Dietary fiber‐derived short‐chain fatty acids: A potential therapeutic target to alleviate obesity‐related nonalcoholic fatty liver disease

Design, optimization, and nanotechnology of antimicrobial peptides: From exploration to applications

(2021) Peng Tan et al.   Nano Today

Alginate oligosaccharide improves lipid metabolism and inflammation by modulating gut microbiota in high-fat diet fed mice

(2020) Yuting Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism

(2020) João R. Araújo et al.   Cell Host & Microbe

Indole Alleviates Diet‐induced Hepatic Steatosis and Inflammation in a Manner Involving Myeloid Cell PFKFB3

(2020) Linqiang Ma et al.   HEPATOLOGY

Fecal microbiome distinguishes alcohol consumption from alcoholic hepatitis but does not discriminate disease severity

(2020) Ekaterina Smirnova et al.   HEPATOLOGY

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication

(2020) Ygor Parladore Silva et al.   Frontiers in Endocrinology

Gut microbiota in children with juvenile idiopathic arthritis: characteristics, biomarker identification, and usefulness in clinical prediction

(2020) Xubo Qian et al.   BMC GENOMICS

Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism

(2020) Alexander Duscha et al.   CELL

Altered Gut Microbiome Profile in Patients With Pulmonary Arterial Hypertension

(2020) Seungbum Kim et al.   HYPERTENSION

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

(2020) Steven Zhao et al.   NATURE

Host–microbiome interactions: the aryl hydrocarbon receptor as a critical node in tryptophan metabolites to brain signaling

(2020) Ning Ma et al.   Gut Microbes

SCFAs alleviated steatosis and inflammation in mice with NASH induced by MCD

(2020) Mingjuan Deng et al.   JOURNAL OF ENDOCRINOLOGY

Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder

(2020) Ying Wang et al.   PHARMACOLOGICAL RESEARCH

Advances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD

(2020) Xiaofan Jiang et al.   Frontiers in Medicine

Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications

(2020) Jianmin Wu et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis

(2019) Eelke Brandsma et al.   CIRCULATION RESEARCH

Deficiency of the mitochondrial glycerol 3-phosphate dehydrogenase contributes to hepatic steatosis

(2019) Yi Zheng et al.   HEPATOLOGY

Parabacteroides acidifaciens sp. nov., isolated from human faeces

(2019) Yu-Jing Wang et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Gut microbial metabolites in obesity, NAFLD and T2DM

(2019) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Hypoglycemic and Hypolipidemic Effects of Phellinus Linteus Mycelial Extract from Solid-State Culture in A Rat Model of Type 2 Diabetes

(2019) Yangyang Liu et al.   Nutrients

Short Chain Fatty Acids, pancreatic dysfunction and type 2 diabetes

(2019) Dipeeka K. Mandaliya et al.   PANCREATOLOGY

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

(2019) Serena Sanna et al.   NATURE GENETICS

Indoles: metabolites produced by intestinal bacteria capable of controlling liver disease manifestation

(2019) T. Hendrikx et al.   JOURNAL OF INTERNAL MEDICINE

Adipocyte Death Preferentially Induces Liver Injury and Inflammation Through the Activation of Chemokine (C‐C Motif) Receptor 2‐Positive Macrophages and Lipolysis

(2019) Seung‐Jin Kim et al.   HEPATOLOGY

A Multi-omics Approach to Unraveling the Microbiome-Mediated Effects of Arabinoxylan Oligosaccharides in Overweight Humans

(2019) Alfonso Benítez-Páez et al.   mSystems

Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination

(2019) Mengda Xu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Enhancing Butyrate Production, Ruminal Fermentation and Microbial Population through Supplementation with Clostridium saccharobutylicum

(2019) Michelle A Miguel et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Grape Seed Proanthocyanidin Affects Lipid Metabolism via Changing Gut Microflora and Enhancing Propionate Production in Weaned Pigs

(2019) Yi Wu et al.   JOURNAL OF NUTRITION

Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis

(2019) Martina Theresa Hackl et al.   Nature Communications

Propionate suppresses hepatic gluconeogenesis via GPR43/AMPK signaling pathway

(2019) Hiroki Yoshida et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Phellinus linteus polysaccharide extract improves insulin resistance by regulating gut microbiota composition

(2019) Yangyang Liu et al.   FASEB JOURNAL

Effect of oat and soybean rich in distinct non-starch polysaccharides on fermentation, appetite regulation and fat accumulation in rat

(2019) Lingmin Tian et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2

(2019) José Luís Fachi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evolution of NAFLD and Its Management

(2019) Manpreet S. Mundi et al.   NUTRITION IN CLINICAL PRACTICE

Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity

(2018) Yuli Cai et al.   HEPATOLOGY

Dietary fiber increases the butyrate-producing bacteria and improves growth performance of weaned piglets

(2018) Jinbiao Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gamma-aminobutyric Acid Enriched Rice Bran Diet Attenuates Insulin Resistance and Balances Energy Expenditure via Modification of Gut Microbiota and Short-Chain Fatty Acids

(2018) Xu Si et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dietary Clostridium butyricum Induces a Phased Shift in Fecal Microbiota Structure and Increases the Acetic Acid-Producing Bacteria in a Weaned Piglet Model

(2018) Jie Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dietary Fermentable Fibers Attenuate Chronic Kidney Disease in Mice by Protecting the Intestinal Barrier

(2018) Tran Van Hung et al.   JOURNAL OF NUTRITION

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

(2018) Lesley Hoyles et al.   NATURE MEDICINE

Sodium butyrate modulates adipocyte expansion, adipogenesis, and insulin receptor signaling by upregulation of PPAR-γ in obese Apo E knockout mice

(2018) Edenil Costa Aguilar et al.   NUTRITION

Gut microbiome may contribute to insulin resistance and systemic inflammation in obese rodents: a meta-analysis

(2018) Na Jiao et al.   PHYSIOLOGICAL GENOMICS

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

(2018) Liping Zhao et al.   SCIENCE

Nonalcoholic fatty liver disease is associated with dysbiosis independent of body mass index and insulin resistance

(2018) Hannah E. Da Silva et al.   Scientific Reports

Butyrate: A Double-Edged Sword for Health?

(2018) Hu Liu et al.   Advances in Nutrition

Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects

(2018) KEC Bouter et al.   Clinical and Translational Gastroenterology

Polysaccharide isolated from Phellinus linteus mycelia exerts anti-inflammatory effects via MAPK and PPAR signaling pathways

(2018) Tao Hu et al.   CARBOHYDRATE POLYMERS

Polysaccharides extracted from Phellinus linteus ameliorate high-fat high-fructose diet induced insulin resistance in mice

(2018) Han Feng et al.   CARBOHYDRATE POLYMERS

Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy

(2018) Yanhai Feng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Regulation of Adipose Tissue Inflammation by Adenosine 2A Receptor in Obese Mice

(2018) Ya Pei et al.   JOURNAL OF ENDOCRINOLOGY

Fat deposition deficiency is critical for the high mortality of pre-weanling newborn piglets

(2018) Ting He et al.   Journal of Animal Science and Biotechnology

Dietary Amino Acids and the Gut-Microbiome-Immune Axis: Physiological Metabolism and Therapeutic Prospects

(2018) Ning Ma et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice

(2018) Xianjun Luo et al.   GASTROENTEROLOGY

Metformin modulates innate immune-mediated inflammation and early progression of NAFLD-associated hepatocellular carcinoma in zebrafish

(2018) Sofia de Oliveira et al.   JOURNAL OF HEPATOLOGY

Gut microbiome production of short-chain fatty acids and obesity in children

(2017) Selvasankar Murugesan et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice

(2017) VA Matheus et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Butyrate stimulates adipose lipolysis and mitochondrial oxidative phosphorylation through histone hyperacetylation-associated β3 -adrenergic receptor activation in high-fat diet-induced obese mice

(2017) Yimin Jia et al.   EXPERIMENTAL PHYSIOLOGY

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

(2017) Oscar Chávez-Talavera et al.   GASTROENTEROLOGY

Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit

(2017) Zhuang Li et al.   GUT

Gut microbiota dysbiosis in patients with non-alcoholic fatty liver disease

(2017) Feng Shen et al.   Hepatobiliary & Pancreatic Diseases International

Triglycerides cross the blood–brain barrier and induce central leptin and insulin receptor resistance

(2017) W A Banks et al.   INTERNATIONAL JOURNAL OF OBESITY

HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production

(2017) Xin Yu et al.   JOURNAL OF HEPATOLOGY

Microbiota-Gut-Brain Axis: Modulator of Host Metabolism and Appetite

(2017) Marcel van de Wouw et al.   JOURNAL OF NUTRITION

Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial

(2017) Emanuel E. Canfora et al.   Scientific Reports

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis

(2016) Filipe De Vadder et al.   Cell Metabolism

Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men

(2016) C. M. van der Beek et al.   CLINICAL SCIENCE

Nonalcoholic Fatty Liver Disease and the Gut Microbiome

(2016) Jerome Boursier et al.   Clinics in Liver Disease

The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro

(2016) Attilio Pingitore et al.   DIABETES OBESITY & METABOLISM

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

(2015) Gijs den Besten et al.   DIABETES

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

(2015) Kristoffer Forslund et al.   NATURE

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

(2014) Edward S Chambers et al.   GUT

Immune tolerance in liver disease

(2014) Ian N. Crispe   HEPATOLOGY

Effects of polysaccharide from fruiting bodies ofAgaricus bisporus, Agaricus brasiliensis, andPhellinus linteuson alcoholic liver injury

(2014) Mustafa Uyanoglu et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

(2014) A Psichas et al.   INTERNATIONAL JOURNAL OF OBESITY

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

The gut microbiota, bacterial metabolites and colorectal cancer

(2014) Petra Louis et al.   NATURE REVIEWS MICROBIOLOGY

Nutrient Control of Energy Homeostasis via Gut-Brain Neural Circuits

(2014) Gilles Mithieux   NEUROENDOCRINOLOGY

Control of appetite and energy intake by SCFA: what are the potential underlying mechanisms?

(2014) Edward S. Chambers et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Links between diet, gut microbiota composition and gut metabolism

(2014) Harry J. Flint et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

Prognostic Significance of AMPK Activation and Therapeutic Effects of Metformin in Hepatocellular Carcinoma

(2013) L. Zheng et al.   CLINICAL CANCER RESEARCH

Butyrate and Colorectal Cancer: The Role of Butyrate Transport

(2013) Pedro Gonçalves et al.   CURRENT DRUG METABOLISM

GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes

(2013) Mark K. Nøhr et al.   ENDOCRINOLOGY

Modulation of the fecal bile acid profile by gut microbiota in cirrhosis

(2013) Genta Kakiyama et al.   JOURNAL OF HEPATOLOGY

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

Short-Chain Fatty Acids Suppress Lipopolysaccharide-Induced Production of Nitric Oxide and Proinflammatory Cytokines Through Inhibition of NF-κB Pathway in RAW264.7 Cells

(2012) Tengfei Liu et al.   INFLAMMATION

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Microbiota and SCFA in Lean and Overweight Healthy Subjects

(2009) Andreas Schwiertz et al.   Obesity

Enzymology of the Wood-Ljungdahl Pathway of Acetogenesis

(2008) Stephen W. Ragsdale   Annals of the New York Academy of Sciences

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE