Galectin-1: A Jack-of-All-Trades in the Resolution of Acute and Chronic Inflammation

Galectin-1–Driven Tolerogenic Programs AggravateYersinia enterocoliticaInfection by Repressing Antibacterial Immunity

(2017) Roberto C. Davicino et al.   JOURNAL OF IMMUNOLOGY

Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance

(2017) Donnele Daley et al.   NATURE MEDICINE

Translating the ‘Sugar Code’ into Immune and Vascular Signaling Programs

(2017) Juan P. Cerliani et al.   TRENDS IN BIOCHEMICAL SCIENCES

Functions of galectins as ‘self/non-self’-recognition and effector factors

(2017) Gerardo R. Vasta et al.   Pathogens and Disease

Combined Anti-VEGF and Anti–CTLA-4 Therapy Elicits Humoral Immunity to Galectin-1 Which Is Associated with Favorable Clinical Outcomes

(2017) Xinqi Wu et al.   Cancer Immunology Research

Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration

(2017) Ping Kei Yip et al.   Scientific Reports

Galectins and Immune Responses—Just How Do They Do Those Things They Do?

(2016) Sandra Thiemann et al.   Annual Review of Immunology

Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms

(2016) J. M. Lykken et al.   BLOOD

Galectin-1 is essential for the induction of MOG35-55-based intravenous tolerance in experimental autoimmune encephalomyelitis

(2016) Elisabeth R. Mari et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Murine Sertoli cells promote the development of tolerogenic dendritic cells: a pivotal role of galectin-1

(2016) Jianxin Gao et al.   IMMUNOLOGY

Galectin-1 Reduces Neuroinflammation via Modulation of Nitric Oxide-Arginase Signaling in HIV-1 Transfected Microglia: a Gold Nanoparticle-Galectin-1 “Nanoplex” a Possible Neurotherapeutic?

(2016) Ravikumar Aalinkeel et al.   Journal of Neuroimmune Pharmacology

Galectin-1 circumvents lysolecithin-induced demyelination through the modulation of microglial polarization/phagocytosis and oligodendroglial differentiation

(2016) Mariana Rinaldi et al.   NEUROBIOLOGY OF DISEASE

Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1

(2016) Xiao Na Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells

(2016) Amelia J. Tesone et al.   Cell Reports

Natural killer cells require monocytic Gr-1+/CD11b+ myeloid cells to eradicate orthotopically engrafted glioma cells

(2016) Gregory J. Baker et al.   OncoImmunology

Turning-Off Signaling by Siglecs, Selectins, and Galectins: Chemical Inhibition of Glycan-Dependent Interactions in Cancer

(2016) Alejandro J. Cagnoni et al.   Frontiers in Oncology

Microbially Driven TLR5-Dependent Signaling Governs Distal Malignant Progression through Tumor-Promoting Inflammation

(2015) Melanie R. Rutkowski et al.   CANCER CELL

Novel role for galectin-1 in T-cells under physiological and pathological conditions

(2015) Magdolna Deák et al.   IMMUNOBIOLOGY

Galectin-1 Regulates Tissue Exit of Specific Dendritic Cell Populations

(2015) Sandra Thiemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trichomonas vaginalisLipophosphoglycan Exploits Binding to Galectin-1 and -3 to Modulate Epithelial Immunity

(2015) Raina N. Fichorova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation Controls Sensitivity of Human and Mouse Intestinal Epithelial Cells to Galectin-1

(2015) Cecilia I. Muglia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Trypanosoma cruziInfection Imparts a Regulatory Program in Dendritic Cells and T Cells via Galectin-1–Dependent Mechanisms

(2015) Carolina V. Poncini et al.   JOURNAL OF IMMUNOLOGY

Galectin-1 reduced the effect of LPS on the IL-6 production in decidual cells by inhibiting LPS on the stimulation of IκBζ

(2015) Fernando Gómez-Chávez et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease

(2015) S C Nalle et al.   Mucosal Immunology

Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions

(2015) Jeremy Bonzi et al.   Nature Communications

Dual roles of endogenous and exogenous galectin-1 in the control of testicular immunopathology

(2015) Cecilia V. Pérez et al.   Scientific Reports

Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells

(2015) T. Kouo et al.   Cancer Immunology Research

Alarmin Function of Galectin-9 in Murine Respiratory Tularemia

(2015) Anthony L. Steichen et al.   PLoS One

Galectin-1 Drives Pancreatic Carcinogenesis through Stroma Remodeling and Hedgehog Signaling Activation

