Glycan–Lectin Interactions in Cancer and Viral Infections and How to Disrupt Them

Can SARS-CoV-2 Virus Use Multiple Receptors to Enter Host Cells?

(2021) Laura Kate Gadanec et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting E-selectin to Tackle Cancer Using Uproleselan

(2021) Barbara Muz et al.   Cancers

Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy

(2021) Riyao Yang et al.   Nature Communications

Blockade of DC-SIGN+ tumor-associated macrophages reactivates anti-tumor immunity and improves immunotherapy in muscle-invasive bladder cancer

(2020) Baoying Hu et al.   CANCER RESEARCH

Activation of the C-Type Lectin MGL by Terminal GalNAc Ligands Reduces the Glycolytic Activity of Human Dendritic Cells

(2020) Anouk Zaal et al.   Frontiers in Immunology

Characterization of Macrophage Galactose-type Lectin (MGL) ligands in colorectal cancer cell lines

(2020) Martina Pirro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

PSGL-1 restricts HIV-1 infectivity by blocking virus particle attachment to target cells

(2020) Yajing Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

(2020) Valerie Barbier et al.   Nature Communications

Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy

(2020) Florent Colomb et al.   Cell Reports

Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation

(2020) Chuan-xia Zhang et al.   Oncogenesis

A potential role for Galectin-3 inhibitors in the treatment of COVID-19

(2020) John L. Caniglia et al.   PeerJ

Kinetic studies of galectin‐10 release from eosinophils exposed to proliferating T cells

(2020) Christine Lingblom et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

PSGL-1 Inhibits the Incorporation of SARS-CoV and SARS-CoV-2 Spike Glycoproteins into Pseudovirions and Impairs Pseudovirus Attachment and Infectivity

(2020) Sijia He et al.   Viruses-Basel

Sensing Glycans as Biochemical Messages by Tissue Lectins: The Sugar Code at Work in Vascular Biology

(2019) Herbert Kaltner et al.   THROMBOSIS AND HAEMOSTASIS

Human Galectin-1 and its inhibitors: Privileged target for cancer and HIV

(2019) Narella Sridhar Goud et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Lack of galectin-1 exacerbates chronic hepatitis, liver fibrosis, and carcinogenesis in murine hepatocellular carcinoma model

(2019) Tamara Potikha et al.   FASEB JOURNAL

Exploitation of glycosylation in enveloped virus pathobiology

(2019) Yasunori Watanabe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Galectin-9 Induces Mitochondria-Mediated Apoptosis of Esophageal Cancer In Vitro and In Vivo in a Xenograft Mouse Model

(2019) Taiga Chiyo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis

(2019) Mark Esposito et al.   NATURE CELL BIOLOGY

Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading?

(2019) Stefan Mereiter et al.   CANCER CELL

L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling

(2019) Aleksandar Ivetic et al.   Frontiers in Immunology

Aberrant fucosylation enables breast cancer clusterin to interact with dendritic cell-specific ICAM-grabbing non-integrin (DC-SIGN)

(2019) Antonela Merlotti et al.   OncoImmunology

The Role of Galectins in Virus Infection - A Systemic Literature Review

(2019) Wen-Hung Wang et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Inhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy

(2019) Barbara Muz et al.   Blood Cancer Journal

High E-Selectin Ligand Expression Contributes to Chemotherapy-Resistance in Poor Risk Relapsed and Refractory (R/R) Acute Myeloid Leukemia (AML) Patients and Can be Overcome with the Addition of Uproleselan

(2019) Daniel J. DeAngelo et al.   BLOOD

Gal-3 is a potential biomarker for spinal cord injury and Gal-3 deficiency attenuates neuroinflammation through ROS/TXNIP/NLRP3 signaling pathway

(2019) Zhouliang Ren et al.   BIOSCIENCE REPORTS

Sweetening the hallmarks of cancer: Galectins as multifunctional mediators of tumor progression

(2019) María Romina Girotti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Capillary Electrophoresis Separations of Glycans

(2018) Grace Lu et al.   CHEMICAL REVIEWS

Role of Galectins in Tumors and in Clinical Immunotherapy

(2018) Feng-Cheng Chou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Galectin Targeted Therapy in Oncology: Current Knowledge and Perspectives

(2018) Kamil Wdowiak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HIV-1 targets L-selectin for adhesion and induces its shedding for viral release

(2018) Joseph Kononchik et al.   Nature Communications

A Critical Domain of Ebolavirus Envelope Glycoprotein Determines Glycoform and Infectivity

