Effect of Microbial Short-Chain Fatty Acids on CYP3A4-Mediated Metabolic Activation of Human Pluripotent Stem Cell-Derived Liver Organoids

Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery

(2020) Arun Sharma et al.   Cell Stem Cell

Gut microbiota maturation during early human life induces enterocyte proliferation via microbial metabolites

(2020) Michael W. Dougherty et al.   BMC MICROBIOLOGY

Gut microbial metabolites in obesity, NAFLD and T2DM

(2019) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Biologically inspired approaches to enhance human organoid complexity

(2019) Emily M. Holloway et al.   DEVELOPMENT

Microbial metabolites in non-alcoholic fatty liver disease

(2019) Da Zhou et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids

(2019) Seon Ju Mun et al.   JOURNAL OF HEPATOLOGY

Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling

(2019) Soheil Akbari et al.   Stem Cell Reports

Drug-Induced Liver Injury: Biomarkers, Requirements, Candidates, and Validation

(2019) Lucy Meunier et al.   Frontiers in Pharmacology

Biotechnology Challenges to In Vitro Maturation of Hepatic Stem Cells

(2018) Chen Chen et al.   GASTROENTEROLOGY

Safety data and withdrawal of hepatotoxic drugs

(2018) Samy Babai et al.   THERAPIE

Highly efficient and expedited hepatic differentiation from human pluripotent stem cells by pure small-molecule cocktails

(2018) Cong Du et al.   Stem Cell Research & Therapy

Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease

(2018) Huikuan Chu et al.   GUT

A liver-specific gene expression panel predicts the differentiation status of in vitro hepatocyte models

(2017) Dae-Soo Kim et al.   HEPATOLOGY

Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice

(2017) Karolin Weitkunat et al.   Scientific Reports

Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models

(2016) Ondřej Zapletal et al.   ARCHIVES OF TOXICOLOGY

Organoid Models of Human Gastrointestinal Development and Disease

(2016) Priya H. Dedhia et al.   GASTROENTEROLOGY

High content analysis assay for prediction of human hepatotoxicity in HepaRG and HepG2 cells

(2016) Junichiro Saito et al.   TOXICOLOGY IN VITRO

Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro

(2016) Deborah G. Nguyen et al.   PLoS One

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

(2015) Gijs den Besten et al.   DIABETES

Microbial-derived lithocholic acid and vitamin K2drive the metabolic maturation of pluripotent stem cells-derived and fetal hepatocytes

(2015) Yishai Avior et al.   HEPATOLOGY

Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology

(2015) Nicholas C. Zachos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Developmental Regulation of Drug-Processing Genes in Livers of Germ-Free Mice

(2015) Felcy Pavithra Selwyn et al.   TOXICOLOGICAL SCIENCES

Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids

(2013) Gijs den Besten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Neonatal liver physiology

(2013) James Grijalva et al.   Seminars in Pediatric Surgery

Drug-Induced Idiosyncratic Hepatotoxicity: Prevention Strategy Developed after the Troglitazone Case

(2010) Toshihiko Ikeda   Drug Metabolism and Pharmacokinetics

Short chain fatty acids exchange across the gut and liver in humans measured at surgery

(2009) Johanne G. Bloemen et al.   CLINICAL NUTRITION

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

(2009) Karim Si-Tayeb et al.   HEPATOLOGY

Derivation and Characterization of Hepatic Progenitor Cells from Human Embryonic Stem Cells

(2009) Dongxin Zhao et al.   PLoS One

Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance

(2009) S. Kidambi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA