Galectin-1 fosters an immunosuppressive microenvironment in colorectal cancer by reprogramming CD8+ regulatory T cells
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Title
Galectin-1 fosters an immunosuppressive microenvironment in colorectal cancer by reprogramming CD8+ regulatory T cells
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 118, Issue 21, Pages e2102950118
Publisher
Proceedings of the National Academy of Sciences
Online
2021-05-19
DOI
10.1073/pnas.2102950118
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Note: Only part of the references are listed.- Suppression of age-related salivary gland autoimmunity by glycosylation-dependent galectin-1-driven immune inhibitory circuits
- (2020) Verónica C. Martínez Allo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Impact of Galectins in Resistance to Anticancer Therapies
- (2020) Pilar Navarro et al. CLINICAL CANCER RESEARCH
- Characterization of a neutralizing anti-human galectin-1 monoclonal antibody with angioregulatory and immunomodulatory activities
- (2020) Juan M. Pérez Sáez et al. ANGIOGENESIS
- N-glycomic signature of stage II colorectal cancer and its association with the tumor microenvironment
- (2020) Fanny Boyaval et al. MOLECULAR & CELLULAR PROTEOMICS
- Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression
- (2020) Mariana C. Silva et al. Cancer Immunology Research
- Tumor-associated carbohydrates and immunomodulatory lectins as targets for cancer immunotherapy
- (2020) Natalia Rodrigues Mantuano et al. Journal for ImmunoTherapy of Cancer
- New functionalities in the TCGAbiolinks package for the study and integration of cancer data from GDC and GTEx
- (2019) Mohamed Mounir et al. PLoS Computational Biology
- Immunotherapy in colorectal cancer: rationale, challenges and potential
- (2019) Karuna Ganesh et al. Nature Reviews Gastroenterology & Hepatology
- Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading?
- (2019) Stefan Mereiter et al. CANCER CELL
- A Galactoside-Binding Protein Tricked into Binding Unnatural Pyranose Derivatives: 3-Deoxy-3-Methyl-Gulosides Selectively Inhibit Galectin-1
- (2019) Kumar Bhaskar Pal et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- PD-1 inhibitors dependent CD8+ T cells inhibit mouse colon cancer cell metastasis
- (2019) Chang E Gao et al. OncoTargets and Therapy
- Future prospects for CD8 + regulatory T cells in immune tolerance
- (2019) Léa Flippe et al. IMMUNOLOGICAL REVIEWS
- Galectin-1–driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance
- (2019) Dhanya K. Nambiar et al. JOURNAL OF CLINICAL INVESTIGATION
- Sweetening the hallmarks of cancer: Galectins as multifunctional mediators of tumor progression
- (2019) María Romina Girotti et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Immune Landscape of Cancer
- (2018) Vésteinn Thorsson et al. IMMUNITY
- Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor–stroma crosstalk
- (2018) Carlos A. Orozco et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection
- (2018) David V. Mathews et al. JOURNAL OF CLINICAL INVESTIGATION
- Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression
- (2017) María L Bacigalupo et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Targeting of CD122 enhances antitumor immunity by altering the tumor immune environment
- (2017) Daniel O. Villarreal et al. Oncotarget
- The expression profiles of the galectin gene family in colorectal adenocarcinomas
- (2016) Vinod Gopalan et al. HUMAN PATHOLOGY
- Mouse and human CD8+CD28lowregulatory T lymphocytes differentiate in the thymus
- (2016) Yirajen Vuddamalay et al. IMMUNOLOGY
- Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways
- (2016) Gabriel A. Rabinovich et al. JOURNAL OF MOLECULAR BIOLOGY
- CD8+CD122+CD49dlowregulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity
- (2016) Kazuyuki Akane et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulatory T Cells: Differentiation and Function
- (2016) G. Plitas et al. Cancer Immunology Research
- Turning-Off Signaling by Siglecs, Selectins, and Galectins: Chemical Inhibition of Glycan-Dependent Interactions in Cancer
- (2016) Alejandro J. Cagnoni et al. Frontiers in Oncology
- Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy
- (2015) Suzanne L. Topalian et al. CANCER CELL
- Re-wiring regulatory cell networks in immunity by galectin-glycan interactions
- (2015) Ada G. Blidner et al. FEBS LETTERS
- Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling
- (2015) James F Sampson et al. IMMUNOLOGY AND CELL BIOLOGY
- The galectin lattice at a glance
- (2015) I. R. Nabi et al. JOURNAL OF CELL SCIENCE
- Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential
- (2015) Erika M. Yazawa et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- The consensus molecular subtypes of colorectal cancer
- (2015) Justin Guinney et al. NATURE MEDICINE
- Cancers Complicating Inflammatory Bowel Disease
- (2015) Laurent Beaugerie et al. NEW ENGLAND JOURNAL OF MEDICINE
- Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells
- (2015) T. Kouo et al. Cancer Immunology Research
- Cancer statistics, 2014
- (2014) Rebecca Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Natural Killer Cells Eradicate Galectin-1-Deficient Glioma in the Absence of Adaptive Immunity
- (2014) G. J. Baker et al. CANCER RESEARCH
- Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors
- (2014) Diego O. Croci et al. CELL
- A naturally occurring CD8+CD122+ T-cell subset as a memory-like Treg family
- (2014) Shanshan Li et al. Cellular & Molecular Immunology
- OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis
- (2014) Lucile Astorgues-Xerri et al. EUROPEAN JOURNAL OF CANCER
- Galectin-9-CD44 Interaction Enhances Stability and Function of Adaptive Regulatory T Cells
- (2014) Chuan Wu et al. IMMUNITY
- Galectin-3 negatively regulates the frequency and function of CD4+CD25+Foxp3+regulatory T cells and influences the course ofLeishmania majorinfection
- (2013) Marise L. Fermino et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Targeting Galectin-1 Overcomes Breast Cancer-Associated Immunosuppression and Prevents Metastatic Disease
- (2012) T. Dalotto-Moreno et al. CANCER RESEARCH
- Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi’s sarcoma
- (2012) Diego O. Croci et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Tumor Galectin-1 Mediates Tumor Growth and Metastasis through Regulation of T-Cell Apoptosis
- (2011) A. Banh et al. CANCER RESEARCH
- The role of galectins in colorectal cancer progression
- (2011) Hannah Barrow et al. INTERNATIONAL JOURNAL OF CANCER
- CD122+CD8+ Treg suppress vaccine-induced antitumor immune responses in lymphodepleted mice
- (2010) Li-Xin Wang et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
- (2010) Irving C. Allen et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cutting Edge: Programmed Death-1 Defines CD8+CD122+ T Cells as Regulatory versus Memory T Cells
- (2010) H. Dai et al. JOURNAL OF IMMUNOLOGY
- Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg
- (2009) Zhe Shi et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- N- andO-Glycans Modulate Galectin-1 Binding, CD45 Signaling, and T Cell Death
- (2009) Lesley A. Earl et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The synthesized 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cells
- (2009) Li-Chen Chou et al. JOURNAL OF GASTROENTEROLOGY
- Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
- (2009) Juan M Ilarregui et al. NATURE IMMUNOLOGY
- Synthesis of stable and selective inhibitors of human galectins-1 and -3
- (2008) Denis Giguère et al. BIOORGANIC & MEDICINAL CHEMISTRY
- CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I–αβTCR interaction and become IL-10-producing active regulatory cells
- (2008) Muhaimin Rifa'i et al. INTERNATIONAL IMMUNOLOGY
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