The vascular basement membrane in the healthy and pathological brain

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

(2016) Alan W. J. Morris et al.   ACTA NEUROPATHOLOGICA

Blood–brain barrier and blood–cerebrospinal fluid barrier in normal and pathological conditions

(2016) Masaki Ueno et al.   Brain Tumor Pathology

Blood-brain barrier properties in vitro depend on composition and assembly of endogenous extracellular matrices

(2016) Kathrin Zobel et al.   CELL AND TISSUE RESEARCH

In vitro blood–brain barrier models for drug research: state-of-the-art and new perspectives on reconstituting these models on artificial basement membrane platforms

(2016) Jayati Banerjee et al.   DRUG DISCOVERY TODAY

Extracellular chloride signals collagen IV network assembly during basement membrane formation

(2016) Christopher F. Cummings et al.   JOURNAL OF CELL BIOLOGY

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

(2016) Hans C Helms et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier

(2016) Maj Schneider Thomsen et al.   JOURNAL OF NEUROCHEMISTRY

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses

(2016) Ulrich Eckhard et al.   MATRIX BIOLOGY

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Delivery of Liposomes with Different Sizes to Mice Brain after Sonication by Focused Ultrasound in the Presence of Microbubbles

(2016) Yuanyuan Shen et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

The role of pericytic laminin in blood brain barrier integrity maintenance

(2016) Jyoti Gautam et al.   Scientific Reports

Cathepsin L Acutely Alters Microvessel Integrity within the Neurovascular Unit during Focal Cerebral Ischemia

(2015) Yu-Huan Gu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Nanoparticle delivery to the brain — By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles

(2015) Andreas K.O. Åslund et al.   JOURNAL OF CONTROLLED RELEASE

Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases

(2015) Marjana Brkic et al.   MEDIATORS OF INFLAMMATION

Early changes in extracellular matrix in Alzheimer's disease

(2015) F.-X. Lepelletier et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Peroxynitrite decomposition catalyst prevents matrix metalloproteinase-9 activation and neurovascular injury after hemoglobin injection into the caudate nucleus of rats

(2015) R. Ding et al.   NEUROSCIENCE

Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration

(2015) Jian Song et al.   Cell Reports

Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer’s disease and mild cognitive impairment

(2014) Niklas Mattsson et al.   BRAIN

The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions

(2014) Esther Steiner et al.   CELL AND TISSUE RESEARCH

Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood−brain barrier using MRI-guided focused ultrasound

(2014) Elizabeth Nance et al.   JOURNAL OF CONTROLLED RELEASE

Emerging Roles of Pericytes in the Regulation of the Neurovascular Unit in Health and Disease

(2014) Jeremy Hill et al.   Journal of Neuroimmune Pharmacology

The Extracellular Matrix Protein Laminin  2 Regulates the Maturation and Function of the Blood-Brain Barrier

(2014) M. J. Menezes et al.   JOURNAL OF NEUROSCIENCE

Matrix Metalloproteinase-9: Dual Role and Temporal Profile in Intracerebral Hemorrhage

(2014) Jason J. Chang et al.   Journal of Stroke & Cerebrovascular Diseases

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

(2014) Y. J. Yu et al.   Science Translational Medicine

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity

(2014) Yao Yao et al.   Nature Communications

Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-β from the mouse brain

(2013) Cheryl A. Hawkes et al.   AGING CELL

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–40 peptide in brain endothelial cells

(2013) Ana Catarina R.G. Fonseca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Nanoparticle- and Liposome-carried Drugs: New Strategies for Active Targeting and Drug Delivery Across Blood-brain Barrier

(2013) Martha Pinzon-Daza et al.   CURRENT DRUG METABOLISM

Glial influence on the blood brain barrier

(2013) Jorge Ivan Alvarez et al.   GLIA

Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke

(2013) Zu-Lin Chen et al.   JOURNAL OF CELL BIOLOGY

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

Pathophysiology of the brain extracellular matrix: a new target for remyelination

(2013) Lorraine W. Lau et al.   NATURE REVIEWS NEUROSCIENCE

Morphometry of the hippocampal microvasculature in post-stroke and age-related dementias

(2013) M. J. C. Burke et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Patterns of cerebral amyloid angiopathy define histopathological phenotypes in Alzheimer's disease

(2013) N. Allen et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Altered Brain Uptake of Therapeutics in a Triple Transgenic Mouse Model of Alzheimer’s Disease

(2013) Dharmini C. Mehta et al.   PHARMACEUTICAL RESEARCH

Laminin isoforms in endothelial and perivascular basement membranes

(2013) Lema F. Yousif et al.   Cell Adhesion & Migration

Laminins in basement membrane assembly

(2013) Erhard Hohenester et al.   Cell Adhesion & Migration

Analysis of intracranial pressure pulse waveform and brain capillary morphology in type 2 diabetes mellitus rats

(2012) Hidetaka Onodera et al.   BRAIN RESEARCH

Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

(2012) Cheryl A. Hawkes et al.   PLoS One

Perlecan and the Blood-Brain Barrier: Beneficial Proteolysis?

(2012) Jill Roberts et al.   Frontiers in Pharmacology

Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice

(2011) Mario Merlini et al.   ACTA NEUROPATHOLOGICA

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

(2011) Cheryl A. Hawkes et al.   ACTA NEUROPATHOLOGICA

Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke

(2011) Kim M. Baeten et al.   Developmental Neurobiology

The impact of pericytes on the blood–brain barrier integrity depends critically on the pericyte differentiation stage

(2011) Gokulan Thanabalasundaram et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Interendothelial Claudin-5 Expression Depends on Cerebral Endothelial Cell–Matrix Adhesion by β1-Integrins

(2011) Takashi Osada et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

β1-Integrin/Matrix Interactions Support Blood–Brain Barrier Integrity

(2011) Britta Engelhardt   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents

(2011) Boyeon Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Changes in Brain β-Amyloid Deposition and Aquaporin 4 Levels in Response to AlteredAgrinExpression in Mice

(2011) Steven M. Rauch et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Progressive neurovascular disturbances in the cerebral cortex of Alzheimer's disease-model mice: protection by atorvastatin and pitavastatin

(2011) T. Kurata et al.   NEUROSCIENCE

Amyloid Triggers Extensive Cerebral Angiogenesis Causing Blood Brain Barrier Permeability and Hypervascularity in Alzheimer's Disease

(2011) Kaan E. Biron et al.   PLoS One

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization

(2010) A. N. Stratman et al.   BLOOD

Vascular Basement Membrane Thickening in Diabetic Retinopathy

(2010) Sayon Roy et al.   CURRENT EYE RESEARCH

Hemoglobin-Induced Oxidative Stress Contributes to Matrix Metalloproteinase Activation and Blood–Brain Barrier Dysfunction in vivo

(2010) Masataka Katsu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Recombinant Osteopontin Attenuates Brain Injury after Intracerebral Hemorrhage in Mice

(2010) Bihua Wu et al.   Neurocritical Care

The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells

(2010) Richard Daneman et al.   PLoS One

Basement Membranes: Cell Scaffoldings and Signaling Platforms

(2010) P. D. Yurchenco   Cold Spring Harbor Perspectives in Biology

Age-Related Vascular Pathology in Transgenic Mice Expressing Presenilin 1-Associated Familial Alzheimer's Disease Mutations

(2009) Miguel A. Gama Sosa et al.   AMERICAN JOURNAL OF PATHOLOGY

Selective Filtering of Particles by the Extracellular Matrix: An Electrostatic Bandpass

(2009) Oliver Lieleg et al.   BIOPHYSICAL JOURNAL

Post-ischemic hypothermia attenuates loss of the vascular basement membrane proteins, agrin and SPARC, and the blood–brain barrier disruption after global cerebral ischemia

(2009) Ewa Baumann et al.   BRAIN RESEARCH

Integrins

(2009) Malgorzata Barczyk et al.   CELL AND TISSUE RESEARCH

Vascular growth factor binding kinetics to the endothelial cell basement membrane, with a kinetics-based correction for substrate binding

(2009) Alisa Morss Clyne et al.   CYTOTECHNOLOGY

Macromolecular drug transport into the brain using targeted therapy

(2009) Jacek Lichota et al.   JOURNAL OF NEUROCHEMISTRY

Intracerebral haemorrhage

(2009) Adnan I Qureshi et al.   LANCET

Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain

(2009) Chuan Wu et al.   NATURE MEDICINE

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease

(2009) Fanchon Bourasset et al.   NEUROPHARMACOLOGY

The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction

(2009) Britta Engelhardt et al.   Seminars in Immunopathology

Diverse Cell Signaling Events Modulated by Perlecan†

(2008) John M. Whitelock et al.   BIOCHEMISTRY

Tissue Plasminogen Activator (tPA) and Matrix Metalloproteinases in the Pathogenesis of Stroke: Therapeutic Strategies

(2008) Rao Adibhatla et al.   CNS & Neurological Disorders-Drug Targets

Pericytes: Pluripotent Cells of the Blood Brain Barrier

(2008) Paula Dore-Duffy   CURRENT PHARMACEUTICAL DESIGN

Neuregulin-1 Signaling in Brain Endothelial Cells

(2008) Josephine Lok et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

MMP-9–Positive Neutrophil Infiltration Is Associated to Blood–Brain Barrier Breakdown and Basal Lamina Type IV Collagen Degradation During Hemorrhagic Transformation After Human Ischemic Stroke

(2008) Anna Rosell et al.   STROKE

Breaching the basement membrane: who, when and how?

(2008) R. Grant Rowe et al.   TRENDS IN CELL BIOLOGY

Responses of Endothelial Cell and Astrocyte Matrix-Integrin Receptors to Ischemia Mimic Those Observed in the Neurovascular Unit

(2007) Richard Milner et al.   STROKE