Health Benefits and Side Effects of Short-Chain Fatty Acids

Propionate alleviates fatty acid–induced mitochondrial dysfunction, oxidative stress, and apoptosis by upregulating PPARG coactivator 1 alpha in hepatocytes

(2022) Xinghui Wang et al.   JOURNAL OF DAIRY SCIENCE

The effect of short-chain fatty acids on glycemic control in humans: A systematic review and Meta-analysis

(2022) Anna Cherta-Murillo et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Short‐chain fatty acids regulate B cells differentiation via the FFA2 receptor to alleviate rheumatoid arthritis

(2022) Yao Yao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Short-chain fatty acids, acetate and propionate, directly upregulate osteoblastic differentiation

(2022) Takashi Kondo et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Propionate Ameliorates Alcohol-Induced Liver Injury in Mice via the Gut–Liver Axis: Focus on the Improvement of Intestinal Permeability

(2022) Qi Xu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Starch acylation of different short-chain fatty acids and its corresponding influence on gut microbiome and diabetic indexes

(2022) Mei Li et al.   FOOD CHEMISTRY

Effect of Microbial Short-Chain Fatty Acids on CYP3A4-Mediated Metabolic Activation of Human Pluripotent Stem Cell-Derived Liver Organoids

(2021) Seon Ju Mun et al.   Cells

The intestinal microbiota as a therapeutic target in the treatment of NAFLD and ALD

(2021) Weifang Huang et al.   BIOMEDICINE & PHARMACOTHERAPY

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

RS5 Produced More Butyric Acid through Regulating the Microbial Community of Human Gut Microbiota

(2021) Renbing Qin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sodium acetate, propionate and butyrate reduce fat accumulation in mice via modulating appetite and relevant genes

(2021) Anran Jiao et al.   NUTRITION

Intraperitoneal Administration of Short-Chain Fatty Acids Improves Lipid Metabolism of Long–Evans Rats in a Sex-Specific Manner

(2021) Shrushti Shah et al.   Nutrients

Non-Digestible Oligosaccharides and Short Chain Fatty Acids as Therapeutic Targets against Enterotoxin-Producing Bacteria and Their Toxins

(2021) Mostafa Asadpoor et al.   Toxins

Sodium Propionate Enhances Nrf2-Mediated Protective Defense Against Oxidative Stress and Inflammation in Lipopolysaccharide-Induced Neonatal Mice

(2021) Dan Chen et al.   Journal of Inflammation Research

Short chain fatty acids released by Fusobacterium nucleatum are neutrophil chemoattractants acting via free fatty acid receptor 2 ( FFAR2 )

(2021) Agnes Dahlstrand Rudin et al.   CELLULAR MICROBIOLOGY

Short-chain fatty acids-producing probiotics: A novel source of psychobiotics

(2021) Yiwen Cheng et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Quality characteristics of yogurts fermented with short-chain fatty acid-producing probiotics and their effects on mucin production and probiotic adhesion onto human colon epithelial cells

(2021) Y.H. Chang et al.   JOURNAL OF DAIRY SCIENCE

Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming

(2021) Jasna Friščić et al.   Nutrients

Serum Short-Chain Fatty Acids and Associations With Inflammation in Newly Diagnosed Patients With Multiple Sclerosis and Healthy Controls

(2021) Anna Olsson et al.   Frontiers in Immunology

Inulin Fermentable Fiber Ameliorates Type I Diabetes via IL22 and Short-Chain Fatty Acids in Experimental Models

(2021) Jun Zou et al.   Cellular and Molecular Gastroenterology and Hepatology

Emerging role of nutritional short-chain fatty acids (SCFAs) against cancer via modulation of hematopoiesis

(2021) Muthu Thiruvengadam et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Propionate and Dietary Fermentable Fibers Upregulate Intestinal Heat Shock protein70 in Intestinal Caco-2 Cells and Mouse Colon

(2021) Precious Adedayo Adesina et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Propionate and Butyrate Produced by Gut Microbiota after Probiotic Supplementation Attenuate Lung Metastasis of Melanoma Cells in Mice

(2021) Lili Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dietary fiber‐derived short‐chain fatty acids: A potential therapeutic target to alleviate obesity‐related nonalcoholic fatty liver disease

(2021) Shumin Zhang et al.   Obesity Reviews

Effects of short-chain fatty acids in inhibiting HDAC and activating p38 MAPK are critical for promoting B10 cell generation and function

(2021) Fagui Zou et al.   Cell Death & Disease

Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer

(2021) Maik Luu et al.   Nature Communications

Effects and Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics on Metabolic Diseases Targeting Gut Microbiota: A Narrative Review

(2021) Hang-Yu Li et al.   Nutrients

Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal γδ T cells

(2021) Louise Dupraz et al.   Cell Reports

Fu instant tea ameliorates fatty liver by improving microbiota dysbiosis and elevating short-chain fatty acids in the intestine of mice fed a high-fat diet

(2021) Fan Yang et al.   Food Bioscience

Effects of Tea against Alcoholic Fatty Liver Disease by Modulating Gut Microbiota in Chronic Alcohol-Exposed Mice