(2018) Haruhiko Fujihira et al.   Scientific Reports

The vesicular stomatitis virus-based Ebola virus vaccine: From concept to clinical trials

(2018) Ellen Suder et al.   Human Vaccines & Immunotherapeutics

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

(2018) Athanasios Blanas et al.   Frontiers in Oncology

Dual regulation of L-selectin (CD62L) by HIV-1: Enhanced expression by Vpr in contrast with cell-surface down-modulation by Nef and Vpu

(2018) Erica Giuliani et al.   VIROLOGY

E-Selectin and markers of HIV disease severity, inflammation and coagulation in HIV-infected treatment-naïve individuals

(2018) Madelein Hoffman et al.   African Health Sciences

Detectable Vesicular Stomatitis Virus (VSV)–Specific Humoral and Cellular Immune Responses Following VSV–Ebola Virus Vaccination in Humans

(2018) Joseph H Poetsch et al.   JOURNAL OF INFECTIOUS DISEASES

Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells

(2017) Emiko Akashi et al.   ONCOLOGY REPORTS

The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells

(2017) Isabel Gonçalves Silva et al.   EBioMedicine

Short Communication: Inhibition of DC-SIGN-Mediated HIV-1 Infection by Complementary Actions of Dendritic Cell Receptor Antagonists and Env-Targeting Virus Inactivators

(2016) Sergey Pustylnikov et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

The Role of Clusterin in Carcinogenesis and its Potential Utility as Therapeutic Target

(2016) T. Tellez et al.   CURRENT MEDICINAL CHEMISTRY

Galectin-3 promotes caspase-independent cell death of HIV-1-infected macrophages

(2016) Jing Xue et al.   FEBS Journal

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

(2016) Avery D. Posey et al.   IMMUNITY

Galectin-9: An anticancer molecule for gallbladder carcinoma

(2016) TOMOKO TADOKORO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Galectin-9: From cell biology to complex disease dynamics

(2016) Sebastian John et al.   JOURNAL OF BIOSCIENCES

Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody

(2016) D. Corti et al.   SCIENCE

Hallmarks of glycosylation in cancer

(2016) Jennifer Munkley et al.   Oncotarget

Pseudo-Mannosylated DC-SIGN Ligands as Immunomodulants

(2016) Angela Berzi et al.   Scientific Reports

L-selectin Is Essential for Delivery of Activated CD8 + T Cells to Virus-Infected Organs for Protective Immunity

(2016) Rebar N. Mohammed et al.   Cell Reports

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation

(2016) Mohamed Abdel-Mohsen et al.   PLoS Pathogens

Structure, Function, and Evolution of Coronavirus Spike Proteins

(2016) Fang Li   Annual Review of Virology

Turning-Off Signaling by Siglecs, Selectins, and Galectins: Chemical Inhibition of Glycan-Dependent Interactions in Cancer

(2016) Alejandro J. Cagnoni et al.   Frontiers in Oncology

Select host restriction factors are associated with HIV persistence during antiretroviral therapy

(2015) Mohamed Abdel-Mohsen et al.   AIDS

Galectin expression in cancer diagnosis and prognosis: A systematic review

(2015) Victor L. Thijssen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

DC-SIGN-expressing macrophages trigger activation of mannosylated IgM B-cell receptor in follicular lymphoma

(2015) R. Amin et al.   BLOOD

Microbially Driven TLR5-Dependent Signaling Governs Distal Malignant Progression through Tumor-Promoting Inflammation

(2015) Melanie R. Rutkowski et al.   CANCER CELL

Downregulating galectin-3 inhibits proinflammatory cytokine production by human monocyte-derived dendritic cells via RNA interference

(2015) Swey-Shen Chen et al.   CELLULAR IMMUNOLOGY

A phase II trial with anti-Lewis-Y monoclonal antibody (hu3S193) for the treatment of platinum resistant/refractory ovarian, fallopian tube and primary peritoneal carcinoma

(2015) Oren Smaletz et al.   GYNECOLOGIC ONCOLOGY

Galectin-9 suppresses the growth of hepatocellular carcinoma via apoptosis in vitro and in vivo

(2015) KOJI FUJITA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The galectin lattice at a glance

