Remodeling of the Neurovascular Unit Following Cerebral Ischemia and Hemorrhage

A single-cell atlas of the normal and malformed human brain vasculature

(2022) Ethan A. Winkler et al.   SCIENCE

Exome-wide Analysis of De Novo and Rare Genetic Variants in Patients With Brain Arteriovenous Malformation

(2022) Kun Wang et al.   NEUROLOGY

Editome landscape of CCM-derived endothelial cells

(2022) Concetta Scimone et al.   RNA Biology

Neurovascular Unit: A critical role in ischemic stroke

(2021) Liyun Wang et al.   CNS Neuroscience & Therapeutics

Brain capillary pericytes exert a substantial but slow influence on blood flow

(2021) David A. Hartmann et al.   NATURE NEUROSCIENCE

Three-dimensional ultrastructure of the brain pericyte-endothelial interface

(2021) Sharon Ornelas et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Review of treatment and therapeutic targets in brain arteriovenous malformation

(2021) Peipei Pan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Role of Sonic Hedgehog Pathway in the Development of the Central Nervous System and Aging-Related Neurodegenerative Diseases

(2021) Chen Yang et al.   Frontiers in Molecular Biosciences

Pericyte Control of Blood Flow Across Microvascular Zones in the Central Nervous System

(2021) David A. Hartmann et al.   Annual Review of Physiology

Matrix Metalloproteinases in Acute Intracerebral Hemorrhage

(2020) Simona Lattanzi et al.   Neurotherapeutics

Identification of region-specific astrocyte subtypes at single cell resolution

(2020) Mykhailo Y. Batiuk et al.   Nature Communications

Mfsd2a Attenuates Blood-Brain Barrier Disruption After Sub-arachnoid Hemorrhage by Inhibiting Caveolae-Mediated Transcellular Transport in Rats

(2020) Chongshun Zhao et al.   Translational Stroke Research

Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

(2020) Ankit Jambusaria et al.   eLife

The Neurovascular Unit: Effects of Brain Insults During the Perinatal Period

(2020) Alexander H. Bell et al.   Frontiers in Neuroscience

Danegaptide Enhances Astrocyte Gap Junctional Coupling and Reduces Ischemic Reperfusion Brain Injury in Mice

(2020) Moises Freitas-Andrade et al.   Biomolecules

Basement Membrane Changes in Ischemic Stroke

(2020) Minkyung Kang et al.   STROKE

Programmed Cell Deaths and Potential Crosstalk With Blood–Brain Barrier Dysfunction After Hemorrhagic Stroke

(2020) Yuanjian Fang et al.   Frontiers in Cellular Neuroscience

β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia

(2020) Lea L. Friker et al.   Cell Reports

Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy

(2020) Charlotte Rawlinson et al.   Brain Sciences

Angiogenesis and Blood-Brain Barrier Permeability in Vascular Remodeling after Stroke

(2020) Yi Yang et al.   Current Neuropharmacology

Redox signalling and regulation of the blood-brain barrier

(2020) Eveline van Leeuwen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Germline Mutation Enrichment in Pathways Controlling Endothelial Cell Homeostasis in Patients with Brain Arteriovenous Malformation: Implication for Molecular Diagnosis

(2020) Concetta Scimone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interpericyte tunnelling nanotubes regulate neurovascular coupling

(2020) Luis Alarcon-Martinez et al.   NATURE

Structural and Functional Remodeling of the Brain Vasculature Following Stroke

(2020) Moises Freitas-Andrade et al.   Frontiers in Physiology

The Multifaceted Role of Astrocyte Connexin 43 in Ischemic Stroke Through Forming Hemichannels and Gap Junctions

(2020) Zhen Liang et al.   Frontiers in Neurology

Transcriptome analysis provides new molecular signatures in sporadic Cerebral Cavernous Malformation endothelial cells

(2020) Concetta Scimone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Loss of Endothelial Laminin α5 Exacerbates Hemorrhagic Brain Injury

(2019) Jyoti Gautam et al.   Translational Stroke Research

Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke

(2019) Moises Freitas-Andrade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of elevation of vascular endothelial growth factor level on exacerbation of hemorrhage in mouse brain arteriovenous malformation

