Engineering chimeric antigen receptor T cells for solid tumour therapy

Safety and early efficacy results from a phase 1, multicenter trial of PSMA-targeted armored CAR T cells in patients with advanced mCRPC.

(2022) Meredith McKean et al.   JOURNAL OF CLINICAL ONCOLOGY

CRISPR activation and interference screens decode stimulation responses in primary human T cells

(2022) Ralf Schmidt et al.   SCIENCE

Extracellular matrix modulates T cell clearance of malignant cells in vitro

(2022) Claire Robertson et al.   BIOMATERIALS

Enhanced safety and efficacy of protease-regulated CAR-T cell receptors

(2022) Louai Labanieh et al.   CELL

A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy

(2022) Lupeng Ye et al.   Cell Metabolism

Targeting Angiogenesis in Breast Cancer: Current Evidence and Future Perspectives of Novel Anti-Angiogenic Approaches

(2022) Nehad M. Ayoub et al.   Frontiers in Pharmacology

Improving CAR-T immunotherapy: Overcoming the challenges of T cell exhaustion

(2022) Diana Gumber et al.   EBioMedicine

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

(2022) Julia A. Belk et al.   CANCER CELL

Mechanosensor Piezo1 mediates bimodal patterns of intracellular calcium and FAK signaling

(2022) Yijia Pan et al.   EMBO JOURNAL

Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells

(2022) Xingying Zhang et al.   CANCER CELL

Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma

(2021) Nikhil C. Munshi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nanoengineered CAR‐T Biohybrids for Solid Tumor Immunotherapy with Microenvironment Photothermal‐Remodeling Strategy

(2021) Ze Chen et al.   Small

T Cell Exhaustion and CAR-T Immunotherapy in Hematological Malignancies

(2021) Lu Tang et al.   Biomed Research International

Tumor Heterogeneity: A Great Barrier in the Age of Cancer Immunotherapy

(2021) Nader El-Sayes et al.   Cancers

Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression

(2021) Devadarssen Murdamoothoo et al.   EMBO Molecular Medicine

Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

(2021) Evan W. Weber et al.   SCIENCE

SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models

(2021) Axel Hyrenius-Wittsten et al.   Science Translational Medicine

Trispecific CD19-CD20-CD22–targeting duoCAR-T cells eliminate antigen-heterogeneous B cell tumors in preclinical models

(2021) Dina Schneider et al.   Science Translational Medicine

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma

(2021) Joseph H. Choe et al.   Science Translational Medicine

Tumor Extracellular Matrix Stiffness Promptly Modulates the Phenotype and Gene Expression of Infiltrating T Lymphocytes

(2021) Maila Chirivì et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

(2021) Alba Nicolas-Boluda et al.   eLife

Secretion of bispecific protein of anti-PD-1 fused with TGF-β trap enhances antitumor efficacy of CAR-T cell therapy

(2021) Xianhui Chen et al.   Molecular Therapy-Oncolytics

Extracellular Matrices and Cancer-Associated Fibroblasts: Targets for Cancer Diagnosis and Therapy?

(2021) Ismahane Belhabib et al.   Cancers

Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis

(2021) Apriliana E. R. Kartikasari et al.   Frontiers in Oncology

An NK-like CAR T cell transition in CAR T cell dysfunction

(2021) Charly R. Good et al.   CELL

Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity

(2021) Brooke Prinzing et al.   Science Translational Medicine

Targeting Myeloid-Derived Suppressor Cells to Enhance the Antitumor Efficacy of Immune Checkpoint Blockade Therapy

(2021) Xueyan Li et al.   Frontiers in Immunology

Facing CAR T Cell Challenges on the Deadliest Paediatric Brain Tumours

(2021) Cristina Ferreras et al.   Cells

CXCR2‐modified CAR‐T cells have enhanced trafficking ability that improves treatment of hepatocellular carcinoma

(2020) Guangna Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Combining microenvironment normalization strategies to improve cancer immunotherapy

(2020) Fotios Mpekris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering light-controllable CAR T cells for cancer immunotherapy

(2020) Ziliang Huang et al.   Science Advances

Matrix-transmitted paratensile signaling enables myofibroblast–fibroblast cross talk in fibrosis expansion

