Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal γδ T cells

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

(2020) Aonghus Lavelle et al.   Nature Reviews Gastroenterology & Hepatology

IL-17–producing γδ T cells protect against Clostridium difficile infection

(2020) Yee-Shiuan Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice

(2019) Xiaoli Tian et al.   Frontiers in Microbiology

Characterization of γδ T Cells in Intestinal Mucosa From Patients With Early-Onset or Long-Standing Inflammatory Bowel Disease and Their Correlation With Clinical Status

(2019) Elena Lo Presti et al.   Journal of Crohns & Colitis

Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway

(2019) Natalia Schneider Nunes et al.   EBioMedicine

Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity

(2019) Eunyoung Chun et al.   IMMUNITY

Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2

(2019) José Luís Fachi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High fiber dietary and sodium butyrate attenuate experimental autoimmune hepatitis through regulation of immune regulatory cells and intestinal barrier

(2018) En-De Hu et al.   CELLULAR IMMUNOLOGY

Differentiation stage-specific effect of histone deacetylase inhibitors on the expression of RORγT in human lymphocytes

(2017) Anna Sałkowska et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner

(2017) Fenglei Li et al.   Nature Communications

Histone deacetylase 3 is required for iNKT cell development

(2017) Puspa Thapa et al.   Scientific Reports

Butyrate and propionate inhibit antigen-specific CD8+ T cell activation by suppressing IL-12 production by antigen-presenting cells

(2017) Claudia Nastasi et al.   Scientific Reports

HDAC6 regulates IL-17 expression in T lymphocytes: implications for HDAC6-targeted therapies

(2017) Bing Yan et al.   Theranostics

Butyrate inhibits interleukin-17 and generates Tregs to ameliorate colorectal colitis in rats

(2016) Mingming Zhang et al.   BMC GASTROENTEROLOGY

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

(2016) Gerard E. Kaiko et al.   CELL

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

Propionate Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress

(2016) Ling-chang Tong et al.   Frontiers in Pharmacology

Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1

(2015) Qingsi Wu et al.   Scientific Reports

γδT Cells: First Line of Defense and Beyond

(2014) Yueh-hsiu Chien et al.   Annual Review of Immunology

Microbiota Modulate Tumoral Immune Surveillance in Lung through a   T17 Immune Cell-Dependent Mechanism

(2014) M. Cheng et al.   CANCER RESEARCH

Experimental immunology Diet-induced obesity mediates a proinflammatory response in pancreatic β cell via toll-like receptor 4

(2014) Juan Li et al.   Central European Journal of Immunology

γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer

(2014) Pin Wu et al.   IMMUNITY

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

γδ T Cells Exhibit Multifunctional and Protective Memory in Intestinal Tissues

(2013) Brian S. Sheridan et al.   IMMUNITY

Proinflammatory V 2+ T Cells Populate the Human Intestinal Mucosa and Enhance IFN-  Production by Colonic    T Cells

(2013) N. E. McCarthy et al.   JOURNAL OF IMMUNOLOGY

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

p40phox Expression Regulates Neutrophil Recruitment and Function during the Resolution Phase of Intestinal Inflammation

(2012) K. L. Conway et al.   JOURNAL OF IMMUNOLOGY

Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing    cells

(2012) M.-L. Michel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

(2011) Ying Li et al.   CELL

Cutting Edge: Generation of Colitogenic Th17 CD4 T Cells Is Enhanced by IL-17+    T Cells

(2011) J.-s. Do et al.   JOURNAL OF IMMUNOLOGY

RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota

(2011) Shinichiro Sawa et al.   NATURE IMMUNOLOGY

Identification of an innate T helper type 17 response to intestinal bacterial pathogens

(2011) Kaoru Geddes et al.   NATURE MEDICINE

Microbial Colonization Drives Expansion of IL-1 Receptor 1-Expressing and IL-17-Producing γ/δ T Cells

(2010) Jinyou Duan et al.   Cell Host & Microbe

Blockade of Dendritic Cell Development by Bacterial Fermentation Products Butyrate and Propionate through a Transporter (Slc5a8)-dependent Inhibition of Histone Deacetylases

(2010) Nagendra Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of Th17 Cells in the Small Intestine by Disruption of Gut Flora in the Absence of Retinoic Acid

(2010) H.-R. Cha et al.   JOURNAL OF IMMUNOLOGY

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE