Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage

IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment

(2022) Xun Lin et al.   IMMUNITY

POU2F3 beyond thymic carcinomas: expression across the spectrum of thymomas hints to medullary differentiation in type A thymoma

(2022) Yosuke Yamada et al.   VIRCHOWS ARCHIV

Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages

(2022) Noella Lopes et al.   eLife

The Lineage Differentiation and Dynamic Heterogeneity of Thymic Epithelial Cells During Thymus Organogenesis

(2022) Hanchao Gao et al.   Frontiers in Immunology

Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine

(2022) Zhen Xiong et al.   IMMUNITY

Expression patterns and prognostic relevance of subtype‐specific transcription factors in surgically resected small‐cell lung cancer: an international multicenter study

(2022) Zsolt Megyesfalvi et al.   JOURNAL OF PATHOLOGY

Respiratory Influenza Virus Infection Causes Dynamic Tuft Cell and Innate Lymphoid Cell Changes in the Small Intestine

(2022) Shanley N. Roach et al.   JOURNAL OF VIROLOGY

Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium

(2022) Tsunaki Higa et al.   Nature Communications

BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13–driven tuft cell hyperplasia

(2022) Håvard T. Lindholm et al.   Science Immunology

Bile acid–sensitive tuft cells regulate biliary neutrophil influx

(2022) Claire E. O’Leary et al.   Science Immunology

Cysteinyl leukotrienes and acetylcholine are biliary tuft cell cotransmitters

(2022) Maryam Keshavarz et al.   Science Immunology

IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function

(2022) Maya E Kotas et al.   JCI Insight

c-MAF coordinates enterocyte zonation and nutrient uptake transcriptional programs

(2022) Alejandra González-Loyola et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells

(2022) Huachao Huang et al.   eLife

P63 Deficiency and CDX2 Overexpression Lead to Barrett’s-Like Metaplasia in Mouse Esophageal Epithelium

(2021) Yu Fang et al.   DIGESTIVE DISEASES AND SCIENCES

Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis

(2021) Pritesh Desai et al.   CELL

Development of epithelial cholinergic chemosensory cells of the urethra and trachea of mice

(2021) Alexander Perniss et al.   CELL AND TISSUE RESEARCH

A Tuft Cell–Like Signature Is Highly Prevalent in Thymic Squamous Cell Carcinoma and Delineates New Molecular Subsets Among the Major Lung Cancer Histotypes

(2021) Yosuke Yamada et al.   Journal of Thoracic Oncology

Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla

(2021) Jhoanne L. Bautista et al.   Nature Communications

Notch signaling drives development of Barrett’s metaplasia from Dclk1-positive epithelial tuft cells in the murine gastric mucosa

(2021) Bettina Kunze et al.   Scientific Reports

A molecular single-cell lung atlas of lethal COVID-19

(2021) Johannes C. Melms et al.   NATURE

TNFAIP8 Regulates Intestinal Epithelial Cell Differentiation and May Alter Terminal Differentiation of Secretory Progenitors

(2021) Ryan Hood et al.   Cells

PGD2 and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection

(2021) Oyebola O. Oyesola et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CISH constrains the tuft–ILC2 circuit to set epithelial and immune tone

(2021) Maya E. Kotas et al.   Mucosal Immunology

A multilocular thymic cyst associated with mediastinal seminoma: evidence for its medullary epithelial origin highlighted by POU2F3-positive thymic tuft cells and concomitant myoid cell proliferation

(2021) Akihiko Sugimoto et al.   VIRCHOWS ARCHIV

Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism

(2021) Zheng Fu et al.   Nature Communications

Tumor suppressor p53 regulates intestinal type 2 immunity

(2021) Chun-Yuan Chang et al.   Nature Communications

Clump sequencing exposes the spatial expression programs of intestinal secretory cells

(2021) Rita Manco et al.   Nature Communications

Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells

(2021) Kaare V. Grunddal et al.   Molecular Metabolism

Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma

(2021) Esther C. Broner et al.   Frontiers in Oncology

Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury

(2021) Zhibo Ma et al.   GASTROENTEROLOGY

RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine

(2021) Tianyun Long et al.   GUT

Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products

(2021) Claire Drurey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-cell sequencing of rotavirus-infected intestinal epithelium reveals cell-type specific epithelial repair and tuft cell infection

(2021) Carolyn Bomidi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimensions of neutrophil life and fate

(2021) Andrés Hidalgo et al.   SEMINARS IN IMMUNOLOGY

DCLK1 and its interaction partners: An effective therapeutic target for colorectal cancer (Review)

(2021) Muthu Vijai et al.   Oncology Letters

Diagnostic and Prognostic Significances of SOX9 in Thymic Epithelial Tumor

(2021) Xiaodong Yuan et al.   Frontiers in Oncology

Tuft cell–produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation

(2021) Saltanat Ualiyeva et al.   Science Immunology

Using single-cell RNA sequencing to unravel cell lineage relationships in the respiratory tract

(2020) L.E. Zaragosi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity

(2020) Roberto R. Ricardo-Gonzalez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche

(2020) Moritz Middelhoff et al.   Nature Communications

Tuft Cell Formation Reflects Epithelial Plasticity in Pancreatic Injury: Implications for Modeling Human Pancreatitis

(2020) Kathleen E. DelGiorno et al.   Frontiers in Physiology

Thymic Epithelial Cells Contribute to Thymopoiesis and T Cell Development

(2020) Hong-Xia Wang et al.   Frontiers in Immunology

BATF acts as an essential regulator of IL-25–responsive migratory ILC2 cell fate and function

(2020) Mindy M. Miller et al.   Science Immunology

Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2

(2020) Saltanat Ualiyeva et al.   Science Immunology

Distribution of duodenal tuft cells is altered in pediatric patients with acute and chronic enteropathy

(2020) Won Jae HUH et al.   BIOMEDICAL RESEARCH-TOKYO

Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides

(2020) Alexander Perniss et al.   IMMUNITY

Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity

(2020) John W. McGinty et al.   IMMUNITY

Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium

(2020) Katherine C. Goldfarbmuren et al.   Nature Communications

Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells

(2020) Beth Lucas et al.   Nature Communications

CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus

(2020) Vincent R. Graziano et al.   PLoS Pathogens

Mucosal Tuft Cell Density Is Increased in Diarrhea-Predominant Irritable Bowel Syndrome Colonic Biopsies

(2020) Jessica Aigbologa et al.   Frontiers in Psychiatry

A Single-cell Atlas of the Human Healthy Airways

(2020) Marie Deprez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2

(2020) Kathleen E. DelGiorno et al.   GASTROENTEROLOGY

Elevating EGFR-MAPK program by a non-conventional Cdc42 enhances intestinal epithelial survival and regeneration

(2020) Xiao Zhang et al.   JCI Insight

Group 2 innate lymphoid cells coordinate damage response in the stomach

(2020) Anne R. Meyer et al.   GASTROENTEROLOGY

Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation

(2020) Amrita Banerjee et al.   GASTROENTEROLOGY

The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice

(2020) Megan T. Hoffman et al.   Cellular and Molecular Gastroenterology and Hepatology

Expression of POU2F3 Transcription Factor Control Inflammation, Immunological Recruitment and Metastasis of Pancreatic Cancer in Mice

(2020) Jennifer Bintz et al.   Biology-Basel

Generation of intestinal chemosensory cells from nonhuman primate organoids

(2020) Akihiko Inaba et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tuning tuft cells: new ligands and effector functions reveal tissue-specific function

(2020) Tyler E Billipp et al.   CURRENT OPINION IN IMMUNOLOGY

Single-Nucleus and In Situ RNA–Sequencing Reveal Cell Topographies in the Human Pancreas

(2020) Luca Tosti et al.   GASTROENTEROLOGY

Infection by the parasitic helminthTrichinella spiralisactivates a Tas2r-mediated signaling pathway in intestinal tuft cells

(2019) Xiao-Cui Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping

(2019) Helmuth Gehart et al.   CELL

Development of solitary chemosensory cells in the distal lung after severe influenza injury

(2019) Chetan K Rane et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis

(2019) Sanghyun Lee et al.   Cell Host & Microbe

Lineage tracing and targeting of IL17RB+tuft cell-like human colorectal cancer stem cells

(2019) Norihiro Goto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures

(2019) Sandra Ruiz García et al.   DEVELOPMENT

Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling

(2019) Monika I. Hollenhorst et al.   FASEB JOURNAL

Gingival solitary chemosensory cells are immune sentinels for periodontitis

(2019) Xin Zheng et al.   Nature Communications

Distribution pattern and molecular signature of cholinergic tuft cells in human gastro-intestinal and pancreatic-biliary tract

(2019) Burkhard Schütz et al.   Scientific Reports

Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion

(2019) Johan H. van Es et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling

(2018) Christoph Schneider et al.   CELL

POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer

(2018) Yu-Han Huang et al.   GENES & DEVELOPMENT

Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit

(2018) Marija S. Nadjsombati et al.   IMMUNITY

Solitary chemosensory cells are a primary epithelial source of IL-25 in patients with chronic rhinosinusitis with nasal polyps

(2018) Michael A. Kohanski et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine

(2018) Weiwei Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tropism for tuft cells determines immune promotion of norovirus pathogenesis

(2018) Craig B. Wilen et al.   SCIENCE

PGD2/PTGDR2 Signaling Restricts the Self-Renewal and Tumorigenesis of Gastric Cancer

(2018) Bin Zhang et al.   STEM CELLS

Solitary chemosensory cells producing interleukin-25 and group-2 innate lymphoid cells are enriched in chronic rhinosinusitis with nasal polyps

(2018) Neil N. Patel et al.   International Forum of Allergy & Rhinology

Unsupervised Trajectory Analysis of Single-Cell RNA-Seq and Imaging Data Reveals Alternative Tuft Cell Origins in the Gut

(2018) Charles A. Herring et al.   Cell Systems

Spatial Reconstruction of Single Enterocytes Uncovers Broad Zonation along the Intestinal Villus Axis

(2018) Andreas E. Moor et al.   CELL

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

(2018) Chamutal Bornstein et al.   NATURE

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development

(2018) Corey N. Miller et al.   NATURE

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

(2018) Daniel T. Montoro et al.   NATURE

Tissue signals imprint ILC2 identity with anticipatory function

(2018) Roberto R. Ricardo-Gonzalez et al.   NATURE IMMUNOLOGY

Formyl-Peptide Receptors in Infection, Inflammation, and Cancer

(2018) Elisabeth Weiß et al.   TRENDS IN IMMUNOLOGY

Tuft Cells—Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry

(2018) Claire E. O'Leary et al.   Annual Review of Immunology

Sox4 Promotes Atoh1-Independent Intestinal Secretory Differentiation Toward Tuft and Enteroendocrine Fates

(2018) Adam D. Gracz et al.   GASTROENTEROLOGY

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

Taste buds: cells, signals and synapses

(2017) Stephen D. Roper et al.   NATURE REVIEWS NEUROSCIENCE

Bacterial d-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells

(2017) Robert J. Lee et al.   Science Signaling

Doublecortin and CaM kinase-like-1 as an independent prognostic factor in patients with resected pancreatic carcinoma

(2017) Kohei Nishio et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Bacterial d-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells

(2017) Robert J. Lee et al.   Science Signaling

Whole transcriptome profiling of taste bud cells

(2017) Sunil K. Sukumaran et al.   Scientific Reports

Physiology of Intestinal Absorption and Secretion

(2016) Pawel R. Kiela et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Chemosensory epithelial cells in the urethra: sentinels of the urinary tract

(2016) Klaus Deckmann et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

(2016) François Gerbe et al.   NATURE

Discovery of a proteinaceous cellular receptor for a norovirus

(2016) R. C. Orchard et al.   SCIENCE

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

(2016) M. R. Howitt et al.   SCIENCE

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

DCLK1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transition

(2015) Parthasarathy Chandrakesan et al.   Oncotarget

Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium

(2014) Tatsuya Yamaguchi et al.   BMC NEUROSCIENCE

Cholinergic epithelial cell with chemosensory traits in murine thymic medulla

(2014) Alexandra Regina Panneck et al.   CELL AND TISSUE RESEARCH

Cyclooxygenase 2 in Gastric Carcinoma Is Expressed in Doublecortin- and CaM Kinase-Like-1-Positive Tuft Cells

(2014) Hiroyuki Mutoh et al.   Gut and Liver

Bitter and sweet taste receptors regulate human upper respiratory innate immunity

(2014) Robert J. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Long-lived intestinal tuft cells serve as colon cancer–initiating cells

(2014) C. Benedikt Westphalen et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-10 Is Produced by a Specific Subset of Taste Receptor Cells and Critical for Maintaining Structural Integrity of Mouse Taste Buds

(2014) P. Feng et al.   JOURNAL OF NEUROSCIENCE

Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation

(2014) C. J. Saunders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemosensory Brush Cells of the Trachea. A Stable Population in a Dynamic Epithelium

(2013) Cecil J. Saunders et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

DCLK1 Marks a Morphologically Distinct Subpopulation of Cells With Stem Cell Properties in Preinvasive Pancreatic Cancer

(2013) Jennifer M. Bailey et al.   GASTROENTEROLOGY

Identification and Manipulation of Biliary Metaplasia in Pancreatic Tumors

(2013) Kathleen E. DelGiorno et al.   GASTROENTEROLOGY

Dclk1 distinguishes between tumor and normal stem cells in the intestine

(2012) Yuki Nakanishi et al.   NATURE GENETICS

Expression and Secretion of TNF-α in Mouse Taste Buds: A Novel Function of a Specific Subset of Type II Taste Cells

(2012) Pu Feng et al.   PLoS One

Origin of the brush cell lineage in the mouse intestinal epithelium

(2011) Matthew Bjerknes et al.   DEVELOPMENTAL BIOLOGY

Gastric tuft cells express DCLK1 and are expanded in hyperplasia

(2011) Milena Saqui-Salces et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

(2011) François Gerbe et al.   JOURNAL OF CELL BIOLOGY

Skn-1a (Pou2f3) specifies taste receptor cell lineage

(2011) Ichiro Matsumoto et al.   NATURE NEUROSCIENCE

Cholinergic chemosensory cells in the trachea regulate breathing

(2011) G. Krasteva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemoreception Regulates Chemical Access to Mouse Vomeronasal Organ: Role of Solitary Chemosensory Cells

(2010) Tatsuya Ogura et al.   PLoS One

Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals

(2010) M. Tizzano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPM5-expressing microvillous cells in the main olfactory epithelium

(2009) Weihong Lin et al.   BMC NEUROSCIENCE

Sox17 Regulates Organ Lineage Segregation of Ventral Foregut Progenitor Cells

(2009) Jason R. Spence et al.   DEVELOPMENTAL CELL

Murine intestinal cells expressing Trpm5 are mostly brush cells and express markers of neuronal and inflammatory cells

(2008) C. Bezençon et al.   JOURNAL OF COMPARATIVE NEUROLOGY