Occludin: One Protein, Many Forms

Stabilization of brain microvascular endothelial barrier function by shear stress involves VE-cadherin signaling leading to modulation of pTyr-occludin levels

(2011) Tony G. Walsh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins

(2011) Saran Feng et al.   PLoS One

Rab5a-mediated localization of claudin-1 is regulated by proteasomes in endothelial cells

(2010) Machiko Asaka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Metalloproteinase mediated occludin cleavage in the cerebral microcapillary endothelium under pathological conditions

(2010) Mira Lischper et al.   BRAIN RESEARCH

Regulation of the blood–brain barrier integrity by pericytes via matrix metalloproteinases mediated activation of vascular endothelial growth factor in vitro

(2010) Gokulan Thanabalasundaram et al.   BRAIN RESEARCH

The Tight Junction Protein, Occludin, Regulates the Directional Migration of Epithelial Cells

(2010) Dan Du et al.   DEVELOPMENTAL CELL

Illuminating the ubiquitin/proteasome system

(2010) Florian A. Salomons et al.   EXPERIMENTAL CELL RESEARCH

Loss of occludin leads to the progression of human breast cancer

(2010) Martin   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Streptolysin S Contributes to Group A Streptococcal Translocation across an Epithelial Barrier

(2010) Tomoko Sumitomo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix Metalloproteinase-9 Mediates Hypoxia-Induced Vascular Leakage in the Brain via Tight Junction Rearrangement

(2010) Alexander T Bauer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reduction of endothelial tight junction proteins is related to cerebral aneurysm formation in rats

(2010) Yoshiteru Tada et al.   JOURNAL OF HYPERTENSION

HIV-1 gp120-Induced Injury to the Blood-Brain Barrier: Role of Metalloproteinases 2 and 9 and Relationship to Oxidative Stress

(2010) Jean-Pierre Louboutin et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The role of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury

(2010) Tetsuhiro Higashida et al.   JOURNAL OF NEUROSURGERY

Tight Junction–associated MARVEL Proteins MarvelD3, Tricellulin, and Occludin Have Distinct but Overlapping Functions

(2010) David R. Raleigh et al.   MOLECULAR BIOLOGY OF THE CELL

Glucocorticoid effects on endothelial barrier function in the murine brain endothelial cell line cEND incubated with sera from patients with multiple sclerosis

(2010) Kinga G Blecharz et al.   Multiple Sclerosis Journal

The effects of Tanshinone IIA on blood–brain barrier and brain edema after transient middle cerebral artery occlusion in rats

(2010) Chao Tang et al.   PHYTOMEDICINE

Dynamics and functions of tight junctions

(2010) Emily Steed et al.   TRENDS IN CELL BIOLOGY

Neisseria meningitidis Induces Brain Microvascular Endothelial Cell Detachment from the Matrix and Cleavage of Occludin: A Role for MMP-8

(2010) Alexandra Schubert-Unkmeir et al.   PLoS Pathogens

Increased Proteasome-Mediated Degradation of Occludin in Irritable Bowel Syndrome

(2009) Moïse Coëffier et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Oligomerization of the Coiled Coil-domain of Occluddin Is Redox Sensitive

(2009) Juliane K. Walter et al.   Annals of the New York Academy of Sciences

Differential Phosphorylation of Occludin and Tricellulin by CK2 and CK1

(2009) Max J. Dörfel et al.   Annals of the New York Academy of Sciences

Occludin Phosphorylation in Regulation of Epithelial Tight Junctions

(2009) Radhakrishna Rao   Annals of the New York Academy of Sciences

Phospholipase D2 regulates endothelial permeability through cytoskeleton reorganization and occludin downregulation

(2009) Caroline Zeiller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family

(2009) Emily Steed et al.   BMC CELL BIOLOGY

TLR2-Induced Calpain Cleavage of Epithelial Junctional Proteins Facilitates Leukocyte Transmigration

(2009) Jarin Chun et al.   Cell Host & Microbe

Redox-sensitivity of the dimerization of occludin

(2009) J. K. Walter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Adaptive Cerebral Neovascularization in a Model of Type 2 Diabetes: Relevance to Focal Cerebral Ischemia

(2009) W. Li et al.   DIABETES

Cytoskeletal modulation and tyrosine phosphorylation of tight junction proteins are associated with mainstream cigarette smoke-induced permeability of airway epithelium

(2009) Dorian Olivera et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Cholesterol efflux stimulates metalloproteinase-mediated cleavage of occludin and release of extracellular membrane particles containing its C-terminal fragments

(2009) Elizabeth Casas et al.   EXPERIMENTAL CELL RESEARCH

PPARα and PPARγ attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities

(2009) Wen Huang et al.   FASEB JOURNAL

Ascorbate protects endothelial barrier function during septic insult: Role of protein phosphatase type 2A

(2009) Min Han et al.   FREE RADICAL BIOLOGY AND MEDICINE

Disruptions of occludin and claudin-5 in brain endothelial cells in vitro and in brains of mice with acute liver failure

(2009) Feng Chen et al.   HEPATOLOGY

Occludin Phosphorylation and Ubiquitination Regulate Tight Junction Trafficking and Vascular Endothelial Growth Factor-induced Permeability

(2009) Tomoaki Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Density-enhanced Phosphatase 1 Regulates Phosphorylation of Tight Junction Proteins and Enhances Barrier Function of Epithelial Cells

(2009) Jennifer L. Sallee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E3 ubiquitin ligase LNX1p80 promotes the removal of claudins from tight junctions in MDCK cells

(2009) S. Takahashi et al.   JOURNAL OF CELL SCIENCE

Inhibition of Src Activity Decreases Tyrosine Phosphorylation of Occludin in Brain Capillaries and Attenuates Increase in Permeability of the Blood-Brain Barrier after Transient Focal Cerebral Ischemia

(2009) Yuji Takenaga et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Matrix metalloproteinases inhibition provides neuroprotection against hypoxia-ischemia in the developing brain

(2009) Wanqiu Chen et al.   JOURNAL OF NEUROCHEMISTRY

Identification and Analysis of Occludin Phosphosites: A Combined Mass Spectrometry and Bioinformatics Approach

(2009) Jeffrey M. Sundstrom et al.   JOURNAL OF PROTEOME RESEARCH

Altered expression of tight junction proteins and matrix metalloproteinases in thiamine-deficient mouse brain

(2009) Élizabeth Beauchesne et al.   NEUROCHEMISTRY INTERNATIONAL

Reversal of West Nile virus-induced blood–brain barrier disruption and tight junction proteins degradation by matrix metalloproteinases inhibitor

(2009) Saguna Verma et al.   VIROLOGY

Phosphorylation of Claudin-5 and Occludin by Rho Kinase in Brain Endothelial Cells

(2008) Masaru Yamamoto et al.   AMERICAN JOURNAL OF PATHOLOGY

Tight junctions and the regulation of gene expression

(2008) Maria S. Balda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The junctional integrity of epithelial cells is modulated by Pseudomonas aeruginosa quorum sensing molecule through phosphorylation-dependent mechanisms

(2008) Elena Vikström et al.   EXPERIMENTAL CELL RESEARCH

A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion

(2008) Jin-Mo Gu et al.   FEBS Journal

Tight junctions and the modulation of barrier function in disease

(2008) Carola Förster   HISTOCHEMISTRY AND CELL BIOLOGY

Phosphorylation of Tyr-398 and Tyr-402 in Occludin Prevents Its Interaction with ZO-1 and Destabilizes Its Assembly at the Tight Junctions

(2008) Bertha C. Elias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Occludin oligomeric assembly at tight junctions of the blood-brain barrier is disrupted by peripheral inflammatory hyperalgesia

(2008) Gwen McCaffrey et al.   JOURNAL OF NEUROCHEMISTRY

Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia

(2008) Wenlan Liu et al.   JOURNAL OF NEUROCHEMISTRY

Endothelial Cell Barrier Impairment Induced by Glioblastomas and Transforming Growth Factor β2Involves Matrix Metalloproteinases and Tight Junction Proteins

(2008) Hideyuki Ishihara et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Protein Kinase A Pathway Contributes to Hg2+-Induced Alterations in Phosphorylation and Subcellular Distribution of Occludin Associated with Increased Tight Junction Permeability of Salivary Epithelial Cell Monolayers

(2008) J. D. Kawedia et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

PKC  regulates occludin phosphorylation and epithelial tight junction integrity

(2008) T. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA