Taste buds: cells, signals and synapses

Humans Can Taste Glucose Oligomers Independent of the hT1R2/hT1R3 Sweet Taste Receptor

(2016) Trina J. Lapis et al.   CHEMICAL SENSES

Positive Allosteric Modulation of the Calcium-sensing Receptor by Physiological Concentrations of Glucose

(2016) Johan Medina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals Different Molecular Receptive Ranges for Orthologous Receptors in Mice and Humans

(2016) Kristina Lossow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amiloride-Insensitive Salt Taste Is Mediated by Two Populations of Type III Taste Cells with Distinct Transduction Mechanisms

(2016) B. C. Lewandowski et al.   JOURNAL OF NEUROSCIENCE

“Tasting” the cerebrospinal fluid: Another function of the choroid plexus?

(2016) J. Tomás et al.   NEUROSCIENCE

Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes

(2016) Alissa A. Nolden et al.   PHYSIOLOGY & BEHAVIOR

Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides

(2016) Sunil K. Sukumaran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sweet Taste Receptor TAS1R2 Polymorphism (Val191Val) Is Associated with a Higher Carbohydrate Intake and Hypertriglyceridemia among the Population of West Mexico

(2016) Omar Ramos-Lopez et al.   Nutrients

The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity

(2015) B. Avau et al.   Acta Physiologica

A permeability barrier surrounds taste buds in lingual epithelia

(2015) Robin Dando et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice

(2015) John I. Glendinning et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Association of Sweet Taste Receptor Gene Polymorphisms with Dental Caries Experience in School Children

(2015) Eda Haznedaroglu et al.   CARIES RESEARCH

Mice Lacking Pannexin 1 Release ATP and Respond Normally to All Taste Qualities

(2015) Aurelie Vandenbeuch et al.   CHEMICAL SENSES

Normal Taste Acceptance and Preference of PANX1 Knockout Mice

(2015) Michael G. Tordoff et al.   CHEMICAL SENSES

TAS2R bitter taste receptors regulate thyroid function

(2015) Adam A. Clark et al.   FASEB JOURNAL

Glucagon-like peptide-1 is specifically involved in sweet taste transmission

(2015) Shingo Takai et al.   FASEB JOURNAL

Calcitonin Gene-Related Peptide Reduces Taste-Evoked ATP Secretion from Mouse Taste Buds

(2015) A. Y. Huang et al.   JOURNAL OF NEUROSCIENCE

The Role of 5-HT3 Receptors in Signaling from Taste Buds to Nerves

(2015) E. D. Larson et al.   JOURNAL OF NEUROSCIENCE

Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice

(2015) Keiko Yasumatsu et al.   JOURNAL OF PHYSIOLOGY-LONDON

The endocrinology of taste receptors

(2015) Sara Santa-Cruz Calvo et al.   Nature Reviews Endocrinology

Calcium homeostasis modulator (CALHM) ion channels

(2015) Zhongming Ma et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The K+channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction

(2015) Wenlei Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and Functional Activity of the Bitter Taste Receptors TAS2R1 and TAS2R38 in Human Keratinocytes

(2015) Ute Wölfle et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Breadth of tuning in taste afferent neurons varies with stimulus strength

(2015) An Wu et al.   Nature Communications

Keratinocytes can modulate and directly initiate nociceptive responses

(2015) Kyle M Baumbauer et al.   eLife

Tasting Pseudomonas aeruginosa Biofilms: Human Neutrophils Express the Bitter Receptor T2R38 as Sensor for the Quorum Sensing Molecule N-(3-Oxododecanoyl)-l-Homoserine Lactone

(2015) Susanne Maurer et al.   Frontiers in Immunology

Lingual lipase activity in the orosensory detection of fat by humans

(2014) Bhushan V. Kulkarni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Behavioral palatability of dietary fatty acids correlates with the intracellular calcium ion levels induced by the fatty acids in GPR120-expressing cells

(2014) Shin-ichi ADACHI et al.   BIOMEDICAL RESEARCH-TOKYO

Mouse neutrophils express functional umami taste receptor T1R1/T1R3

(2014) NaHye Lee et al.   BMB Reports

Genetic variation in taste receptor pseudogenes provides evidence for a dynamic role in human evolution

(2014) Davide Risso et al.   BMC EVOLUTIONARY BIOLOGY

Endocrine taste cells

(2014) Zaza Kokrashvili et al.   BRITISH JOURNAL OF NUTRITION

Salty Taste Deficits in CALHM1 Knockout Mice

(2014) Michael G. Tordoff et al.   CHEMICAL SENSES

Bitter and sweet taste receptors regulate human upper respiratory innate immunity

(2014) Robert J. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa

(2014) Michael C Campbell et al.   JOURNAL OF HUMAN GENETICS

The role of lipolysis in human orosensory fat perception

(2014) Nadine Voigt et al.   JOURNAL OF LIPID RESEARCH

Synaptic communication and signal processing among sensory cells in taste buds

(2014) Nirupa Chaudhari   JOURNAL OF PHYSIOLOGY-LONDON

The neural representation of taste quality at the periphery

(2014) Robert P. J. Barretto et al.   NATURE

A Physiologic Role for Serotonergic Transmission in Adult Rat Taste Buds

(2014) Luc Jaber et al.   PLoS One

Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation

(2014) C. J. Saunders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components

(2013) Robert J Lee et al.   Innate Immunity

Taste responses in mice lacking taste receptor subunit T1R1

(2013) Yoko Kusuhara et al.   JOURNAL OF PHYSIOLOGY-LONDON

High salt recruits aversive taste pathways

(2013) Yuki Oka et al.   NATURE

CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes

(2013) Akiyuki Taruno et al.   NATURE

Variations in Bitter-Taste Receptor Genes, Dietary Intake, and Colorectal Adenoma Risk

(2013) Susan M. Schembre et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart

(2013) Simon R. Foster et al.   PLoS One

Temporal Characteristics of Gustatory Responses in Rat Parabrachial Neurons Vary by Stimulus and Chemosensitive Neuron Type

(2013) Laura Geran et al.   PLoS One

A Subset of Mouse Colonic Goblet Cells Expresses the Bitter Taste Receptor Tas2r131

(2013) Simone Prandi et al.   PLoS One

Role of the ectonucleotidase NTPDase2 in taste bud function

(2013) Aurelie Vandenbeuch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility

(2013) B. Mosinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orosensory detection of sucrose, maltose, and glucose is severely impaired in mice lacking T1R2 or T1R3, but Polycose sensitivity remains relatively normal

(2012) Yada Treesukosol et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Immunocytochemical analysis of P2X2 in rat circumvallate taste buds

(2012) Ruibiao Yang et al.   BMC NEUROSCIENCE

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection

(2012) Robert J. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Adenosine Enhances Sweet Taste through A2B Receptors in the Taste Bud

(2012) R. Dando et al.   JOURNAL OF NEUROSCIENCE

Acetylcholine is released from taste cells, enhancing taste signalling

(2012) Robin Dando et al.   JOURNAL OF PHYSIOLOGY-LONDON

Functional characterization of bitter-taste receptors expressed in mammalian testis

(2012) J. Xu et al.   MOLECULAR HUMAN REPRODUCTION

Tachykinins Stimulate a Subset of Mouse Taste Cells

(2012) Jeff Grant   PLoS One

Glutamate May Be an Efferent Transmitter That Elicits Inhibition in Mouse Taste Buds

(2012) Yijen A. Huang et al.   PLoS One

Kokumi Substances, Enhancers of Basic Tastes, Induce Responses in Calcium-Sensing Receptor Expressing Taste Cells

(2012) Yutaka Maruyama et al.   PLoS One

Characterization of the Modes of Binding between Human Sweet Taste Receptor and Low-Molecular-Weight Sweet Compounds

(2012) Katsuyoshi Masuda et al.   PLoS One

Bitter Taste Stimuli Induce Differential Neural Codes in Mouse Brain

(2012) David M. Wilson et al.   PLoS One

Bitter taste receptor research comes of age: From characterization to modulation of TAS2Rs

(2012) Maik Behrens et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Nutrient sensing in the gut: new roads to therapeutics?

(2012) Sara Janssen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

T1R3: A human calcium taste receptor

(2012) Michael G. Tordoff et al.   Scientific Reports

Functional bitter taste receptors are expressed in brain cells

(2011) Nisha Singh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

G Protein-Coupled Receptors in Human Fat Taste Perception

(2011) M. M. Galindo et al.   CHEMICAL SENSES

The Capsaicin Receptor TRPV1 Is a Crucial Mediator of the Noxious Effects of Mustard Oil

(2011) Wouter Everaerts et al.   CURRENT BIOLOGY

Characteristics of sodium currents in rat geniculate ganglion neurons

(2011) Shiro Nakamura et al.   JOURNAL OF NEUROPHYSIOLOGY

GABA, Its Receptors, and GABAergic Inhibition in Mouse Taste Buds

(2011) G. Dvoryanchikov et al.   JOURNAL OF NEUROSCIENCE

Knocking Out P2X Receptors Reduces Transmitter Secretion in Taste Buds

(2011) Y. A. Huang et al.   JOURNAL OF NEUROSCIENCE

The functional role of the T1R family of receptors in sweet taste and feeding

(2011) Yada Treesukosol et al.   PHYSIOLOGY & BEHAVIOR

How neural mediation of anticipatory and compensatory insulin release helps us tolerate food

(2011) Karen L. Teff   PHYSIOLOGY & BEHAVIOR

Association Between TAS2R38 Gene Polymorphisms and Colorectal Cancer Risk: A Case-Control Study in Two Independent Populations of Caucasian Origin

(2011) Maura Carrai et al.   PLoS One

Sour Taste Responses in Mice Lacking PKD Channels

(2011) Nao Horio et al.   PLoS One

Acid Stimulation (Sour Taste) Elicits GABA and Serotonin Release from Mouse Taste Cells

(2011) Yijen A. Huang et al.   PLoS One

Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells

(2011) K. K. Yee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations

(2010) Karen M Eny et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer

(2010) Daniele Campa et al.   BMC Medical Genetics

Evidence for a role of glutamate as an efferent transmitter in taste buds

(2010) Aurelie Vandenbeuch et al.   BMC NEUROSCIENCE

Oligomerization of TAS2R Bitter Taste Receptors

(2010) Christina Kuhn et al.   CHEMICAL SENSES

Key Amino Acid Residues Involved in Multi-Point Binding Interactions between Brazzein, a Sweet Protein, and the T1R2–T1R3 Human Sweet Receptor

(2010) Fariba M. Assadi-Porter et al.   JOURNAL OF MOLECULAR BIOLOGY

Capacitance Measurements of Regulated Exocytosis in Mouse Taste Cells

(2010) A. Vandenbeuch et al.   JOURNAL OF NEUROSCIENCE

Taste Preference for Fatty Acids Is Mediated by GPR40 and GPR120

(2010) C. Cartoni et al.   JOURNAL OF NEUROSCIENCE

The cells and peripheral representation of sodium taste in mice

(2010) Jayaram Chandrashekar et al.   NATURE

Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction

(2010) Deepak A Deshpande et al.   NATURE MEDICINE

A proton current drives action potentials in genetically identified sour taste cells

(2010) R. B. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals

(2010) M. Tizzano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coding in the mammalian gustatory system

(2010) Alan Carleton et al.   TRENDS IN NEUROSCIENCES

Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women

(2009) Cedrick D. Dotson et al.   APPETITE

Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes

(2009) Qing-Ying Chen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Metabotropic glutamate receptor type 1 in taste tissue

(2009) Ana San Gabriel et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Taste receptors for umami: the case for multiple receptors

(2009) Nirupa Chaudhari et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Common Sense about Taste: From Mammals to Insects

(2009) David A. Yarmolinsky et al.   CELL

The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors

(2009) Wolfgang Meyerhof et al.   CHEMICAL SENSES

Allelic Polymorphism within the TAS1R3 Promoter Is Associated with Human Taste Sensitivity to Sucrose

(2009) Alexey A. Fushan et al.   CURRENT BIOLOGY

Involvement of the Calcium-sensing Receptor in Human Taste Perception

(2009) Takeaki Ohsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inward rectifier channel, ROMK, is localized to the apical tips of glial-like cells in mouse taste buds

(2009) Gennady Dvoryanchikov et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Bitter-Responsive Gustatory Neurons in the Rat Parabrachial Nucleus

(2009) Laura C. Geran et al.   JOURNAL OF NEUROPHYSIOLOGY

Autocrine and Paracrine Roles for ATP and Serotonin in Mouse Taste Buds

(2009) Y. A. Huang et al.   JOURNAL OF NEUROSCIENCE

Discrimination of taste qualities among mouse fungiform taste bud cells

(2009) Ryusuke Yoshida et al.   JOURNAL OF PHYSIOLOGY-LONDON

Nicotine activates TRPM5-dependent and independent taste pathways

(2009) A. J. Oliveira-Maia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Motile Cilia of Human Airway Epithelia Are Chemosensory

(2009) A. S. Shah et al.   SCIENCE

T1R3 taste receptor is critical for sucrose but not Polycose taste

(2008) Steven Zukerman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Expression of Galpha14 in sweet-transducing taste cells of the posterior tongue

(2008) Marco Tizzano et al.   BMC NEUROSCIENCE

Amiloride-sensitive channels in type I fungiform taste cells in mouse

(2008) Aurelie Vandenbeuch et al.   BMC NEUROSCIENCE

Glucose Sensing in L Cells: A Primary Cell Study

(2008) Frank Reimann et al.   Cell Metabolism

Tonic activity of Gα-gustducin regulates taste cell responsivity

(2008) Tod R. Clapp et al.   FEBS LETTERS

Norepinephrine Is Coreleased with Serotonin in Mouse Taste Buds

(2008) Y. A. Huang et al.   JOURNAL OF NEUROSCIENCE

Presynaptic (Type III) cells in mouse taste buds sense sour (acid) taste

(2008) Yijen A. Huang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Colocalization of GPR120 with phospholipase-Cβ2 and α-gustducin in the taste bud cells in mice

(2008) Shigenobu Matsumura et al.   NEUROSCIENCE LETTERS

Involvement of T1R3 in calcium-magnesium taste

(2008) Michael G. Tordoff et al.   PHYSIOLOGICAL GENOMICS

The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse

(2007) Dany Gaillard et al.   FASEB JOURNAL