Neurovascular Unit: A critical role in ischemic stroke

CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation

(2020) Yeomyeong Kim et al.   Journal of Neuroinflammation

Microglial IRF5-IRF4 regulatory axis regulates neuroinflammation after cerebral ischemia and impacts stroke outcomes

(2020) Abdullah Al Mamun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glial Cells: Role of the Immune Response in Ischemic Stroke

(2020) Shenbin Xu et al.   Frontiers in Immunology

Exosomes-carried microRNA-26b-5p regulates microglia M1 polarization after cerebral ischemia/reperfusion

(2020) Guangying Li et al.   CELL CYCLE

P2Y6 receptor inhibition aggravates ischemic brain injury by reducing microglial phagocytosis

(2020) Ruo‐Xue Wen et al.   CNS Neuroscience & Therapeutics

VX‐765 enhances autophagy of human umbilical cord mesenchymal stem cells against stroke‐induced apoptosis and inflammatory responses via AMPK/mTOR signaling pathway

(2020) Zhezhe Sun et al.   CNS Neuroscience & Therapeutics

Thrombin-induced miRNA-24–1-5p upregulation promotes angiogenesis by targeting prolyl hydroxylase domain 1 in intracerebral hemorrhagic rats

(2020) Hanjin Cui et al.   JOURNAL OF NEUROSURGERY

Mechanisms in blood-brain barrier opening and metabolism-challenged cerebrovascular ischemia with emphasis on ischemic stroke

(2020) Sajad Sarvari et al.   METABOLIC BRAIN DISEASE

Hypertonic saline mediates the NLRP3/IL‐1β signaling axis in microglia to alleviate ischemic blood‐brain barrier permeability by downregulating astrocyte‐derived VEGF in rats

(2020) Qiao‐sheng Wang et al.   CNS Neuroscience & Therapeutics

Role of pericyte‐derived SENP1 in neuronal injury after brain ischemia

(2020) Meiling Sun et al.   CNS Neuroscience & Therapeutics

Interpericyte tunnelling nanotubes regulate neurovascular coupling

(2020) Luis Alarcon-Martinez et al.   NATURE

Interaction of Microglia and Astrocytes in the Neurovascular Unit

(2020) Li-rong Liu et al.   Frontiers in Immunology

Targeting pericyte–endothelial cell crosstalk by circular RNA-cPWWP2A inhibition aggravates diabetes-induced microvascular dysfunction

(2019) Chang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allogeneic adipose-derived mesenchymal stem cell sheet that produces neurological improvement with angiogenesis and neurogenesis in a rat stroke model

(2019) Bikei Ryu et al.   JOURNAL OF NEUROSURGERY

Electrical stimulation affects neural stem cell fate and function in vitro

(2019) Rong Zhu et al.   EXPERIMENTAL NEUROLOGY

Long non-coding RNAs and cell death following ischemic stroke

(2019) Masoumeh Alishahi et al.   METABOLIC BRAIN DISEASE

Glutamate-Releasing SWELL1 Channel in Astrocytes Modulates Synaptic Transmission and Promotes Brain Damage in Stroke

(2019) Junhua Yang et al.   NEURON

MicroRNA-365 Knockdown Prevents Ischemic Neuronal Injury by Activating Oxidation Resistance 1-Mediated Antioxidant Signals

(2019) Jia-Lin Mo et al.   Neuroscience Bulletin

Inhibition of miR-19a protects neurons against ischemic stroke through modulating glucose metabolism and neuronal apoptosis

(2019) Xiao-Li Ge et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Acute ischaemic stroke: challenges for the intensivist

(2019) M. Smith et al.   INTENSIVE CARE MEDICINE

MicroRNA‐194 reduces inflammatory response and human dermal microvascular endothelial cells permeability through suppression of TGF‐β/SMAD pathway by inhibiting THBS1 in chronic idiopathic urticaria

(2019) Shengming Qu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

(2019) Angeliki M. Nikolakopoulou et al.   NATURE NEUROSCIENCE

Silencing of Long Noncoding RNA Nespas Aggravates Microglial Cell Death and Neuroinflammation in Ischemic Stroke

(2019) Yiming Deng et al.   STROKE

Perlecan regulates pericyte dynamics in the maintenance and repair of the blood–brain barrier

(2019) Kuniyuki Nakamura et al.   JOURNAL OF CELL BIOLOGY

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

(2019) Amit U. Joshi et al.   NATURE NEUROSCIENCE

Involvement of Epigenetic Mechanisms and Non-coding RNAs in Blood-Brain Barrier and Neurovascular Unit Injury and Recovery After Stroke

(2019) Svetlana M. Stamatovic et al.   Frontiers in Neuroscience

Protective effect of 4-Methoxy benzyl alcohol on the neurovascular unit after cerebral ischemia reperfusion injury

(2019) Fangyan He et al.   BIOMEDICINE & PHARMACOTHERAPY

Rosiglitazone ameliorates tissue plasminogen activator‐induced brain hemorrhage after stroke

(2019) Yan Li et al.   CNS Neuroscience & Therapeutics

Pharmacological hypothermia induced neurovascular protection after severe stroke of transient middle cerebral artery occlusion in mice

(2019) Yingying Zhao et al.   EXPERIMENTAL NEUROLOGY

Oligodendrocytes in Development, Myelin Generation and Beyond

(2019) Sarah Kuhn et al.   Cells

CircRNA cRAPGEF5 inhibits the growth and metastasis of renal cell carcinoma via the miR-27a-3p/TXNIP pathway

(2019) Qiong Chen et al.   CANCER LETTERS

Reduction of circular RNA Foxo3 promotes prostate cancer progression and chemoresistance to docetaxel

(2019) Zhiyuan Shen et al.   CANCER LETTERS

Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti‐inflammatory phenotype through STAT3 pathway

(2019) Zong‐Jian Liu et al.   CNS Neuroscience & Therapeutics

Enhancing Neurogenesis of Neural Stem Cells Using Homogeneous Nanohole Pattern-Modified Conductive Platform

(2019) Yeon-Woo Cho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Up-regulation of Sirt1/miR-149-5p signaling may play a role in resveratrol induced protection against ischemia via p53 in rat brain

(2019) Sireesh Kumar Teertam et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Neuroprotective Action of Teriflunomide in a Mouse Model of Transient Middle Cerebral Artery Occlusion

(2019) Zhengfang Lu et al.   NEUROSCIENCE

Immune cell modulation of oligodendrocyte lineage cells

(2019) Emily P. Harrington et al.   NEUROSCIENCE LETTERS

MicroRNA-126-3p/-5p Overexpression Attenuates Blood-Brain Barrier Disruption in a Mouse Model of Middle Cerebral Artery Occlusion

(2019) Jiaji Pan et al.   STROKE

Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke

(2018) Bing Han et al.   Autophagy

Interleukin 15 blockade protects the brain from cerebral ischemia-reperfusion injury

(2018) Gilbert Aaron Lee et al.   BRAIN BEHAVIOR AND IMMUNITY

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury

(2018) David Oliveira Dias et al.   CELL

Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization

(2018) Mei Jiang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Endothelial C-Type Natriuretic Peptide Acts on Pericytes to Regulate Microcirculatory Flow and Blood Pressure

(2018) Katarina Špiranec et al.   CIRCULATION

Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice

(2018) Masaya Tachibana et al.   EXPERIMENTAL NEUROLOGY

PDGFR-β restores blood-brain barrier functions in a mouse model of focal cerebral ischemia

(2018) Jie Shen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Early Blood-Brain Barrier Disruption after Mechanical Thrombectomy in Acute Ischemic Stroke

(2018) Zhong-Song Shi et al.   JOURNAL OF NEUROIMAGING

Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development

(2018) Ilia D. Vainchtein et al.   SCIENCE

Targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice

(2018) Ali Alawieh et al.   Science Translational Medicine

Post-stroke inflammation—target or tool for therapy?

(2018) Kate Lykke Lambertsen et al.   ACTA NEUROPATHOLOGICA

Microglial cell loss after ischemic stroke favors brain neutrophil accumulation

(2018) Amaia Otxoa-de-Amezaga et al.   ACTA NEUROPATHOLOGICA

Combined treatment of sodium ferulate, n -butylidenephthalide, and ADSCs rehabilitates neurovascular unit in rats after photothrombotic stroke

(2018) Yong-Hua Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Involvement of caveolin-1 in neurovascular unit remodeling after stroke: Effects on neovascularization and astrogliosis

(2018) Camille Blochet et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Claudin-1 dependent destabilization of the blood-brain barrier in chronic stroke

(2018) Nikola Sladojevic et al.   JOURNAL OF NEUROSCIENCE

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

(2018) Minako Ito et al.   NATURE

MALAT1 lncRNA Induces Autophagy and Protects Brain Microvascular Endothelial Cells Against Oxygen–Glucose Deprivation by Binding to miR-200c-3p and Upregulating SIRT1 Expression

(2018) Shan Wang et al.   NEUROSCIENCE

New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration

(2018) N. Kaneko et al.   Science Advances

MiRNA-27b Regulates Angiogenesis by Targeting AMPK in Mouse Ischemic Stroke Model

(2018) Yimei Yuan et al.   NEUROSCIENCE

miR-191 suppresses angiogenesis by activation of NF-κB signaling

(2017) Yuan Gu et al.   FASEB JOURNAL

Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke

(2017) Richard Leigh et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity

(2017) Kelly S. Kirkley et al.   Journal of Neuroinflammation

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Long noncoding RNA Malat1 is a potent autophagy inducer protecting brain microvascular endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury by sponging miR-26b and upregulating ULK2 expression

(2017) Zhijun Li et al.   NEUROSCIENCE

Early Reperfusion After Brain Ischemia Has Beneficial Effects Beyond Rescuing Neurons

(2017) Masaki Tachibana et al.   STROKE

LncRNA BANCR facilitates vascular smooth muscle cell proliferation and migration through JNK pathway

(2017) He Li et al.   Oncotarget

MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia

(2016) Somayyeh Hamzei Taj et al.   BIOMATERIALS

Stroke: a global response is needed

(2016) Walter Johnson et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Mesenchymal stem cells generate pericytes to promote tumor recurrence via vasculogenesis after stereotactic body radiation therapy

(2016) Huan-Huan Wang et al.   CANCER LETTERS

Inhibition of MicroRNA-383 Ameliorates Injury After Focal Cerebral Ischemia via Targeting PPARγ

(2016) Lichun Pei et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Circulating miR-181a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction

(2016) Jianbing Zhu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting

(2016) Christopher S. von Bartheld et al.   JOURNAL OF COMPARATIVE NEUROLOGY

β-Caryophyllene protectsin vitroneurovascular unit against oxygen-glucose deprivation and re-oxygenation-induced injury

(2016) Xiaocui Tian et al.   JOURNAL OF NEUROCHEMISTRY

miR-140-5p regulates angiogenesis following ischemic stroke by targeting VEGFA

(2016) JIJUN SUN et al.   Molecular Medicine Reports

An Antagomir to MicroRNA-106b-5p Ameliorates Cerebral Ischemia and Reperfusion Injury in Rats Via Inhibiting Apoptosis and Oxidative Stress

(2016) Pengfei Li et al.   MOLECULAR NEUROBIOLOGY

A novel lineage restricted, pericyte-like cell line isolated from human embryonic stem cells

(2016) Midori Greenwood-Goodwin et al.   Scientific Reports

Pericytes in Brain Injury and Repair After Ischemic Stroke

(2016) Wei Cai et al.   Translational Stroke Research

The burden of stroke in Africa: a glance at the present and a glimpse into the future: review article

(2015) MO Owolabi et al.   Cardiovascular Journal of Africa

Perspective for Stroke and Brain Injury Research: Mechanisms and Potential Therapeutic Targets

(2015) Jun Chen et al.   CNS Neuroscience & Therapeutics

Current developments in cell- and biomaterial-based approaches for stroke repair

(2015) Pavla Jendelová et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Targeting Neutrophils in Ischemic Stroke: Translational Insights from Experimental Studies

(2015) Glen C Jickling et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

In Vivo Inhibition of miR-155 Promotes Recovery after Experimental Mouse Stroke

(2015) E. Caballero-Garrido et al.   JOURNAL OF NEUROSCIENCE

Brain Vascular Pericytes Following Ischemia Have Multipotential Stem Cell Activity to Differentiate Into Neural and Vascular Lineage Cells

(2015) Takayuki Nakagomi et al.   STEM CELLS

MicroRNA-107 contributes to post-stroke angiogenesis by targeting Dicer-1

(2015) Yanan Li et al.   Scientific Reports

Rational modulation of the innate immune system for neuroprotection in ischemic stroke

(2015) Diana Amantea et al.   Frontiers in Neuroscience

Pericyte protection by edaravone after tissue plasminogen activator treatment in rat cerebral ischemia

(2014) Kentaro Deguchi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials

(2014) Jonathan Emberson et al.   LANCET

Hemorrhagic Transformation after Tissue Plasminogen Activator Reperfusion Therapy for Ischemic Stroke: Mechanisms, Models, and Biomarkers

(2014) Wei Wang et al.   MOLECULAR NEUROBIOLOGY

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

Neurovascular protection of cilostazol in stroke-prone spontaneous hypertensive rats associated with angiogenesis and pericyte proliferation

(2013) Yoshio Omote et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Pericytes Derived from Adipose-Derived Stem Cells Protect against Retinal Vasculopathy

(2013) Thomas A. Mendel et al.   PLoS One

Factors Secreted by Endothelial Progenitor Cells Enhance Neurorepair Responses after Cerebral Ischemia in Mice

(2013) Anna Rosell et al.   PLoS One

Reprogramming of Pericyte-Derived Cells of the Adult Human Brain into Induced Neuronal Cells

(2012) Marisa Karow et al.   Cell Stem Cell

PDGF Receptor β Signaling in Pericytes Following Ischemic Brain Injury

(2012) Koichi Arimura et al.   CURRENT NEUROVASCULAR RESEARCH

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

Clinical Trials for Neuroprotective Therapies in Intracerebral Hemorrhage: A New Roadmap from Bench to Bedside

(2012) Amit Ayer et al.   Translational Stroke Research

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Pericyte-derived Glial Cell Line-derived Neurotrophic Factor Increase the Expression of Claudin-5 in the Blood–brain Barrier and the Blood-nerve Barrier

(2011) Fumitaka Shimizu et al.   NEUROCHEMICAL RESEARCH

Ischemia-Induced Neural Stem/Progenitor Cells in the Pia Mater Following Cortical Infarction

(2011) Takayuki Nakagomi et al.   STEM CELLS AND DEVELOPMENT

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Purinergic Receptor Stimulation Reduces Cytotoxic Edema and Brain Infarcts in Mouse Induced by Photothrombosis by Energizing Glial Mitochondria

(2010) Wei Zheng et al.   PLoS One

Dissociation and Protection of the Neurovascular Unit after Thrombolysis and Reperfusion in Ischemic Rat Brain

(2009) Toru Yamashita et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Costs and Rehabilitation Use of Stroke Survivors: A Retrospective Study of Medicare Beneficiaries

(2009) Richard D. Zorowitz et al.   Topics in Stroke Rehabilitation

Astrocytes are More Resistant to Focal Cerebral Ischemia Than Neurons and Die by a Delayed Necrosis

(2008) Günfer Gürer et al.   BRAIN PATHOLOGY

Down-regulation of neurocan expression in reactive astrocytes promotes axonal regeneration and facilitates the neurorestorative effects of bone marrow stromal cells in the ischemic rat brain

(2008) Li Hong Shen et al.   GLIA

Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

(2008) Werner Hacke et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Neurovascular Unit in Health and Disease: Introduction

(2008) E. H. Lo et al.   STROKE

Neocortical glial cell numbers in human brains

(2007) D.P. Pelvig et al.   NEUROBIOLOGY OF AGING