Inducible nitric oxide synthase: Regulation, structure, and inhibition
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Inducible nitric oxide synthase: Regulation, structure, and inhibition
Authors
Keywords
-
Journal
MEDICINAL RESEARCH REVIEWS
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2019-06-13
DOI
10.1002/med.21599
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- 1400W, a highly selective inducible nitric oxide synthase inhibitor is a potential disease modifier in the rat kainate model of temporal lobe epilepsy
- (2016) Sreekanth Puttachary et al. NEUROBIOLOGY OF DISEASE
- N,N′-Disubstituted thiourea and urea derivatives: design, synthesis, docking studies and biological evaluation against nitric oxide synthase
- (2016) Mariem Chayah et al. MedChemComm
- Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity
- (2016) Jeremy S. Torrisi et al. Scientific Reports
- Inhibition of Nitric Oxide Synthases, But Not Inducible Nitric Oxide Synthase, Selectively Worsens Left Ventricular Function After Successful Resuscitation From Cardiac Arrest in Swine
- (2015) Betsy B. Dokken et al. ACADEMIC EMERGENCY MEDICINE
- Mechanistic Studies of Inactivation of Inducible Nitric Oxide Synthase by Amidines
- (2015) Wei Tang et al. BIOCHEMISTRY
- Development of Urea and Thiourea Kynurenamine Derivatives: Synthesis, Molecular Modeling, and Biological Evaluation as Nitric Oxide Synthase Inhibitors
- (2015) Mariem Chayah et al. ChemMedChem
- Role of nitric oxide synthase in the development of bone cancer pain and effect of L-NMMA
- (2015) YAN YANG et al. Molecular Medicine Reports
- The dual role of iNOS in cancer
- (2015) Federica Vannini et al. Redox Biology
- Communication between the Zinc and Tetrahydrobiopterin Binding Sites in Nitric Oxide Synthase
- (2014) Georges Chreifi et al. BIOCHEMISTRY
- Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain
- (2014) Paramita Mukherjee et al. CHEMICAL SOCIETY REVIEWS
- Nitric oxide synthase inhibitors: a review of patents from 2011 to the present
- (2014) Yanyan Yang et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Inhibition of Arginase Activity Enhances Inflammation in Mice with Allergic Airway Disease, in Association with Increases in Protein S-Nitrosylation and Tyrosine Nitration
- (2014) K. Ckless et al. JOURNAL OF IMMUNOLOGY
- Discovery of a Natural Product-Like iNOS Inhibitor by Molecular Docking with Potential Neuroprotective Effects In Vivo
- (2014) Hai-Jing Zhong et al. PLoS One
- Molecular architecture of mammalian nitric oxide synthases
- (2014) M. G. Campbell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interaction of Inducible Nitric Oxide Synthase with Rac2 Regulates Reactive Oxygen and Nitrogen Species Generation in the Human Neutrophil Phagosomes: Implication in Microbial Killing
- (2013) Anupam Jyoti et al. ANTIOXIDANTS & REDOX SIGNALING
- Regulatory Role of Glu546 in Flavin Mononucleotide — Heme Electron Transfer in Human Inducible Nitric Oxide Synthase
- (2013) Wenbing Li et al. INORGANIC CHEMISTRY
- Mechanism of Inducible Nitric-oxide Synthase Dimerization Inhibition by Novel Pyrimidine Imidazoles
- (2013) Latika Nagpal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee
- (2012) Marie-Pierre Hellio le Graverand et al. ANNALS OF THE RHEUMATIC DISEASES
- Mechanism and Kinetics of Inducible Nitric Oxide Synthase Auto-S-nitrosation and Inactivation
- (2012) Brian C. Smith et al. BIOCHEMISTRY
- iNOS-selective inhibitors for cancer prevention: promise and progress
- (2012) Naveena B Janakiram et al. Future Medicinal Chemistry
- A Role for cGMP in Inducible Nitric-oxide Synthase (iNOS)-induced Tumor Necrosis Factor (TNF) α-converting Enzyme (TACE/ADAM17) Activation, Translocation, and TNF Receptor 1 (TNFR1) Shedding in Hepatocytes
- (2012) R. Savanh Chanthaphavong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of an isoform-specific serine residue in FMN–heme electron transfer in inducible nitric oxide synthase
- (2012) Wenbing Li et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Neuroprotection by Silencing iNOS Expression in a 6-OHDA Model of Parkinson’s Disease
- (2012) Min Li et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress
- (2012) Yun-Li Peng et al. Journal of Neuroinflammation
- Reactive Oxygen Species and Inhibitors of Inflammatory Enzymes, NADPH Oxidase, and iNOS in Experimental Models of Parkinson’s Disease
- (2012) Sushruta Koppula et al. MEDIATORS OF INFLAMMATION
- Efficacy of the selective inducible nitric oxide synthase inhibitor sd-6010 in nonclinical inflammatory, neuropathic, and osteoarthritis pain
- (2012) J.R. Connor et al. OSTEOARTHRITIS AND CARTILAGE
- Is iNOS Beginning to Smoke?
- (2011) Carl Nathan CELL
- Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice
- (2011) Michael Seimetz et al. CELL
- Nitric oxide synthases: regulation and function
- (2011) U. Forstermann et al. EUROPEAN HEART JOURNAL
- Arg375 tunes tetrahydrobiopterin functions and modulates catalysis by inducible nitric oxide synthase
- (2011) Zhi-Qiang Wang et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Inhibition of iNOS induces antidepressant-like effects in mice: Pharmacological and genetic evidence
- (2011) Karina Montezuma et al. NEUROPHARMACOLOGY
- Lack of efficacy of the selective iNOS inhibitor GW274150 in prophylaxis of migraine headache
- (2010) Hans Olav Høivik et al. CEPHALALGIA
- Targeted Inhibition of Inducible Nitric Oxide Synthase Inhibits Growth of Human Melanoma In vivo and Synergizes with Chemotherapy
- (2010) A. G. Sikora et al. CLINICAL CANCER RESEARCH
- Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease
- (2010) Lauren Broom et al. FREE RADICAL BIOLOGY AND MEDICINE
- Discovery of Dual Inducible/Neuronal Nitric Oxide Synthase (iNOS/nNOS) Inhibitor Development Candidate 4-((2-Cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) Part 2: Identification of a Novel, Potent, and Selective Series of Benzimidazole-Quinolinone iNOS/nNOS Dimerization Inhibitors That Are Orally Active in Pain Models
- (2010) Joseph E. Payne et al. JOURNAL OF MEDICINAL CHEMISTRY
- NO synthase: Structures and mechanisms
- (2010) Simon Daff NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Regulation of the expression of inducible nitric oxide synthase
- (2010) Andrea Pautz et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Endotoxin Mediated-iNOS Induction Causes Insulin Resistance via ONOO− Induced Tyrosine Nitration of IRS-1 in Skeletal Muscle
- (2010) Geneviève Pilon et al. PLoS One
- INHIBITION OF NITRIC OXIDE SYNTHASE DURING SEPSIS
- (2010) Wolfgang Stahl et al. SHOCK
- EFFECTS OF A SELECTIVE iNOS INHIBITOR VERSUS NOREPINEPHRINE IN THE TREATMENT OF SEPTIC SHOCK
- (2010) Fuhong Su et al. SHOCK
- Regulation of Interdomain Interactions by Calmodulin in Inducible Nitric-oxide Synthase
- (2009) Chuanwu Xia et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of Arginine Guanidinium Moiety in Nitric-oxide Synthase Mechanism of Oxygen Activation
- (2009) Claire Giroud et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of Inducible Nitric Oxide Synthase (iNOS) Inhibitor Development Candidate KD7332, Part 1: Identification of a Novel, Potent, and Selective Series of Quinolinone iNOS Dimerization Inhibitors that are Orally Active in Rodent Pain Models
- (2009) Céline Bonnefous et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, Biological Evaluation, and Docking Studies of N-Substituted Acetamidines as Selective Inhibitors of Inducible Nitric Oxide Synthase
- (2009) Cristina Maccallini et al. JOURNAL OF MEDICINAL CHEMISTRY
- Is There NO Treatment for Severe Sepsis?
- (2009) A Bredan et al. Libyan Journal of Medicine
- KLYP956 Is a Non-Imidazole-Based Orally Active Inhibitor of Nitric-Oxide Synthase Dimerization
- (2009) K. T. Symons et al. MOLECULAR PHARMACOLOGY
- Animal models of pain: progress and challenges
- (2009) Jeffrey S. Mogil NATURE REVIEWS NEUROSCIENCE
- Pharmacological inhibition of inducible nitric oxide synthase attenuates the development of seizures in mice
- (2009) Ashish K. Rehni et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase
- (2009) N. B. Fernhoff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Expert opinion on tilarginine in the treatment of shock
- (2008) Laurence Guy Howes et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Catalytic Reduction of a Tetrahydrobiopterin Radical within Nitric-oxide Synthase
- (2008) Chin-Chuan Wei et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Progression of Amyloid Pathology to Alzheimer's Disease Pathology in an Amyloid Precursor Protein Transgenic Mouse Model by Removal of Nitric Oxide Synthase 2
- (2008) D. M. Wilcock et al. JOURNAL OF NEUROSCIENCE
- BYK191023 (2-[2-(4-Methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine) Is an NADPH- and Time-Dependent Irreversible Inhibitor of Inducible Nitric-Oxide Synthase
- (2008) M. Tiso et al. MOLECULAR PHARMACOLOGY
- Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase
- (2008) Elsa D Garcin et al. Nature Chemical Biology
- Identification of Critical Amino Acid Residues for Human iNOS Functional Activity
- (2008) Saule Naureckiene et al. PROTEIN JOURNAL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started