(2019) Philip Cheng et al.   JOURNAL OF NEUROSURGERY

Intracranial Aneurysms: Pathology, Genetics, and Molecular Mechanisms

(2019) Zhen Xu et al.   NEUROMOLECULAR MEDICINE

Risk factors for hemorrhage of brain arteriovenous malformation

(2019) Sonali S. Shaligram et al.   CNS Neuroscience & Therapeutics

Collateral Vessels Have Unique Endothelial and Smooth Muscle Cell Phenotypes

(2019) Hua Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroinflammation: friend and foe for ischemic stroke

(2019) Richard L. Jayaraj et al.   Journal of Neuroinflammation

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

(2019) Angeliki M. Nikolakopoulou et al.   NATURE NEUROSCIENCE

Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke

(2019) An-Qi Chen et al.   Cell Death & Disease

Age-Related Functional and Expressional Changes in Efflux Pathways at the Blood-Brain Barrier

(2019) Franciska Erdő et al.   Frontiers in Aging Neuroscience

Impaired Collateral Flow in Pial Arterioles of Aged Rats During Ischemic Stroke

(2019) Junqiang Ma et al.   Translational Stroke Research

Inflammation within the neurovascular unit: Focus on microglia for stroke injury and recovery

(2019) Wael Eldahshan et al.   PHARMACOLOGICAL RESEARCH

Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

(2019) Roeben Nocon Munji et al.   NATURE NEUROSCIENCE

Pericytes in Cerebrovascular Diseases: An Emerging Therapeutic Target

(2019) Xiaojuan Su et al.   Frontiers in Cellular Neuroscience

Cortical astrocytes develop in a plastic manner at both clonal and cellular levels

(2019) Solène Clavreul et al.   Nature Communications

Type 2 Diabetes Mellitus Increases The Risk of Late-Onset Alzheimer’s Disease: Ultrastructural Remodeling of the Neurovascular Unit and Diabetic Gliopathy

(2019) Hayden   Brain Sciences

Models of poststroke depression and assessments of core depressive symptoms in rodents: How to choose?

(2019) Xi Tao et al.   EXPERIMENTAL NEUROLOGY

Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

(2019) Koichiro Haruwaka et al.   Nature Communications

Vessel-Associated Immune Cells in Cerebrovascular Diseases: From Perivascular Macrophages to Vessel-Associated Microglia

(2019) Takashi Koizumi et al.   Frontiers in Neuroscience

Role of astrocyte connexin hemichannels in cortical spreading depression

(2018) Maximiliano Rovegno et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury

(2018) Xintong Ge et al.   BRAIN RESEARCH

Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice

(2018) Yukio Hiroi et al.   CIRCULATION JOURNAL

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

(2018) Lara Al-Olabi et al.   JOURNAL OF CLINICAL INVESTIGATION

Reductions in brain pericytes are associated with arteriovenous malformation vascular instability

(2018) Ethan A. Winkler et al.   JOURNAL OF NEUROSURGERY

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

(2018) Mark A. Petersen et al.   NATURE REVIEWS NEUROSCIENCE

Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain

(2018) Sergey I. Nikolaev et al.   NEW ENGLAND JOURNAL OF MEDICINE

Blood-brain barrier dysfunction and recovery after ischemic stroke

(2018) Xiaoyan Jiang et al.   PROGRESS IN NEUROBIOLOGY

Thalidomide Reduces Hemorrhage of Brain Arteriovenous Malformations in a Mouse Model

(2018) Wan Zhu et al.   STROKE

Astrocytes and the Warning Signs of Intracerebral Hemorrhagic Stroke

(2018) Annalisa Scimemi   NEURAL PLASTICITY

Basement membrane and stroke

(2018) Yao Yao   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage

(2018) Jordi Pedragosa et al.   Acta Neuropathologica Communications

High prevalence of KRAS/BRAF somatic mutations in brain and spinal cord arteriovenous malformations

(2018) Tao Hong et al.   BRAIN

Augmented astrocyte microdomain Ca2+ dynamics and parenchymal arteriole tone in angiotensin II-infused hypertensive mice

