Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors

A chimeric poxvirus with J2R (thymidine kinase) deletion shows safety and anti-tumor activity in lung cancer models

(2019) Shyambabu Chaurasiya et al.   CANCER GENE THERAPY

A Novel Chimeric Poxvirus Encoding hNIS Is Tumor-Tropic, Imageable, and Synergistic with Radioiodine to Sustain Colon Cancer Regression

(2019) Susanne G. Warner et al.   Molecular Therapy-Oncolytics

Oncolytic Viruses and Immune Checkpoint Inhibition: The Best of Both Worlds

(2019) Venkatesh Sivanandam et al.   Molecular Therapy-Oncolytics

Phase I study of oncolytic vaccinia virus GL-ONC1 in patients with peritoneal carcinomatosis

(2018) Ulrich M. Lauer et al.   CLINICAL CANCER RESEARCH

Novel oncolytic chimeric orthopoxvirus causes regression of pancreatic cancer xenografts and exhibits abscopal effect at a single low dose

(2018) Michael P. O’Leary et al.   Journal of Translational Medicine

Oncolytic Virus Combination Therapy: Killing One Bird with Two Stones

(2018) Nikolas Tim Martin et al.   MOLECULAR THERAPY

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus–Driven Production of a Bispecific T-cell Engager

(2018) Anna Wing et al.   Cancer Immunology Research

Endogenous Akt Activity Promotes Virus Entry and Predicts Efficacy of Novel Chimeric Orthopoxvirus in Triple-Negative Breast Cancer

(2018) Audrey H. Choi et al.   Molecular Therapy-Oncolytics

A Novel Oncolytic Chimeric Orthopoxvirus Encoding Luciferase Enables Real-Time View of Colorectal Cancer Cell Infection

(2018) Michael P. O’Leary et al.   Molecular Therapy-Oncolytics

Making CAR T Cells a Solid Option for Solid Tumors

(2018) Andrea Schmidts et al.   Frontiers in Immunology

Effective Targeting of TAG72+ Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells

(2018) John P. Murad et al.   Frontiers in Immunology

Vaccinia virus hijacks EGFR signalling to enhance virus spread through rapid and directed infected cell motility

(2018) Corina Beerli et al.   Nature Microbiology

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

(2017) Donald M. O’Rourke et al.   Science Translational Medicine

Endothelial Activation and Blood–Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells

(2017) Juliane Gust et al.   Cancer Discovery

Review: Oncolytic virotherapy, updates and future directions

(2017) Christos Fountzilas et al.   Oncotarget

Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer

(2017) Saul J. Priceman et al.   OncoImmunology

Prospects for combined use of oncolytic viruses and CAR T-cells

(2017) Adam Ajina et al.   Journal for ImmunoTherapy of Cancer

Modulation of the Intratumoral Immune Landscape by Oncolytic Herpes Simplex Virus Virotherapy

(2017) Jie Yin et al.   Frontiers in Oncology

Phase 1 studies of central memory-derived CD19 CAR T-cell therapy following autologous HSCT in patients with B-cell NHL

(2016) X. Wang et al.   BLOOD

Biology and clinical application of CAR T cells for B cell malignancies

(2016) Marco L. Davila et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Phase 1 Study of Intravenous Oncolytic Poxvirus (vvDD) in Patients With Advanced Solid Cancers

(2016) Stephanie Downs-Canner et al.   MOLECULAR THERAPY

Into the clinic: Talimogene laherparepvec (T-VEC), a first-in-class intratumoral oncolytic viral therapy

(2016) Hasan Rehman et al.   Journal for ImmunoTherapy of Cancer

CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia

(2015) S. L. Maude et al.   BLOOD

Smart CARs engineered for cancer immunotherapy

(2015) Saul J. Priceman et al.   CURRENT OPINION IN ONCOLOGY

Phase 1 Study of Intratumoral Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus, in Pediatric Cancer Patients

(2015) Timothy P Cripe et al.   MOLECULAR THERAPY

Oncolytic viruses: a new class of immunotherapy drugs

(2015) Howard L. Kaufman et al.   NATURE REVIEWS DRUG DISCOVERY

Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor-Modified T Cells in Solid Tumors

(2014) N. Nishio et al.   CANCER RESEARCH

Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection

(2014) P. R. Kumaresan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

(2014) M. L. Davila et al.   Science Translational Medicine

Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade Immunotherapy

(2014) D. Zamarin et al.   Science Translational Medicine

Regulating Cytokine Function Enhances Safety and Activity of Genetic Cancer Therapies

(2013) Hannah Chen et al.   MOLECULAR THERAPY

Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

(2011) R. J. Brentjens et al.   BLOOD

Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans

(2011) Caroline J. Breitbach et al.   NATURE

Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

(2010) J. N. Kochenderfer et al.   BLOOD

Successful Eradication of Established Peritoneal Ovarian Tumors in SCID-Beige Mice following Adoptive Transfer of T Cells Genetically Targeted to the MUC16 Antigen

(2010) A. A. Chekmasova et al.   CLINICAL CANCER RESEARCH

Comparison of intravenous versus intraperitoneal administration of oncolytic herpes simplex virus 1 for peritoneal carcinomatosis in mice

(2008) Y Kulu et al.   CANCER GENE THERAPY

Enhancing Poxvirus Oncolytic Effects through Increased Spread and Immune Evasion

(2008) D. H. Kirn et al.   CANCER RESEARCH