Origin and Fate of Acrolein in Foods

Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction

(2021) Rongfeng Zhu et al.   Nature Communications

Catechins in green tea powder (matcha) are heat-stable scavengers of acrolein, a lipid peroxide-derived reactive carbonyl species

(2021) Koichi Sugimoto et al.   FOOD CHEMISTRY

Cytotoxicity of adducts formed between quercetin and methylglyoxal in PC-12 cells

(2021) Pengzhan Liu et al.   FOOD CHEMISTRY

Acrolein-conjugated proteomics in brains of adult C57BL/6 mice chronically exposed to acrolein and aged APP/PS1 transgenic AD mice

(2021) Chen Chen et al.   TOXICOLOGY LETTERS

Acrolein contributes to human colorectal tumorigenesis through the activation of RAS-MAPK pathway

(2021) Hong-Chieh Tsai et al.   Scientific Reports

Identification of adducts formed between acrolein and alanine or serine in fried potato crisps and the cytotoxicity-lowering effect of acrolein in three cell lines

(2021) Zhaojia Zou et al.   FOOD CHEMISTRY

Glycine and serine markedly eliminate methylglyoxal in the presence of formaldehyde via the formation of imidazole salts

(2021) Jiaman Hu et al.   FOOD CHEMISTRY

Inhibitory Effect on Acrolein by Cyanidin-3-O-glucoside and Its Acrolein Adducts from the Pigment of Mynica Red

(2021) Xiaoli Song et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Acrolein contributes to urothelial carcinomas in patients with chronic kidney disease

(2020) Jian-Hua Hong et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Albumin Protects Lung Cells against Acrolein Cytotoxicity and Acrolein-Adducted Albumin Increases Heme Oxygenase 1 Transcripts

(2020) Kiflai Bein et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Identification of Precursors and Formation Pathway for the Heterocyclic Aromatic Amine 2-Amino-3-methylimidazo(4,5-f)quinoline (IQ)

(2020) Rosario Zamora et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Acrolein Trapping Mechanism of Theophylline in Green Tea, Coffee and Cocoa: Speedy and Successful

(2020) Xiaoyun Jiang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structural change and degradation of cytoskeleton due to the acrolein conjugation with vimentin and actin during brain infarction

(2020) Takeshi Uemura et al.   Cytoskeleton

Mechanistic studies of inhibition on acrolein by myricetin

(2020) Dingmin Zhang et al.   FOOD CHEMISTRY

Analysis of the acrolein-modified sites of apolipoprotein B-100 in LDL

(2020) Mizuki Kobayashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Trapping of Acrolein by Curcumin and the Synergistic Inhibition Effect of Curcumin Combined with Quercetin

(2020) Xiaoyun Jiang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Trapping Acrolein by Theophylline/Caffeine and Their Metabolites from Green Tea and Coffee in Mice and Humans

(2020) Xiaoyun Jiang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Quantitative Determination of Acrolein in Cider by 1H NMR Spectrometry

(2020) Enaitz de las Heras et al.   Foods

Identification of acrolein as the reactive carbonyl responsible for the formation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)

(2020) Francisco J. Hidalgo et al.   FOOD CHEMISTRY

Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein

(2019) Ying Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Analysis of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human lung DNA from smokers and non-smokers

(2019) Jing Yang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Exposure risk to carbonyl compounds and furfuryl alcohol through the consumption of sparkling wines

(2019) Gabriela Pelizza Peterle et al.   CIENCIA RURAL

Acrolein is involved in the synergistic potential of cigarette smoking- and betel quid chewing-related human oral cancer.

(2019) Hsiang-Tsui Wang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Assessing acrolein for determination of the severity of brain stroke, dementia, renal failure, and Sjögren's syndrome

(2019) Kazuei Igarashi et al.   AMINO ACIDS

Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation

(2019) Jianbo Zhang et al.   BMC MICROBIOLOGY

Inhibition of dendritic spine extension through acrolein conjugation with α-, β-tubulin proteins

(2019) Takeshi Uemura et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Oligomerization of reactive carbonyls in the presence of ammonia-producing compounds: A route for the production of pyridines in foods

(2019) Rosario Zamora et al.   FOOD CHEMISTRY

Short-chain lipid peroxidation products form covalent adducts with pyruvate kinase and inhibit its activity in vitro and in breast cancer cells

(2019) Bebiana C. Sousa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Scavenging of Acrolein by Food-Grade Antioxidant Propyl Gallate in a Model Reaction System and Cakes

(2019) Jiaqi Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Acrolein-mediated alpha-synuclein pathology involvement in the early post-injury pathogenesis of mild blast-induced Parkinsonian neurodegeneration

(2019) Glen Acosta et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The relationship between acrolein and oxidative stress in COPD: in systemic plasma and in local lung tissue

(2019) Masanori Yasuo et al.   International Journal of Chronic Obstructive Pulmonary Disease

A Simple HS-SPME/GC-MS Method for Determination of Acrolein from Sourdough to Bread

(2019) Saša Drakula et al.   Food Analytical Methods

Cellular Uptake and Clearance of Oxidatively-modified Apolipoprotein E3 by Cerebral Cortex Endothelial Cells

(2019) Siobanth Cruz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Validation of an analytical method using HS-SPME-GC/MS-SIM to assess the exposure risk to carbonyl compounds and furan derivatives through beer consumption

(2019) Karolina C. Hernandes et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Formation of di-cysteine acrolein adduct decreases cytotoxicity of acrolein by ROS alleviation and apoptosis intervention

(2019) Zhao Yin et al.   JOURNAL OF HAZARDOUS MATERIALS

Scavenging activity and mechanism study of ferulic acid against reactive carbonyl species acrolein

(2019) Zhi-hao Tao et al.   Journal of Zhejiang University-SCIENCE B

Translating In Vitro Acrolein‐Trapping Capacities of Tea Polyphenol and Soy Genistein to In Vivo Situation is Mediated by the Bioavailability and Biotransformation of Individual Polyphenols

(2019) Qiju Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Bitterness in alcoholic beverages: The profiles of perception, constituents, and contributors

(2019) Yi Luo et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

A mass spectrometry approach for the identification and localization of small aldehyde modifications of proteins

(2018) Catarina B. Afonso et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cigarette smoke modifies and inactivates SPLUNC1, leading to airway dehydration

(2018) Patrick J. Moore et al.   FASEB JOURNAL

Acrolein, a commonly found environmental toxin, causes oocyte mitochondrial dysfunction and negatively affects embryo development

(2018) Roohi Jeelani et al.   FREE RADICAL RESEARCH

Acrolein as a Major Volatile in the Early Stages of Fish Oil TAG Oxidation

(2018) Ako Shibata et al.   Journal of Oleo Science

Gut Microbial Glycerol Metabolism as an Endogenous Acrolein Source

(2018) Jianbo Zhang et al.   mBio

Development of a Method for Determination of Target Toxic Carbonyl Compounds in Must and Wine Using HS-SPME-GC/MS-SIM After Preliminary GC×GC/TOFMS Analyses

(2018) Daiani Cecchin Ferreira et al.   Food Analytical Methods

Adducts formed during protein digestion decreased the toxicity of five carbonyl compounds against Caco-2 cells

(2018) Kaiyu Jiang et al.   JOURNAL OF HAZARDOUS MATERIALS

Phenelzine: An Old Drug That May Hold Clues to The Development of New Neuroprotective Agents

(2018) Erin M. MacKenzie et al.   KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY

Evaluation of carbonyl species in fish oil: An improved LC–MS/MS method

(2017) Joon Hyuk Suh et al.   FOOD CONTROL

Activation of MMP-9 activity by acrolein in saliva from patients with primary Sjögren’s syndrome and its mechanism

(2017) Takeshi Uemura et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Gut Microbial Transformation of the Dietary Imidazoquinoxaline Mutagen MelQx Reduces Its Cytotoxic and Mutagenic Potency

(2017) Jianbo Zhang et al.   TOXICOLOGICAL SCIENCES

Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke

(2017) Rina Takamiya et al.   Scientific Reports

Effects of various roasting conditions on acrylamide, acrolein, and polycyclic aromatic hydrocarbons content in cocoa bean and the derived chocolates

(2016) Dorota Żyżelewicz et al.   DRYING TECHNOLOGY

Acrolein metabolites, diabetes and insulin resistance

(2016) Aliya G. Feroe et al.   ENVIRONMENTAL RESEARCH

Albumin Cys34 adducted by acrolein as a marker of oxidative stress in ischemia-reperfusion injury during hepatectomy

(2016) Ewa Witort et al.   FREE RADICAL RESEARCH

Mechanisms Underlying Acrolein-Mediated Inhibition of Chromatin Assembly

(2016) Lei Fang et al.   MOLECULAR AND CELLULAR BIOLOGY

Nucleotide excision repair deficiency increases levels of acrolein-derived cyclic DNA adduct and sensitizes cells to apoptosis induced by docosahexaenoic acid and acrolein

(2016) Jishen Pan et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The tobacco smoke component acrolein induces glucocorticoid resistant gene expression via inhibition of histone deacetylase

(2016) Matthew J. Randall et al.   TOXICOLOGY LETTERS

1,5-Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid-β(1-40) Fibrillization

(2016) Ayumi Tsutsui et al.   Advanced Science

Covalent modification of DNA by α, β-unsaturated aldehydes derived from lipid peroxidation: Recent progress and challenges

(2015) X. Wei et al.   FREE RADICAL RESEARCH

Scavenging of Toxic Acrolein by Resveratrol and Hesperetin and Identification of Adducts

(2015) Weixin Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Formation of Acrolein in the Autoxidation of Triacylglycerols with Different Fatty Acid Compositions

(2015) Ako Shibata et al.   JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY

Acrolein- and 4-Aminobiphenyl-DNA adducts in human bladder mucosa and tumor tissue and their mutagenicity in human urothelial cells

(2015) Hyun-Wook Lee et al.   Oncotarget

Isotope-Labeling Studies on the Formation Pathway of Acrolein during Heat Processing of Oils

(2014) Alice Ewert et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: a previously unrecognized mechanism for acrolein-mediated oxidative stress

(2014) Ayumi Tsutsui et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Acrolein induced both pulmonary inflammation and the death of lung epithelial cells

(2014) Yang Sun et al.   TOXICOLOGY LETTERS

Acrolein Modification Impairs Key Functional Features of Rat Apolipoprotein E: Identification of Modified Sites by Mass Spectrometry

(2013) Tuyen N. Tran et al.   BIOCHEMISTRY

Using SPME-GC/MS to Evaluate Acrolein Production in Cassava and Pork Sausage Fried in Different Vegetable Oils

(2013) Vanessa Moreira Osório et al.   JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY

Linolenic Acid as the Main Source of Acrolein Formed During Heating of Vegetable Oils

(2013) Yasushi Endo et al.   JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY

Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo

(2013) Ying-Juan Huang et al.   TOXICOLOGY LETTERS

Inactivation of GAPDH as one mechanism of acrolein toxicity

(2012) Mizuho Nakamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regioselective Formation of Acrolein-Derived Cyclic 1,N2-Propanodeoxyguanosine Adducts Mediated by Amino Acids, Proteins, and Cell Lysates

(2012) Fung-Lung Chung et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Quantitative Analysis of Acrolein-Specific Adducts Generated during Lipid Peroxidation–Modification of Proteins in Vitro: Identification of Nτ-(3-Propanal)histidine as the Major Adduct

(2012) Takuya Maeshima et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Comparative Review of Petroleum-Based and Bio-Based Acrolein Production

(2012) Lu Liu et al.   ChemSusChem

Urinary biomarkers of oxidative status

(2012) Dora Il'yasova et al.   CLINICA CHIMICA ACTA

In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple

(2012) Qin Zhu et al.   FOOD CHEMISTRY

Profiling of mercapturic acids of acrolein and acrylamide in human urine after consumption of potato crisps*

(2012) Nico Watzek et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Tobacco Smoke Component, Acrolein, Suppresses Innate Macrophage Responses by Direct Alkylation of c-Jun N-Terminal Kinase

(2011) Milena Hristova et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Development of Two Stable Isotope Dilution Assays for the Quantitation of Acrolein in Heat-Processed Fats

(2011) Alice Ewert et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chemical and sensory changes in fresh cider spirits during maturation in inert containers

(2011) Roberto Rodríguez Madrera et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Acrolein induced DNA damage, mutagenicity and effect on DNA repair

(2011) Moon-shong Tang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Toxicology and risk assessment of acrolein in food

(2011) Klaus Abraham et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Analysis of Acrolein-Derived 1,N2-Propanodeoxyguanosine Adducts in Human Leukocyte DNA from Smokers and Nonsmokers

(2010) Siyi Zhang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

MESNA for chemically assisted tissue dissection

(2010) Manuele Casale et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Investigation of Reactive α-Dicarbonyl Compounds Generated from the Maillard Reactions ofl-Methionine with Reducing Sugars via Their Stable Quinoxaline Derivatives

(2010) Yvonne V. Pfeifer et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mutagenicity of acrolein and acrolein-induced DNA adducts

(2010) Xing-yu Liu et al.   TOXICOLOGY MECHANISMS AND METHODS

Edaravone Inhibits Protein Carbonylation by a Direct Carbonyl-Scavenging Mechanism: Focus on Reactivity, Selectivity, and Reaction Mechanisms

(2009) Giancarlo Aldini et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of acrolein-conjugated protein in plasma of patients with brain infarction

(2009) Madoka Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Natural Polyphenols as Direct Trapping Agents of Lipid Peroxidation-Derived Acrolein and 4-Hydroxy-trans-2-nonenal

(2009) Qin Zhu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Protein Modification by Acrolein: Formation and Stability of Cysteine Adducts

(2009) Jian Cai et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Acrolein scavenging: a potential novel mechanism of attenuating oxidative stress following spinal cord injury

(2009) Kristin Hamann et al.   JOURNAL OF NEUROCHEMISTRY

Acrolein toxicity: Comparison with reactive oxygen species

(2008) Madoka Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Potentialities and Pitfalls Accompanying Chemico-Pharmacological Strategies against Endogenous Electrophiles and Carbonyl Stress

(2008) Philip C. Burcham   CHEMICAL RESEARCH IN TOXICOLOGY

Acrolein sequestering ability of the endogenous tripeptide glycyl-histidyl-lysine (GHK): Characterization of conjugation products by ESI-MSn and theoretical calculations

(2008) Giangiacomo Beretta et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease

(2008) Jan F. Stevens et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Carbohydrate pyrolysis mechanisms from isotopic labeling

(2007) John B. Paine et al.   JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS