Facing CAR T Cell Challenges on the Deadliest Paediatric Brain Tumours
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Facing CAR T Cell Challenges on the Deadliest Paediatric Brain Tumours
Authors
Keywords
-
Journal
Cells
Volume 10, Issue 11, Pages 2940
Publisher
MDPI AG
Online
2021-11-02
DOI
10.3390/cells10112940
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Toxicity and effectiveness of CD19 CAR T therapy in children with high-burden central nervous system refractory B-ALL
- (2021) Yue Tan et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma
- (2021) Giulia Agliardi et al. Nature Communications
- CAR T cells in solid tumors: challenges and opportunities
- (2021) Faroogh Marofi et al. Stem Cell Research & Therapy
- Cytokines in CAR T Cell–Associated Neurotoxicity
- (2021) Juliane Gust et al. Frontiers in Immunology
- Use of Antiangiogenic Therapies in Pediatric Solid Tumors
- (2021) Claudia Ollauri-Ibáñez et al. Cancers
- CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
- (2021) Alba Rodriguez-Garcia et al. Nature Communications
- Dual-Target CAR-Ts with On- and Off-Tumour Activity May Override Immune Suppression in Solid Cancers: A Mathematical Proof of Concept
- (2021) Odelaisy León-Triana et al. Cancers
- Current perspectives on exosomes in the diagnosis and treatment of hepatocellular carcinoma (review)
- (2021) Dongdong Xue et al. CANCER BIOLOGY & THERAPY
- Identification of key methylation differentially expressed genes in posterior fossa ependymoma based on epigenomic and transcriptome analysis
- (2021) Guanyi Wang et al. Journal of Translational Medicine
- SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
- (2021) Joseph H. Choe et al. Science Translational Medicine
- CAR-T cell therapy: current limitations and potential strategies
- (2021) Robert C. Sterner et al. Blood Cancer Journal
- IFNg is Critical for CAR T Cell Mediated Myeloid Activation and Induction of Endogenous Immunity
- (2021) Darya Alizadeh et al. Cancer Discovery
- Nanoparticles for Enhanced Adoptive T Cell Therapies and Future Perspectives for CNS Tumors
- (2021) Preethi Bala Balakrishnan et al. Frontiers in Immunology
- Epigenomics and immunotherapeutic advances in pediatric brain tumors
- (2021) Malak Abedalthagafi et al. npj Precision Oncology
- New insights into M1/M2 macrophages: key modulators in cancer progression
- (2021) Jiuyang Liu et al. Cancer Cell International
- Opening of the Blood–Brain Barrier Using Low-Intensity Pulsed Ultrasound Enhances Responses to Immunotherapy in Preclinical Glioma Models
- (2021) Aria Sabbagh et al. CLINICAL CANCER RESEARCH
- Pediatric brain tumors: the era of molecular diagnostics, targeted and immune-based therapeutics, and a focus on long term neurologic sequelae
- (2021) Ashley S. Plant-Fox et al. CURRENT PROBLEMS IN CANCER
- The 2021 WHO Classification of Tumors of the Central Nervous System: a summary
- (2021) David N Louis et al. NEURO-ONCOLOGY
- Remote controlling of CAR-T cells and toxicity management: Molecular switches and next generation CARs
- (2021) Ehsan Moghanloo et al. Translational Oncology
- B7-H3/CD276: An Emerging Cancer Immunotherapy
- (2021) Wu-Tong Zhou et al. Frontiers in Immunology
- CARTmath—A Mathematical Model of CAR-T Immunotherapy in Preclinical Studies of Hematological Cancers
- (2021) Luciana R. C. Barros et al. Cancers
- ACCELERATE and European Medicines Agency Paediatric Strategy Forum for medicinal product development of checkpoint inhibitors for use in combination therapy in paediatric patients
- (2020) Andrew D.J. Pearson et al. EUROPEAN JOURNAL OF CANCER
- Mathematical deconvolution of CAR T-cell proliferation and exhaustion from real-time killing assay data
- (2020) Prativa Sahoo et al. Journal of the Royal Society Interface
- Blood-brain barrier disruption with low-intensity pulsed ultrasound for the treatment of pediatric brain tumors: a review and perspectives
- (2020) Kévin Beccaria et al. Neurosurgical Focus
- An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors
- (2020) Katharina Reinhard et al. SCIENCE
- Modeling medulloblastoma in vivo and with human cerebellar organoids
- (2020) Claudio Ballabio et al. Nature Communications
- Emerging Approaches for Regulation and Control of CAR T Cells: A Mini Review
- (2020) Lærke J. B. Brandt et al. Frontiers in Immunology
- Design and Characterization of an “All-in-One” Lentiviral Vector System Combining Constitutive Anti-GD2 CAR Expression and Inducible Cytokines
- (2020) Katharina Zimmermann et al. Cancers
- Chimeric antigen receptor‐modified T‐cell therapy for platelet‐derived growth factor receptor α‐positive rhabdomyosarcoma
- (2020) Wei Xiao et al. CANCER
- Replacing CAR-T cell resistance with persistence by changing a single residue
- (2020) Emily M. Hsieh et al. JOURNAL OF CLINICAL INVESTIGATION
- Advances in the molecular classification of pediatric brain tumors: A guide to the galaxy
- (2020) Chantel Cacciotti et al. JOURNAL OF PATHOLOGY
- Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors
- (2020) Johanna Theruvath et al. NATURE MEDICINE
- Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma
- (2020) Laura K. Donovan et al. NATURE MEDICINE
- Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes
- (2020) Matthew Clarke et al. Cancer Discovery
- Prolonged Persistence of Chimeric Antigen Receptor (CAR) T Cell in Adoptive Cancer Immunotherapy: Challenges and Ways Forward
- (2020) Leila Jafarzadeh et al. Frontiers in Immunology
- Immune profiling of pediatric solid tumors
- (2020) Rachael L. Terry et al. JOURNAL OF CLINICAL INVESTIGATION
- VEGFR2 as a target for CAR T cell therapy of Ewing sarcoma
- (2020) Alexander Englisch et al. PEDIATRIC BLOOD & CANCER
- Next-Generation Manufacturing Protocols Enriching TSCM CAR T Cells Can Overcome Disease-Specific T Cell Defects in Cancer Patients
- (2020) Silvia Arcangeli et al. Frontiers in Immunology
- Disialoganglioside GD2 Expression in Solid Tumors and Role as a Target for Cancer Therapy
- (2020) Bassel Nazha et al. Frontiers in Oncology
- CAR T Cell Therapy for Pediatric Brain Tumors
- (2020) John D. Patterson et al. Frontiers in Oncology
- Pediatric posterior fossa tumors outcomes: Experience in a tertiary care center in the Middle East
- (2020) Charbel Moussalem et al. CLINICAL NEUROLOGY AND NEUROSURGERY
- Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity
- (2020) Yura Grabovska et al. Nature Communications
- Neurotoxicity and Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy: Insights Into Mechanisms and Novel Therapies
- (2020) Elizabeth L. Siegler et al. Frontiers in Immunology
- Arming Anti-EGFRvIII CAR-T With TGFβ Trap Improves Antitumor Efficacy in Glioma Mouse Models
- (2020) You Li et al. Frontiers in Oncology
- Improving Tumor Retention of Effector Cells in Adoptive Cell Transfer Therapies by Magnetic Targeting
- (2020) Laura Sanz-Ortega et al. Pharmaceutics
- Trends and challenges in modeling glioma using 3D human brain organoids
- (2020) Aruljothi Mariappan et al. CELL DEATH AND DIFFERENTIATION
- Engineering Next-Generation CAR-T Cells for Better Toxicity Management
- (2020) Alain E. Andrea et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cell surface antigen profiling of pediatric brain tumors: B7-H3 is consistently expressed and can be targeted via local or systemic CAR T-cell delivery
- (2020) Dalia Haydar et al. NEURO-ONCOLOGY
- Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma
- (2020) Karin Straathof et al. Science Translational Medicine
- Classification of pediatric gliomas based on immunological profiling: implications for immunotherapy strategies
- (2020) Zihao Wang et al. Molecular Therapy-Oncolytics
- Cancer stem cell-targeted chimeric antigen receptor (CAR)-T cell therapy: Challenges and prospects
- (2020) Javad Masoumi et al. Acta Pharmaceutica Sinica B
- The exosomes derived from CAR-T cell efficiently target mesothelin and reduce triple-negative breast cancer growth
- (2020) Pengxiang Yang et al. CELLULAR IMMUNOLOGY
- CAR T cells targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors
- (2019) Robbie G. Majzner et al. CLINICAL CANCER RESEARCH
- Eradication of neuroblastoma by T cells redirected with an optimized GD2-specific chimeric antigen receptor and interleukin-15
- (2019) Yuhui Chen et al. CLINICAL CANCER RESEARCH
- Modelling CAR-T therapy in humanized mice
- (2019) Yongxia Wu et al. EBioMedicine
- Preclinical Evaluation of Bispecific Adaptor Molecule Controlled Folate Receptor CAR-T Cell Therapy With Special Focus on Pediatric Malignancies
- (2019) Yingjuan J. Lu et al. Frontiers in Oncology
- Treatment Strategies in Diffuse Midline Gliomas With the H3K27M Mutation: The Role of Convection-Enhanced Delivery in Overcoming Anatomic Challenges
- (2019) Benjamin T. Himes et al. Frontiers in Oncology
- IL-15-mediated reduction of mTORC1 activity preserves the stem cell memory phenotype of CAR-T cells and confers superior antitumor activity
- (2019) Darya Alizadeh et al. Cancer Immunology Research
- Childhood brain tumors: current management, biological insights, and future directions
- (2019) Ian F. Pollack et al. Journal of Neurosurgery-Pediatrics
- Pilot Trial of Adoptive Transfer of Chimeric Antigen Receptor–transduced T Cells Targeting EGFRvIII in Patients With Glioblastoma
- (2019) Stephanie L. Goff et al. JOURNAL OF IMMUNOTHERAPY
- Platelet derived growth factor receptor alpha is essential for cardiac fibroblast survival
- (2019) Malina J Ivey et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- A safe and potent anti-CD19 CAR T cell therapy
- (2019) Zhitao Ying et al. NATURE MEDICINE
- Nanotechnology Meets Oncology: Nanomaterials in Brain Cancer Research, Diagnosis and Therapy
- (2019) Alja Zottel et al. Materials
- CAR T cells for brain tumors: Lessons learned and road ahead
- (2019) David Akhavan et al. IMMUNOLOGICAL REVIEWS
- Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma
- (2019) Victor Maximov et al. Nature Communications
- Diverse immunotherapies can effectively treat syngeneic brainstem tumors in the absence of overt toxicity
- (2019) Matthew R. Schuelke et al. Journal for ImmunoTherapy of Cancer
- Immunotherapy for pediatric brain tumors: past and present
- (2019) Jessica B Foster et al. NEURO-ONCOLOGY
- WHO grade has no prognostic value in the pediatric high-grade glioma included in the HERBY trial
- (2019) Pascale Varlet et al. NEURO-ONCOLOGY
- Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial
- (2019) E. Antonio Chiocca et al. Science Translational Medicine
- Towards Immunotherapy for Pediatric Brain Tumors
- (2019) Stacie Shiqi Wang et al. TRENDS IN IMMUNOLOGY
- Magnetic targeting of adoptively transferred tumour-specific nanoparticle-loaded CD8+ T cells does not improve their tumour infiltration in a mouse model of cancer but promotes the retention of these cells in tumour-draining lymph nodes
- (2019) Laura Sanz-Ortega et al. JOURNAL OF NANOBIOTECHNOLOGY
- Mechanisms of failure of chimeric antigen receptor T-cell therapy
- (2019) Xiaoqing Li et al. CURRENT OPINION IN HEMATOLOGY
- Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice
- (2019) Matthias Mulazzani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
- (2019) Linchun Jin et al. Nature Communications
- CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity
- (2019) Wenyan Fu et al. Nature Communications
- GMP-Compliant Manufacturing of NKG2D CAR Memory T Cells Using CliniMACS Prodigy
- (2019) Lucía Fernández et al. Frontiers in Immunology
- CRISPR-Cas9 disruption of PD-1 enhances activity of universal EGFRvIII CAR T cells in a preclinical model of human glioblastoma
- (2019) Bryan D. Choi et al. Journal for ImmunoTherapy of Cancer
- Understanding the Mechanisms of Resistance to CAR T-Cell Therapy in Malignancies
- (2019) Jiali Cheng et al. Frontiers in Oncology
- A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity
- (2019) Fadi Jacob et al. CELL
- Engineering strategies to overcome the current roadblocks in CAR T cell therapy
- (2019) Sarwish Rafiq et al. Nature Reviews Clinical Oncology
- B7–H3 as a Prognostic Biomarker and Therapeutic Target in Pediatric central nervous system Tumors
- (2019) Uday B. Maachani et al. Translational Oncology
- Eradicating Cancer Stem Cells: Concepts, Issues, and Challenges
- (2018) Gurpreet Kaur et al. CURRENT TREATMENT OPTIONS IN ONCOLOGY
- Strategies for enhancing adoptive T-cell immunotherapy against solid tumors using engineered cytokine signaling and other modalities
- (2018) Thomas Shum et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Preclinical Models in Chimeric Antigen Receptor–Engineered T-Cell Therapy
- (2018) Elizabeth Louise Siegler et al. HUMAN GENE THERAPY
- When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma
- (2018) Saskia Roesch et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Immunophenotyping of pediatric brain tumors: correlating immune infiltrate with histology, mutational load, and survival and assessing clonal T cell response
- (2018) Ashley S. Plant et al. JOURNAL OF NEURO-ONCOLOGY
- CD28-ζ CAR T cells resist TGF-β repression through IL-2 signaling which can be mimicked by IL-7 and an engineered IL-7/IL-2Rβ autocrine loop
- (2018) Viktória Golumba-Nagy et al. MOLECULAR THERAPY
- Optimization of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma
- (2018) Christine E. Brown et al. MOLECULAR THERAPY
- Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells
- (2018) Margherita Norelli et al. NATURE MEDICINE
- Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas
- (2018) Christopher W. Mount et al. NATURE MEDICINE
- Chimeric Antigen Receptor Therapy
- (2018) Carl H. June et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia
- (2018) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- Clinical and Biologic Correlates of Neurotoxicity Associated with CAR T Cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia (B-ALL)
- (2018) Bianca D. Santomasso et al. Cancer Discovery
- Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System
- (2018) Mauro P. Avanzi et al. Cell Reports
- Targeting VEGF/VEGFR to Modulate Antitumor Immunity
- (2018) Ju Yang et al. Frontiers in Immunology
- Durable regression of Medulloblastoma after regional and intravenous delivery of anti-HER2 chimeric antigen receptor T cells
- (2018) Anandani Nellan et al. Journal for ImmunoTherapy of Cancer
- Editorial: Immunotherapy for Tumor in the Brain: Insights From—and For—Other Tumor Sites
- (2018) Lois A. Lampson Frontiers in Oncology
- Characterization of the immune microenvironment of diffuse intrinsic pontine glioma: Implications for development of immunotherapy
- (2018) Nicole A P Lieberman et al. NEURO-ONCOLOGY
- Tumor Antigen Escape from CAR T-cell Therapy
- (2018) Robbie G. Majzner et al. Cancer Discovery
- ASBMT Consensus Grading for Cytokine Release Syndrome and Neurological Toxicity Associated with Immune Effector Cells
- (2018) Daniel W Lee et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- Immunotherapy for Glioblastoma: Adoptive T-cell Strategies
- (2018) Bryan D. Choi et al. CLINICAL CANCER RESEARCH
- Functional Improvement of Chimeric Antigen Receptor Through Intrinsic Interleukin-15Ra Signaling
- (2018) Sushmita Nair et al. CURRENT GENE THERAPY
- Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma
- (2018) Stephen J. Schuster et al. NEW ENGLAND JOURNAL OF MEDICINE
- Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology
- (2018) Keisuke Watanabe et al. Frontiers in Immunology
- Carbohydrate Targets for CAR T Cells in Solid Childhood Cancers
- (2018) Claudia Rossig et al. Frontiers in Oncology
- The roles of microglia macrophages in tumor progression of brain cancer and metastatic disease
- (2017) Shih-Ying Wu Frontiers in Bioscience-Landmark
- CAR T-cell therapy of solid tumors
- (2017) Carmen S M Yong et al. IMMUNOLOGY AND CELL BIOLOGY
- CNS: Not an immunoprivilaged site anymore but a virtual secondary lymphoid organ
- (2017) Neema Negi et al. INTERNATIONAL REVIEWS OF IMMUNOLOGY
- New development in CAR-T cell therapy
- (2017) Zhenguang Wang et al. Journal of Hematology & Oncology
- Pediatric high-grade glioma: current molecular landscape and therapeutic approaches
- (2017) Steve Braunstein et al. JOURNAL OF NEURO-ONCOLOGY
- A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization
- (2017) Esther Drent et al. MOLECULAR THERAPY
- Tumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase
- (2017) Alec J. Walker et al. MOLECULAR THERAPY
- Magnetic nanoparticles in cancer therapy: how can thermal approaches help?
- (2017) Jelena Kolosnjaj-Tabi et al. Nanomedicine
- Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
- (2017) Stephen C. Mack et al. NATURE
- Cancer stem cells revisited
- (2017) Eduard Batlle et al. NATURE MEDICINE
- The role of peripheral immune cells in the CNS in steady state and disease
- (2017) Marco Prinz et al. NATURE NEUROSCIENCE
- Chimeric antigen receptor T-cell therapy — assessment and management of toxicities
- (2017) Sattva S. Neelapu et al. Nature Reviews Clinical Oncology
- Molecular Basis of Pediatric Brain Tumors
- (2017) Alexia Klonou et al. NEUROMOLECULAR MEDICINE
- Anti-CD19 CAR T Cells in CNS Diffuse Large-B-Cell Lymphoma
- (2017) Jeremy S. Abramson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
- (2017) Sattva S. Neelapu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Molecular mechanisms and therapeutic targets in pediatric brain tumors
- (2017) Kun-Wei Liu et al. Science Signaling
- A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
- (2017) Donald M. O’Rourke et al. Science Translational Medicine
- Endothelial Activation and Blood–Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells
- (2017) Juliane Gust et al. Cancer Discovery
- Differential expression of folate receptor 1 in medulloblastoma and the correlation with clinicopathological characters and target therapeutic potential
- (2017) Hailong Liu et al. Oncotarget
- CAR T Cells Releasing IL-18 Convert to T-Bet high FoxO1 low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors
- (2017) Markus Chmielewski et al. Cell Reports
- Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18
- (2017) Biliang Hu et al. Cell Reports
- Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
- (2017) Zachary R. Chalmers et al. Genome Medicine
- Molecular mechanisms and therapeutic targets in pediatric brain tumors
- (2017) Kun-Wei Liu et al. Science Signaling
- HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma
- (2017) Nabil Ahmed et al. JAMA Oncology
- The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
- (2016) David N. Louis et al. ACTA NEUROPATHOLOGICA
- Defining the optimal murine models to investigate immune checkpoint blockers and their combination with other immunotherapies
- (2016) M. F. Sanmamed et al. ANNALS OF ONCOLOGY
- Armored CAR T-cells: utilizing cytokines and pro-inflammatory ligands to enhance CAR T-cell anti-tumour efficacy
- (2016) Oladapo O. Yeku et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype
- (2016) Timothy N. Phoenix et al. CANCER CELL
- Adoptive cell therapy: a highly successful individualized therapy for melanoma with great potential for other malignancies
- (2016) Els ME Verdegaal CURRENT OPINION IN IMMUNOLOGY
- Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier
- (2016) David S. Hersh et al. CURRENT PHARMACEUTICAL DESIGN
- Shared target antigens on cancer cells and tissue stem cells: go or no-go for CAR T cells?
- (2016) Andreas A. Hombach et al. Expert Review of Clinical Immunology
- Characterization and Functional Analysis of scFv-based Chimeric Antigen Receptors to Redirect T Cells to IL13Rα2-positive Glioma
- (2016) Giedre Krenciute et al. MOLECULAR THERAPY
- Pediatric high-grade glioma: biologically and clinically in need of new thinking
- (2016) Chris Jones et al. NEURO-ONCOLOGY
- Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy
- (2016) Christine E. Brown et al. NEW ENGLAND JOURNAL OF MEDICINE
- Multifaceted interactions between adaptive immunity and the central nervous system
- (2016) J. Kipnis SCIENCE
- Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia
- (2016) D. T. Teachey et al. Cancer Discovery
- Characterizing and targeting PDGFRA alterations in pediatric high-grade glioma
- (2016) Carl Koschmann et al. Oncotarget
- Atypical teratoid/rhabdoid tumors: challenges and search for solutions
- (2016) Ahitagni Biswas et al. Cancer Management and Research
- Targeting the Tumor Microenvironment to Enhance Pediatric Brain Cancer Treatment
- (2015) Ana Batista et al. CANCER JOURNAL
- Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases
- (2015) Thanh-Huyen Tran et al. CLINICAL IMMUNOLOGY
- A phase I clinical trial of adoptive T cell therapy using IL-12 secreting MUC-16ecto directed chimeric antigen receptors for recurrent ovarian cancer
- (2015) Mythili Koneru et al. Journal of Translational Medicine
- T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
- (2015) Daniel W Lee et al. LANCET
- Sex, Age, Anatomic Location, and Extent of Resection Influence Outcomes in Children With High-grade Glioma
- (2015) Heather J. McCrea et al. NEUROSURGERY
- Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio
- (2015) Tianzhi Yang et al. PHARMACEUTICAL RESEARCH
- Remote control of therapeutic T cells through a small molecule-gated chimeric receptor
- (2015) C.-Y. Wu et al. SCIENCE
- Therapeutic potential of CAR-T cell-derived exosomes: a cell-free modality for targeted cancer therapy
- (2015) Xiang-Jun Tang et al. Oncotarget
- Molecular Biology in Pediatric High-Grade Glioma: Impact on Prognosis and Treatment
- (2015) Daniela Rizzo et al. Biomed Research International
- Patient-derived glioblastoma stem cells are killed by CD133-specific CAR T cells but induce the T cell aging marker CD57
- (2015) Xuekai Zhu et al. Oncotarget
- Childhood Brain Tumor Epidemiology: A Brain Tumor Epidemiology Consortium Review
- (2014) K. J. Johnson et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Trafficking of T Cells into Tumors
- (2014) C. Y. Slaney et al. CANCER RESEARCH
- Efficacy of CAR T-cell Therapy in Large Tumors Relies upon Stromal Targeting by IFN
- (2014) A. Textor et al. CANCER RESEARCH
- Management of Pediatric and Adult Patients with Medulloblastoma
- (2014) Allison M. Martin et al. CURRENT TREATMENT OPTIONS IN ONCOLOGY
- Cancer stem cells - important players in tumor therapy resistance
- (2014) Selcuk Colak et al. FEBS Journal
- Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
- (2014) M. L. Davila et al. Science Translational Medicine
- Improving the safety of cell therapy products by suicide gene transfer
- (2014) Benjamin S. Jones et al. Frontiers in Pharmacology
- Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas
- (2013) B. S. Paugh et al. CANCER RESEARCH
- Targeting Placental Growth Factor/Neuropilin 1 Pathway Inhibits Growth and Spread of Medulloblastoma
- (2013) Matija Snuderl et al. CELL
- Anti-angiogenic therapy in pediatric brain tumors: An effective strategy?
- (2013) Mariska Sie et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- CSF-1R inhibition alters macrophage polarization and blocks glioma progression
- (2013) Stephanie M Pyonteck et al. NATURE MEDICINE
- PD-1- and CTLA-4-Based Inhibitory Chimeric Antigen Receptors (iCARs) Divert Off-Target Immunotherapy Responses
- (2013) V. D. Fedorov et al. Science Translational Medicine
- In vitro Natural Killer Cell Immunotherapy for Medulloblastoma
- (2013) Lucia Fernández et al. Frontiers in Oncology
- The discovery of placenta growth factor and its biological activity
- (2012) Sandro De Falco EXPERIMENTAL AND MOLECULAR MEDICINE
- T Cells Redirected to EphA2 for the Immunotherapy of Glioblastoma
- (2012) Kevin KH Chow et al. MOLECULAR THERAPY
- Mesenchymal Transition and PDGFRA Amplification/Mutation Are Key Distinct Oncogenic Events in Pediatric Diffuse Intrinsic Pontine Gliomas
- (2012) Stephanie Puget et al. PLoS One
- Comparison of Different Suicide-Gene Strategies for the Safety Improvement of Genetically Manipulated T Cells
- (2012) Virna Marin et al. Human Gene Therapy Methods
- Pediatric High Grade Glioma: a Review and Update on Tumor Clinical Characteristics and Biology
- (2012) Jason Fangusaro Frontiers in Oncology
- Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
- (2011) C. U. Louis et al. BLOOD
- Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
- (2011) S. A. Rosenberg et al. CLINICAL CANCER RESEARCH
- Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
- (2011) Lydia Alvarez-Erviti et al. NATURE BIOTECHNOLOGY
- Treatment of posterior fossa tumors in children
- (2010) Dattatraya Muzumdar et al. Expert Review of Neurotherapeutics
- Lack of Efficacy of Bevacizumab Plus Irinotecan in Children With Recurrent Malignant Glioma and Diffuse Brainstem Glioma: A Pediatric Brain Tumor Consortium Study
- (2010) Sridharan Gururangan et al. JOURNAL OF CLINICAL ONCOLOGY
- Integrated Molecular Genetic Profiling of Pediatric High-Grade Gliomas Reveals Key Differences With the Adult Disease
- (2010) Barbara S. Paugh et al. JOURNAL OF CLINICAL ONCOLOGY
- Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme
- (2010) Klaus Maier-Hauff et al. JOURNAL OF NEURO-ONCOLOGY
- Review: Leucocyte-endothelial cell crosstalk at the blood-brain barrier: A prerequisite for successful immune cell entry to the brain
- (2010) J. Greenwood et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Interferon-γ reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages
- (2009) Dorothée Duluc et al. INTERNATIONAL JOURNAL OF CANCER
- Chimeric NKG2D Expressing T Cells Eliminate Immunosuppression and Activate Immunity within the Ovarian Tumor Microenvironment
- (2009) A. Barber et al. JOURNAL OF IMMUNOLOGY
- Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomas
- (2008) Hideho Okada et al. JOURNAL OF NEURO-ONCOLOGY
- NKG2D ligands in tumor immunity
- (2008) N Nausch et al. ONCOGENE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started