IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment

Severe drug-associated colitis with Crohn’s features in setting of ixekizumab therapy for chronic plaque psoriasis

(2021) Xin Mu et al.   BMC GASTROENTEROLOGY

New onset inflammatory bowel disease in patient treated with secukinumab: Case report and review of literature

(2021) Ailia K. Ali et al.   Dermatologic Therapy

An Intestinal Organoid-Based Platform That Recreates Susceptibility to T Cell-Mediated Tissue Injury

(2020) Yu Matsuzawa-Ishimoto et al.   BLOOD

Paradoxical gastrointestinal effects of interleukin-17 blockers

(2020) Marine Fauny et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity

(2020) Stephen J. Gaudino et al.   Mucosal Immunology

Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases

(2020) Masayuki Fujii et al.   NATURE MATERIALS

Atoh1+ secretory progenitors possess renewal capacity independent of Lgr5+ cells during colonic regeneration

(2019) David Castillo‐Azofeifa et al.   EMBO JOURNAL

The IL-17 Family of Cytokines in Health and Disease

(2019) Mandy J. McGeachy et al.   IMMUNITY

Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell

(2019) Arshad Ayyaz et al.   NATURE

IFN-I and IL-22 mediate protective effects of intestinal viral infection

(2019) Jessica A Neil et al.   Nature Microbiology

Somatic inflammatory gene mutations in human ulcerative colitis epithelium

(2019) Kosaku Nanki et al.   NATURE

Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization

(2018) Curtis A. Thorne et al.   DEVELOPMENTAL CELL

Automated brightfield morphometry of 3D organoid populations by OrganoSeg

(2018) Michael A. Borten et al.   Scientific Reports

Contribution of ATOH1 + Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium

(2018) Fumiaki Ishibashi et al.   Stem Cell Reports

Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration

(2018) Goran Tomic et al.   Cell Stem Cell

Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism

(2018) Kairui Mao et al.   NATURE

Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling

(2018) Mark Schmitt et al.   Cell Reports

Autophagy proteins suppress protective type I interferon signalling in response to the murine gut microbiota

(2018) Patricia K. Martin et al.   Nature Microbiology

A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5+ intestinal stem cell maintenance

(2018) Yehua Li et al.   Cell Discovery

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

(2018) Masayuki Fujii et al.   Cell Stem Cell

Sox4 Promotes Atoh1-Independent Intestinal Secretory Differentiation Toward Tuft and Enteroendocrine Fates

(2018) Adam D. Gracz et al.   GASTROENTEROLOGY

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

(2017) Yu Matsuzawa-Ishimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

IL-17 Signaling: The Yin and the Yang

(2017) Nilesh Amatya et al.   TRENDS IN IMMUNOLOGY

A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Brodalumab in Patients With Moderate-to-Severe Crohn’s Disease

(2016) Stephan R Targan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Intrinsic Defense Mechanisms of the Intestinal Epithelium

(2016) Deepshika Ramanan et al.   Cell Host & Microbe

Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation

(2016) Pawan Kumar et al.   IMMUNITY

Wnt pathway regulation of intestinal stem cells

(2016) Amanda T. Mah et al.   JOURNAL OF PHYSIOLOGY-LONDON

Phase 3 Trials of Ixekizumab in Moderate-to-Severe Plaque Psoriasis

(2016) Kenneth B. Gordon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

(2015) Jacob S. Lee et al.   IMMUNITY

Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage

(2015) Xinyang Song et al.   IMMUNITY

Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation

(2015) Joseph R. Maxwell et al.   IMMUNITY

Unipotent,Atoh1+progenitors maintain the Merkel cell population in embryonic and adult mice

(2015) Margaret C. Wright et al.   JOURNAL OF CELL BIOLOGY

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

Interleukin-17 Receptor A Signaling in Transformed Enterocytes Promotes Early Colorectal Tumorigenesis

(2014) Kepeng Wang et al.   IMMUNITY

Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials

(2014) Richard G. Langley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adult Stem Cells in the Small Intestine Are Intrinsically Programmed with Their Location-Specific Function

(2014) Sabine Middendorp et al.   STEM CELLS

A Deficiency in the Autophagy Gene Atg16L1 Enhances Resistance to Enteric Bacterial Infection

(2013) Amanda M. Marchiando et al.   Cell Host & Microbe

Genetic Variants Synthesize to Produce Paneth Cell Phenotypes That Define Subtypes of Crohn's Disease

(2013) Kelli L. VanDussen et al.   GASTROENTEROLOGY

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

(2013) Xiaolei Yin et al.   NATURE METHODS

In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture

(2013) Hiroyuki Miyoshi et al.   Nature Protocols

Role of IL-17A in the development of colitis-associated cancer

(2012) Y. S. Hyun et al.   CARCINOGENESIS

Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells

(2012) Henner F. Farin et al.   GASTROENTEROLOGY

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2 and antibacterial peptides

(2012) A L Frantz et al.   Mucosal Immunology

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

(2012) Kim A. Papp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1)

(2012) A. Durand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Interleukin-17A is involved in enhancement of tumor progression in murine intestine

(2011) Kiyotetsu Oshiro et al.   IMMUNOBIOLOGY

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

(2011) François Gerbe et al.   JOURNAL OF CELL BIOLOGY

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

(2010) Ken Cadwell et al.   CELL

Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells

(2010) Nick Barker et al.   GASTROENTEROLOGY

Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease

(2010) Reiko M. Onishi et al.   IMMUNOLOGY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

(2009) Shaoguang Wu et al.   NATURE MEDICINE

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

(2008) S. Vaishnava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA