Extracellular matrix modulates T cell clearance of malignant cells in vitro

Integrin αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer

(2021) Archis Bagati et al.   CANCER CELL

Laminin γ2–mediating T cell exclusion attenuates response to anti–PD-1 therapy

(2021) Lei Li et al.   Science Advances

The Immunosuppressive Niche of Soft Tissue Sarcomas is Sustained by Tumor Associated Macrophages and Characterized by Intratumoral Tertiary Lymphoid Structures

(2020) Lingling Chen et al.   CLINICAL CANCER RESEARCH

Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer

(2020) Aimy Sebastian et al.   Cancers

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion

(2020) David H. Peng et al.   Nature Communications

Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice

(2020) Ivana Peran et al.   GASTROENTEROLOGY

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

A biologic scaffold–associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy

(2019) Matthew T. Wolf et al.   Science Translational Medicine

The landscape of cancer cell line metabolism

(2019) Haoxin Li et al.   NATURE MEDICINE

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

(2019) Yuxing Liao et al.   NUCLEIC ACIDS RESEARCH

Current Landscape of Immunotherapy in Breast Cancer

(2019) Sylvia Adams et al.   JAMA Oncology

αvβ3-integrin regulates PD-L1 expression and is involved in cancer immune evasion

(2019) Andrea Vannini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Immune Landscape of Cancer

(2018) Vésteinn Thorsson et al.   IMMUNITY

Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy

(2018) Carsten Denkert et al.   LANCET ONCOLOGY

A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing

(2018) Deng Pan et al.   SCIENCE

Selective targeting of collagen IV in the cancer cell microenvironment reduces tumor burden

(2018) Fernando Revert et al.   Oncotarget

The hallmarks of successful anticancer immunotherapy

(2018) Lorenzo Galluzzi et al.   Science Translational Medicine

A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain

(2018) Muneyoshi Okada et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

MMP-9 inhibition promotes anti-tumor immunity through disruption of biochemical and physical barriers to T-cell trafficking to tumors

(2018) Vladi Juric et al.   PLoS One

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy

(2018) Razvan Cristescu et al.   SCIENCE

TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

(2018) Ankur Chakravarthy et al.   Nature Communications

Divergent immune responses to synthetic and biological scaffolds

(2018) Kaitlyn Sadtler et al.   BIOMATERIALS

Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses

(2017) Byron H. Kwan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis

(2017) Corina M. Borza et al.   MATRIX BIOLOGY

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

(2017) Vinod P. Balachandran et al.   NATURE

A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy

(2017) Marta Łuksza et al.   NATURE

Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration

(2017) Monica Gordon-Alonso et al.   Nature Communications

Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers

(2017) Oliver M.T. Pearce et al.   Cancer Discovery

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

(2017) Darshan S. Chandrashekar et al.   NEOPLASIA

The extracellular matrix in breast cancer predicts prognosis through composition, splicing, and crosslinking

(2016) Claire Robertson   EXPERIMENTAL CELL RESEARCH

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

Tumor-infiltrating lymphocyte composition, organization and PD-1/ PD-L1 expression are linked in breast cancer

(2016) Laurence Buisseret et al.   OncoImmunology

Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization

(2015) Hiroe Toba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

Perforin: an important player in immune response

(2014) Iwona Osińska et al.   Central European Journal of Immunology

Normalization of RNA-seq data using factor analysis of control genes or samples

(2014) Davide Risso et al.   NATURE BIOTECHNOLOGY

Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126

(2014) K. J. Paavola et al.   Science Signaling

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

(2013) Kun Zhang et al.   NATURE CELL BIOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Tetrastatin, the NC1 Domain of the α4(IV) Collagen Chain: A Novel Potent Anti-Tumor Matrikine

(2012) Sylvie Brassart-Pasco et al.   PLoS One

Arresten, a Collagen-Derived Angiogenesis Inhibitor, Suppresses Invasion of Squamous Cell Carcinoma

(2012) Mari Aikio et al.   PLoS One

Pentastatin-1, a collagen IV derived 20-mer peptide, suppresses tumor growth in a small cell lung cancer xenograft model

(2010) Jacob E Koskimaki et al.   BMC CANCER

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

Disease candidate gene identification and prioritization using protein interaction networks

(2009) Jing Chen et al.   BMC BIOINFORMATICS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Collagen IV levels are elevated in the serum of patients with primary breast cancer compared to healthy volunteers

(2008) C Mazouni et al.   BRITISH JOURNAL OF CANCER

Mammalian collagen IV

(2008) Jamshid Khoshnoodi et al.   MICROSCOPY RESEARCH AND TECHNIQUE