(2015) I. R. Nabi et al.   JOURNAL OF CELL SCIENCE

HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+T Lymphocytes

(2015) Lia Vassena et al.   JOURNAL OF VIROLOGY

Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest

(2015) KIYOYUKI KOBAYASHI et al.   ONCOLOGY REPORTS

Galectin-9 suppresses the proliferation of gastric cancer cells in vitro

(2015) JITSUKO TAKANO et al.   ONCOLOGY REPORTS

MGL Receptor and Immunity: When the Ligand Can Make the Difference

(2015) Ilaria Grazia Zizzari et al.   Journal of Immunology Research

Changed Expression of E-cadherin and Galectin-9 in Oral Squamous Cell Carcinomas but Lack of Potential as Prognostic Markers

(2014) Siew Wui Chan et al.   Asian Pacific Journal of Cancer Prevention

Structural Characterization of the DC-SIGN–LewisX Complex

(2014) Kari Pederson et al.   BIOCHEMISTRY

A multivalent inhibitor of the DC-SIGN dependent uptake of HIV-1 and Dengue virus

(2014) Norbert Varga et al.   BIOMATERIALS

Characterization ofLGALS3(galectin-3) as a player in DNA damage response

(2014) Renato S Carvalho et al.   CANCER BIOLOGY & THERAPY

Antiviral activity of aloe-emodin against influenza A virus via galectin-3 up-regulation

(2014) Shih-Wen Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Galectin-3 inhibitors: a patent review (2008–present)

(2014) Helen Blanchard et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Galectin-3 promotes HIV-1 budding via association with Alix and Gag p6

(2014) Sheng-Fan Wang et al.   GLYCOBIOLOGY

Glycosylation-Dependent Interactions of C-Type Lectin DC-SIGN with Colorectal Tumor-Associated Lewis Glycans Impair the Function and Differentiation of Monocyte-Derived Dendritic Cells

(2014) M. Nonaka et al.   JOURNAL OF IMMUNOLOGY

Receptor Recognition Mechanisms of Coronaviruses: a Decade of Structural Studies

(2014) Fang Li   JOURNAL OF VIROLOGY

Increased Levels of Plasma Galectin-9 in Patients with Influenza Virus Infection

(2014) Shigeki Katoh et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Comprehensive Functional Analysis of N-Linked Glycans on Ebola Virus GP1

(2014) N. J. Lennemann et al.   mBio

Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression

(2014) Wendy WJ Unger et al.   OncoImmunology

Galectin-3 Modulates Th17 Responses by Regulating Dendritic Cell Cytokines

(2013) Agnes Fermin Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased Circulation of Galectin-3 in Cancer Induces Secretion of Metastasis-Promoting Cytokines from Blood Vascular Endothelium

(2013) C. Chen et al.   CLINICAL CANCER RESEARCH

Glycodendrimers prevent HIV transmission via DC-SIGN on dendritic cells

(2013) J. J. Garcia-Vallejo et al.   INTERNATIONAL IMMUNOLOGY

The Macrophage Galactose-Type Lectin Can Function as an Attachment and Entry Receptor for Influenza Virus

(2013) W. C. Ng et al.   JOURNAL OF VIROLOGY

Galectin-3 Silencing Inhibits Epirubicin-Induced ATP Binding Cassette Transporters and Activates the Mitochondrial Apoptosis Pathway via β-Catenin/GSK-3β Modulation in Colorectal Carcinoma

(2013) Yung-Kuo Lee et al.   PLoS One

Dysregulated Tim-3 expression on natural killer cells is associated with increased Galectin-9 levels in HIV-1 infection

(2013) Stephanie Jost et al.   Retrovirology

Eosinophil-expressed galectin-3 regulates cell trafficking and migration

(2013) Xiao Na Ge et al.   Frontiers in Pharmacology

Galectin-9 Acts as a Prognostic Factor with Antimetastatic Potential in Hepatocellular Carcinoma

(2012) Zhao-Yang Zhang et al.   Asian Pacific Journal of Cancer Prevention

Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9

(2012) M. K. Gleason et al.   BLOOD

Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection

(2012) S. Elahi et al.   BLOOD

Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation

(2012) Chiara Napoletano et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Aberrantly glycosylated MUC1 is expressed on the surface of breast cancer cells and a target for antibody-dependent cell-mediated cytotoxicity

(2012) Kirstine Lavrsen et al.   GLYCOCONJUGATE JOURNAL

Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma

(2012) Hang Li et al.   HEPATOLOGY

Colonic carcinogenesis along different genetic routes: glycophenotyping of tumor cases separated by microsatellite instability/stability

(2012) Johannes Gebert et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The Glycan-Binding Protein Galectin-9 Has Direct Apoptotic Activity toward Melanoma Cells

(2012) Valerie R. Wiersma et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance

(2012) Ingrid G Winkler et al.   NATURE MEDICINE

Protective Efficacy of Neutralizing Monoclonal Antibodies in a Nonhuman Primate Model of Ebola Hemorrhagic Fever

(2012) Andrea Marzi et al.   PLoS One

Virus-like glycodendrinanoparticles displaying quasi-equivalent nested polyvalency upon glycoprotein platforms potently block viral infection

(2012) Renato Ribeiro-Viana et al.   Nature Communications

Ebola GP-Specific Monoclonal Antibodies Protect Mice and Guinea Pigs from Lethal Ebola Virus Infection

(2012) Xiangguo Qiu et al.   PLoS Neglected Tropical Diseases

Galectin-1-Specific Inhibitors as a New Class of Compounds To Treat HIV-1 Infection

(2011) Christian St-Pierre et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Involvement of viral envelope GP2 in Ebola virus entry into cells expressing the macrophage galactose-type C-type lectin

(2011) Katsuaki Usami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of Galectins with Small Molecules

(2011) Christopher T. Öberg et al.   CHIMIA

Semen Clusterin Is a Novel DC-SIGN Ligand

(2011) Juan Sabatte et al.   JOURNAL OF IMMUNOLOGY

Galectin-1 Binds to Influenza Virus and Ameliorates Influenza Virus Pathogenesis

(2011) M.-L. Yang et al.   JOURNAL OF VIROLOGY

The Shedding of CD62L (L-Selectin) Regulates the Acquisition of Lytic Activity in Human Tumor Reactive T Lymphocytes

(2011) Shicheng Yang et al.   PLoS One

T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses

(2011) S. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry

(2011) S. Bi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of DC-SIGN-Mediated HIV Infection by a Linear Trimannoside Mimic in a Tetravalent Presentation

(2010) Sara Sattin et al.   ACS Chemical Biology

Glycomic Analysis of Sialic Acid Linkages in Glycans Derived from Blood Serum Glycoproteins

(2010) William R. Alley et al.   JOURNAL OF PROTEOME RESEARCH

High numbers of DC-SIGN+ dendritic cells in lesional skin of cutaneous T-cell lymphoma

(2010) Christoph Schlapbach et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Macrophage Receptors for Influenza A Virus: Role of the Macrophage Galactose-Type Lectin and Mannose Receptor in Viral Entry

(2010) J. P. Upham et al.   JOURNAL OF VIROLOGY

Targeting Activating Transcription Factor 3 by Galectin-9 Induces Apoptosis and Overcomes Various Types of Treatment Resistance in Chronic Myelogenous Leukemia

(2010) J. Kuroda et al.   MOLECULAR CANCER RESEARCH

Steric Shielding of Surface Epitopes and Impaired Immune Recognition Induced by the Ebola Virus Glycoprotein

(2010) Joseph R. Francica et al.   PLoS Pathogens

Multivalent Manno-Glyconanoparticles Inhibit DC-SIGN-Mediated HIV-1 Trans-Infection of Human T Cells

(2009) Olga Martínez-Ávila et al.   CHEMBIOCHEM

Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells

(2009) F. L Oliveira et al.   GLYCOBIOLOGY

The  -galactomannan Davanat binds galectin-1 at a site different from the conventional galectin carbohydrate binding domain

(2009) M. C Miller et al.   GLYCOBIOLOGY

From carbohydrate leads to glycomimetic drugs

(2009) Beat Ernst et al.   NATURE REVIEWS DRUG DISCOVERY

Galectin–glycan lattices regulate cell-surface glycoprotein organization and signalling: Table 1

(2008) Omai B. Garner et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

(2008) J. Klibi et al.   BLOOD

Dendritic cells and C-type lectin receptors: coupling innate to adaptive immune responses

(2008) Sandra J van Vliet et al.   IMMUNOLOGY AND CELL BIOLOGY

Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71

(2008) Cheng-Wen Lin et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Galectin-9 expression links to malignant potential of cervical squamous cell carcinoma

(2008) Meiyan Liang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling

(2008) Alexander Zarbock et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protein-glycan interactions in the control of innate and adaptive immune responses

(2008) Yvette van Kooyk et al.   NATURE IMMUNOLOGY

Sweet preferences of MGL: carbohydrate specificity and function

(2008) Sandra J. van Vliet et al.   TRENDS IN IMMUNOLOGY

Galectin-1 promotes HIV-1 infectivity in macrophages through stabilization of viral adsorption

(2007) Simon Mercier et al.   VIROLOGY