Galectin-1: A Traditionally Immunosuppressive Protein Displays Context-Dependent Capacities

Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden

(2022) Julia Femel et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Galectin-1 orchestrates an inflammatory tumor-stroma crosstalk in hepatoma by enhancing TNFR1 protein stability and signaling in carcinoma-associated fibroblasts

(2022) Yao-Tsung Tsai et al.   ONCOGENE

Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin

(2021) Ashley J. Russo et al.   NATURE IMMUNOLOGY

An Antibody-like Polymeric Nanoparticle Removes Intratumoral Galectin-1 to Enhance Antitumor T-Cell Responses in Cancer Immunotherapy

(2021) Yu Gu et al.   ACS Applied Materials & Interfaces

Galectin-1 fosters an immunosuppressive microenvironment in colorectal cancer by reprogramming CD8+ regulatory T cells

(2021) Alejandro J. Cagnoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor

(2021) Brendan D Curti et al.   Journal for ImmunoTherapy of Cancer

A minigene DNA vaccine encoding peptide epitopes derived from Galectin-1 has protective antitumoral effects in a model of neuroblastoma

(2021) Laura Liebscher et al.   CANCER LETTERS

Enhanced Susceptibility of Galectin-1 Deficient Mice to Experimental Colitis

(2021) Raquel Fernandez-Perez et al.   Frontiers in Immunology

Glycan–Lectin Interactions in Cancer and Viral Infections and How to Disrupt Them

(2021) Stefanie Maria Kremsreiter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Galectin-1 Cooperates with Yersinia Outer Protein (Yop) P to Thwart Protective Immunity by Repressing Nitric Oxide Production

(2021) Brenda Lucila Jofre et al.   Biomolecules

Oligo-Fucoidan Prevents M2 Macrophage Differentiation and HCT116 Tumor Progression

(2020) Li-Mei Chen et al.   Cancers

The therapeutic potential of galectin-1 and galectin-3 in the treatment of neurodegenerative diseases

(2020) Eleazar Ramírez Hernández et al.   Expert Review of Neurotherapeutics

Oligosaccharide‐dependent anti‐inflammatory role of galectin‐1 for macrophages in ulcerative colitis

(2020) Shuko Iwatani et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Angiostrongylus cantonensis Galectin-1 interacts with Annexin A2 to impair the viability of macrophages via activating JNK pathway

(2020) Xiaomeng Shi et al.   Parasites & Vectors

Suppression of age-related salivary gland autoimmunity by glycosylation-dependent galectin-1-driven immune inhibitory circuits

(2020) Verónica C. Martínez Allo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of a neutralizing anti-human galectin-1 monoclonal antibody with angioregulatory and immunomodulatory activities

(2020) Juan M. Pérez Sáez et al.   ANGIOGENESIS

Galectin-1 Expression in CD8+ T Lymphocytes Controls Inflammation in Contact Hypersensitivity

(2020) Raquel Castillo-González et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Immunogenomic analysis reveals LGALS1 contributes to the immune heterogeneity and immunosuppression in glioma

(2019) Qun Chen et al.   INTERNATIONAL JOURNAL OF CANCER

Anti-inflammatory Property of Galectin-1 in a Murine Model of Allergic Airway Inflammation

(2019) Yunxiang Lv et al.   Journal of Immunology Research

Altered Cell Surface N-Glycosylation of Resting and Activated T Cells in Systemic Lupus Erythematosus

(2019) Enikő Szabó et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Galectin-1–driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance

(2019) Dhanya K. Nambiar et al.   JOURNAL OF CLINICAL INVESTIGATION

Galectin-1 promotes hepatocellular carcinoma and the combined therapeutic effect of OTX008 galectin-1 inhibitor and sorafenib in tumor cells

(2019) Zoe Leung et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Ginseng-derived nanoparticles alter macrophage polarization to inhibit melanoma growth

(2019) Meng Cao et al.   Journal for ImmunoTherapy of Cancer

Effects of Belapectin, an Inhibitor of Galectin-3, in Patients With Nonalcoholic Steatohepatitis With Cirrhosis and Portal Hypertension