(2021) Bangyan Li et al.   Foods

Oral Supplementation With Butyrate Improves Myocardial Ischemia/Reperfusion Injury via a Gut-Brain Neural Circuit

(2021) Zhiyao Yu et al.   Frontiers in Cardiovascular Medicine

Deep stool microbiome analysis in cirrhosis reveals an association between short-chain fatty acids and hepatic encephalopathy

(2021) Patricia P. Bloom et al.   Annals of Hepatology

Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism

(2021) Arash Haghikia et al.   EUROPEAN HEART JOURNAL

Short-Chain Fatty Acid Decreases the Expression of CEBPB to Inhibit miR-145-Mediated DUSP6 and Thus Further Suppresses Intestinal Inflammation

(2021) Qian Liu et al.   INFLAMMATION

Association between the faecal short-chain fatty acid propionate and infant sleep

(2020) Anne-Louise M. Heath et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Dynamic balancing of intestinal short-chain fatty acids: The crucial role of bacterial metabolism

(2020) Youqiang Xu et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease

(2020) David M. Kaye et al.   CIRCULATION

Short-chain fatty acid, acylation and cardiovascular diseases

(2020) Xiao-Feng Chen et al.   CLINICAL SCIENCE

Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids

(2020) Martin Trapecar et al.   Cell Systems

Acute and chronic improvement in postprandial glucose metabolism by a diet resembling the traditional Mediterranean dietary pattern: Can SCFAs play a role?

(2020) Marilena Vitale et al.   CLINICAL NUTRITION

Anti-neuroinflammatory Effect of Short-Chain Fatty Acid Acetate against Alzheimer’s Disease via Upregulating GPR41 and Inhibiting ERK/JNK/NF-κB

(2020) Jiaming Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Astragaloside IV alleviates mouse slow transit constipation by modulating gut microbiota profile and promoting butyric acid generation

(2020) Qiulan He et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Acetic acid and butyric acid released in large intestine play different roles in the alleviation of constipation

(2020) Linlin Wang et al.   Journal of Functional Foods

The Combinatorial Effect of Acetate and Propionate on High-Fat Diet Induced Diabetic Inflammation or Metaflammation and T Cell Polarization

(2020) Dipeeka K. Mandaliya et al.   INFLAMMATION

Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

(2020) Wenjing Yang et al.   Nature Communications

Short chain fatty acids in human gut and metabolic health

(2020) E.E. Blaak et al.   Beneficial Microbes

Review of short-chain fatty acids effects on the immune system and cancer

(2020) Yasin Fattahi et al.   Food Bioscience

Valeric Acid Suppresses Liver Cancer Development by Acting as a Novel HDAC Inhibitor

(2020) Rui Han et al.   Molecular Therapy-Oncolytics

The Short-Chain Fatty Acid Propionate Protects from Hypertensive Cardiovascular Damage

(2019) Hendrik Bartolomaeus et al.   CIRCULATION

Loss of Gut Microbiota Alters Immune System Composition and Cripples Post-Infarction Cardiac Repair

(2019) Tony WH Tang et al.   CIRCULATION

Targeting gut microbiota with dietary components on cancer: Effects and potential mechanisms of action

(2019) Jun Tao et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Oncoprotective Effects of Short-Chain Fatty Acids on Uterine Cervical Neoplasia

(2019) Madoka Matsuya-Ogawa et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

(2019) Serena Sanna et al.   NATURE GENETICS

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

(2019) Julie Schulthess et al.   IMMUNITY

Human Milk Short-Chain Fatty Acid Composition is Associated with Adiposity Outcomes in Infants

(2019) Philippa M Prentice et al.   JOURNAL OF NUTRITION

The role of short-chain fatty acids in microbiota–gut–brain communication

(2019) Boushra Dalile et al.   Nature Reviews Gastroenterology & Hepatology

Targeting on Gut Microbial Metabolite Trimethylamine‐ N ‐Oxide and Short‐Chain Fatty Acid to Prevent Maternal High‐Fructose‐Diet‐Induced Developmental Programming of Hypertension in Adult Male Offspring

(2019) Chien‐Ning Hsu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

In vitro colonic fermentation of dietary fibers: Fermentation rate, short-chain fatty acid production and changes in microbiota

(2019) Miaomiao Wang et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Propionate suppresses hepatic gluconeogenesis via GPR43/AMPK signaling pathway

(2019) Hiroki Yoshida et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Butyric Acid from Probiotic Staphylococcus epidermidis in the Skin Microbiome Down-Regulates the Ultraviolet-Induced Pro-Inflammatory IL-6 Cytokine via Short-Chain Fatty Acid Receptor

(2019) Sunita Keshari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Abundance of Probiotics and Butyrate‐Production Microbiome Manages Constipation Via Short‐Chain Fatty Acids Production and Hormones Secretion

(2019) Min Zhuang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

Targeting Gut Microbiota for the Prevention and Management of Diabetes Mellitus by Dietary Natural Products

(2019) Li et al.   Foods

Dietary plants, gut microbiota, and obesity: Effects and mechanisms

(2019) Shi-Yu Cao et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

The Short-Chain Fatty Acid Acetate in Body Weight Control and Insulin Sensitivity

