Galectin-1 Inhibitor OTX008 Induces Tumor Vessel Normalization and Tumor Growth Inhibition in Human Head and Neck Squamous Cell Carcinoma Models

A Novel Galectin-1 Inhibitor Discovered through One-Bead Two-Compound Library Potentiates the Antitumor Effects of Paclitaxel in vivo

(2017) Tsung-Chieh Shih et al.   MOLECULAR CANCER THERAPEUTICS

Galectin-1 is a useful marker for detecting neoplastic squamous cells in oral cytology smears

(2016) Yuri Noda et al.   HUMAN PATHOLOGY

Galectin-1 induces hepatocellular carcinoma EMT and sorafenib resistance by activating FAK/PI3K/AKT signaling

(2016) P-F Zhang et al.   Cell Death & Disease

Targeting Artificial Tumor Stromal Targets for Molecular Imaging of Tumor Vascular Hypoxia

(2015) Nathan A. Koonce et al.   PLoS One

Galectin-1 Drives Pancreatic Carcinogenesis through Stroma Remodeling and Hedgehog Signaling Activation

(2014) N. Martinez-Bosch et al.   CANCER RESEARCH

OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis

(2014) Lucile Astorgues-Xerri et al.   EUROPEAN JOURNAL OF CANCER

Polycationic calixarene PTX013, a potent cytotoxic agent against tumors and drug resistant cancer

(2013) Ruud P. M. Dings et al.   INVESTIGATIONAL NEW DRUGS

Blood Outgrowth Endothelial Cells Increase Tumor Growth Rates and Modify Tumor Physiology: Relevance for Therapeutic Targeting

(2013) Jonathan Pagan et al.   Cancers

Abstract 4520: Targeting galectin-1 with PTX-008 inhibits invasion, tumor growth and metastasis in human carcinoma models

(2012) Lucile Astorgues-Xerri et al.   CANCER RESEARCH

Abstract 1926: Antitumor and antiangiogenic effects of OTX-008, a novel calyx[4]arene, are mediated by galectin-1 inhibition in human tumor xenograft models

(2012) Lucile Astorgues-Xerri et al.   CANCER RESEARCH

Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: Increased expression of galectin-1 and induction of poor prognosis factors

(2012) Jaroslav Valach et al.   INTERNATIONAL JOURNAL OF CANCER

Antitumor Agent Calixarene 0118 Targets Human Galectin-1 as an Allosteric Inhibitor of Carbohydrate Binding

(2012) Ruud P. M. Dings et al.   JOURNAL OF MEDICINAL CHEMISTRY

Abstract B166: Effects of PTX-008, a non-peptidic topomimetic targeting galectin-1 in human epithelial cancer cells

(2012) L. Astorgues-Xerri et al.   MOLECULAR CANCER THERAPEUTICS

Galectin-1-Specific Inhibitors as a New Class of Compounds To Treat HIV-1 Infection

(2011) Christian St-Pierre et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Taloside Inhibitors of Galectin-1 and Galectin-3

(2011) Patrick M. Collins et al.   Chemical Biology & Drug Design

Enhancement of T-cell-Mediated Antitumor Response: Angiostatic Adjuvant to Immunotherapy against Cancer

(2011) R. P. M. Dings et al.   CLINICAL CANCER RESEARCH

Antibody validation

(2010) Jennifer Bordeaux et al.   BIOTECHNIQUES

Tumor Cells Secrete Galectin-1 to Enhance Endothelial Cell Activity

(2010) V. L. Thijssen et al.   CANCER RESEARCH