Roy et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease

(2008) Jan F. Stevens et al.   MOLECULAR NUTRITION & FOOD RESEARCH