Oligo-Fucoidan Prevents M2 Macrophage Differentiation and HCT116 Tumor Progression

Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms

(2019) Geert van Weelden et al.   Marine Drugs

Triple negative breast cancer: Key role of Tumor-Associated Macrophages in regulating the activity of anti-PD-1/PD-L1 agents

(2018) Matteo Santoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Fucoidan upregulates TLR4/CHOP-mediated caspase-3 and PARP activation to enhance cisplatin-induced cytotoxicity in human lung cancer cells

(2018) Hsien-Yeh Hsu et al.   CANCER LETTERS

NADPH oxidase activation in neutrophils: Role of the phosphorylation of its subunits

(2018) Sahra A. Belambri et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Reactive Oxygen Species-Mediated Tumor Microenvironment Transformation: The Mechanism of Radioresistant Gastric Cancer

(2018) Huifeng Gu et al.   Oxidative Medicine and Cellular Longevity

THE ROLE OF METABOLIC REMODELING IN MACROPHAGE POLARIZATION AND ITS EFFECT ON SKELETAL MUSCLE REGENERATION

(2018) Francesca De Santa et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative stress-elicited YY1 potentiates antioxidative response via enhancement of NRF2-driven transcriptional activity: A potential neuronal defensive mechanism against ischemia/reperfusion cerebral injury

(2018) Wei Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization

(2018) Chih-Chan Lee et al.   Nature Communications

Fucoidan induces Toll-like receptor 4-regulated reactive oxygen species and promotes endoplasmic reticulum stress-mediated apoptosis in lung cancer

(2017) Hsien-Yeh Hsu et al.   Scientific Reports

Oncogenic MCT-1 activation promotes YY1-EGFR-MnSOD signaling and tumor progression

(2017) H-Y Tseng et al.   Oncogenesis

Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression

(2017) Li-Mei Chen et al.   Scientific Reports

Cytokines in cancer drug resistance: Cues to new therapeutic strategies

(2016) Valerie Sloane Jones et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer

(2016) Iok In Christine Chio et al.   CELL

Fucoidan as a Potential Therapeutic for Major Blinding Diseases—A Hypothesis

(2016) Alexa Klettner   Marine Drugs

Combined administration of fucoidan ameliorates tumor and chemotherapy-induced skeletal muscle atrophy in bladder cancer-bearing mice

(2016) Meng-Chuan Chen et al.   Oncotarget

DNA Repair and Cytokines: TGF-β, IL-6, and Thrombopoietin as Different Biomarkers of Radioresistance

(2016) Lucia Centurione et al.   Frontiers in Oncology

Fucoidan inhibits CCL22 production through NF-κB pathway in M2 macrophages: a potential therapeutic strategy for cancer

(2016) Jia Sun et al.   Scientific Reports

DNA damage checkpoint recovery and cancer development

(2015) Haiyong Wang et al.   EXPERIMENTAL CELL RESEARCH

Prophylactic Administration of Fucoidan Represses Cancer Metastasis by Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) in Lewis Tumor-Bearing Mice

(2015) Tse-Hung Huang et al.   Marine Drugs

Fucoidan from Macrocystis pyrifera Has Powerful Immune-Modulatory Effects Compared to Three Other Fucoidans

(2015) Wei Zhang et al.   Marine Drugs

Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia

(2015) Meng-Chuan Chen et al.   Marine Drugs

MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer

(2015) Peter C. Hart et al.   Nature Communications

Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGFβ receptor degradation

(2015) Hsien-Yeh Hsu et al.   Oncotarget

The CCL2/CCR2 axis enhances IL-6-induced epithelial-mesenchymal transition by cooperatively activating STAT3-Twist signaling

(2014) Wei Chen et al.   TUMOR BIOLOGY

Serum levels of IL-6 and IL-1β can predict the efficacy of gemcitabine in patients with advanced pancreatic cancer

(2013) S Mitsunaga et al.   BRITISH JOURNAL OF CANCER

Critical Role of STAT3 in IL-6–Mediated Drug Resistance in Human Neuroblastoma

(2013) Tasnim Ara et al.   CANCER RESEARCH

ROS sets the stage for macrophage differentiation

(2013) Anthony Covarrubias et al.   CELL RESEARCH

ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

(2013) Yan Zhang et al.   CELL RESEARCH

Accelerated Development of Pulmonary Fibrosis via Cu,Zn-superoxide Dismutase-induced Alternative Activation of Macrophages

(2013) Chao He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

DNA damage induces the IL-6/STAT3 signaling pathway, which has anti-senescence and growth-promoting functions in human tumors

(2012) Un Jung Yun et al.   CANCER LETTERS

Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGF  receptor degradation in breast cancer

(2012) H.-Y. Hsu et al.   CARCINOGENESIS

The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities

(2012) Hung-Ju Shih et al.   CELL CYCLE

Endoplasmic Reticulum Stress Controls M2 Macrophage Differentiation and Foam Cell Formation

(2012) Jisu Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p21Cip1/WAF1mediates cyclin B1 degradation in response to DNA damage

(2011) Laura D. Gillis et al.   CELL CYCLE

Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo

(2011) Marcel Tutor Ale et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Inflammation, Oxidative Stress, and Obesity

(2011) Alba Fernández-Sánchez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of Lipopolysaccharide (LPS)-Induced Inflammatory Responses by Sargassum hemiphyllum Sulfated Polysaccharide Extract in RAW 264.7 Macrophage Cells

(2011) Pai-An Hwang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The antagonism between MCT-1 and p53 affects the tumorigenic outcomes

(2011) Ravi Kasiappan et al.   Molecular Cancer

Regulation of reactive oxygen species generation in cell signaling

(2011) Yun Soo Bae et al.   MOLECULES AND CELLS

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Tumor-Conditioned Macrophages Secrete Migration-Stimulating Factor: A New Marker for M2-Polarization, Influencing Tumor Cell Motility

(2010) G. Solinas et al.   JOURNAL OF IMMUNOLOGY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

CCL2 and Interleukin-6 Promote Survival of Human CD11b+Peripheral Blood Mononuclear Cells and Induce M2-type Macrophage Polarization

(2009) Hernan Roca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure, biological activity, and enzymatic transformation of fucoidans from the brown seaweeds

(2008) Mikhail Kusaykin et al.   Biotechnology Journal

Fucoidan: Structure and Bioactivity

(2008) Bo Li et al.   MOLECULES