Galectin-1 Couples Glycobiology to Inflammation in Osteoarthritis through the Activation of an NF-κB–Regulated Gene Network

Osteoarthritis

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The magic of the sugar code

(2015) Hans-Joachim Gabius   TRENDS IN BIOCHEMICAL SCIENCES

The glycobiology of the CD system: a dictionary for translating marker designations into glycan/lectin structure and function

(2015) Hans-Joachim Gabius et al.   TRENDS IN BIOCHEMICAL SCIENCES

Galectin-3 expressed on different lung compartments promotes organ specific metastasis by facilitating arrest, extravasation and organ colonization via high affinity ligands on melanoma cells

(2014) Manohar C. Dange et al.   CLINICAL & EXPERIMENTAL METASTASIS

Resolution of inflammation: examples of peptidergic players and pathways

(2014) Tazeen J. Ahmed et al.   DRUG DISCOVERY TODAY

Human osteoarthritic knee cartilage: fingerprinting of adhesion/growth-regulatory galectins in vitro and in situ indicates differential upregulation in severe degeneration

(2014) Stefan Toegel et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Molecular basis for MMP9 induction and disruption of epithelial cell-cell contacts by galectin-3

(2014) J. Mauris et al.   JOURNAL OF CELL SCIENCE

Galectin-1 stimulates motility of human umbilical cord blood-derived mesenchymal stem cells by downregulation of smad2/3-dependent collagen 3/5 and upregulation of NF-κB-dependent fibronectin/laminin 5 expression

(2014) S P Yun et al.   Cell Death & Disease

Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target

(2013) Karel Smetana et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Novel Mechanism of PositiveversusNegative Regulation by Thyroid Hormone Receptor β1 (TRβ1) Identified by Genome-wide Profiling of Binding Sites in Mouse Liver

(2013) Preeti Ramadoss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous Galectin-1 Exerts Tonic Inhibition on Experimental Arthritis

(2013) A. J. Iqbal et al.   JOURNAL OF IMMUNOLOGY

Glycophenotyping of osteoarthritic cartilage and chondrocytes by RT-qPCR, mass spectrometry, histochemistry with plant/human lectins and lectin localization with a glycoprotein

(2013) Stefan Toegel et al.   ARTHRITIS RESEARCH & THERAPY

Galectins in acute and chronic inflammation

(2012) Fu-Tong Liu et al.   Annals of the New York Academy of Sciences

Gremlin 1, Frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis

(2012) J. C. H. Leijten et al.   ARTHRITIS AND RHEUMATISM

Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression

(2012) Yuan-Guo Wang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Tumour suppressor p16INK4a- anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model

(2012) Maho Amano et al.   FEBS Journal

Autoantibodies against galectins are associated with antiphospholipid syndrome in patients with systemic lupus erythematosus

(2012) K. Sarter et al.   GLYCOBIOLOGY

Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: Increased expression of galectin-1 and induction of poor prognosis factors

(2012) Jaroslav Valach et al.   INTERNATIONAL JOURNAL OF CANCER

Differential expression of galectin-1 and its interactions with cells and laminins in the intervertebral disc

(2012) Liufang Jing et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

A decrease in galectin-1 (Gal-1) levels correlates with an increase in anti-Gal-1 antibodies at the synovial level in patients with rheumatoid arthritis

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Proteases involved in cartilage matrix degradation in osteoarthritis

(2011) Linda Troeberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Gene symbol precision

(2011) Barbara Bennani-Baiti et al.   GENE

Caesalpinia sappan extract inhibits IL1β-mediated overexpression of matrix metalloproteinases in human chondrocytes

(2011) Stefan Toegel et al.   Genes and Nutrition

Notch signalling is off and is uncoupled from HES1 expression in Ewing's sarcoma

(2011) Idriss M Bennani-Baiti et al.   JOURNAL OF PATHOLOGY

Nuclear factor (NF)-κB controls expression of the immunoregulatory glycan-binding protein galectin-1

(2011) Marta A. Toscano et al.   MOLECULAR IMMUNOLOGY

Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?

(2011) P.M. van der Kraan et al.   OSTEOARTHRITIS AND CARTILAGE

MIQE précis: Practical implementation of minimum standard guidelines for fluorescence-based quantitative real-time PCR experiments

(2010) Stephen A Bustin et al.   BMC MOLECULAR BIOLOGY

Galectin-1 is silenced by promoter hypermethylation and its re-expression induces apoptosis in human colorectal cancer cells

(2010) Arun Satelli et al.   CANCER LETTERS

Intercohort Gene Expression Co-Analysis Reveals Chemokine Receptors as Prognostic Indicators in Ewing's Sarcoma

(2010) I. M. Bennani-Baiti et al.   CLINICAL CANCER RESEARCH

NF-κB Signaling: Multiple Angles to Target OA

(2010) Kenneth B. Marcu et al.   CURRENT DRUG TARGETS

Tumor suppressor p16INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model

(2010) Hugo Sanchez-Ruderisch et al.   FEBS Journal

Galectin-1 is a powerful marker to distinguish chondroblastic osteosarcoma and conventional chondrosarcoma

(2010) Anne Gomez-Brouchet et al.   HUMAN PATHOLOGY

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Lectin binding patterns reflect the phenotypic status of in vitro chondrocyte models

(2009) S. Toegel et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Phenotype-related differential α-2,6- or α-2,3-sialylation of glycoprotein N-glycans in human chondrocytes

(2009) S. Toegel et al.   OSTEOARTHRITIS AND CARTILAGE

CD7 expression and galectin-1-induced apoptosis of immature thymocytes are directly regulated by NF-κB upon T-cell activation

(2008) Han S. Koh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Detection and chromatographic removal of lipopolysaccharide in preparations of multifunctional galectins

(2008) Kerstin Sarter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Galectin-1 in cartilage: Expression, influence on chondrocyte growth and interaction with ECM components

(2008) Eleonora Marsich et al.   MATRIX BIOLOGY