(2014) N. Martinez-Bosch et al.   CANCER RESEARCH

Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors

(2014) Diego O. Croci et al.   CELL

Integration of lectin–glycan recognition systems and immune cell networks in CNS inflammation

(2014) Santiago P. Mendez-Huergo et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Differential Roles of Galectin-1 and Galectin-3 in Regulating Leukocyte Viability and Cytokine Secretion

(2014) S. R. Stowell et al.   JOURNAL OF IMMUNOLOGY

The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells

(2014) A. Schneider et al.   JOURNAL OF IMMUNOLOGY

T Cell Leukemia/Lymphoma 1 and Galectin-1 Regulate Survival/Cell Death Pathways in Human Naive and IgM+ Memory B Cells through Altering Balances in Bcl-2 Family Proteins

(2014) S. J. Tabrizi et al.   JOURNAL OF IMMUNOLOGY

Targeting galectin-1-induced angiogenesis mitigates the severity of endometriosis

(2014) Juan I Bastón et al.   JOURNAL OF PATHOLOGY

Phosphoproteomic analyses reveal that galectin-1 augments the dynamics of B-cell receptor signaling

(2014) Chih-Ming Tsai et al.   Journal of Proteomics

The Leukocyte Activation Receptor CD69 Controls T Cell Differentiation through Its Interaction with Galectin-1

(2014) H. de la Fuente et al.   MOLECULAR AND CELLULAR BIOLOGY

Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus

(2014) S. M. Blois et al.   MOLECULAR HUMAN REPRODUCTION

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

‘Sweetening’ Pregnancy: Galectins at the Fetomaternal Interface

(2013) Ada G. Blidner et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Glioma-derived galectin-1 regulates innate and adaptive antitumor immunity

(2013) Tina Verschuere et al.   INTERNATIONAL JOURNAL OF CANCER

Galectin 1 Modulates Plasma Cell Homeostasis and Regulates the Humoral Immune Response

(2013) A. Anginot et al.   JOURNAL OF IMMUNOLOGY

Galectin-1-Mediated Suppression of Pseudomonas aeruginosa-Induced Corneal Immunopathology

(2013) A. Suryawanshi et al.   JOURNAL OF IMMUNOLOGY

Endogenous Galectin-1 Exerts Tonic Inhibition on Experimental Arthritis

(2013) A. J. Iqbal et al.   JOURNAL OF IMMUNOLOGY

Galectin-1 induces 12/15-lipoxygenase expression in murine macrophages and favors their conversion toward a pro-resolving phenotype

(2013) Ran Rostoker et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Mast cells rescue implantation defects caused by c-kit deficiency

(2013) K Woidacki et al.   Cell Death & Disease

Galectin-1 Controls Cardiac Inflammation and Ventricular Remodeling during Acute Myocardial Infarction

(2012) Ignacio M. Seropian et al.   AMERICAN JOURNAL OF PATHOLOGY

Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma

(2012) F. Cedeno-Laurent et al.   BLOOD

Targeting Galectin-1 Overcomes Breast Cancer-Associated Immunosuppression and Prevents Metastatic Disease

(2012) T. Dalotto-Moreno et al.   CANCER RESEARCH

Inhibiting galectin-1 reduces murine lung metastasis with increased CD4+ and CD8+ T cells and reduced cancer cell adherence

(2012) Koichi Ito et al.   CLINICAL & EXPERIMENTAL METASTASIS

Reduced expression of galectin-1 and galectin-9 by leucocytes in asthma patients

(2012) S. Sanchez-Cuellar et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Galectin-1 confers immune privilege to human trophoblast: implications in recurrent fetal loss

(2012) R. E. Ramhorst et al.   GLYCOBIOLOGY

Galectin-1 promotes human neutrophil migration

(2012) C. Auvynet et al.   GLYCOBIOLOGY

Galectin-1 Deactivates Classically Activated Microglia and Protects from Inflammation-Induced Neurodegeneration

(2012) Sarah C. Starossom et al.   IMMUNITY

Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation

(2012) Latifa Elantak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+T cells

(2012) Atsushi Nishida et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi’s sarcoma

(2012) Diego O. Croci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Galectin-1 Reduces the Severity of Herpes Simplex Virus-Induced Ocular Immunopathological Lesions

(2012) N. K. Rajasagi et al.   JOURNAL OF IMMUNOLOGY

Galectin-1 Triggers an Immunoregulatory Signature in Th Cells Functionally Defined by IL-10 Expression

