PGD2 and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection

The Prostaglandin D2 Receptor CRTH2 Promotes IL-33–Induced ILC2 Accumulation in the Lung

(2020) Oyebola O. Oyesola et al.   JOURNAL OF IMMUNOLOGY

A novel role for lipoxin A4 in driving a lymph node-eye axis that controls autoimmunity to the neuroretina

(2020) Jessica Wei et al.   eLife

Tuft Cell Formation Reflects Epithelial Plasticity in Pancreatic Injury: Implications for Modeling Human Pancreatitis

(2020) Kathleen E. DelGiorno et al.   Frontiers in Physiology

Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity

(2020) John W. McGinty et al.   IMMUNITY

An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products

(2020) Marta de los Reyes Jiménez et al.   Science Translational Medicine

The Intestinal Epithelium at the Forefront of Host–Helminth Interactions

(2020) Gillian Coakley et al.   TRENDS IN PARASITOLOGY

Immunity to Soil-Transmitted Helminths: Evidence From the Field and Laboratory Models

(2020) Stefano A. P. Colombo et al.   Frontiers in Immunology

NAIP-NLRC4-deficient mice are susceptible to shigellosis

(2020) Patrick S Mitchell et al.   eLife

Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap

(2019) Jüri Reimand et al.   Nature Protocols

Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine

(2019) Yalong Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit

(2018) Marija S. Nadjsombati et al.   IMMUNITY

Immunity to gastrointestinal nematode infections

(2018) D Sorobetea et al.   Mucosal Immunology

Cytokines and beyond: Regulation of innate immune responses during helminth infection

(2018) Oyebola O. Oyesola et al.   CYTOKINE

Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche

(2018) Ysbrand M. Nusse et al.   NATURE

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

(2018) Moshe Biton et al.   CELL

Prostaglandin D2 receptor antagonists in allergic disorders: safety, efficacy, and future perspectives

(2018) Giancarlo Marone et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

(2018) Rick M. Maizels et al.   IMMUNITY

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8

(2017) Isabella Rauch et al.   IMMUNITY

Astrocyte-derived lipoxins A4 and B4 promote neuroprotection from acute and chronic injury

(2017) Izhar Livne-Bar et al.   JOURNAL OF CLINICAL INVESTIGATION

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Lipid mediators as regulators of human ILC2 function in allergic diseases

(2016) Viktoria Konya et al.   IMMUNOLOGY LETTERS

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

(2016) François Gerbe et al.   NATURE

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

(2016) M. R. Howitt et al.   SCIENCE

IgE and mast cells in host defense against parasites and venoms

(2016) Kaori Mukai et al.   Seminars in Immunopathology

A Versatile Strategy for Isolating a Highly Enriched Population of Intestinal Stem Cells

(2016) Christian M. Nefzger et al.   Stem Cell Reports

The prostaglandin D2 receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung

(2015) E D Tait Wojno et al.   Mucosal Immunology

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

(2015) Charles N. Serhan et al.   SEMINARS IN IMMUNOLOGY

PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia

(2015) Tatsuro Nakamura et al.   Nature Communications

Mast Cell-Derived Prostaglandin D2 Inhibits Colitis and Colitis-Associated Colon Cancer in Mice

(2014) K. Iwanaga et al.   CANCER RESEARCH

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ

(2014) Henner F. Farin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon

(2014) K A Knoop et al.   Mucosal Immunology

Paneth cells expand from newly created and preexisting cells during repair after doxorubicin-induced damage

(2013) Stephanie L. King et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Prostaglandin D2 pathway upregulation: Relation to asthma severity, control, and TH2 inflammation

(2013) Merritt L. Fajt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement

(2013) T. Murata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Susceptibility and immunity to helminth parasites

(2012) Rick M Maizels et al.   CURRENT OPINION IN IMMUNOLOGY

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

(2012) Jakob von Moltke et al.   NATURE

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

(2012) Vivian W. Y. Wong et al.   NATURE CELL BIOLOGY

Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines

(2012) M. R. Hepworth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Paradigms in Type 2 Immunity

(2012) B. Pulendran et al.   SCIENCE

Serine Protease(s) Secreted by the Nematode Trichuris muris Degrade the Mucus Barrier

(2012) Sumaira Z. Hasnain et al.   PLoS Neglected Tropical Diseases

Dual Functions of Prostaglandin D2 in Murine Contact Hypersensitivity via DP and CRTH2

(2011) Yoshihiro Yamamoto et al.   AMERICAN JOURNAL OF PATHOLOGY

A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma

(2011) N. Barnes et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Mast Cell Phenotype, Location, and Activation in Severe Asthma

(2010) Silvana Balzar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lipidomics reveals a remarkable diversity of lipids in human plasma,

(2010) Oswald Quehenberger et al.   JOURNAL OF LIPID RESEARCH

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

Basophils Protect against Reinfection with Hookworms Independently of Mast Cells and Memory Th2 Cells

(2009) Caspar Ohnmacht et al.   JOURNAL OF IMMUNOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Murine intestinal cells expressing Trpm5 are mostly brush cells and express markers of neuronal and inflammatory cells

(2008) C. Bezençon et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The intestinal epithelium: sensors to effectors in nematode infection

(2008) D Artis et al.   Mucosal Immunology

The roles of the prostaglandin D2 receptors DP1 and CRTH2 in promoting allergic responses

(2007) R Pettipher   BRITISH JOURNAL OF PHARMACOLOGY