(2019) Naga Chalasani et al.   GASTROENTEROLOGY

Galectin-1 modulation of neutrophil reactive oxygen species production depends on the cell activation state

(2019) Lílian C. Rodrigues et al.   MOLECULAR IMMUNOLOGY

A DNA Aptamer Targeting Galectin-1 as a Novel Immunotherapeutic Strategy for Lung Cancer

(2019) Yao-Tsung Tsai et al.   Molecular Therapy-Nucleic Acids

Galectin-1 Restores Immune Tolerance to Liver Transplantation Through Activation of Hepatic Stellate Cells

(2018) Zhi-Jun Jiang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Targeting Galectin-1 Impairs Castration-Resistant Prostate Cancer Progression and Invasion

(2018) Tsung-Chieh Shih et al.   CLINICAL CANCER RESEARCH

Dissecting the Structure–Activity Relationship of Galectin–Ligand Interactions

(2018) Yi-Chen Chan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Galectins in Tumors and in Clinical Immunotherapy

(2018) Feng-Cheng Chou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Galectin Targeted Therapy in Oncology: Current Knowledge and Perspectives

(2018) Kamil Wdowiak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor–stroma crosstalk

(2018) Carlos A. Orozco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysfunctional immunoregulation in human liver allograft rejection associated with compromised galectin-1/CD7 pathway function

(2018) Sidong Wei et al.   Cell Death & Disease

Galectin-1 enhances TNFα-induced inflammatory responses in Sertoli cells through activation of MAPK signalling

(2018) Tao Lei et al.   Scientific Reports

Utility and variability of three non-invasive liver fibrosis imaging modalities to evaluate efficacy of GR-MD-02 in subjects with NASH and bridging fibrosis during a phase-2 randomized clinical trial

(2018) Stephen A. Harrison et al.   PLoS One

Endogenous Galectin-1 in T Lymphocytes Regulates Anti-prostate Cancer Immunity

(2018) Enrique Corapi et al.   Frontiers in Immunology

Galectin-1-induced tolerogenic dendritic cells combined with apoptotic lymphocytes prolong liver allograft survival

(2018) Yifan Peng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Galectin–Carbohydrate Interactions in Biomedicine and Biotechnology

(2018) Dominic Laaf et al.   TRENDS IN BIOTECHNOLOGY

Galectin-1 Inhibitor OTX008 Induces Tumor Vessel Normalization and Tumor Growth Inhibition in Human Head and Neck Squamous Cell Carcinoma Models

(2017) Nathan Koonce et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Galectin-1–Driven Tolerogenic Programs AggravateYersinia enterocoliticaInfection by Repressing Antibacterial Immunity

(2017) Roberto C. Davicino et al.   JOURNAL OF IMMUNOLOGY

Galectin-1: A Jack-of-All-Trades in the Resolution of Acute and Chronic Inflammation

(2017) Victoria Sundblad et al.   JOURNAL OF IMMUNOLOGY

Serum galectin-1 in patients with multiple myeloma: associations with survival, angiogenesis, and biomarkers of macrophage activation

(2017) Morten N Andersen et al.   OncoTargets and Therapy

Tumor-derived exosomes induce CD8+ T cell suppressors

(2017) Brian T. Maybruck et al.   Journal for ImmunoTherapy of Cancer

Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy

(2017) Matthias Van Woensel et al.   Scientific Reports

Randomised clinical study: GR-MD-02, a galectin-3 inhibitor, vs. placebo in patients having non-alcoholic steatohepatitis with advanced fibrosis

(2016) S. A. Harrison et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Reversal of galectin-1 gene silencing on resistance to cisplatin in human lung adenocarcinoma A549 cells

(2016) Lei Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Galectin-1 is essential for the induction of MOG35-55-based intravenous tolerance in experimental autoimmune encephalomyelitis

(2016) Elisabeth R. Mari et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Murine Sertoli cells promote the development of tolerogenic dendritic cells: a pivotal role of galectin-1

(2016) Jianxin Gao et al.   IMMUNOLOGY

Development of siRNA-loaded chitosan nanoparticles targeting Galectin-1 for the treatment of glioblastoma multiforme via intranasal administration

(2016) Matthias Van Woensel et al.   JOURNAL OF CONTROLLED RELEASE

Galectin-1 Couples Glycobiology to Inflammation in Osteoarthritis through the Activation of an NF-κB–Regulated Gene Network

(2016) Stefan Toegel et al.   JOURNAL OF IMMUNOLOGY

Galectin-1 circumvents lysolecithin-induced demyelination through the modulation of microglial polarization/phagocytosis and oligodendroglial differentiation

(2016) Mariana Rinaldi et al.   NEUROBIOLOGY OF DISEASE

Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1

(2016) Xiao Na Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic Cells and Cancer Immunity

(2016) Alycia Gardner et al.   TRENDS IN IMMUNOLOGY

Immunomodulatory Effects of Galectin-1 on an IgE-Mediated Allergic Conjunctivitis Model

(2015) C. B. Mello et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Glycans and glycan-binding proteins in immune regulation: A concise introduction to glycobiology for the allergist

(2015) Ronald L. Schnaar   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Galectin-1 Regulates Tissue Exit of Specific Dendritic Cell Populations

(2015) Sandra Thiemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation Controls Sensitivity of Human and Mouse Intestinal Epithelial Cells to Galectin-1

(2015) Cecilia I. Muglia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Trypanosoma cruziInfection Imparts a Regulatory Program in Dendritic Cells and T Cells via Galectin-1–Dependent Mechanisms

(2015) Carolina V. Poncini et al.   JOURNAL OF IMMUNOLOGY

Dual roles of endogenous and exogenous galectin-1 in the control of testicular immunopathology

(2015) Cecilia V. Pérez et al.   Scientific Reports

Natural Killer Cells Eradicate Galectin-1-Deficient Glioma in the Absence of Adaptive Immunity

(2014) G. J. Baker et al.   CANCER RESEARCH

A Short Treatment with Galactomannan GM-CT-01 Corrects the Functions of Freshly Isolated Human Tumor-Infiltrating Lymphocytes

(2014) N. Demotte et al.   CLINICAL CANCER RESEARCH

Integration of lectin–glycan recognition systems and immune cell networks in CNS inflammation

(2014) Santiago P. Mendez-Huergo et al.   CYTOKINE & GROWTH FACTOR REVIEWS

OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis

(2014) Lucile Astorgues-Xerri et al.   EUROPEAN JOURNAL OF CANCER

Galectin-1 and -9 in angiogenesis: A sweet couple

(2014) V. L. Thijssen et al.   GLYCOBIOLOGY

Structural basis of redox-dependent modulation of galectin-1 dynamics and function

(2014) Carlos M Guardia et al.   GLYCOBIOLOGY

Differential Roles of Galectin-1 and Galectin-3 in Regulating Leukocyte Viability and Cytokine Secretion

(2014) S. R. Stowell et al.   JOURNAL OF IMMUNOLOGY

Timing of Galectin-1 Exposure Differentially Modulates Nipah Virus Entry and Syncytium Formation in Endothelial Cells

(2014) Omai B. Garner et al.   JOURNAL OF VIROLOGY

The Leukocyte Activation Receptor CD69 Controls T Cell Differentiation through Its Interaction with Galectin-1

(2014) H. de la Fuente et al.   MOLECULAR AND CELLULAR BIOLOGY

Galectin-1 Exerts Inhibitory Effects during DENV-1 Infection

(2014) Karina Alves Toledo et al.   PLoS One

A New Human 3D-Liver Model Unravels the Role of Galectins in Liver Infection by the Parasite Entamoeba histolytica

(2014) Debora B. Petropolis et al.   PLoS Pathogens

Galectin-1 Prolongs Survival of Mouse Liver Allografts From Flt3L-Pretreated Donors

(2013) Y. Ye et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Involvement of galectin-1 in reproduction: past, present and future

(2013) Gabriela Barrientos et al.   HUMAN REPRODUCTION UPDATE

Glioma-derived galectin-1 regulates innate and adaptive antitumor immunity

(2013) Tina Verschuere et al.   INTERNATIONAL JOURNAL OF CANCER

Galectin-1-Mediated Suppression of Pseudomonas aeruginosa-Induced Corneal Immunopathology

(2013) A. Suryawanshi et al.   JOURNAL OF IMMUNOLOGY

Endogenous Galectin-1 Exerts Tonic Inhibition on Experimental Arthritis

(2013) A. J. Iqbal et al.   JOURNAL OF IMMUNOLOGY

Therapy of Experimental NASH and Fibrosis with Galectin Inhibitors

(2013) Peter G. Traber et al.   PLoS One

Regression of Fibrosis and Reversal of Cirrhosis in Rats by Galectin Inhibitors in Thioacetamide-Induced Liver Disease

(2013) Peter G. Traber et al.   PLoS One

Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma

(2012) F. Cedeno-Laurent et al.   BLOOD

Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment

(2012) Koichi Ito et al.   CANCER AND METASTASIS REVIEWS

Targeting Galectin-1 Overcomes Breast Cancer-Associated Immunosuppression and Prevents Metastatic Disease

(2012) T. Dalotto-Moreno et al.   CANCER RESEARCH

A Unique Galectin Signature in Human Prostate Cancer Progression Suggests Galectin-1 as a Key Target for Treatment of Advanced Disease

(2012) D. J. Laderach et al.   CANCER RESEARCH

Reduced expression of galectin-1 and galectin-9 by leucocytes in asthma patients

(2012) S. Sanchez-Cuellar et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Absence of Galectin-1 accelerates CD8+ T cell-mediated graft rejection

(2012) Aurélie Moreau et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Galectin-1 promotes human neutrophil migration

(2012) C. Auvynet et al.   GLYCOBIOLOGY

Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer

(2012) Gabriel A. Rabinovich et al.   IMMUNITY

Galectin-1 Deactivates Classically Activated Microglia and Protects from Inflammation-Induced Neurodegeneration

(2012) Sarah C. Starossom et al.   IMMUNITY

Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi’s sarcoma

(2012) Diego O. Croci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Morphine and Galectin-1 Modulate HIV-1 Infection of Human Monocyte-Derived Macrophages

(2012) J. L. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Galectin-1 Triggers an Immunoregulatory Signature in Th Cells Functionally Defined by IL-10 Expression

(2012) F. Cedeno-Laurent et al.   JOURNAL OF IMMUNOLOGY

Antitumor Agent Calixarene 0118 Targets Human Galectin-1 as an Allosteric Inhibitor of Carbohydrate Binding

(2012) Ruud P. M. Dings et al.   JOURNAL OF MEDICINAL CHEMISTRY

Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy

(2012) I. Tirado-Gonzalez et al.   MOLECULAR HUMAN REPRODUCTION

Regulation of Transforming Growth Factor-β1–driven Lung Fibrosis by Galectin-3

(2011) Alison C. MacKinnon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress

(2011) Koichi Ito et al.   ANGIOGENESIS

Viral induction and targeted inhibition of galectin-1 in EBV+ posttransplant lymphoproliferative disorders

(2011) J. Ouyang et al.   BLOOD

Tumor Galectin-1 Mediates Tumor Growth and Metastasis through Regulation of T-Cell Apoptosis

(2011) A. Banh et al.   CANCER RESEARCH

Galectins distinctively regulate central monocyte and macrophage function

(2011) Daniela Paclik et al.   CELLULAR IMMUNOLOGY

Structural aspects of binding of α-linked digalactosides to human galectin-1

(2011) Michelle C Miller et al.   GLYCOBIOLOGY

Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments

(2011) Rocio Soldati et al.   INTERNATIONAL JOURNAL OF CANCER

The Anti-angiogenic Peptide Anginex Greatly Enhances Galectin-1 Binding Affinity for Glycoproteins

