Article
Cell Biology
Anran Zhang, Jinpo Yang, Chao Ma, Feng Li, Huan Luo
Summary: This study established a novel 15-gene signature related to ferroptosis, which accurately predicts the prognosis of LUAD and is associated with specific immune cells. The findings demonstrate the independent prognostic value of this gene signature in patients with LUAD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Ying Guo, Zehao Wang, Ye Tian, Lin Li, Jing Dong
Summary: By analyzing RNA sequencing data and clinical information of patients with colon adenocarcinoma, it was found that a signature of five ferroptosis-related lncRNAs can accurately predict the survival rate and potential role in anti-COAD immunity of patients.
Article
Genetics & Heredity
Qianhui Zhou, Jiali Xiong, Yan Gao, Rong Yi, Yuzhu Xu, Quefei Chen, Lin Wang, Ying Chen
Summary: Lung cancer is a common and deadly disease, and lung adenocarcinoma is a highly prevalent subtype. This study aimed to identify potential biomarkers for predicting the prognosis of lung adenocarcinoma. By analyzing clinical and RNA sequencing data, a risk prediction model containing 13 mitochondria-associated lncRNAs was developed, which could accurately predict the prognosis of patients.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Genetics & Heredity
Chen Gao, Ning Kong, Fan Zhang, Tianyu Tang, Jiaying Li, Honglei Ding, Zhichao Sun, Linyu Wu, Maosheng Xu
Summary: This study identified and constructed a prognostic model related to ferroptosis-related long noncoding RNAs (FRLs) in LUAD patients, forming a risk score, and found that the model performed well in survival analysis in the training set and validation set, indicating that FRLs may serve as potential therapeutic targets for LUAD.
BMC MEDICAL GENOMICS
(2022)
Article
Oncology
Xiaoqing Ma, Zilin Deng, Zhen Li, Ting Ma, Guiqing Li, Cuijia Zhang, Wentao Zhang, Jin Chang
Summary: By analyzing multiple data sources including RNA sequencing data, we have identified four disulfidptosis/ferroptosis-related genes that are associated with the prognosis of lung adenocarcinoma. We have constructed a robust prognostic model and found that the high-risk group has significantly lower overall survival compared to the low-risk group.
CANCER CELL INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Xiangyun Wei, Xiaohe Li, Shuming Hu, Jinke Cheng, Rong Cai
Summary: Lung adenocarcinoma (LUAD) is the most common type of lung cancer, and there is a need to explore novel targets and drugs to improve outcomes. Ferroptosis, an iron-dependent regulated cell death, has gained attention as a potential therapeutic target for LUAD. This review provides an overview of the mechanisms and regulation of ferroptosis in LUAD, as well as its application in therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Min Liang, Mafeng Chen, Yinghua Zhong, Shivank Singh, Shantanu Singh
Summary: This study established a prognostic model based on ferroptosis-related genes in lung adenocarcinoma, identifying seven FRGs with prognostic significance using various statistical analyses. The model demonstrated excellent predictive performance for overall survival and revealed the importance of these FRGs in various biological processes related to tumor progression.
FRONTIERS IN GENETICS
(2021)
Article
Orthopedics
Mingyi Yang, Yani Su, Ke Xu, Haishi Zheng, Qiling Yuan, Yongsong Cai, Yirixiati Aihaiti, Peng Xu
Summary: This study identified FRLncs that have the potential to influence OS prognosis and immune microenvironment, as well as immune checkpoint-related genes linked to OS prognosis. These findings establish a foundation for further investigations into OS survival and offer valuable insights for clinical decision making in the management of OS.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Cell Biology
Fada Xia, Yuanliang Yan, Cong Shen
Summary: This study established a prognostic signature for COAD based on 15 pyroptosis-related lncRNAs, which was found to be associated with the immune landscape of COAD patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Jingjing Jin, Chuan Liu, Shanshan Yu, Lingyi Cai, Andriamifahimanjaka Sitrakiniaina, Ruihong Gu, Wenfeng Li, Fangfang Wu, Xiangyang Xue
Summary: A novel prognostic signature for lung adenocarcinoma patients was identified in this study using data from the TCGA database. Patients in the high-risk group had significantly worse overall survival compared to the low-risk group. Gene set variation analysis indicated differences in the tumor microenvironment between the two groups may explain the variations in survival outcomes for LUAD patients.
Article
Oncology
Ning Zhou, Min Zhou, Ning Ding, Qinglin Li, Guangming Ren
Summary: This study aimed to construct a risk model for predicting the prognosis of lung adenocarcinoma patients using miRNA-regulated target genes. By analyzing miRNA and gene data, five prognosis-related miRNAs and 11 key genes were identified to establish an accurate prognostic model for patient survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qinglin Li, Huangjie Zhang, Jinguo Hu, Lizhuo Zhang, Aiguang Zhao, He Feng
Summary: We established a prognostic model based on anoikis-related lncRNAs (ARLs) for gastric adenocarcinoma (STAD), which showed high accuracy in prognosis prediction and could be used for precise therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Huikai Miao, Qiannan Ren, Hongmu Li, Mingyue Zeng, Dongni Chen, Chunmei Xu, Youfang Chen, Zhesheng Wen
Summary: This study revealed the significance of the autophagy-dependent ferroptosis-related gene FANCD2 in the occurrence and prognosis of LUAD. High expression of FANCD2 was associated with poor prognosis and chemotherapy resistance in LUAD patients.
Article
Medicine, General & Internal
Tong Xin, Yue Sun, Hongxue Meng, Ningzhi Zhang, Bo Peng, Xinxin Yang, Jing Hu, Mengru Cao
Summary: In this study, a prognostic model based on ERs-related lncRNAs was constructed using co-expression analysis, LASSO regression, and multivariate Cox regression. The model can predict the prognosis of patients with lung adenocarcinoma (LUAD), providing new insights for clinical decision-making and personalized medicine.
ANNALS OF MEDICINE
(2023)
Article
Cell Biology
Bo Peng, Huawei Li, Ruisi Na, Tong Lu, Yongchao Li, Jiaying Zhao, Han Zhang, Linyou Zhang
Summary: This study identified lncRNAs associated with genomic instability and constructed a predictive signature for early stage lung adenocarcinoma patients. The developed six-lncRNA signature showed good predictive performance and was confirmed to be an independent prognostic factor. Validation with external datasets further supported the utility of this prognostic lncRNA signature.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)