(2012) F. Cedeno-Laurent et al.   JOURNAL OF IMMUNOLOGY

Nurse-like cells control the activity of chronic lymphocytic leukemia B cells via galectin-1

(2012) D O Croci et al.   LEUKEMIA

Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy

(2012) I. Tirado-Gonzalez et al.   MOLECULAR HUMAN REPRODUCTION

Endogenous Galectin-1 and Acute Inflammation

(2011) Asif J. Iqbal et al.   AMERICAN JOURNAL OF PATHOLOGY

When Galectins Recognize Glycans: From Biochemistry to Physiology and Back Again

(2011) Santiago Di Lella et al.   BIOCHEMISTRY

Viral induction and targeted inhibition of galectin-1 in EBV+ posttransplant lymphoproliferative disorders

(2011) J. Ouyang et al.   BLOOD

Tumor Galectin-1 Mediates Tumor Growth and Metastasis through Regulation of T-Cell Apoptosis

(2011) A. Banh et al.   CANCER RESEARCH

Resolution-associated molecular patterns (RAMP): RAMParts defending immunological homeostasis?

(2011) A. M. Shields et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Ganglioside GM1 Deficiency in Effector T Cells From NOD Mice Induces Resistance to Regulatory T-Cell Suppression

(2011) G. Wu et al.   DIABETES

Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments

(2011) Rocio Soldati et al.   INTERNATIONAL JOURNAL OF CANCER

Metabolic Inhibition of Galectin-1-Binding Carbohydrates Accentuates Antitumor Immunity

(2011) Filiberto Cedeno-Laurent et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The glycan-binding protein galectin-1 controls survival of epithelial cells along the crypt-villus axis of small intestine

(2011) C Muglia et al.   Cell Death & Disease

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis

(2010) C-R Wang et al.   GENE THERAPY

Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways

(2009) Andrew Filer et al.   ARTHRITIS AND RHEUMATISM

Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions

(2009) M. Espeli et al.   BLOOD

Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway

(2009) R. K J Malik et al.   GLYCOBIOLOGY

Conveying glycan information into T-cell homeostatic programs: a challenging role for galectin-1 in inflammatory and tumor microenvironments

(2009) Gabriel A. Rabinovich et al.   IMMUNOLOGICAL REVIEWS

Galectins in innate immunity: dual functions of host soluble β-galactoside-binding lectins as damage-associated molecular patterns (DAMPs) and as receptors for pathogen-associated molecular patterns (PAMPs)

(2009) Sachiko Sato et al.   IMMUNOLOGICAL REVIEWS

Galectin-1 Co-clusters CD43/CD45 on Dendritic Cells and Induces Cell Activation and Migration through Syk and Protein Kinase C Signaling

(2009) Jennifer A. Fulcher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of Autoimmune Diabetes by Soluble Galectin-1

(2009) M. J. Perone et al.   JOURNAL OF IMMUNOLOGY

Cross-Linking of GM1 Ganglioside by Galectin-1 Mediates Regulatory T Cell Activity Involving TRPC5 Channel Activation: Possible Role in Suppressing Experimental Autoimmune Encephalomyelitis

(2009) J. Wang et al.   JOURNAL OF IMMUNOLOGY

Galectin-1 Tunes TCR Binding and Signal Transduction to Regulate CD8 Burst Size

(2009) S. D. Liu et al.   JOURNAL OF IMMUNOLOGY

Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10

(2009) Juan M Ilarregui et al.   NATURE IMMUNOLOGY

Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function

(2008) Claudia C. Motran et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Restoring the Association of the T Cell Receptor with CD8 Reverses Anergy in Human Tumor-Infiltrating Lymphocytes

(2008) Nathalie Demotte et al.   IMMUNITY

Ligand Reduces Galectin-1 Sensitivity to Oxidative Inactivation by Enhancing Dimer Formation

(2008) Sean R. Stowell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow

(2008) D. Cooper et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Galectin-1 Induces Reversible Phosphatidylserine Exposure at the Plasma Membrane

(2008) Sean R. Stowell et al.   MOLECULAR BIOLOGY OF THE CELL

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Galectin-4 Controls Intestinal Inflammation by Selective Regulation of Peripheral and Mucosal T Cell Apoptosis and Cell Cycle

(2008) Daniela Paclik et al.   PLoS One

T cell apoptosis at the maternal-fetal interface in early human pregnancy, involvement of galectin-1

(2008) H. D. Kopcow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors

(2008) A. M. D'Alise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking

(2007) Lucy V. Norling et al.   FASEB JOURNAL