(2020) Longwei Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptome profiling identifies TIGIT as a marker of T cell exhaustion in liver cancer

(2020) Dmitrij Ostroumov et al.   HEPATOLOGY

Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo

(2020) Sarah A. Richman et al.   MOLECULAR THERAPY

In Vivo Tumor Vascular Imaging with Light Emitting Diode-Based Photoacoustic Imaging System

(2020) Marvin Xavierselvan et al.   SENSORS

Myeloid-Derived Suppressor Cells in Tumors: From Mechanisms to Antigen Specificity and Microenvironmental Regulation

(2020) Yuhui Yang et al.   Frontiers in Immunology

Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors

(2020) Vid Leko et al.   CANCER CELL

Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors

(2020) Anthony K. Park et al.   Science Translational Medicine

CAR T cells targeting tumor endothelial marker CLEC14A inhibit tumor growth

(2020) Xiaodong Zhuang et al.   JCI Insight

Multi Targeted CAR-T Cell Therapies for B-Cell Malignancies

(2019) Nirav N. Shah et al.   Frontiers in Oncology

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice

(2019) Yushu Joy Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CAR T-Cells Targeting the Integrin αvβ6 and Co-Expressing the Chemokine Receptor CXCR2 Demonstrate Enhanced Homing and Efficacy against Several Solid Malignancies

(2019) Lynsey M. Whilding et al.   Cancers

Hypoxia Selectively Impairs CAR-T Cells In Vitro

(2019) Robert Berahovich et al.   Cancers

Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells

(2019) Matthew B. Dong et al.   CELL

Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins

(2019) Cédric Zeltz et al.   SEMINARS IN CANCER BIOLOGY

1226PA phase I clinical trial of malignant pleural mesothelioma treated with locally delivered autologous anti-FAP-targeted CAR T-cells

(2019) A Curioni et al.   ANNALS OF ONCOLOGY

B7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse models

(2019) Baozhu Huang et al.   OncoImmunology

Doxycycline Inducible Chimeric Antigen Receptor T Cells Targeting CD147 for Hepatocellular Carcinoma Therapy

(2019) Ren-Yu Zhang et al.   Frontiers in Cell and Developmental Biology

Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses

(2018) Jang Hwan Cho et al.   CELL

A guide to chemokines and their receptors

(2018) Catherine E. Hughes et al.   FEBS Journal

Hybrid pH-sensitive nanogels surface-functionalized with collagenase for enhanced tumor penetration

(2018) Xin Wang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication

(2018) Christopher C. Kloss et al.   MOLECULAR THERAPY

Rewiring T-cell responses to soluble factors with chimeric antigen receptors

(2018) ZeNan L Chang et al.   Nature Chemical Biology

State-of-the-Art Techniques in Treating Peripheral Nerve Injury

(2018) Carrie A. Kubiak et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System

(2018) Mauro P. Avanzi et al.   Cell Reports

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

(2018) Sarwish Rafiq et al.   NATURE BIOTECHNOLOGY

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function

(2018) Eric Shifrut et al.   CELL

Extracellular matrix (ECM) stiffness and degradation as cancer drivers

(2018) Masoud Najafi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

(2017) Paul A. Beavis et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase 1 Results of ZUMA-1: A Multicenter Study of KTE-C19 Anti-CD19 CAR T Cell Therapy in Refractory Aggressive Lymphoma

(2017) Frederick L. Locke et al.   MOLECULAR THERAPY

Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis

(2017) Longwei Liu et al.   NATURE MATERIALS

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

(2017) Sattva S. Neelapu et al.   NEW ENGLAND JOURNAL OF MEDICINE

An oxygen sensitive self-decision making engineered CAR T-cell

(2017) Alexandre Juillerat et al.   Scientific Reports

CAR T Cells Releasing IL-18 Convert to T-Bet high FoxO1 low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors

(2017) Markus Chmielewski et al.   Cell Reports

Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18

(2017) Biliang Hu et al.   Cell Reports

mSA2 affinity-enhanced biotin-binding CAR T cells for universal tumor targeting

(2017) Jason J. Lohmueller et al.   OncoImmunology

CXCL16/CXCR6-mediated adhesion of human peripheral blood mononuclear cells to inflamed endothelium

(2017) Bona Linke et al.   CYTOKINE

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy

(2016) Hanren Dai et al.   JNCI-Journal of the National Cancer Institute

Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma

(2016) Ke Hu et al.   Oncotarget

Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy

(2016) Hanren Dai et al.   JNCI-Journal of the National Cancer Institute

Mechanotransduction in cancer

(2016) LiKang Chin et al.   Current Opinion in Chemical Engineering

Fas–Fas Ligand: Checkpoint of T Cell Functions in Multiple Sclerosis

(2016) Elisabetta Volpe et al.   Frontiers in Immunology

Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment

(2015) Xiao-xiao Sun et al.   ACTA PHARMACOLOGICA SINICA

Cancer stem cells and the tumor microenvironment: interplay in tumor heterogeneity

(2015) Adriana Albini et al.   CONNECTIVE TISSUE RESEARCH

VEGF-A modulates expression of inhibitory checkpoints on CD8+T cells in tumors

(2015) Thibault Voron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enhancing Antitumor Efficacy of Chimeric Antigen Receptor T Cells Through Constitutive CD40L Expression

(2015) Kevin J Curran et al.   MOLECULAR THERAPY

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

(2015) Ignazio Caruana et al.   NATURE MEDICINE

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

(2015) David L. Porter et al.   Science Translational Medicine

Normalization of the tumor microenvironment: evidence for tissue inhibitor of metalloproteinase-2 as a cancer therapeutic

(2014) William G. Stetler-Stevenson et al.   CONNECTIVE TISSUE RESEARCH

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

(2014) Gregory T Motz et al.   NATURE MEDICINE

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

(2014) M. L. Davila et al.   Science Translational Medicine

Inference of Tumor Evolution during Chemotherapy by Computational Modeling and In Situ Analysis of Genetic and Phenotypic Cellular Diversity

(2014) Vanessa Almendro et al.   Cell Reports

Mechanisms Driving Macrophage Diversity and Specialization in Distinct Tumor Microenvironments and Parallelisms with Other Tissues

(2014) Eva Van Overmeire et al.   Frontiers in Immunology

Genetically modified T cells targeting neovasculature efficiently destroy tumor blood vessels, shrink established solid tumors and increase nanoparticle delivery

(2013) Xinping Fu et al.   INTERNATIONAL JOURNAL OF CANCER

Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma

(2013) Sunitha Kakarla et al.   MOLECULAR THERAPY

The causes and consequences of genetic heterogeneity in cancer evolution

(2013) Rebecca A. Burrell et al.   NATURE

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

(2013) Andrew L Doedens et al.   NATURE IMMUNOLOGY

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD44 Expressed on Cancer-Associated Fibroblasts Is a Functional Molecule Supporting the Stemness and Drug Resistance of Malignant Cancer Cells in the Tumor Microenvironment

(2013) Yumi Kinugasa et al.   STEM CELLS

Multifunctional Albumin Nanoparticles As Combination Drug Carriers for Intra-Tumoral Chemotherapy

(2013) Mingjie Cui et al.   Advanced Healthcare Materials

TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy

(2013) Zakaria Grada et al.   Molecular Therapy-Nucleic Acids

Interleukin-18 and IL-18 Binding Protein

(2013) Charles A. Dinarello et al.   Frontiers in Immunology

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Cell Plasticity and Heterogeneity in Cancer

(2012) N. D. Marjanovic et al.   CLINICAL CHEMISTRY

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

(2012) Hélène Salmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression

(2012) Marco Reis et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

(2011) Piyush B. Gupta et al.   CELL

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

Increased methylation variation in epigenetic domains across cancer types

(2011) Kasper Daniel Hansen et al.   NATURE GENETICS

Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice

(2010) Dhanalakshmi Chinnasamy et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced Tumor Trafficking of GD2 Chimeric Antigen Receptor T Cells by Expression of the Chemokine Receptor CCR2b

(2010) John A. Craddock et al.   JOURNAL OF IMMUNOTHERAPY

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1

(2008) Shigetomo Fukuhara et al.   NATURE CELL BIOLOGY