Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer

Crohn's disease

(2017) Joana Torres et al.   LANCET

Ulcerative colitis

(2017) Ryan Ungaro et al.   LANCET

MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

(2017) G-T Ho et al.   Mucosal Immunology

Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization

(2017) Laura Formentini et al.   Cell Reports

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

(2016) Xiang Xue et al.   Cell Metabolism

Clinical Experience With Deferiprone Treatment for Friedreich Ataxia

(2016) Sandra Elincx-Benizri et al.   JOURNAL OF CHILD NEUROLOGY

Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice

(2016) Suzanne M Cloonan et al.   NATURE MEDICINE

Altered intestinal microbiota–host mitochondria crosstalk in new onset Crohn’s disease

(2016) Walid Mottawea et al.   Nature Communications

Colon cancer subtypes: concordance, effect on survival and selection of the most representative preclinical models

(2016) Zsófia Sztupinszki et al.   Scientific Reports

STAMP2 increases oxidative stress and is critical for prostate cancer

(2015) Y. Jin et al.   EMBO Molecular Medicine

Hepatic STAMP2 alleviates high fat diet-induced hepatic steatosis and insulin resistance

(2015) Hye Y. Kim et al.   JOURNAL OF HEPATOLOGY

The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer

(2014) H B Ragnum et al.   BRITISH JOURNAL OF CANCER

Hypoxia-Inducible Factor/MAZ-Dependent Induction of Caveolin-1 Regulates Colon Permeability through Suppression of Occludin, Leading to Hypoxia-Induced Inflammation

(2014) Liwei Xie et al.   MOLECULAR AND CELLULAR BIOLOGY

Long-term treatment with deferiprone enhances left ventricular ejection function when compared to deferoxamine in patients with thalassemia major

(2013) Aldo Filosa et al.   BLOOD CELLS MOLECULES AND DISEASES

Endothelial PAS Domain Protein 1 Activates the Inflammatory Response in the Intestinal Epithelium to Promote Colitis in Mice

(2013) Xiang Xue et al.   GASTROENTEROLOGY

Mitochondria and Tumor Progression in Ulcerative Colitis

(2013) Cigdem Himmetoglu Ussakli et al.   JNCI-Journal of the National Cancer Institute

Intestinal HIF2  promotes tissue-iron accumulation in disorders of iron overload with anemia

(2013) E. R. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Inducible Factor-2  Activation Promotes Colorectal Cancer Progression by Dysregulating Iron Homeostasis

(2012) X. Xue et al.   CANCER RESEARCH

Hypoxia-inducible factor-2  is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer

(2012) X. Xue et al.   CARCINOGENESIS

Stamp2 Controls Macrophage Inflammation through Nicotinamide Adenine Dinucleotide Phosphate Homeostasis and Protects against Atherosclerosis

(2012) Henrik ten Freyhaus et al.   Cell Metabolism

Mitochondrial electron transport chain complex dysfunction in the colonic mucosa in ulcerative colitis

(2012) Srikanth Santhanam et al.   INFLAMMATORY BOWEL DISEASES

Hypoxia-inducible factors: Crosstalk between inflammation and metabolism

(2012) Jessica E.S. Shay et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice

(2011) Matthew Taylor et al.   GASTROENTEROLOGY

STAMP1 Is Both a Proliferative and an Antiapoptotic Factor in Prostate Cancer

(2010) L. Wang et al.   CANCER RESEARCH

Inflammatory Bowel Disease as a Risk Factor for Colorectal Cancer

(2010) Milan Lukas   DIGESTIVE DISEASES

Hypoxia: an alarm signal during intestinal inflammation

(2010) Sean P. Colgan et al.   Nature Reviews Gastroenterology & Hepatology