(2011) Emma Salomonsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Inhibition of Galectin-1-Binding Carbohydrates Accentuates Antitumor Immunity

(2011) Filiberto Cedeno-Laurent et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Galectin-1 Binds to Influenza Virus and Ameliorates Influenza Virus Pathogenesis

(2011) M.-L. Yang et al.   JOURNAL OF VIROLOGY

Host-Soluble Galectin-1 Promotes HIV-1 Replication through a Direct Interaction with Glycans of Viral gp120 and Host CD4

(2011) C. St-Pierre et al.   JOURNAL OF VIROLOGY

Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells

(2010) F. Gieseke et al.   BLOOD

Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model

(2010) Kimberley A. Stannard et al.   CANCER LETTERS

Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells

(2010) Xu-Yun Zhao et al.   CARCINOGENESIS

Characterization and Functionality of Proliferative Human Sertoli Cells

(2010) Kitty Chui et al.   CELL TRANSPLANTATION

Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis

(2010) C-R Wang et al.   GENE THERAPY

Immunological tolerance induced by galectin-1 in rat allogeneic renal transplantation

(2010) Gaosi Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Lung Cancer-Derived Galectin-1 Mediates Dendritic Cell Anergy through Inhibitor of DNA Binding 3/IL-10 Signaling Pathway

(2010) P.-L. Kuo et al.   JOURNAL OF IMMUNOLOGY

Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death

(2010) B Brandt et al.   Cell Death & Disease

Endothelial Galectin-1 Binds to Specific Glycans on Nipah Virus Fusion Protein and Inhibits Maturation, Mobility, and Function to Block Syncytia Formation

(2010) Omai B. Garner et al.   PLoS Pathogens

The  -galactomannan Davanat binds galectin-1 at a site different from the conventional galectin carbohydrate binding domain

(2009) M. C Miller et al.   GLYCOBIOLOGY

Mechanism of tumor cell-induced T-cell apoptosis mediated by galectin-1

(2009) Ferenc Kovács-Sólyom et al.   IMMUNOLOGY LETTERS

Suppression of Autoimmune Diabetes by Soluble Galectin-1

(2009) M. J. Perone et al.   JOURNAL OF IMMUNOLOGY

Galectin-1 Tunes TCR Binding and Signal Transduction to Regulate CD8 Burst Size

(2009) S. D. Liu et al.   JOURNAL OF IMMUNOLOGY

Knocking Down Galectin 1 in Human Hs683 Glioblastoma Cells Impairs Both Angiogenesis and Endoplasmic Reticulum Stress Responses

(2009) Marie Le Mercier et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Graft-versus-host disease

(2009) James LM Ferrara et al.   LANCET

HIV-1 and microvesicles from T cells share a common glycome, arguing for a common origin

(2009) Lakshmi Krishnamoorthy et al.   Nature Chemical Biology

Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10

(2009) Juan M Ilarregui et al.   NATURE IMMUNOLOGY

The immunological potential of galectin-1 and -3

(2008) Amy Dhirapong et al.   AUTOIMMUNITY REVIEWS

Galectin-1 on cervical epithelial cells is a receptor for the sexually transmitted human parasiteTrichomonas vaginalis

(2008) Cheryl Y. M. Okumura et al.   CELLULAR MICROBIOLOGY

Galectins: structure, function and therapeutic potential

(2008) Ri-Yao Yang et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes

(2008) Bettina Brandt et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Galectin-1 Induces Reversible Phosphatidylserine Exposure at the Plasma Membrane

(2008) Sean R. Stowell et al.   MOLECULAR BIOLOGY OF THE CELL

Protein-glycan interactions in the control of innate and adaptive immune responses

(2008) Yvette van Kooyk et al.   NATURE IMMUNOLOGY

Galectin-1 promotes HIV-1 infectivity in macrophages through stabilization of viral adsorption

(2007) Simon Mercier et al.   VIROLOGY