CAR T Cells Releasing IL-18 Convert to T-Bet high FoxO1 low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors

Published 2017 View Full Article

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Title
CAR T Cells Releasing IL-18 Convert to T-Bet high FoxO1 low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors
Authors
Keywords
chimeric antigen receptor, CAR, adoptive cell therapy, pancreatic carcinoma, carcinoembryonic antigen, CEA, IL-12, IL-18, TRUCK
Journal
Cell Reports
Volume 21, Issue 11, Pages 3205-3219
Publisher
Elsevier BV
Online
2017-12-13
DOI
10.1016/j.celrep.2017.11.063

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