Review
Immunology
Jun Sun, Ming-xin Li, Yi-meng Xie, Ya-ru Zhang, Yu-rong Chai
Summary: The thymus is the central immune organ where T cells differentiate and mature, and it plays a crucial role in regulating the adaptive immune response. Tuft cells, as chemosensory cells, have been found in various tissues and show functions similar to cholinergic and immune cells. Thymic tuft cells, a newly discovered type of tuft cell, have been shown to participate in immune responses, tumorigenesis, and SARS-CoV-2 infection.
IMMUNOLOGIC RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Lin Li, Mengmeng Ma, Ting Duan, Xinbing Sui
Summary: Tuft cells are solitary chemosensory epithelial cells with microvilli, found in hollow organs. They have chemotactic and immune function and may play important roles in tumors. The expression of specific genes is related to carcinogenesis and cancer development. However, the interaction between tuft cells and cancer requires further investigation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Botao Fa, Ting Wei, Yuan Zhou, Luke Johnston, Xin Yuan, Yanran Ma, Yue Zhang, Zhangsheng Yu
Summary: The study introduces a light-weight algorithm GapClust that can efficiently and accurately identify rare cell types, demonstrating superior performance in experimental datasets.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Akiisa Omura, Kenji Kimura, Seiji Taniguchi, Yasushi Shintani
Summary: This report describes a rare case of extremely late thymic metastasis after ovarian cancer surgery, emphasizing the importance of considering thymic metastasis in the differential diagnosis of thymic tumor in patients with a history of ovarian cancer.
ANNALS OF THORACIC SURGERY
(2021)
Article
Oncology
Ranya Guennoun, Jennet Hojanazarova, Kathryn E. Trerice, Marjan Azin, Matthew T. McGoldrick, Erik B. Schiferle, Michael P. Stover, Shadmehr Demehri
Summary: This study demonstrates the potential of immunotherapy for lung cancer by examining the impact of Thymic Stromal Lymphopoietin (TSLP) cytokine induction on early lung cancer development. TSLP induction suppresses the development of invasive lung tumors, dependent on CD4(+) T cells. This highlights the importance of adaptive immune response in protecting against lung cancer progression.
Article
Oncology
Chiara Corti, Fabio Conforti, Laura Pala, Chiara Catania, Emilia Cocorocchio, Pier Francesco Ferrucci, Giuseppe Curigliano, Paola Queirolo, Tommaso de Pas
Summary: This study investigated the potential activity of avapritinib in mucosal melanoma and thymic carcinoma, two diseases with limited second-line treatment options. The results showed differential activity of avapritinib on KIT exon 17 mutations and potential implications for precision oncology.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Oncology
Ling Ding, Nathaniel Weygant, Chenhuan Ding, Yi Lai, He Li
Summary: This article reviews the roles of DCLK1 and tuft cells in tumors, highlighting their involvement in immune response, maintenance of epithelial homeostasis, and immune escape mechanisms in the tumor microenvironment. It also discusses recent advances in anti-tumor immunity mediated by DCLK1/tuft cells and their potential as immunotherapeutic targets.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Pathology
Akihiko Sugimoto, Yosuke Yamada, Masakazu Fujimoto, Sachiko Minamiguchi, Takuma Sato, Shusuke Akamatsu, Alexander Marx, Hironori Haga
Summary: Multilocular thymic cyst (MTC) and germ cell tumors are common mediastinal diseases that can be challenging to correctly diagnose due to potential mimics. A case study of a male patient with both MTC and mediastinal seminoma highlights the significance of recognizing histological features and reveals novel findings in MTC pathogenesis.
Article
Biology
Qian Zhang, Jiayu Zhang, Tong Lei, Zhanfeng Liang, Xue Dong, Liguang Sun, Yong Zhao
Summary: Thymic epithelial cells (TECs) are crucial for the generation of self-tolerant T cells, and the epigenetic regulation mediated by Sirt6 may play a key role in the development of thymic tuft cells.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Minoru Matsumoto, Takuya Ohmura, Yuto Hanibuchi, Mayuko Ichimura-Shimizu, Yasuyo Saijo, Hirohisa Ogawa, Ryuichiro Miyazawa, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto, Takeshi Oya
Summary: Despite the physiological distinction between cTECs and mTECs, the origin of TCs and other thymic epithelial tumors has been unclear. By studying the mTEC-specific transcriptional regulator AIRE, it was found that a significant proportion of TCs express AIRE with characteristic nuclear dot morphology. This expression was supported by RNA-seq data and further analysis revealed that TCs exhibit molecular characteristics of multiple mTEC subpopulations, suggesting their derivation from mTECs.
