The Role of Sonic Hedgehog Pathway in the Development of the Central Nervous System and Aging-Related Neurodegenerative Diseases

Primary lateral sclerosis: consensus diagnostic criteria

(2020) Martin R Turner et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Alzheimer’s Disease and Vascular Aging

(2020) Marta Cortes-Canteli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Protease nexin-1 protects against Alzheimer’s disease by regulating the sonic hedgehog signaling pathway

(2020) Xiao-Long Li et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Disease-modifying therapies in amyotrophic lateral sclerosis

(2020) Adriano Chiò et al.   NEUROPHARMACOLOGY

Diminished ventral oligodendrocyte precursor generation results in the subsequent over-production of dorsal oligodendrocyte precursors of aberrant morphology and function

(2020) Lev Starikov et al.   NEUROSCIENCE

Sigma 1 receptor as a therapeutic target for Amyotrophic Lateral Sclerosis

(2020) Mireia Herrando‐Grabulosa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sonic Hedgehog-Gli1 Signaling and Cellular Retinoic Acid Binding Protein 1 Gene Regulation in Motor Neuron Differentiation and Diseases

(2020) Yu-Lung Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Regenerative Potential of Facial Nerve Motoneurons following Chronic Axotomy in Rats

(2020) Yusu Ni et al.   NEURAL PLASTICITY

Mitochondrial Dysfunction, Neurogenesis, and Epigenetics: Putative Implications for Amyotrophic Lateral Sclerosis Neurodegeneration and Treatment

(2020) Michele Longoni Calió et al.   Frontiers in Neuroscience

Emerging Roles of Inhibitor of Differentiation-1 in Alzheimer’s Disease: Cell Cycle Reentry and Beyond

(2020) Shang-Der Chen et al.   Cells

Deciphering the roles of caveolin in neurodegenerative diseases: The good, the bad and the importance of context

(2020) Wenwen Yang et al.   AGEING RESEARCH REVIEWS

The Hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development

(2020) Martha L. Echevarría-Andino et al.   DEVELOPMENT

Holoprosencephaly

(2020) Ana Monteagudo   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Medulloblastoma

(2019) Paul A. Northcott et al.   Nature Reviews Disease Primers

State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures

(2019) Christian Espinosa-Bustos et al.   Future Medicinal Chemistry

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Temporal and partial inhibition of GLI1 in neural stem cells (NSCs) results in the early maturation of NSC derived oligodendrocytes in vitro

(2019) Poommaree Namchaiw et al.   Stem Cell Research & Therapy

Sonic hedgehog signaling pathway promotes pancreatic cancer pain via nerve growth factor

(2019) Liang Han et al.   REGIONAL ANESTHESIA AND PAIN MEDICINE

Epigenetics in amyotrophic lateral sclerosis: a role for histone post-translational modifications in neurodegenerative disease

(2018) Seth A. Bennett et al.   Translational Research

Dental Pulp Stem Cells: Their Potential in Reinnervation and Angiogenesis by Using Scaffolds

(2017) Ivo Lambrichts et al.   JOURNAL OF ENDODONTICS

Sonic Hedgehog Regulation of the Neural Precursor Cell Fate During Chicken Optic Tectum Development

(2017) Ciqing Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection

(2017) Christopher I. Ugbode et al.   JOURNAL OF NEUROCHEMISTRY

Activation of Sonic hedgehog signal by Purmorphamine, in a mouse model of Parkinson's disease, protects dopaminergic neurons and attenuates inflammatory response by mediating PI3K/AKt signaling pathway

(2017) Shuai Shao et al.   Molecular Medicine Reports

Crosstalk between Notch and Sonic hedgehog signaling in a mouse model of amyotrophic lateral sclerosis

(2017) Xiaoxing Ma et al.   NEUROREPORT

Targeting sonic hedgehog signaling in neurological disorders

(2017) Sita Sharan Patel et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Cerebrospinal fluid from patients with amyotrophic lateral sclerosis inhibits sonic hedgehog function

(2017) Anna Drannik et al.   PLoS One

Dopaminergic Neurons and Brain Reward Pathways

(2016) Sarah X. Luo et al.   AMERICAN JOURNAL OF PATHOLOGY

Progressive Loss of Function in a Limb Enhancer during Snake Evolution

(2016) Evgeny Z. Kvon et al.   CELL

SHH desmoplastic/nodular medulloblastoma and Gorlin syndrome in the setting of Down syndrome: case report, molecular profiling, and review of the literature

(2016) Ross Mangum et al.   CHILDS NERVOUS SYSTEM

Role of Sonic Hedgehog Signaling in Oligodendrocyte Differentiation

(2016) Li-Chun Wang et al.   NEUROCHEMICAL RESEARCH

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

(2016) Tadas Rimkus et al.   Cancers

BMP-SHH Signaling Network Controls Epithelial Stem Cell Fate via Regulation of Its Niche in the Developing Tooth

(2015) Jingyuan Li et al.   DEVELOPMENTAL CELL

nNOS Translocates into the Nucleus and Interacts with Sox2 to Protect Neurons Against Early Excitotoxicity via Promotion of Shh Transcription

(2015) Dongmei Zhang et al.   MOLECULAR NEUROBIOLOGY

Hedgehog regulates cerebellar progenitor cell and medulloblastoma apoptosis

(2015) Kevin Kiyoshi Noguchi et al.   NEUROBIOLOGY OF DISEASE

Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons

(2014) Yu-Hsing Hung et al.   MOLECULAR NEUROBIOLOGY

Targeting of Smoothened for therapeutic gain

(2014) Martial Ruat et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sonic hedgehog signaling coordinates the proliferation and differentiation of neural stem/progenitor cells by regulating cell cycle kinetics during development of the neocortex

(2012) Munekazu Komada   CONGENITAL ANOMALIES

The protective effect of sonic hedgehog is mediated by the propidium iodide 3-kinase/AKT/Bcl-2 pathway in cultured rat astrocytes under oxidative stress

(2012) Y.-P. Xia et al.   NEUROSCIENCE

Sonic Hedgehog is Cytoprotective against Oxidative Challenge in a Cellular Model of Amyotrophic Lateral Sclerosis

(2011) Randy Peterson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Inhibition of sonic hedgehog signaling aggravates brain damage associated with the down-regulation of Gli1, Ptch1 and SOD1 expression in acute ischemic stroke

(2011) Hui Ji et al.   NEUROSCIENCE LETTERS

The metalloendopeptidase genePitrm1is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors

(2009) Liam Town et al.   DEVELOPMENTAL DYNAMICS

Transplantation of primed or unprimed mouse embryonic stem cell-derived neural precursor cells improves cognitive function in Alzheimerian rats

(2009) Farshad Homayouni Moghadam et al.   DIFFERENTIATION