(2018) Juan Ramiro Diaz et al.   GLIA

Intracerebral haemorrhage: current approaches to acute management

(2018) Charlotte Cordonnier et al.   LANCET

The vascular basement membrane in the healthy and pathological brain

(2017) Maj S Thomsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

EGb761 Ameliorates Neuronal Apoptosis and Promotes Angiogenesis in Experimental Intracerebral Hemorrhage via RSK1/GSK3β Pathway

(2017) Chao Pan et al.   MOLECULAR NEUROBIOLOGY

Modulators of microglial activation and polarization after intracerebral haemorrhage

(2017) Xi Lan et al.   Nature Reviews Neurology

Connexin Channels at the Glio-Vascular Interface: Gatekeepers of the Brain

(2017) Marijke De Bock et al.   NEUROCHEMICAL RESEARCH

The quantification of blood-brain barrier disruption using dynamic contrast-enhanced magnetic resonance imaging in aging rhesus monkeys with spontaneous type 2 diabetes mellitus

(2017) Ziqian Xu et al.   NEUROIMAGE

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation

(2017) Brian Wai Chow et al.   NEURON

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

(2017) Marietta Zille et al.   STROKE

Cystatin C as a potential therapeutic mediator against Parkinson’s disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units

(2017) Jing Zou et al.   Cell Death & Disease

Pericyte: Potential Target for Hemorrhagic Stroke Prevention and Treatment

(2017) Qiang Li et al.   Current Drug Delivery

The Prevention of Hemorrhagic Stroke

(2017) J. Raymond et al.   INTERVENTIONAL NEURORADIOLOGY

Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking

(2016) E. Maggioli et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroinflammatory Markers in Spontaneously Hypertensive Rat Brain: An Immunohistochemical Study

(2016) Seyed K. Tayebati et al.   CNS & Neurological Disorders-Drug Targets

Hyperglycemia Increases the Production of Amyloid Beta-Peptide Leading to Decreased Endothelial Tight Junction

(2016) A-Ching Chao et al.   CNS Neuroscience & Therapeutics

Astragaloside IV improves the isoproterenol-induced vascular dysfunction via attenuating eNOS uncoupling-mediated oxidative stress and inhibiting ROS-NF-κB pathways

(2016) Chonghua Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

‘Spreading depression of Leão’ and its emerging relevance to acute brain injury in humans

(2016) Martin Lauritzen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The blood–brain barrier after stroke: Structural studies and the role of transcytotic vesicles

(2016) Michael J Haley et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension

(2016) Giuseppe Faraco et al.   JOURNAL OF CLINICAL INVESTIGATION

Pericytes as Inducers of Rapid, Matrix Metalloproteinase-9-Dependent Capillary Damage during Ischemia

(2016) Robert G. Underly et al.   JOURNAL OF NEUROSCIENCE

Chronic type 2 diabetes reduces the integrity of the blood-brain barrier by reducing tight junction proteins in the hippocampus

(2016) Dae Young YOO et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Albumin microvascular leakage in brains with diabetes mellitus

(2016) Ryuji Fujihara et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage

(2016) Zhen Zhang et al.   MOLECULAR NEUROBIOLOGY

Exendin-4 Reverses Biochemical and Functional Alterations in the Blood–Brain and Blood–CSF Barriers in Diabetic Rats

(2016) Caroline Zanotto et al.   MOLECULAR NEUROBIOLOGY

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Purinergic receptor P2RY12-dependent microglial closure of the injured blood–brain barrier

(2016) Nanhong Lou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke

(2016) Zhenxing Liang et al.   PROGRESS IN NEUROBIOLOGY

Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke

(2016) Zhongwu Liu et al.   PROGRESS IN NEUROBIOLOGY

Neurons diversify astrocytes in the adult brain through sonic hedgehog signaling

(2016) W. T. Farmer et al.   SCIENCE

Impaired Collateral Flow Compensation During Chronic Cerebral Hypoperfusion in the Type 2 Diabetic Mice

(2016) Yasuo Nishijima et al.   STROKE

Intracranial Pressure and Collateral Blood Flow

(2016) Daniel J. Beard et al.   STROKE

Pericytes in Brain Injury and Repair After Ischemic Stroke

(2016) Wei Cai et al.   Translational Stroke Research

VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis

(2016) Chandran S. Abhinand et al.   Journal of Cell Communication and Signaling

The role of pericytic laminin in blood brain barrier integrity maintenance

(2016) Jyoti Gautam et al.   Scientific Reports

Astrocyte morphology after ischemic and hemorrhagic experimental stroke has no influence on the different recovery patterns

(2015) Régis Gemerasca Mestriner et al.   BEHAVIOURAL BRAIN RESEARCH

Collaterals: Implications in cerebral ischemic diseases and therapeutic interventions

(2015) Yasuo Nishijima et al.   BRAIN RESEARCH

Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases

(2015) Bernhard F. Becker et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Receptor-Interacting Protein Kinase 3 Contributes to Abdominal Aortic Aneurysms via Smooth Muscle Cell Necrosis and Inflammation

(2015) Q. Wang et al.   CIRCULATION RESEARCH

The regulation of immune cell trafficking by the extracellular matrix

(2015) Rupert Hallmann et al.   CURRENT OPINION IN CELL BIOLOGY

Ultrastructural Changes of Brain Tissues Surrounding Hematomas after Intracerebral Hemorrhage

(2015) Kai-Yu Wang et al.   EUROPEAN NEUROLOGY

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

Intracranial Pressure Elevation Reduces Flow through Collateral Vessels and the Penetrating Arterioles they Supply. a Possible Explanation for ‘Collateral Failure’ and Infarct Expansion after Ischemic Stroke

(2015) Daniel J Beard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ultrastructural analysis of blood–brain barrier breakdown in the peri-infarct zone in young adult and aged mice

(2015) Patrick C Nahirney et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glucagon-Like Peptide-1 Strengthens the Barrier Integrity in Primary Cultures of Rat Brain Endothelial Cells Under Basal and Hyperglycemia Conditions

(2015) Shuji Fukuda et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Impaired Leptomeningeal Collateral Flow Contributes to the Poor Outcome following Experimental Stroke in the Type 2 Diabetic Mice

(2015) Y. Akamatsu et al.   JOURNAL OF NEUROSCIENCE

Characterizing blood-brain barrier perturbations after exposure to human triglyceride-rich lipoprotein lipolysis products using MRI in a rat model

(2015) Kit Fai Ng et al.   MAGNETIC RESONANCE IN MEDICINE

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

(2015) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Supply-Demand Mismatch Transients in Susceptible Peri-infarct Hot Zones Explain the Origins of Spreading Injury Depolarizations

(2015) Daniel von Bornstädt et al.   NEURON

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

(2015) Robert A. Hill et al.   NEURON

Tight junction disruption of blood–brain barrier in white matter lesions in chronic hypertensive rats

(2015) Yuhua Fan et al.   NEUROREPORT

Brain Vascular Pericytes Following Ischemia Have Multipotential Stem Cell Activity to Differentiate Into Neural and Vascular Lineage Cells

(2015) Takayuki Nakagomi et al.   STEM CELLS

Poststroke Angiogenesis: Blood, Bloom, or Brood?

(2015) J. Liu   STROKE

Collateral Circulation in Ischemic Stroke

(2015) Oh Young Bang et al.   STROKE

The Molecular Constituents of the Blood–Brain Barrier

(2015) Brian Wai Chow et al.   TRENDS IN NEUROSCIENCES

Blood–brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment

(2015) Mina Elahy et al.   Immunity & Ageing

Brain arteriovenous malformations

(2015) Michael T. Lawton et al.   Nature Reviews Disease Primers

Collateral Perfusion: Time for Novel Paradigms in Cerebral Ischemia

(2015) David S. Liebeskind   International Journal of Stroke

Perivascular microglia promote blood vessel disintegration in the ischemic penumbra

(2014) Valérie Jolivel et al.   ACTA NEUROPATHOLOGICA

Toll-like receptor 2/4 heterodimer mediates inflammatory injury in intracerebral hemorrhage

(2014) Yan-Chun Wang et al.   ANNALS OF NEUROLOGY

A Brief Etymology of the Collateral Circulation

(2014) James E. Faber et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypercholesterolaemia-induced oxidative stress at the blood–brain barrier

(2014) Irundika H.K. Dias et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Pericyte: A Forgotten Cell Type with Important Implications for Alzheimer's Disease?

(2014) Ethan A. Winkler et al.   BRAIN PATHOLOGY

The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions

(2014) Esther Steiner et al.   CELL AND TISSUE RESEARCH

The Role of Pericytes in Neurovascular Unit Remodeling in Brain Disorders

(2014) Ayman ElAli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intracranial Pressure Elevation after Ischemic Stroke in Rats: Cerebral Edema is Not the Only Cause, and Short-Duration Mild Hypothermia is a Highly Effective Preventive Therapy

(2014) Lucy A Murtha et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions

(2014) Claire L. Gibson et al.   JOURNAL OF NEUROCHEMISTRY

Effects of insulin combined with idebenone on blood-brain barrier permeability in diabetic rats

(2014) Yan-Na Sun et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Untreated brain arteriovenous malformation: Patient-level meta-analysis of hemorrhage predictors

(2014) H. Kim et al.   NEUROLOGY

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

Acute hypertension induces brain injury and blood–brain barrier disruption through reduction of claudins mRNA expression in rat

(2014) Mohammad Taghi Mohammadi et al.   PATHOLOGY RESEARCH AND PRACTICE

Subarachnoid Hemorrhage: a Review of Experimental Studies on the Microcirculation and the Neurovascular Unit

(2014) Michael K. Tso et al.   Translational Stroke Research

Leptomeningeal collaterals are associated with modifiable metabolic risk factors

(2013) Bijoy K. Menon et al.   ANNALS OF NEUROLOGY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Neurovascular development and links to disease

(2013) Christiana Ruhrberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Microglial Responses after Ischemic Stroke and Intracerebral Hemorrhage

(2013) Roslyn A. Taylor et al.   Clinical & Developmental Immunology

Oxidative Stress and Pathophysiology of Ischemic Stroke: Novel Therapeutic Opportunities

(2013) Ramon Rodrigo et al.   CNS & Neurological Disorders-Drug Targets

Hyperglycaemia promotes cerebral barrier dysfunction through activation of protein kinase C-β

(2013) B. Shao et al.   DIABETES OBESITY & METABOLISM

AMP-dependent Kinase Inhibits Oxidative Stress-induced Caveolin-1 Phosphorylation and Endocytosis by Suppressing the Dissociation between c-Abl and Prdx1 Proteins in Endothelial Cells

(2013) Kimio Takeuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke

(2013) Zu-Lin Chen et al.   JOURNAL OF CELL BIOLOGY

Failure of Collateral Blood Flow is Associated with Infarct Growth in Ischemic Stroke

(2013) Bruce CV Campbell et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased 20-HETE Synthesis Explains Reduced Cerebral Blood Flow But Not Impaired Neurovascular Coupling after Cortical Spreading Depression in Rat Cerebral Cortex

(2013) J. C. Fordsmann et al.   JOURNAL OF NEUROSCIENCE

Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial

(2013) J P Mohr et al.   LANCET

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Pearls & Oy-sters: Small but consequential: Intracerebral hemorrhage caused by lenticulostriate artery aneurysm

(2013) O. Heck et al.   NEUROLOGY

Risk Factors and Their Combined Effects on the Incidence Rate of Subarachnoid Hemorrhage – A Population-Based Cohort Study

(2013) Miikka Korja et al.   PLoS One

Vascular remodeling after ischemic stroke: Mechanisms and therapeutic potentials

(2013) Jialing Liu et al.   PROGRESS IN NEUROBIOLOGY

Modifiable Risk Factors for Aneurysmal Subarachnoid Hemorrhage

(2013) Trine H. Andreasen et al.   STROKE

Reduced Mural Cell Coverage and Impaired Vessel Integrity After Angiogenic Stimulation in the Alk1 -deficient Brain

(2012) Wanqiu Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

PDGF Receptor β Signaling in Pericytes Following Ischemic Brain Injury

(2012) Koichi Arimura et al.   CURRENT NEUROVASCULAR RESEARCH

Astrocytes and disease: a neurodevelopmental perspective

(2012) A. V. Molofsky et al.   GENES & DEVELOPMENT

Striking crosstalk of ROCK signaling with endothelial function

(2012) Kensuke Noma et al.   Journal of Cardiology

Early Loss of Pericytes and Perivascular Stromal Cell-Induced Scar Formation after Stroke

(2012) Francisco Fernández-Klett et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Biology of Intracranial Aneurysms: Role of Inflammation

(2012) Nohra Chalouhi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Effects of high-mobility group box1 on cerebral angiogenesis and neurogenesis after intracerebral hemorrhage

(2012) C. Lei et al.   NEUROSCIENCE

Astrocyte Inositol Triphosphate Receptor Type 2 and Cytosolic Phospholipase A2 Alpha Regulate Arteriole Responses in Mouse Neocortical Brain Slices

(2012) Lihua He et al.   PLoS One

Correction: Endothelial Expression of TGFβ Type II Receptor Is Required to Maintain Vascular Integrity during Postnatal Development of the Central Nervous System

(2012) Kathleen R. Allinson et al.   PLoS One

Nuclear localization of Matrix metalloproteinases

(2012) Ferdinando Mannello et al.   PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY

Angiogenesis

(2012) Adviye Ergul et al.   STROKE

Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in anin VitroBlood-Brain Barrier Model

(2011) Kazuchika Nishitsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood–Brain Barrier in a Focal Cerebral Ischemic Insult

(2011) Haixia Jiao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Occludin: One Protein, Many Forms

(2011) P. M. Cummins   MOLECULAR AND CELLULAR BIOLOGY

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Intracranial aneurysms: from vessel wall pathology to therapeutic approach

(2011) Timo Krings et al.   Nature Reviews Neurology

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor

(2011) K. D. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Pathophysiology of Cerebral Hemorrhage

(2011) Jaroslaw Aronowski et al.   STROKE

Astrocyte–neuron metabolic relationships: for better and for worse

(2011) Igor Allaman et al.   TRENDS IN NEUROSCIENCES

Spreading depolarizations cycle around and enlarge focal ischaemic brain lesions

(2010) Hajime Nakamura et al.   BRAIN

Luminal platelet aggregates in functional deficits in parenchymal vessels after subarachnoid hemorrhage

(2010) Victor Friedrich et al.   BRAIN RESEARCH

Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches

(2010) Filipa Lourenço Cardoso et al.   BRAIN RESEARCH REVIEWS

Protective effects of recombinant osteopontin on early brain injury after subarachnoid hemorrhage in rats*

(2010) Hidenori Suzuki et al.   CRITICAL CARE MEDICINE

Intracellular substrate cleavage: a novel dimension in the biochemistry, biology and pathology of matrix metalloproteinases

(2010) Bénédicte Cauwe et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Skilled reaching training promotes astroglial changes and facilitated sensorimotor recovery after collagenase-induced intracerebral hemorrhage

(2010) R.G. Mestriner et al.   EXPERIMENTAL NEUROLOGY

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

The Development and the Use of Experimental Animal Models to Study the Underlying Mechanisms of CA Formation

(2010) Tomohiro Aoki et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Review: Leucocyte-endothelial cell crosstalk at the blood-brain barrier: A prerequisite for successful immune cell entry to the brain

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Claudin-5 as a Novel Estrogen Target in Vascular Endothelium

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Niaspan Treatment Increases Tumor Necrosis Factor-α-Converting Enzyme and Promotes Arteriogenesis after Stroke

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(2009) V. Friedrich et al.   NEUROSCIENCE

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Sonic Hedgehog Promotes Angiogenesis and Osteogenesis in a Coculture System Consisting of Primary Osteoblasts and Outgrowth Endothelial Cells

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Egr-1 Regulates Expression of the Glial Scar Component Phosphacan in Astrocytes after Experimental Stroke

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(2008) Wolfgang Schaper   BASIC RESEARCH IN CARDIOLOGY

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Wnt/β-catenin signaling controls development of the blood–brain barrier

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The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

RISK FACTORS FOR HEMORRHAGIC PRESENTATION IN PATIENTS WITH DURAL ARTERIOVENOUS FISTULAE

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The Natural History and Predictive Features of Hemorrhage From Brain Arteriovenous Malformations

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