Article
Cell Biology
Makoto Ohmoto, Satsuki Kitamoto, Junji Hirota
Summary: Taste substances are detected by taste receptor cells in the oral epithelium, which are continuously replaced by new ones generated from local epithelial stem cells. Pou2f3 is a key transcription factor that regulates the generation and differentiation of sweet, umami, and bitter cells. Through RNA-sequence data analysis, Eya1 was identified as the only transcription factor gene showing higher expression in bitter cells than in sweet cells, suggesting it plays a role in regulating the generation and differentiation of bitter cells.
CELL AND TISSUE RESEARCH
(2021)
Article
Behavioral Sciences
Quan T. Nguyen, Grace E. Beck Coburn, Amber Valentino, Bekir Karabucak, Marco Tizzano
Summary: A newly discovered chemosensory structure in the rear of the mandibular mucosa in mice may play a role in taste sensation and serve as a potential novel pharmacological target for taste disorders. This structure contains unorganized taste buds associated with the ducts of a minor salivary gland and expresses various taste receptors and signaling molecules, similar to other lingual and palate taste buds.
Article
Multidisciplinary Sciences
Alizee Vercauteren Drubbel, Benjamin Beck
Summary: Using single-cell RNA sequencing, we discovered taste buds specifically in the cervical segment of the mouse esophagus. These taste buds have similar cellular composition to those in the tongue, but express fewer taste receptor types. Through transcriptional regulatory network analysis, specific transcription factors associated with the differentiation of immature progenitors into different taste bud cell types were identified. Lineage tracing experiments revealed that esophageal taste buds arise from squamous bipotent progenitors, indicating that all esophageal progenitors are not unipotent. Our characterization of the cervical esophagus epithelium at the cellular level will provide a better understanding of esophageal progenitor potency and the development of taste buds.
Article
Biochemistry & Molecular Biology
Yuta Yoshida, Fuminori Kawabata, Shotaro Nishimura, Shoji Tabata
Summary: This study characterizes the peripheral taste-sensing systems in chickens by analyzing the distributions of mammalian types I, II, and III taste cell markers in chicken taste buds. The results demonstrate a unique subset of chicken taste cells expressing multiple taste cell type marker proteins, providing new insights into the taste-sensing mechanisms in vertebrate taste buds.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Behavioral Sciences
Anish A. Sarkar, David M. Allyn, Rona J. Delay, Eugene R. Delay
Summary: Taste buds in the oral cavity have a complex immune system that regulates normal functions and inflammatory reactions. Cyclophosphamide disrupts the taste system, inducing inflammation in taste buds and affecting taste function. Pretreatment with the antioxidant drug amifostine may reduce the adverse effects of CYP on the taste system.
Article
Cell Biology
Chia-Chien Hsu, Yuji Seta, Kae Matsuyama, Shinji Kataoka, Mitsushiro Nakatomi, Takashi Toyono, Kaori K. Gunjigake, Kayoko N. Kuroishi, Tatsuo Kawamoto
Summary: This study revealed that Mash1-positive precursor cells differentiate into type III taste bud cells, but not into most type II cells. Additionally, Mash1-expressing cells can differentiate into PLC beta 2-positive cells, which have a shorter lifespan compared to other taste bud cells.
CELL AND TISSUE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ye Huang, Wen-Kai Wang, Xiao-Mei Zheng, Long Yang, Li-Hui Wang, Xiang-Hong Qiu, Long-Hui Chen, Ru-Liu Li, Chuan-Quan Lin
Summary: Salivary biochemical characteristics are abnormally altered in malnourished patients with myasthenia gravis, and altered sAA activity responding to acid stimulation is associated with malnutrition.
Article
Neurosciences
Rio Ikuta, Kanae Myoenzono, Jun Wasano, Kayoko Hamaguchi-Hamada, Shun Hamada, Mami Kurumata-Shigeto
Summary: The study examined the localization of N-cadherin in mouse taste buds, showing it is important for the formation and maintenance of synapses in type II cells. N-cadherin was detected in nerve fibers and connective tissues, suggesting its role in afferent synapses.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Developmental Biology
Wenxin Yu, Zhonghou Wang, Brett Marshall, Yuta Yoshida, Renita Patel, Xiaogang Cui, Rebecca Ball, Linlin Yin, Fuminori Kawabata, Shoji Tabata, Wenbiao Chen, Robert N. Kelsh, James D. Lauderdale, Hong-Xiang Liu
Summary: Lineage tracing studies in mice, chickens, and zebrafish revealed that taste buds are not derived from neural crest cells in these species. This supports earlier findings in axolotls, indicating a lack of neural crest origin for taste buds across rodents, birds, amphibians, and teleost fish.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Toru Yamamoto, Yuhei Koyama, Tomoaki Ujita, Emi Sawada, Naotaka Kishimoto, Kenji Seo
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections can cause taste and smell alterations, and this study investigated the mechanism behind it. The spike protein of SARS-CoV-2 induced taste cell apoptosis and increased expression of the apoptosis-related cytokine TNF-a. These findings suggest that the spike protein contributes to the taste malfunction caused by COVID-19.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jie Liu, Ji Yong Jang, Mehdi Pirooznia, Shihui Liu, Toren Finkel
Summary: This study utilizes proximity biotinylation to elucidate tissue-specific secretome in vivo, identifying endothelial and muscle-derived serum proteins. The genetic platform is valuable for understanding normal and disease physiology, and designing tissue-specific disease biomarkers.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Eriko Koyanagi-Matsumura, Hirohito Miura, Mitsuru Saito, Shuitsu Harada
Summary: By comparing different cell markers, the study found that the ratio between Type II and III cells varied widely among taste buds in different taste regions, indicating that they are contained rather independently in respective taste buds.
CELL AND TISSUE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Gaku Takahashi, Kouichi Hoshikawa, Rioto Suzuki, Kotaro Sato, Shintaro Hoshi, Daisuke Yoshinao, Kamon Shirakawa
Summary: This study describes a sensitive sandwich enzyme-linked immunosorbent assay for detecting mouse presepsin and investigating its association with diseases. The developed analytical method has a linear detection range of 4.7-300 pg/mL and high specificity to presepsin. Comparison with normal levels and a sepsis mouse model demonstrates the effectiveness of the method.
SCIENTIFIC REPORTS
(2022)
Article
Anatomy & Morphology
Kiyosato Hino, Shingo Hirashima, Risa Tsuneyoshi, Akinobu Togo, Tasuku Hiroshige, Jingo Kusukawa, Kei-Ichiro Nakamura, Keisuke Ohta
Summary: This study used FIB-SEM to analyze taste buds at different developmental stages and found that immature cells extend to the surface of epithelium before the formation of taste pores. The formation of taste pores and maturation of taste buds progress simultaneously.
Review
Peripheral Vascular Disease
Patrick Crorkin, Shoujin Hao, Nicholas R. Ferreri
Summary: TNF-alpha is a cytokine that has both proinflammatory and important immunomodulatory functions. It has different physiological and pathophysiological effects in organs such as the lung, colon, and kidney, which are related to the severity of inflammation, TNF-alpha levels, and the specific cell types that produce this cytokine. Studies have found that the production of TNF-alpha by renal epithelial cells plays an important role in regulating electrolyte excretion and blood pressure homeostasis, while maintaining the appropriate high-salinity environment in the kidney is beneficial for optimizing the innate immune response to bacterial infections.
Article
Immunology
Pu Feng, Masafumi Jyotaki, Agnes Kim, Jinghua Chai, Nirvine Simon, Minliang Zhou, Alexander A. Bachmanov, Liquan Huang, Hong Wang
BRAIN BEHAVIOR AND IMMUNITY
(2015)
Article
Immunology
Pu Feng, Jinghua Chai, Huilan Yi, Kevin Redding, Robert F. Margolskee, Liquan Huang, Hong Wang
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Article
Toxicology
Xiujuan Li, Liqun Huang, Na Wang, Huilan Yi, Hong Wang
TOXICOLOGY LETTERS
(2018)
Article
Behavioral Sciences
Pu Feng, Liquan Huang, Hong Wang
Article
Environmental Sciences
Xiujuan Li, Huilan Yi, Hong Wang
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2018)
Article
Environmental Sciences
Qun Zeng, Huilan Yi, Liqun Huang, Quan An, Hong Wang
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2018)
Article
Neurosciences
Feng Li, Samsudeen Ponissery-Saidu, Karen K. Yee, Hong Wang, Meng-Ling Chen, Naoko Iguchi, Genhua Zhang, Ping Jiang, Johannes Reisert, Liquan Huang
JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
Pu Feng, Jinghua Chai, Minliang Zhou, Nirvine Simon, Liquan Huang, Hong Wang
JOURNAL OF NEUROSCIENCE
(2014)
Article
Multidisciplinary Sciences
Agnes Kim, Pu Feng, Tadahiro Ohkuri, Daniel Sauers, Zachary J. Cohn, Jinghua Chai, Theodore Nelson, Alexander A. Bachmanov, Liquan Huang, Hong Wang
Article
Pharmacology & Pharmacy
Qun Zeng, Huilan Yi, Liqun Huang, Quan An, Hong Wang
Article
Multidisciplinary Sciences
Keiichi Yoshikawa, Hong Wang, Cristina Jaen, Mai Haneoka, Naoko Saito, Junji Nakamura, Nithin D. Adappa, Noam A. Cohen, Pamela Dalton
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Ya-Wen Du, Qun Liu, Xiao-Cui Luo, Dong-Xiao Zhao, Jian-Bo Xue, Pu Feng, Robert F. Margolskee, Hong Wang, Liquan Huang
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Environmental Sciences
Peng-yu Ji, Zhuo-yu Li, Hong Wang, Jin-tang Dong, Xiu-juan Li, Hui-lan Yi
Article
Behavioral Sciences
Shan Feng, Leyitha Achoute, Robert F. Margolskee, Peihua Jiang, Hong Wang
Meeting Abstract
Behavioral Sciences
Hong Wang, Cristina Jaen, Keiichi Yoshikawa, Naoko Saitou, Mai Haneoka, Junji Nakamura, Atsushi Ouchi, Nithin Adappa, Noam Cohen, Pamela Dalton