Role of Galectins in Tumors and in Clinical Immunotherapy

Cancer Therapy Due to Apoptosis: Galectin-9

(2017) Koji Fujita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance

(2017) Donnele Daley et al.   NATURE MEDICINE

Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration

(2017) Monica Gordon-Alonso et al.   Nature Communications

The immunologic advantage of recurrent nasopharyngeal carcinoma from the viewpoint of Galectin-9/Tim-3-related changes in the tumour microenvironment

(2017) Tseng-Cheng Chen et al.   Scientific Reports

Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms

(2016) J. M. Lykken et al.   BLOOD

Galectin-9: An anticancer molecule for gallbladder carcinoma

(2016) TOMOKO TADOKORO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

PD-1 says goodbye, TIM-3 says hello

(2016) Diana Romero   Nature Reviews Clinical Oncology

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

(2016) Shohei Koyama et al.   Nature Communications

Identification of galectin-1 as a novel mediator for chemoresistance in chronic myeloid leukemia cells

(2016) Wu Luo et al.   Oncotarget

An increase in galectin-3 causes cellular unresponsiveness to IFN-γ-induced signal transduction and growth inhibition in gastric cancer cells

(2016) Po-Chun Tseng et al.   Oncotarget

Galectin expression in cancer diagnosis and prognosis: A systematic review

(2015) Victor L. Thijssen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Galectin-9 suppresses the growth of hepatocellular carcinoma via apoptosis in vitro and in vivo

(2015) KOJI FUJITA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest

(2015) KIYOYUKI KOBAYASHI et al.   ONCOLOGY REPORTS

Galectin-9 suppresses the proliferation of gastric cancer cells in vitro

(2015) JITSUKO TAKANO et al.   ONCOLOGY REPORTS

Extracellular galectin-3 programs multidrug resistance through Na+/K+-ATPase and P-glycoprotein signaling

(2015) Yosuke Harazono et al.   Oncotarget

Galectin-9 controls the therapeutic activity of 4-1BB–targeting antibodies

(2014) Shravan Madireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Galectin-9 Acts as a Prognostic Factor with Antimetastatic Potential in Hepatocellular Carcinoma

(2012) Zhao-Yang Zhang et al.   Asian Pacific Journal of Cancer Prevention

Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma

(2012) F. Cedeno-Laurent et al.   BLOOD

Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma

(2012) Hang Li et al.   HEPATOLOGY

The Glycan-Binding Protein Galectin-9 Has Direct Apoptotic Activity toward Melanoma Cells

(2012) Valerie R. Wiersma et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Galectin-9 Controls CD40 Signaling through a Tim-3 Independent Mechanism and Redirects the Cytokine Profile of Pathogenic T Cells in Autoimmunity

(2012) Gisela M. Vaitaitis et al.   PLoS One

Upregulation of the Tim-3/Galectin-9 Pathway of T Cell Exhaustion in Chronic Hepatitis B Virus Infection

(2012) Gaia Nebbia et al.   PLoS One

Galectin-1 sensitizes carcinoma cells to anoikis via the fibronectin receptor α5β1-integrin

(2010) H Sanchez-Ruderisch et al.   CELL DEATH AND DIFFERENTIATION

Galectin-9 exhibits anti-myeloma activity through JNK and p38 MAP kinase pathways

(2010) T Kobayashi et al.   LEUKEMIA

Targeting Activating Transcription Factor 3 by Galectin-9 Induces Apoptosis and Overcomes Various Types of Treatment Resistance in Chronic Myelogenous Leukemia

(2010) J. Kuroda et al.   MOLECULAR CANCER RESEARCH

Circulating Galectin-3 Promotes Metastasis by Modifying MUC1 Localization on Cancer Cell Surface

(2009) Q. Zhao et al.   CANCER RESEARCH

Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse

(2009) H.-Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological Modulation by Lectins and Their Ligands in Tumor Progression and Metastasis

(2008) Avraham Raz et al.   Anti-Cancer Agents in Medicinal Chemistry

Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

(2008) J. Klibi et al.   BLOOD

Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices

(2008) A. Nobumoto et al.   GLYCOBIOLOGY

Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells

(2008) S H Hsieh et al.   ONCOGENE