(2019) Hernández et al.   Nutrients

Butyric Acid and Leucine Induce α-Defensin Secretion from Small Intestinal Paneth Cells

(2019) Akiko Takakuwa et al.   Nutrients

Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3

(2019) Hidenori Shimizu et al.   Scientific Reports

Pectin Alleviates High Fat (Lard) Diet-Induced Nonalcoholic Fatty Liver Disease in Mice: Possible Role of Short-Chain Fatty Acids and Gut Microbiota Regulated by Pectin

(2018) Wenfeng Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

OUP accepted manuscript

(2018)   JOURNAL OF NUTRITION

Butyrate from pectin fermentation inhibits intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E-deficient mice

(2018) Ying Chen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Short-chain fatty acids suppress food intake by activating vagal afferent neurons

(2018) Chayon Goswami et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Short-chain fatty acids administration is protective in colitis-associated colorectal cancer development

(2018) Yun Tian et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Short-Chain Fatty Acids Enhance the Lipid Accumulation of 3T3-L1 Cells by Modulating the Expression of Enzymes of Fatty Acid Metabolism

(2018) Haining Yu et al.   LIPIDS

Jaboticaba berry peel intake increases short chain fatty acids production and prevent hepatic steatosis in mice fed high-fat diet

(2018) Ângela Giovana Batista et al.   Journal of Functional Foods

Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss

(2018) Sébastien Lucas et al.   Nature Communications

Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy

(2018) Yanhai Feng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Alcoholic liver disease

(2018) Helmut K. Seitz et al.   Nature Reviews Disease Primers

Social Stress Affects Colonic Inflammation, the Gut Microbiome, and Short Chain Fatty Acid Levels and Receptors

(2018) Ross M. Maltz et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

(2018) Xiao Meng et al.   Nutrients

Faecal Short Chain Fatty Acids Profile is Changed in Polish Depressive Women

(2018) Karolina Skonieczna-Żydecka et al.   Nutrients

Short-Chain Fatty Acids Suppress Inflammatory Reactions in Caco-2 Cells and Mouse Colons

(2017) Tran Van Hung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structure-Specific Effects of Short-Chain Fatty Acids on Plasma Cholesterol Concentration in Male Syrian Hamsters

(2017) Yimin Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Key role of short-chain fatty acids in epithelial barrier failure during ruminal acidosis

(2017) Svenja Meissner et al.   JOURNAL OF DAIRY SCIENCE

Glutamate excitotoxicity induced by orally administered propionic acid, a short chain fatty acid can be ameliorated by bee pollen

(2017) Afaf El-Ansary et al.   Lipids in Health and Disease

Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids

(2017) A Cait et al.   Mucosal Immunology

Role of short-chain fatty acids in colonic inflammation, carcinogenesis, and mucosal protection and healing

(2017) Christina M. van der Beek et al.   NUTRITION REVIEWS

Repeated treatments with acetic acid vapors during storage preserve table grapes fruit quality

(2017) Tullio Venditti et al.   POSTHARVEST BIOLOGY AND TECHNOLOGY

The Inflammation Induced by Lipopolysaccharide can be Mitigated by Short-chain Fatty Acid, Butyrate, through Upregulation of IL-10 in Septic Shock

(2017) F. Wang et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Effects of different oligosaccharides at various dosages on the composition of gut microbiota and short-chain fatty acids in mice with constipation

(2017) Linlin Wang et al.   Food & Function

Short Chain Fatty Acids in the Colon and Peripheral Tissues: A Focus on Butyrate, Colon Cancer, Obesity and Insulin Resistance

(2017) Sean McNabney et al.   Nutrients

Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods

(2016) Claire S Byrne et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Therapeutic potency of bee pollen against biochemical autistic features induced through acute and sub-acute neurotoxicity of orally administered propionic acid

(2016) Huda S. Al-Salem et al.   BMC Complementary and Alternative Medicine

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Function and clinical implications of short-chain fatty acids in patients with mixed refractory constipation

(2016) Y. Shi et al.   Colorectal Disease

Short chain and polyunsaturated fatty acids in host gut health and foodborne bacterial pathogen inhibition

(2016) Mengfei Peng et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate

(2016) M Sahuri-Arisoylu et al.   INTERNATIONAL JOURNAL OF OBESITY

Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice

(2016) Angélica T. Vieira et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Importance of propionate for the repression of hepatic lipogenesis and improvement of insulin sensitivity in high-fat diet-induced obesity

(2016) Karolin Weitkunat et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Colon microbiota fermentation of dietary prebiotics towards short-chain fatty acids and their roles as anti-inflammatory and antitumour agents: A review

(2016) Javier Fernández et al.   Journal of Functional Foods

Impacts of Gut Bacteria on Human Health and Diseases

(2015) Yu-Jie Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Propionate Promotes Fatty Acid Oxidation through the Up-Regulation of Peroxisome Proliferator-Activated Receptor α in Intestinal Epithelial Cells

(2015) Yasuki HIGASHIMURA et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis

(2015) Muriel Aldunate et al.   Frontiers in Physiology

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE