Article
Oncology
Jiecheng Yang, Fangzhou Liu, Ying Wang, Lei Qu, Aifu Lin
Summary: Long non-coding RNAs (lncRNAs) play important roles in cellular programs, modulating gene transcription and kinase cascades to impact tumor initiation and progression. This review summarizes the role of lncRNAs in tumor metabolic reprogramming and immune environment remodeling, and discusses the advancements in clinical applications.
Review
Biochemistry & Molecular Biology
Jin Xiang, Kai Wang, Ni Tang
Summary: In the past few decades, significant progress has been made in understanding the metabolic reprogramming of cancer cells. PCK1, a key enzyme in gluconeogenesis, plays different roles in different tissues and organs, with both anti-oncogenic and tumor-promoting effects. Aberrant expression of PCK1 leads to the activation of oncogenic pathways and metabolic rewiring.
Review
Cell Biology
Qifan Hu, Yutong Li, Dan Li, Yi Yuan, Keru Wang, Lu Yao, Zhujun Cheng, Tianyu Han
Summary: Metabolic reprogramming, a key characteristic of cancer cells, is crucial for their proliferation and survival. Long non-coding RNAs (lncRNAs) have been found to play an important role in regulating amino acid metabolism in cancer cells. Understanding the role of lncRNAs in cancer metabolic reprogramming, especially in amino acid metabolism, could provide new insights for anti-cancer drug development.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Melissa Garcia-Caballero, Liliana Sokol, Anne Cuypers, Peter Carmeliet
Summary: The dynamic crosstalk between different components of the tumor microenvironment plays a critical role in cancer progression and metastasis. Angiogenesis is crucial for tumor growth, but abnormal blood vessels can lead to hypoxia and acidosis in the tumor microenvironment. Cancer and stromal cells can alter their metabolism to meet high energy demands and promote tumor proliferation. Recent studies have shown that the metabolism of tumor endothelial cells is reprogrammed and targeting these metabolic pathways can affect blood vessel formation. Therefore, metabolic antiangiogenic therapies combined with immunotherapies offer a clinical opportunity for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Mahdi Gholipour, Mohammad Taheri, Jafar Mehvari Habibabadi, Naghme Nazer, Arezou Sayad, Soudeh Ghafouri-Fard
Summary: The study revealed that lncRNAs such as HULC, PVT1, DSCAM-AS1, SPRY4-IT1, LINC-ROR, and MEG3 showed differential expression levels in CIDP and GBS patients compared to healthy controls, indicating their potential involvement in the development of CIDP and GBS.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Xiao-yan Wang, Xiao-xia Yang, Peng-fei Shang, Zong-xue Zheng, Xiu-li Guo
Summary: Glutamine, the most abundant amino acid in the body, plays a crucial role in nucleotide and non-essential amino acid synthesis during cell metabolism. Recent studies have shown that glutamine metabolic reprogramming serves as a significant signal in cancer development and progression. This metabolic signature in cancer cells can activate multiple signaling pathways and oncogenes, promoting cancer growth, tumor immune regulation, and drug resistance. This review summarizes the impact of glutamine metabolic reprogramming in tumors, focusing on the regulation of various signaling pathways. Additionally, potential tumor treatment strategies by targeting glutamine metabolism alone or in combination with chemotherapy are discussed.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Lunxu Li, Yu Tian
Summary: Macrophages in the tumor micro-environment (TME) play a significant role in innate immunity and have dual effects. Tumor-associated macrophages (TAMs) are a major component of immune cells in the TME. TAMs, like M1/M2 macrophages, are highly adaptable and their functions are influenced by cytokines, chemokines, and other TME factors. Metabolic changes in TAMs are closely associated with their polarization towards promoting or suppressing tumor growth. The metabolic reprogramming of TAMs generates metabolites that contribute to tumor progression and immune evasion. This review examines the metabolic reprogramming of TAMs in terms of energy, amino acid, and fatty acid metabolism, and explores their potential roles in immune suppression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Roger Carles-Fontana, Nigel Heaton, Elena Palma, Shirin Khorsandi
Summary: Mitochondria are important organelles involved in cellular processes and are altered in pathological states, including cancer. Cancer cells adapt different strategies to generate sufficient energy for their high proliferation rates, often mediated by extracellular signals such as extracellular vesicles (EVs). This review discusses EV-mediated mitochondrial reprogramming mechanisms that support cancer survival and progression, as well as the potential of using EVs as delivery vectors for targeting mitochondria in cancer therapy.
Review
Medicine, Research & Experimental
Zhanbo Sun, Lingyun Zhang, Lixian Liu
Summary: This article summarizes the lipid metabolism of dendritic cells (DCs) under physiological conditions, analyzes the role of reprogramming the lipid metabolism of DCs in tumor immune regulation, and discusses potential immunotherapeutic strategies.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, General & Internal
Ying Wang, Dan Wang, Li Yang, Yi Zhang
Summary: Tumor-associated macrophages (TAMs) play a crucial role in the tumor immune microenvironment and have immunosuppressive functions. The metabolic reprogramming of TAMs has a significant impact on their function and phenotype, and targeting metabolism-related pathways shows potential as an anti-tumor therapy.
CHINESE MEDICAL JOURNAL
(2022)
Review
Cell Biology
Yu Ping, Chunyi Shen, Bo Huang, Yi Zhang
Summary: This review discusses how metabolic pathways influence T cells in exerting their anti-tumor effects and how to remodel these metabolic programs to enhance T cell-mediated anti-tumor immune responses. Glycolysis, carboxylic acid cycle, fatty acid oxidation, cholesterol metabolism, amino acid metabolism, and nucleotide metabolism work together to regulate tumor-reactive T-cell activation and proliferation.
Article
Chemistry, Multidisciplinary
Junlong Zhao, Zhimin Tian, Shoujie Zhao, Dayun Feng, Zhixiong Guo, Liangzhi Wen, Yejing Zhu, Fenghua Xu, Jun Zhu, Shouzheng Ma, Jie Hu, Tao Jiang, Yongquan Qu, Dongfeng Chen, Lei Liu
Summary: This study illustrates the instructive relationships between intratumoral lactate regulation, metabolic reprogramming, and immune activation for catalytic immunotherapy of tumors. The catalysts efficiently oxidize intratumoral lactate, induce tumor cell apoptosis, reprogram metabolism, and activate antitumor immunity.
Review
Nutrition & Dietetics
Shunxi Wang, Xiaoxue Yuan, Guanbin Song, Li Yang, Junyu Jin, Wanqian Liu
Summary: Serine is a crucial metabolite that plays a significant role in the development and progression of tumors. Abnormal activation of serine metabolism leads to malignant transformation, unlimited proliferation, metastasis, immunosuppression, and drug resistance. Restricting dietary serine or depleting phosphoglycerate dehydrogenase can mitigate tumor growth and improve patient survival. These findings have led to the development of new therapeutic agents targeting serine metabolism, which hold great promise in tumor treatment.
ADVANCES IN NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Silviu Constantin Badoiu, Maria Greabu, Daniela Miricescu, Iulia-Ioana Stanescu-Spinu, Radu Ilinca, Daniela Gabriela Balan, Andra-Elena Balcangiu-Stroescu, Doina-Andrada Mihai, Ileana Adela Vacaroiu, Constantin Stefani, Viorel Jinga
Summary: Renal cell carcinoma (RCC) is the most frequent type of renal cancer, accounting for 85-95% of cases. The dysregulation of the PI3K/AKT/mTOR signaling pathway is commonly observed in renal cancer and plays a significant role in tumor growth and survival. Metabolic reprogramming is an important characteristic of cancer cells, allowing them to adapt to nutrient and oxygen-deprived environments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xia Liu, Celine L. Hartman, Lingyun Li, Carolyn J. Albert, Fusheng Si, Aiqin Gao, Lan Huang, Yangjing Zhao, Wenli Lin, Eddy C. Hsueh, Lizong Shen, Qixiang Shao, Daniel F. Hoft, David A. Ford, Guangyong Peng
Summary: The functional state of T cells is critical for effective antitumor immunity. T cell senescence driven by malignant tumor cells and regulatory T cells is a common feature in cancers, characterized by unbalanced lipid metabolism and accumulation of lipid droplets. Inhibition of group IVA phospholipase A(2) can reprogram effector T cell lipid metabolism, prevent T cell senescence, and enhance antitumor immunity and immunotherapy efficacy.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Zhen-Xiong Zhao, Yan-Qiu Zhang, Hui Sun, Zi-Qi Chen, Jin-Jia Chang, Xin Wang, Xu Wang, Cong Tan, Shu-Juan Ni, Wei-Wei Weng, Meng Zhang, Lei Wang, Dan Huang, Yun Feng, Wei-Qi Sheng, Mi-Die Xu
Summary: This study confirms the specific localization of VDR in gastric cancer tissues and demonstrates that activation of VDR can suppress CAF-induced chemotherapy resistance in gastric cancer. The study also reveals that CAF-derived IL-8 induces oxaliplatin resistance through activating the PI3K/AKT pathway, and treatment with vitamin D can attenuate the tumor-supportive effect of IL-8 on gastric cancer cells.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Oncology
Jing Zhang, Xin Zhang, Qian Wang, Yu-yin Xu, Qian-lan Yao, Dan Huang, Wei-qi Sheng, Xiao-li Zhu, Xiao-yan Zhou, Qian-ming Bai
Summary: The study aims to understand the clinicopathological characteristics and molecular alterations in different intratumoral components of colorectal cancer (CRC) with heterogeneity of mismatch repair (MMR) protein expression and microsatellite instability (MSI) status. Important clues for intratumoral heterogeneity of driver gene mutations in CRC were identified, emphasizing the importance of detecting MMR protein expression and other gene mutations in metastases before treatment.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Wenchao Gu, Hui Sun, Meng Zhang, Shaocong Mo, Cong Tan, Shujuan Ni, Zongcheng Yang, Yulin Wang, Weiqi Sheng, Lei Wang
Summary: ITGB1 expression is positively associated with poor clinicopathological features and prognosis in gastric cancer. It is an upstream molecule of the Wnt/beta-catenin signaling pathway and plays a role in immune suppression in gastric cancer.
Review
Oncology
Fan Yang, Zehua Bian, Peiwen Xu, Shengbai Sun, Zhaohui Huang
Summary: MiR-204-5p is a non-coding RNA molecule that regulates gene expression and is frequently downregulated in various cancer types. It has been found to suppress tumor proliferation, metastasis, autophagy, and chemoresistance, making it a potential prognostic biomarker and therapeutic target for cancer.
Article
Oncology
Jianpeng Gao, Zhenxiong Zhao, Hena Zhang, Shenglin Huang, Midie Xu, Hongda Pan
Summary: Transcriptomic sequencing and follow-up analyses revealed unique molecular and immune features of paired normal mucosae, primary and ovarian metastatic tumors. A novel OM- and M2 macrophage-related signature, M2GO, was established and served as a promising prognostic and immunotherapeutic biomarker in gastric cancer patients. The M2GO score was significantly associated with clinical outcomes, molecular and immune features, and differential responses to immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Lu Gan, Qingguo Li, Wei Nie, Yi Zhang, Hesheng Jiang, Cong Tan, Long Zhang, Jieyun Zhang, Qian Li, Pengcong Hou, Yitao Yuan, Xun Sun, Dongmei Liu, Weiqi Sheng, Tianshu Liu, Midie Xu, Weijian Guo
Summary: PROX1 is a transcription factor that promotes malignant transformation and stemness in colorectal cancer (CRC). It has been found that PROX1 is associated with cell glucose metabolism and regulates cell proliferation and glucose metabolism through interaction with SIRT3. High PROX1 expression combined with low SIRT3 expression predicts poor prognosis in CRC patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tengyu Wang, Qinghao Zhen, Tong Wu, Lan Jin, Surui Yao, Yuyang Feng, Jinghua Chen, Chen Chen, Zhaohui Huang
Summary: GABRP is identified as a potential drug target for mediating oxaliplatin or 5-FU resistance in colorectal cancer.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Pathology
Fan Yang, Peiwen Xu, Surui Yao, Min Li, Zehua Bian, Zhaohui Huang
Summary: This study found that the signaling receptor and transporter STRA6 is highly up-regulated in colorectal cancer (CRC) and promotes CRC cell proliferation. It was also discovered that STRA6 suppresses apoptosis by controlling BCL2 expression, leading to resistance to LOHP treatment in CRC. These findings demonstrate that STRA6 is a potential prognostic factor and oncogene in CRC by promoting tumor growth and chemoresistance.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Respiratory System
Liuying Huang, Yuan Yin, Danqi Qian, Yulin Cao, Duo Wang, Xiaohan Wu, Liang Ming, Zhaohui Huang, Leyuan Zhou
Summary: Lung cancer, especially non-small cell lung cancer (NSCLC), has high morbidity and mortality rates worldwide. Severe pulmonary hemorrhage (PH) is a potential adverse event in the treatment of lung cancer with bevacizumab. This study aimed to investigate the underlying causes for the observed clinical differences between patients with lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) after bevacizumab treatment.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Endocrinology & Metabolism
Lin Qian, Na Li, Xiao-Chen Lu, Midie Xu, Ying Liu, Kaiyue Li, Yi Zhang, Kewen Hu, Yu-Ting Qi, Jun Yao, Ying-Li Wu, Wenyu Wen, Shenglin Huang, Zheng-Jun Chen, Miao Yin, Qun-Ying Lei
Summary: In this study, the researchers identified a relationship between branched-chain amino acid metabolism and cell growth and motility through RhoC signaling. They found that enhanced BCAT1 activity, caused by a mutation enriched in gastric cancer, leads to increased production of a metabolite that activates RhoC signaling. The study also found that the BCAA-derived metabolite can directly bind to the small GTPase protein RhoC and enhance its activity. The researchers also discovered that the drug candesartan can inhibit BCAT1 activity, leading to decreased RhoC activity and cancer cell motility.
Article
Cell Biology
Xiaoqi Ma, Midie Xu, Xing Zhang, Xin Wang, Kexin Su, Zihang Xu, Xiaoyu Wang, Yifu Yang
Summary: The present study investigates the mechanism of gambogenic acid (GNA), a natural compound, on apoptosis and ferroptosis in colorectal cancer (CRC). The results show that GNA inhibits tumor growth by suppressing the proliferation of CRC cell lines and induces ferroptosis by activating endoplasmic reticulum stress and ROS production. Furthermore, GNA regulates iron metabolism to further induce ferroptosis.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Clinical Neurology
Yan-Yan Chen, Zhi-Cheng Gong, Mei-Mei Zhang, Zhao-Hui Huang
Summary: In this study, emodin was encapsulated in a PEG/cRGD-modified liposome to achieve brain-targeted delivery and maximize therapeutic efficacy. The study revealed that encapsulated emodin significantly enhanced its accumulation in the infarct region and improved its therapeutic efficacy. Furthermore, the critical target of emodin responsible for alleviating ischemic stroke was identified, providing a potential drug delivery strategy for ischemic stroke and other brain injuries.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Oncology
Lu Tian, Liang Gong, Chu Hao, Yuyang Feng, Surui Yao, Bojian Fei, Xue Wang, Zhaohui Huang
Summary: In this study, we found that ELOA is upregulated in gastric cancer and is associated with malignant characteristics and poor prognosis. Functional experiments showed that ELOA promotes gastric cancer proliferation and metastasis. Mechanistic studies revealed that ELOA exerts its oncogenic properties by activating the expression of RBP1.
Article
Biochemistry & Molecular Biology
Peng Teng, Kaisa Cui, Surui Yao, Bojian Fei, Feng Ling, Chaoqun Li, Zhaohui Huang
Summary: In this study, researchers found that ME2 is highly expressed in human colorectal cancer (CRC) tissues and its knockdown inhibits CRC cell proliferation. They also discovered that SIRT5 can desuccinylate ME2, activating its enzymatic activity. Activated ME2 enhances mitochondrial respiration, supporting cell proliferation and tumor development. Additionally, the levels of succinylated ME2 and SIRT5 are associated with patient prognosis.
CELL DEATH AND DIFFERENTIATION
(2023)
