Short-chain fatty acid, acylation and cardiovascular diseases

Elevated plasma β-hydroxybutyrate predicts adverse outcomes and disease progression in patients with arrhythmogenic cardiomyopathy

(2020) Jiang-Ping Song et al.   Science Translational Medicine

Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer

(2020) Kezhi Yan et al.   Science Advances

Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease

(2020) David M. Kaye et al.   CIRCULATION

The Short-Chain Fatty Acid Propionate Protects from Hypertensive Cardiovascular Damage

(2019) Hendrik Bartolomaeus et al.   CIRCULATION

Loss of Gut Microbiota Alters Immune System Composition and Cripples Post-Infarction Cardiac Repair

(2019) Tony WH Tang et al.   CIRCULATION

A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis

(2019) Eelke Brandsma et al.   CIRCULATION RESEARCH

Fueling Ketone Metabolism Quenches Salt-Induced Hypertension

(2019) David E. Place et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Malonylation of GAPDH is an inflammatory signal in macrophages

(2019) Silvia Galván-Peña et al.   Nature Communications

p53 β-hydroxybutyrylation attenuates p53 activity

(2019) Kun Liu et al.   Cell Death & Disease

The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity

(2019) Michele Russo et al.   EUROPEAN JOURNAL OF HEART FAILURE

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

(2019) Emelia J. Benjamin et al.   CIRCULATION

Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive

(2019) M. Kohlhauer et al.   BASIC RESEARCH IN CARDIOLOGY

Bacillus subtilis DSM29784 modulates cecal microbiome, short chain fatty acids concentration, and apparent retention of dietary components in Shaver Whites during grower, developer and laying phases

(2019) Mohamed Neijat et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Effects of a lactulose-rich diet on fecal microbiome and metabolome in pregnant mice

(2019) Zheng Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gut microbiota mediates the protective effects of dietary β-hydroxy-β-methylbutyrate (HMB) against obesity induced by high-fat diets

(2019) Yehui Duan et al.   FASEB JOURNAL

Circulating levels of butyrate are inversely related to portal hypertension, endotoxemia, and systemic inflammation in patients with cirrhosis

(2019) Oriol Juanola et al.   FASEB JOURNAL

Sodium butyrate recovers high-fat diet-fed female Wistar rats from glucose dysmetabolism and uric acid-associated cardiac tissue damage

(2019) Caroline Badejogbin et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Blood Pressure Abnormalities Associated with Gut Microbiota-Derived Short Chain Fatty Acids in Children with Congenital Anomalies of the Kidney and Urinary Tract

(2019) Chien-Ning Hsu et al.   Journal of Clinical Medicine

Molecular basis for hierarchical histone de-β-hydroxybutyrylation by SIRT3

(2019) Xingrun Zhang et al.   Cell Discovery

Gut microbiota regulates cardiac ischemic tolerance and aortic stiffness in obesity

(2019) Micah L. Battson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Identification of Malonylation, Succinylation and Glutarylation in Serum Proteins of Acute Myocardial Infartion Patients

(2019) Boda Zhou et al.   Proteomics Clinical Applications

Propionic acid counteracts the inflammation of human subcutaneous adipose tissue: a new avenue for drug development

(2019) Sa’ad Al-Lahham et al.   DARU-Journal of Pharmaceutical Sciences

Gut dysbiosis and lack of short chain fatty acids in a Chinese cohort of patients with multiple sclerosis

(2019) Qin Zeng et al.   NEUROCHEMISTRY INTERNATIONAL

Transplantation of fecal microbiota rich in short chain fatty acids and butyric acid treat cerebral ischemic stroke by regulating gut microbiota

(2019) Runzhi Chen et al.   PHARMACOLOGICAL RESEARCH

Changes in Plasma Free Fatty Acids Associated with Type-2 Diabetes

(2019) Amélie I. S. Sobczak et al.   Nutrients

Metabolic Coordination of Physiological and Pathological Cardiac Remodeling

(2018) Andrew A. Gibb et al.   CIRCULATION RESEARCH

Treatment with D-β-hydroxybutyrate protects heart from ischemia/reperfusion injury in mice

(2018) Yongsheng Yu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Butyrate from pectin fermentation inhibits intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E-deficient mice

(2018) Ying Chen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis

(2018) He Huang et al.   MOLECULAR CELL

Sodium butyrate modulates adipocyte expansion, adipogenesis, and insulin receptor signaling by upregulation of PPAR-γ in obese Apo E knockout mice

(2018) Edenil Costa Aguilar et al.   NUTRITION

Oral administration of short chain fatty acids could attenuate fat deposition of pigs

(2018) A. R. Jiao et al.   PLoS One

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

(2018) Liping Zhao et al.   SCIENCE

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

(2018) Rachel Fellows et al.   Nature Communications

Selective Inhibition of Succinate Dehydrogenase in Reperfused Myocardium with Intracoronary Malonate Reduces Infarct Size

(2018) Laura Valls-Lacalle et al.   Scientific Reports

Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity

(2018) Jimmy Zhang et al.   Cell Reports

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

(2018) Ulrike Bruning et al.   Cell Metabolism

β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

(2018) Young-min Han et al.   MOLECULAR CELL

Comparative study on the modulation of incretin and insulin homeostasis by butyrate in chicken and rabbit

(2018) Gábor Mátis et al.   PLoS One

Microbial metabolite sensor GPR43 controls severity of experimental GVHD

(2018) Hideaki Fujiwara et al.   Nature Communications

A High Salt Diet Modulates the Gut Microbiota and Short Chain Fatty Acids Production in a Salt-Sensitive Hypertension Rat Model

(2018) Ariel Bier et al.   Nutrients

Functional modulation of caecal fermentation and microbiota in rat by feeding bean husk as a dietary fibre supplement

(2018) H. Myint et al.   Beneficial Microbes

National Burden of Heart Failure Events in the United States, 2006 to 2014

(2018) Sandra L. Jackson et al.   Circulation-Heart Failure

Effects of Dietary Fiber Supplementation on Fatty Acid Metabolism and Intestinal Microbiota Diversity in C57BL/6J Mice Fed with a High-Fat Diet

(2018) Xichuan Zhai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension

(2018) Saroj Chakraborty et al.   Cell Reports

Sirtuins and Insulin Resistance

(2018) Shuang Zhou et al.   Frontiers in Endocrinology

Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model

(2018) Kazuyuki Kasahara et al.   Nature Microbiology

Sirtuin 5 is required for mouse survival in response to cardiac pressure overload

(2017) Kathleen A. Hershberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium butyrate suppresses angiotensin II-induced hypertension by inhibition of renal (pro)renin receptor and intrarenal renin–angiotensin system

(2017) Lei Wang et al.   JOURNAL OF HYPERTENSION

Large-Scale Identification of Protein Crotonylation Reveals Its Role in Multiple Cellular Functions

(2017) Wei Wei et al.   JOURNAL OF PROTEOME RESEARCH

The diabetic heart utilizes ketone bodies as an energy source

(2017) Yuji Mizuno et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone propionylation is a mark of active chromatin

(2017) Adam F Kebede et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Short-Chain Fatty Acid Propionate Inhibits Adipogenic Differentiation of Human Chorion-Derived Mesenchymal Stem Cells Through the Free Fatty Acid Receptor 2

(2017) Judit Iván et al.   STEM CELLS AND DEVELOPMENT

Histone propionylation is a mark of active chromatin

(2017) Adam F Kebede et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The short chain fatty acid receptor GPR43 regulates inflammatory signals in adipose tissue M2-type macrophages

(2017) Akira Nakajima et al.   PLoS One

β-Hydroxybutyrate elevation as a compensatory response against oxidative stress in cardiomyocytes

(2016) Manabu Nagao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exploration of candidate biomarkers for human psoriasis based on gas chromatography-mass spectrometry serum metabolomics

(2016) H. Kang et al.   BRITISH JOURNAL OF DERMATOLOGY

Succinate metabolism: a new therapeutic target for myocardial reperfusion injury

(2016) Victoria R. Pell et al.   CARDIOVASCULAR RESEARCH

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Complex Pharmacology of Free Fatty Acid Receptors

(2016) Graeme Milligan et al.   CHEMICAL REVIEWS

The Failing Heart Relies on Ketone Bodies as a Fuel

(2016) Gregory Aubert et al.   CIRCULATION

Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease

(2016) José J. Fuster et al.   CIRCULATION RESEARCH

Assessing Cardiac Metabolism

(2016) Heinrich Taegtmeyer et al.   CIRCULATION RESEARCH

Histone lysine crotonylation during acute kidney injury in mice

(2016) Olga Ruiz-Andres et al.   Disease Models & Mechanisms

Targeting fatty acid metabolism in heart failure: is it a suitable therapeutic approach?

(2016) Somasundaram Arumugam et al.   DRUG DISCOVERY TODAY

SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense

(2016) Lisha Zhou et al.   EMBO REPORTS

Characterization of gut microbiota profiles in coronary artery disease patients using data mining analysis of terminal restriction fragment length polymorphism: gut microbiota could be a diagnostic marker of coronary artery disease

(2016) Takuo Emoto et al.   HEART AND VESSELS

Increased Systolic and Diastolic Blood Pressure Is Associated With Altered Gut Microbiota Composition and Butyrate Production in Early PregnancyNovelty and Significance

(2016) Luisa F. Gomez-Arango et al.   HYPERTENSION

Analysis of Gut Microbiota in Coronary Artery Disease Patients: a Possible Link between Gut Microbiota and Coronary Artery Disease

(2016) Takuo Emoto et al.   Journal of Atherosclerosis and Thrombosis

Oral butyrate reduces oxidative stress in atherosclerotic lesion sites by a mechanism involving NADPH oxidase down-regulation in endothelial cells

(2016) Edenil C. Aguilar et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Butyrate attenuates lipolysis in adipocytes co-cultured with macrophages through non-prostaglandin E2–mediated and prostaglandin E2–mediated pathways

(2016) Hideo Ohira et al.   Lipids in Health and Disease

Anti-inflammatory effects of the hydroxycarboxylic acid receptor 2

(2016) Emily C. Graff et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

Diet-induced extinctions in the gut microbiota compound over generations

(2016) Erica D. Sonnenburg et al.   NATURE

Metabolic regulation of gene expression through histone acylations

(2016) Benjamin R. Sabari et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41

(2016) Niranjana Natarajan et al.   PHYSIOLOGICAL GENOMICS

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

(2016) Sushabhan Sadhukhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation

(2016) Ha Ram Bae et al.   Oncotarget

The Succinate Receptor GPR91 Is Involved in Pressure Overload-Induced Ventricular Hypertrophy

(2016) Lei Yang et al.   PLoS One

Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice

(2015) Youfang Chen et al.   Cardiovascular Diabetology

Insulin resistance: an additional risk factor in the pathogenesis of cardiovascular disease in type 2 diabetes

(2015) Tushar P. Patel et al.   HEART FAILURE REVIEWS

Role of the Gut Microbiome in Obstructive Sleep Apnea–Induced Hypertension

(2015) David J. Durgan et al.   HYPERTENSION

Gut Dysbiosis Is Linked to HypertensionNovelty and Significance

(2015) Tao Yang et al.   HYPERTENSION

Characterization of the cardiac succinylome and its role in ischemia–reperfusion injury

(2015) Jennifer A. Boylston et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation

(2015) Gozde Colak et al.   MOLECULAR & CELLULAR PROTEOMICS

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

(2015) Yuya Nishida et al.   MOLECULAR CELL

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation

(2015) Benjamin R. Sabari et al.   MOLECULAR CELL

Short-chain fatty acids in control of body weight and insulin sensitivity

(2015) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Nutritional or pharmacological activation of HCA2 ameliorates neuroinflammation

(2015) Stefan Offermanns et al.   TRENDS IN MOLECULAR MEDICINE

Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway

(2015) Xukai Wang et al.   Scientific Reports

Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology

(2014) Takayuki Sassa et al.   Biomolecules & Therapeutics

Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation

(2014) Carla J Aguiar et al.   Cell Communication and Signaling

Starving our Microbial Self: The Deleterious Consequences of a Diet Deficient in Microbiota-Accessible Carbohydrates