Article
Oncology
Adam Szpechcinski, Malgorzata Szolkowska, Sebastian Winiarski, Urszula Lechowicz, Piotr Wisniewski, Magdalena Knetki-Wroblewska
Summary: The molecular dysregulation of thymic epithelial tumors, including thymomas and thymic carcinomas, is poorly understood. Through next-generation sequencing, this study identified more single nucleotide variants (SNVs) in thymic carcinomas compared to thymomas. Somatic pathogenic gene variants in TP53, ERBB2, KIT, or KRAS were found in a subset of thymic carcinomas, while uncertain clinical significance variants in KIT, ERBB2, and FOXL2 were exclusively found in thymomas. The presence of somatic pathogenic variants was associated with shorter disease-free survival in thymic carcinoma patients. This study expands our understanding of the genetic alterations in these tumors and highlights potential therapeutic targets.
Article
Cell Biology
Jillian Hattaway Luttman, Jacob P. Hoj, Kevin H. Lin, Jiaxing Lin, Jing Jin Gu, Clay Rouse, Amanda G. Nichols, Nancie J. MacIver, Kris C. Wood, Ann Marie Pendergast
Summary: Targeting mitochondrial metabolism and the mevalonate pathway through ABL tyrosine kinase inhibition and statin therapy can synergistically decrease the survival of metastatic lung cancer cells, leading to decreased metastatic outgrowth and increased survival rates for patients with advanced lung cancer.
Review
Oncology
Shoubao Ma, Michael A. Caligiuri, Jianhua Yu
Summary: This review provides an in-depth analysis of the cross-talk between lung cancer TME and NK cells. The mechanisms used by TME to modulate NK cell phenotypes and limit infiltration, the role of TME in limiting NK cell antitumor activity, and the current challenges and obstacles hindering NK cell-based immunotherapy for lung cancer are highlighted. Potential opportunities and strategies to optimize NK cell-based immunotherapy for lung cancer are also discussed.
Article
Biology
Justinn Barr, Maria Elena Gentile, Sunyoung Lee, Maya E. Kotas, Maria Fernanda de Mello Costa, Nicolas P. Holcomb, Abigail Jaquish, Gargi Palashikar, Marcella Soewignjo, Margaret McDaniel, Ichiro Matsumoto, Robert Margolskee, Jakob Von Moltke, Noam A. Cohen, Xin Sun, Andrew E. Vaughan
Summary: This study found that tuft cell development in the lung does not require specific immune signals, unlike intestinal tuft cells. The expansion of tuft cells may be a general response to severe lung injury.
Article
Oncology
Hongling Chen, Li Zhao, Yuting Meng, Xixi Qian, Ya Fan, Quanli Zhang, Chao Wang, Fan Lin, Baoan Chen, Lin Xu, Wenbin Huang, Jing Chen, Xuerong Wang
Summary: SUR1-expressing cancer cells induce the transformation of normal fibroblasts into cancer-associated fibroblasts (CAFs) in the tumor microenvironment and promote the progression of non-small cell lung carcinoma (NSCLC) by transferring less exosomal let-7a-5p. Glibenclamide targeting SUR1 is a promising anti-cancer drug, and the level of plasma exosomal let-7a-5p serves as a potential diagnostic biomarker for NSCLC patients.
Letter
Cell Biology
Akihiko Sugimoto, Masakazu Fujimoto, Hirotake Fujii, Yasuhide Takeuchi, Masahiro Hirata, Shunya Usui, Satoshi Nakamizo, Kohei Ikezoe, Satoshi Ikeo, Yosuke Yamada, Sachiko Minamiguchi, Akio Morinobu, Hironori Haga
Article
Immunology
Tatsuya Okamoto, Hideaki Okajima, Eri Ogawa, Elena Yukie Uebayashi, Miki Yamamoto, Masashi Kadohisa, Yosuke Yamada, Sachiko Minamiguchi, Hironori Haga, Etsurou Hatano
Summary: In post-liver transplant recipients, SARS-CoV-2 infection poses a health threat, and mRNA vaccines like Pfizer BioNTech BNT162b2 and Moderna mRNA-1273 are strongly recommended. However, there are limited reports on their adverse effects, some of which may be potentially fatal. We present two cases of post-liver transplant recipients experiencing exacerbated chronic rejection after vaccination, with one requiring retransplantation and the other showing no improvement in liver function.
TRANSPLANTATION PROCEEDINGS
(2023)
Article
Cell Biology
Yosuke Yamada, Djeda Belharazem-Vitacolonnna, Hanibal Bohnenberger, Christel Weiss, Naoko Matsui, Mark Kriegsmann, Katharina Kriegsmann, Peter Sinn, Katja Simon-Keller, Gerhard Hamilton, Thomas Graeter, Gerhard Preissler, German Ott, Sebastian Scholch, Naoki Nakajima, Akihiko Yoshizawa, Hironori Haga, Hiroshi Date, Roman K. Thomas, Iacopo Petrini, Giuseppe Giaccone, Philipp Strobel, Alexander Marx
Summary: The presence of tuft cell-like gene expression in different types of lung cancer indicates shared characteristics and potential therapeutic vulnerabilities. Identification of tuft cell-like large cell neuroendocrine carcinomas (LCNECs) may be important for treatment strategies due to their similarities with tuft cell-like small cell lung cancer (SCLC).
CELL DEATH & DISEASE
(2022)
Article
Endocrinology & Metabolism
Yamato Keidai, Takaaki Murakami, Nana Yamamura, Shigeru Tsunoda, Atsushi Ikeda, Koya Hida, Mototsugu Nagao, Yosuke Yamada, Ayaka Fukui, Masahito Ogura, Izumi Fukuda, Yuji Nakamoto, Kazutaka Obama, Nobuya Inagaki
Summary: Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome caused by a tumor-producing big IGF2. Surgical resection is the only curative treatment, but it may not be feasible for cases with multiple metastases. Pharmacological therapies are often inefficient and difficult to predict.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Yosuke Yamada, Ronald Simon, Kosuke Iwane, Yuki Nakanishi, Yasuhide Takeuchi, Akihiko Yoshizawa, Masahiro Takada, Masakazu Toi, Hironori Haga, Alexander Marx, Guido Sauter
Summary: POU2F3 expression is associated with different subtypes of breast cancer and with DCIS. POU2F3-positive cells are found in normal breast tissues, and further analysis of the relationship between POU2F3 and SOX9 will enhance our understanding of breast physiology and the significance of the tuft cell-like phenotype for TNBCs.
Article
Biochemistry & Molecular Biology
Rita Casadonte, Mark Kriegsmann, Katharina Kriegsmann, Helene Streit, Rolf Ruediger Meliss, Cornelia S. L. Mueller, Joerg Kriegsmann
Summary: This study used proteomic technology to compare the molecular profiles of BRAF and NRAS mutated and wildtype melanoma patients' tissue samples. The results showed molecular differences between BRAF and NRAS mutated melanoma, and accurate identification was possible with an accuracy of 87-89% and 76-79% depending on the classification method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Takahiro Utsumi, Yosuke Yamada, Maria Teresa Diaz-Meco, Jorge Moscat, Yuki Nakanishi
Summary: The serrated neoplasia pathway is an alternative route to colorectal cancer (CRC), and sessile serrated lesions with dysplasia (SSLDs) are an intermediate step between sessile serrated lesions (SSLs) and invasive CRC in this pathway. SSLs show indolent growth before becoming dysplastic, while SSLDs rapidly progress to either immunogenic microsatellite instable-high (MSI-H) CRC or mesenchymal microsatellite stable (MSS) CRC. Confusing terminology and lack of longitudinal observation data of serrated polyps have hampered our understanding of SSLDs, but recent studies have started to clarify their characteristics and biology. This review article aims to assess the current knowledge of SSLDs and highlight their clinical implications.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Cell Biology
Takashi Noguchi, Akio Sakamoto, Yoshiki Murotani, Koichi Murata, Masahiro Hirata, Yosuke Yamada, Junya Toguchida, Shuichi Matsuda
Summary: Giant cell tumors of bone (GCTBs) are locally aggressive tumors with the histological features of giant cells and stromal cells. Denosumab is a human monoclonal antibody that binds to the cytokine receptor activator of nuclear factor-kappa B ligand (RANKL). RANKL inhibition blocks tumor-induced osteoclastogenesis, and survival, and is used to treat unresectable GCTBs.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rie Ota, Masako Kataoka, Mami Iima, Maya Honda, Ayami Ohno Kishimoto, Kanae Kawai Miyake, Yosuke Yamada, Yasuhide Takeuchi, Masakazu Toi, Yuji Nakamoto
Summary: This study evaluated the performance of a non-contrast MRI protocol combining HR-DWI, T1WI, and T2WI using a modified BI-RADS for breast lesion diagnosis. The results showed promising diagnostic performance and suggest the need for further study.
MAGNETIC RESONANCE IMAGING
(2023)
Review
Pathology
Yosuke Yamada
Summary: Thymic epithelial tumors (TETs) have various subtypes, and exploring their expression profiles is important for classification and understanding. Pathologists have identified different histogenetic features in TETs related to thymic physiology. This review summarizes the reported histogenetic phenotypes of TETs, including their genetic signatures, and discusses the future direction of TET classification.
PATHOLOGY INTERNATIONAL
(2023)
Article
Pathology
Hirotake Fujii, Yosuke Yamada, Kentaro Yamamura, Yoshihiro Ishida, Marina Tsujimura, Kazuhisa Matsumoto, Satona Tanaka, Hiroshi Date, Tadaaki Nishikawa, Yukihiro Yoshida, Jumpei Kashima, Yasushi Yatabe, Seishi Ogawa, Alexander Marx, Thomas M. Ulbright, Hironori Haga
Summary: VMT is a new type of tumor that occurs in mediastinal germ cell tumors after chemotherapy, characterized by abnormal vessels. Patients with VMT in residual tumors have an increased risk of developing sarcomas or hematopoietic malignancies.
Article
Oncology
Rita Casadonte, Joerg Kriegsmann, Mark Kriegsmann, Katharina Kriegsmann, Roberta Torcasio, Maria Eugenia Gallo Cantafio, Giuseppe Viglietto, Nicola Amodio
Summary: Appropriate sample preparation is critical for the analysis of cell cultures with mass spectrometry. In this study, two different sample preparation procedures for proteomic analysis of multiple myeloma (MM) cells were evaluated using imaging mass spectrometry (IMS). The results showed that cytospin preparation resulted in better signal-to-noise ratios compared to formalin fixation and paraffin embedding. IMS technology holds the potential to stratify different cell lines and identify differentially expressed proteins.
Article
Pathology
Ryota Nakagawa, Sachiko Minamiguchi, Tatsuki R. Kataoka, Junji Fujikura, Toshihiko Masui, Masakazu Fujimoto, Yosuke Yamada, Yasuhide Takeuchi, Yuki Teramoto, Hiroaki Ito, Manduwa Saka, Kyohei Kitamura, Shinya Otsuki, Ryohei Nishijima, Hironori Haga
Summary: This study aims to establish more quantitative criteria for evaluating islet morphology and discover the potential diagnostic value of islet circularity and percentage of recognizable nucleoli for ANHH.
DIAGNOSTIC PATHOLOGY
(2023)
Article
Immunology
Yusuke Uemoto, Kojiro Taura, Yosuke Yamada, Haruhiko Takeda, Shigeharu Nakano, Atsushi Takai, Hironori Haga, Etsuro Hatano
Summary: Donor-origin cancer is extremely rare after liver transplantation. We report a rare case of intrahepatic cholangiocarcinoma derived from the donor liver. Screening and monitoring for donor tumors are crucial for timely treatment.
TRANSPLANTATION PROCEEDINGS
(2023)
Article
Oncology
Henrike Staemmler, Sandra Sauer, Emma Pauline Kreutzer, Juliane Brandt, Karin Jordan, Michael Kreuter, Mark Kriegsmann, Hartmut Goldschmidt, Carsten Muller-Tidow, Gerlinde Egerer, Katharina Kriegsmann
Summary: Online information has the potential to enhance patients' abilities and involvement, but concerns exist regarding the validity of the information. An evaluation of websites and videos related to multiple myeloma revealed that the overall quality was poor, with low patient-focused quality and content level. Incorporating quality indices and regular review is necessary.