Iron metabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns

Cellular degradation systems in ferroptosis

(2021) Xin Chen et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells

(2021) Xia Qin et al.   Autophagy

Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin

(2021) Zheng Tang et al.   Clinical and Translational Medicine

A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid–liquid phase separation to promote oncogenic YAP signaling

(2021) Rui-Hua Li et al.   CELL RESEARCH

LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling

(2021) Yangyi Zhang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

LncRNA MAYA promotes iron overload and hepatocyte senescence through inhibition of YAP in non‐alcoholic fatty liver disease

(2021) Ping Yuan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A noncoding RNA modulator potentiates phenylalanine metabolism in mice

(2021) Yajuan Li et al.   SCIENCE

Identification and Validation of a Ferroptosis-Related Long Non-coding RNA Signature for Predicting the Outcome of Lung Adenocarcinoma

(2021) Zhiyuan Zheng et al.   Frontiers in Genetics

Identification of a Ferroptosis-Related LncRNA Signature as a Novel Prognosis Model for Lung Adenocarcinoma

(2021) Lu Lu et al.   Frontiers in Oncology

Identification of a Ferroptosis-Related Signature Model Including mRNAs and lncRNAs for Predicting Prognosis and Immune Activity in Hepatocellular Carcinoma

(2021) Zi-An Chen et al.   Frontiers in Oncology

A Ferroptosis-Related lncRNAs Signature Predicts Prognosis and Immune Microenvironment for Breast Cancer

(2021) Kaiming Zhang et al.   Frontiers in Molecular Biosciences

LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancer

(2021) Wenjie Luo et al.   Cell Death & Disease

Molecular basis for redox control by the human cystine/glutamate antiporter system xc−

(2021) Joanne L. Parker et al.   Nature Communications

Mechanisms of Mitochondrial Iron-Sulfur Protein Biogenesis

(2020) Roland Lill et al.   Annual Review of Biochemistry

The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression

(2020) Yuqing Wu et al.   Molecular Cancer

Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification

(2020) Maria C. Ferreira dos Santos et al.   Nature Communications

Identification of Frataxin as a regulator of ferroptosis

(2020) Jing Du et al.   Redox Biology

Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells

(2020) Chun-Jie Guo et al.   CELL

Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming

(2020) Jia Liu et al.   Nature Communications

Transferrin Receptor Is a Specific Ferroptosis Marker

(2020) Huizhong Feng et al.   Cell Reports

Hypoxia induced ferritin light chain (FTL) promoted epithelia mesenchymal transition and chemoresistance of glioma

(2020) Junhui Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Emerging Mechanisms and Disease Relevance of Ferroptosis

(2020) Brent R. Stockwell et al.   TRENDS IN CELL BIOLOGY

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2

(2020) Chunqing Wang et al.   Nature Communications

Emerging relationship between RNA helicases and autophagy

(2020) Miao-miao Zhao et al.   Journal of Zhejiang University-SCIENCE B

Roles of miRNA and IncRNA in triple-negative breast cancer

(2020) Juan Xu et al.   Journal of Zhejiang University-SCIENCE B

xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling

(2020) Jinyun Liu et al.   MOLECULAR THERAPY

A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis

(2020) Zuli Wang et al.   MOLECULAR THERAPY

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

(2020) Christian B. Billesbølle et al.   NATURE

MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p/NRF2 axis in non-small cell lung cancer cells

(2020) Chengcheng Gai et al.   Cell Death & Disease

Iron deficiency

(2020) Sant-Rayn Pasricha et al.   LANCET

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Ferroptosis is a type of autophagy-dependent cell death

(2019) Borong Zhou et al.   SEMINARS IN CANCER BIOLOGY

Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis

(2019) Yoshiharu Muto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

(2019) Min Wang et al.   CELL DEATH AND DIFFERENTIATION

Long Noncoding RNA MALAT1 regulates cancer glucose metabolism by enhancing mTOR-mediated translation of TCF7L2

(2019) Pushkar Malakar et al.   CANCER RESEARCH

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism

(2019) Po-Han Chen et al.   CELL DEATH AND DIFFERENTIATION

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–

(2019) Liyuan Wang et al.   CELL DEATH AND DIFFERENTIATION

Inducible nitric oxide synthase: Regulation, structure, and inhibition

(2019) Maris A. Cinelli et al.   MEDICINAL RESEARCH REVIEWS

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

Targeting the transferrin receptor for brain drug delivery

(2019) Kasper Bendix Johnsen et al.   PROGRESS IN NEUROBIOLOGY

Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation

(2019) Beatrice Dufrusine et al.   Frontiers in Immunology

Mechanism of activation of the human cysteine desulfurase complex by frataxin

(2019) Shachin Patra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediated activation of innate immune responses by stabilizing Stat1 mRNA

(2019) Henan Xu et al.   NATURE IMMUNOLOGY

LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells

(2019) Wenchuan Qi et al.   Scientific Reports

Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway

(2019) Sen Wei et al.   JOURNAL OF HAZARDOUS MATERIALS

A G3BP1-interacting lncRNA promotes ferroptosis and apoptosis in cancer via nuclear sequestration of p53

(2018) Chao Mao et al.   CANCER RESEARCH

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

(2018) Behrouz Hassannia et al.   JOURNAL OF CLINICAL INVESTIGATION

Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation

(2018) Xirui Liu et al.   Molecular Cancer

Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

(2018) Tomohiro Yamazaki et al.   MOLECULAR CELL

12/15 lipoxygenase: A crucial enzyme in diverse types of cell death

(2018) Qiu-Qi Li et al.   NEUROCHEMISTRY INTERNATIONAL

Paraspeckles: Where Long Noncoding RNA Meets Phase Separation

(2018) Archa H. Fox et al.   TRENDS IN BIOCHEMICAL SCIENCES

Long Noncoding RNA in Cancer: Wiring Signaling Circuitry

(2018) Chunru Lin et al.   TRENDS IN CELL BIOLOGY

Emerging roles of long non-coding RNAs in tumor metabolism

(2018) Hui Sun et al.   Journal of Hematology & Oncology

LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling

(2018) Ling-jie Sang et al.   MOLECULAR CELL

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

STEAP1 Regulates Tumorigenesis and Chemoresistance During Peritoneal Metastasis of Gastric Cancer

(2018) Yuan-Yu Wu et al.   Frontiers in Physiology

Phospholipid Remodeling in Physiology and Disease

(2018) Bo Wang et al.   Annual Review of Physiology

Carcinogens and DNA damage

(2018) Jessica L. Barnes et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Iron Metabolism in Cancer

(2018) Yafang Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression

(2017) Delin Chen et al.   MOLECULAR CELL

Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

(2017) John D. Hayes et al.   MOLECULAR CELL

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

(2017) Samantha W. Alvarez et al.   NATURE

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors

(2017) Aifu Lin et al.   NATURE CELL BIOLOGY

Targeting iron metabolism in drug discovery and delivery

(2017) Bart J. Crielaard et al.   NATURE REVIEWS DRUG DISCOVERY

Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer

(2017) Xiang Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

(2017) Jong-Lyel Roh et al.   Redox Biology

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Long Noncoding RNAs in Cancer Pathways

(2016) Adam M. Schmitt et al.   CANCER CELL

EGFR regulates iron homeostasis to promote cancer growth through redistribution of transferrin receptor 1

(2016) Biao Wang et al.   CANCER LETTERS

LncRNA HOXA11-AS Promotes Proliferation and Invasion of Gastric Cancer by Scaffolding the Chromatin Modification Factors PRC2, LSD1, and DNMT1

(2016) Ming Sun et al.   CANCER RESEARCH

Lipocalin-2 deficiency or blockade protects against aortic abdominal aneurysm development in mice

(2016) Carlos Tarín et al.   CARDIOVASCULAR RESEARCH

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

(2016) Xiang Xue et al.   Cell Metabolism

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

(2016) Aifu Lin et al.   NATURE CELL BIOLOGY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

(2016) Alexander R. Bogdan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Macrophages and iron trafficking at the birth and death of red cells

(2015) T. Korolnek et al.   BLOOD

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

(2015) David L. Schonberg et al.   CANCER CELL

Decreased Ferroportin Promotes Myeloma Cell Growth and Osteoclast Differentiation

(2015) Zhimin Gu et al.   CANCER RESEARCH

Hepcidin Regulation in Prostate and Its Disruption in Prostate Cancer

(2015) Lia Tesfay et al.   CANCER RESEARCH

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

(2015) M Hayano et al.   CELL DEATH AND DIFFERENTIATION

Ironing out Ferroportin

(2015) Hal Drakesmith et al.   Cell Metabolism

X-linked macrocytic dyserythropoietic anemia in females with an ALAS2 mutation

(2015) Vijay G. Sankaran et al.   JOURNAL OF CLINICAL INVESTIGATION

SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery

(2015) Neetu Saxena et al.   JNCI-Journal of the National Cancer Institute

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

(2015) R. J. A. Bell et al.   SCIENCE

SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery

(2015) Neetu Saxena et al.   JNCI-Journal of the National Cancer Institute

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

A long noncoding RNA connects c-Myc to tumor metabolism

(2014) Chiu-Lien Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities

(2014) Caiguo Zhang et al.   Protein & Cell

Hepcidin antagonists for potential treatments of disorders with hepcidin excess

(2014) Maura Poli et al.   Frontiers in Pharmacology

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages

(2013) Ahmed A. Alkhateeb et al.   BREAST CANCER RESEARCH AND TREATMENT

IRP2 Regulates Breast Tumor Growth

(2013) Wei Wang et al.   CANCER RESEARCH

HIC1 Silencing in Triple-Negative Breast Cancer Drives Progression through Misregulation of LCN2

(2013) G. Cheng et al.   CANCER RESEARCH

Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins

(2013) Oliver Stehling et al.   Cell Metabolism

Metabolic Regulation by p53 Family Members

(2013) Celia R. Berkers et al.   Cell Metabolism

Molecular Pathways: Fumarate Hydratase-Deficient Kidney Cancer--Targeting the Warburg Effect in Cancer

(2013) W. M. Linehan et al.   CLINICAL CANCER RESEARCH

Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin

(2013) VASYL F. CHEKHUN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Iron metabolism in the CNS: implications for neurodegenerative diseases

(2013) Tracey A. Rouault   NATURE REVIEWS NEUROSCIENCE

Genome Regulation by Long Noncoding RNAs

(2012) John L. Rinn et al.   Annual Review of Biochemistry

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Hypoxia-Inducible Factor-2  Activation Promotes Colorectal Cancer Progression by Dysregulating Iron Homeostasis

(2012) X. Xue et al.   CANCER RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat

(2012) Claudia Carrieri et al.   NATURE

Fe2+ binds iron responsive element-RNA, selectively changing protein-binding affinities and regulating mRNA repression and activation

(2012) J. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MMS19 Assembles Iron-Sulfur Proteins Required for DNA Metabolism and Genomic Integrity

(2012) O. Stehling et al.   SCIENCE

MMS19 Links Cytoplasmic Iron-Sulfur Cluster Assembly to DNA Metabolism

(2012) K. Gari et al.   SCIENCE

Luminal Iron Levels Govern Intestinal Tumorigenesis after Apc Loss In Vivo

(2012) Sorina Radulescu et al.   Cell Reports

The transferrin receptor and the targeted delivery of therapeutic agents against cancer

(2011) Tracy R. Daniels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

ALAS2 acts as a modifier gene in patients with congenital erythropoietic porphyria

(2011) J. To-Figueras et al.   BLOOD

The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels

(2011) Wing-Hang Tong et al.   CANCER CELL

An Iron Regulatory Gene Signature Predicts Outcome in Breast Cancer

(2011) L. D. Miller et al.   CANCER RESEARCH

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes

(2011) Daili J A Netz et al.   Nature Chemical Biology

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Circadian Rhythm of Transferrin Receptor 1 Gene Expression Controlled by c-Myc in Colon Cancer-Bearing Mice

(2010) F. Okazaki et al.   CANCER RESEARCH

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis

(2010) T. Berger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis

(2010) Z. K. Pinnix et al.   Science Translational Medicine

Inhibition of Lipocalin 2 Impairs Breast Tumorigenesis and Metastasis

(2009) X. Leng et al.   CANCER RESEARCH

HFE C282Y homozygotes are at increased risk of breast and colorectal cancer

(2009) Nicholas J. Osborne et al.   HEPATOLOGY

Direct Fe2+Sensing by Iron-responsive Messenger RNA·Repressor Complexes Weakens Binding

(2009) Mateen A. Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria

(2009) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis

(2009) A. A. Salahudeen et al.   SCIENCE

Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network

(2008) Martina U. Muckenthaler et al.   Annual Review of Nutrition

The xc− cystine/glutamate antiporter: A potential target for therapy of cancer and other diseases

(2008) Maisie Lo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lipocalin 2 promotes lung metastasis of murine breast cancer cells

(2008) Han Shi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Localization and functionality of microsporidian iron–sulphur cluster assembly proteins

(2008) Alina V. Goldberg et al.   NATURE

A Heme Export Protein Is Required for Red Blood Cell Differentiation and Iron Homeostasis

(2008) S. B. Keel et al.   SCIENCE