‘Spreading depression of Leão’ and its emerging relevance to acute brain injury in humans

Activity-dependent calcium, oxygen, and vascular responses in a mouse model of familial hemiplegic migraine type 1

(2016) Lila Khennouf et al.   ANNALS OF NEUROLOGY

PSD-95 uncoupling from NMDA receptors by Tat-N-dimer ameliorates neuronal depolarization in cortical spreading depression

(2016) Krzysztof Kucharz et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy

(2016) Patrick M. Kochanek et al.   JOURNAL OF NEUROTRAUMA

Professor Leão’s original note

(2015) Péricles Maranhão Filho   ARQUIVOS DE NEURO-PSIQUIATRIA

Dynamics of Ionic Shifts in Cortical Spreading Depression

(2015) Rune Enger et al.   CEREBRAL CORTEX

Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions

(2015) Jason M. Hinzman et al.   EXPERIMENTAL NEUROLOGY

Consensus statement from the 2014 International Microdialysis Forum

(2015) Peter J. Hutchinson et al.   INTENSIVE CARE MEDICINE

Matrix Metalloproteinase Expression in Contusional Traumatic Brain Injury: A Paired Microdialysis Study

(2015) Mathew R. Guilfoyle et al.   JOURNAL OF NEUROTRAUMA

Robust research: Institutions must do their part for reproducibility

(2015) C. Glenn Begley et al.   NATURE

Supply-Demand Mismatch Transients in Susceptible Peri-infarct Hot Zones Explain the Origins of Spreading Injury Depolarizations

(2015) Daniel von Bornstädt et al.   NEURON

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

(2015) Robert A. Hill et al.   NEURON

The Stroke-Migraine Depolarization Continuum

(2015) Jens P. Dreier et al.   NEURON

Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature

(2015) Cenk Ayata et al.   PHYSIOLOGICAL REVIEWS

Tumor necrosis factor reduces the amplitude of rat cortical spreading depressionin vivo

(2014) Frank Richter et al.   ANNALS OF NEUROLOGY

Spreading depression in continuous electroencephalography of brain trauma

(2014) Jed A. Hartings et al.   ANNALS OF NEUROLOGY

Inverse neurovascular coupling to cortical spreading depolarizations in severe brain trauma

(2014) Jason M. Hinzman et al.   BRAIN

Unification of Neuronal Spikes, Seizures, and Spreading Depression

(2014) Y. Wei et al.   JOURNAL OF NEUROSCIENCE

Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations

(2014) Daniela Pietrobon et al.   NATURE REVIEWS NEUROSCIENCE

Radial, spiral and reverberating waves of spreading depolarization occur in the gyrencephalic brain

(2014) Edgar Santos et al.   NEUROIMAGE

The effect of ketamine on optical and electrical characteristics of spreading depolarizations in gyrencephalic swine cortex

(2014) Renán Sánchez-Porras et al.   NEUROPHARMACOLOGY

CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomized Trials

(2013) Kenneth F. Schulz   ANNALS OF INTERNAL MEDICINE

Regenerative Glutamate Release by Presynaptic NMDA Receptors Contributes to Spreading Depression

(2013) Ning Zhou et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased 20-HETE Synthesis Explains Reduced Cerebral Blood Flow But Not Impaired Neurovascular Coupling after Cortical Spreading Depression in Rat Cerebral Cortex

(2013) J. C. Fordsmann et al.   JOURNAL OF NEUROSCIENCE

Propagation of cortical spreading depolarization in the human cortex after malignant stroke

(2013) J. Woitzik et al.   NEUROLOGY

Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels

(2013) H. Karatas et al.   SCIENCE

Effect of analgesics and sedatives on the occurrence of spreading depolarizations accompanying acute brain injury

(2012) D. N. Hertle et al.   BRAIN

Correlates of spreading depolarization in human scalp electroencephalography

(2012) C. Drenckhahn et al.   BRAIN

Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury*

(2012) Marcel J. H. Aries et al.   CRITICAL CARE MEDICINE

International, Multicenter Randomized Preclinical Trials in Translational Stroke Research: It's Time to Act

(2012) Ulrich Dirnagl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sustained NMDA receptor activation by spreading depolarizations can initiate excitotoxic injury in metabolically compromised neurons

(2012) Isamu Aiba et al.   JOURNAL OF PHYSIOLOGY-LONDON

Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex

(2011) J. P. Dreier et al.   BRAIN

Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study

(2011) Jed A Hartings et al.   LANCET NEUROLOGY

The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease

(2011) Jens P Dreier   NATURE MEDICINE

Spreading depolarizations cycle around and enlarge focal ischaemic brain lesions

(2010) Hajime Nakamura et al.   BRAIN

Dynamic Metabolic Response to Multiple Spreading Depolarizations in Patients with Acute Brain Injury: An Online Microdialysis Study

(2010) Delphine Feuerstein et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury

(2010) Martin Lauritzen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage

(2009) J. P. Dreier et al.   BRAIN

Persistent Increase in Oxygen Consumption and Impaired Neurovascular Coupling after Spreading Depression in Rat Neocortex

(2009) Henning Piilgaard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Preliminary Evidence That Ketamine Inhibits Spreading Depolarizations in Acute Human Brain Injury

(2009) Oliver W. Sakowitz et al.   STROKE

Stroke Therapy Academic Industry Roundtable (STAIR) Recommendations for Extended Window Acute Stroke Therapy Trials

(2009) Jeffrey L. Saver et al.   STROKE

Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study

(2008) A. Belli et al.   ACTA NEUROCHIRURGICA

Spreading depolarizations occur in human ischemic stroke with high incidence

(2008) Christian Dohmen et al.   ANNALS OF NEUROLOGY

Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain

(2008) Martin Fabricius et al.   CLINICAL NEUROPHYSIOLOGY

Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: A microdialysis study*

(2008) Mauro Oddo et al.   CRITICAL CARE MEDICINE

Professor Aristides Leão. Much More Than Spreading Depression

(2008) Péricles Maranhão-Filho et al.   HEADACHE

Diffusion in Brain Extracellular Space

(2008) Eva Syková et al.   PHYSIOLOGICAL REVIEWS