(2014) Erica D. Sonnenburg et al.   Cell Metabolism

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

Short-Chain Fatty Acids Enhance Adipocyte Differentiation in the Stromal Vascular Fraction of Porcine Adipose Tissue

(2014) Genlai Li et al.   JOURNAL OF NUTRITION

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark

(2014) Lunzhi Dai et al.   Nature Chemical Biology

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Butyrate impairs atherogenesis by reducing plaque inflammation and vulnerability and decreasing NFκB activation

(2014) E.C. Aguilar et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

The Involvement of NFAT Transcriptional Activity Suppression in SIRT1-Mediated Inhibition of COX-2 Expression Induced by PMA/Ionomycin

(2014) Yu-Yan Jia et al.   PLoS One

Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure

(2014) WenLi Mu et al.   Science China-Life Sciences

The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages

(2014) Mahbubur Rahman et al.   Nature Communications

Mitochondria, endothelial cell function, and vascular diseases

(2014) Xiaoqiang Tang et al.   Frontiers in Physiology

Ketone body metabolism and cardiovascular disease

(2013) David G. Cotter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nox2-Induced Production of Mitochondrial Superoxide in Angiotensin II-Mediated Endothelial Oxidative Stress and Hypertension

(2013) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The annual global economic burden of heart failure

(2013) Christopher Cook et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Butyrate Attenuates Inflammation and Lipolysis Generated by the Interaction of Adipocytes and Macrophages

(2013) Hideo Ohira et al.   Journal of Atherosclerosis and Thrombosis

Adipocytokines in relation to cardiovascular disease

(2013) Johan Van de Voorde et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase

(2013) Gaëlle Laurent et al.   MOLECULAR CELL

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of energy metabolism by long-chain fatty acids

(2013) Manabu T. Nakamura et al.   PROGRESS IN LIPID RESEARCH

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

Lysine Succinylation and Lysine Malonylation in Histones

(2012) Zhongyu Xie et al.   MOLECULAR & CELLULAR PROTEOMICS

G protein-coupled receptors for energy metabolites as new therapeutic targets

(2012) Clara C. Blad et al.   NATURE REVIEWS DRUG DISCOVERY

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

Short-Chain Fatty Acid Propionate Alleviates Akt2 Knockout-Induced Myocardial Contractile Dysfunction

(2011) Linlin Li et al.   Experimental Diabetes Research

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Regulation of adipokine production in human adipose tissue by propionic acid

(2010) Sa’ad H. Al-Lahham et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

(2010) Mohamed S. Zaibi et al.   FEBS LETTERS

Energy Metabolic Phenotype of the Cardiomyocyte During Development, Differentiation, and Postnatal Maturation

(2010) Gary D Lopaschuk et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Biosynthesis of 2-hydroxyisobutyric acid (2-HIBA) from renewable carbon

(2010) Thore Rohwerder et al.   Microbial Cell Factories

Identification of lysine succinylation as a new post-translational modification

(2010) Zhihong Zhang et al.   Nature Chemical Biology

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

Activation of the Succinate Receptor GPR91 in Macula Densa Cells Causes Renin Release

(2009) S. L. Vargas et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The endogenous mitochondrial complex II inhibitor malonate regulates mitochondrial ATP-sensitive potassium channels: Implications for ischemic preconditioning

(2008) Andrew P. Wojtovich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids

(2008) Hongfei Ge et al.   ENDOCRINOLOGY

Leptin Resistance

(2008) Seth S. Martin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Molecular Characterization of Propionyllysines in Non-histone Proteins

(2008) Zhongyi Cheng et al.   MOLECULAR & CELLULAR PROTEOMICS

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis

(2008) Przemyslaw Sapieha et al.   NATURE MEDICINE

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Dietary fatty acids and cardiovascular disease: An epidemiological approach

(2008) Arja Erkkilä et al.   PROGRESS IN LIPID RESEARCH