Article
Oncology
Jian Hou, Zhenquan Lu, Xiaobao Cheng, Runan Dong, Yi Jiang, Guoqing Wu, Genyi Qu, Yong Xu
Summary: This study suggests that ferroptosis-associated long non-coding RNAs can serve as prognostic predictors for bladder cancer patients, and explores the inter-regulatory relationships between ferroptosis-related genes and immune cell infiltration, immune checkpoints, and m(6)A methylation genes.
Article
Cell Biology
Bo Peng, Huawei Li, Ruisi Na, Tong Lu, Yongchao Li, Jiaying Zhao, Han Zhang, Linyou Zhang
Summary: This study identified lncRNAs associated with genomic instability and constructed a predictive signature for early stage lung adenocarcinoma patients. The developed six-lncRNA signature showed good predictive performance and was confirmed to be an independent prognostic factor. Validation with external datasets further supported the utility of this prognostic lncRNA signature.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Xiaoqing Ma, Zilin Deng, Zhen Li, Ting Ma, Guiqing Li, Cuijia Zhang, Wentao Zhang, Jin Chang
Summary: By analyzing multiple data sources including RNA sequencing data, we have identified four disulfidptosis/ferroptosis-related genes that are associated with the prognosis of lung adenocarcinoma. We have constructed a robust prognostic model and found that the high-risk group has significantly lower overall survival compared to the low-risk group.
CANCER CELL INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Mi Zhou, Xin Zhu
Summary: This study constructed and validated a signature predictive of prognosis in lung adenocarcinoma based on ferroptosis-associated genes, revealing associations between different risk groups and cancer biology.
Article
Genetics & Heredity
Shuqiong Zhang, Naisheng Zheng, Xiaocui Chen, Kun Du, Junyao Yang, Lisong Shen
Summary: We identified a three-ferroptosis-related-lncRNA signature (AP000695.2, AL365181.3, and LINC01615) that can predict the prognosis of STAD patients. The GSEA indicated that these three ferroptosis-related lncRNAs might be related to the extracellular matrix and cellular activities.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Anran Zhang, Jinpo Yang, Chao Ma, Feng Li, Huan Luo
Summary: This study established a novel 15-gene signature related to ferroptosis, which accurately predicts the prognosis of LUAD and is associated with specific immune cells. The findings demonstrate the independent prognostic value of this gene signature in patients with LUAD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Jianming Wei, Ye Zeng, Xibo Gao, Tong Liu
Summary: In this study, a prognostic ferroptosis-related lncRNA signature was constructed for gastric cancer, with the low-risk group showing significantly better prognosis than the high-risk group. The risk score was identified as an independent prognostic factor. This risk model provides a novel method for predicting prognosis in gastric cancer patients.
Article
Cell Biology
Jingjing Jin, Chuan Liu, Shanshan Yu, Lingyi Cai, Andriamifahimanjaka Sitrakiniaina, Ruihong Gu, Wenfeng Li, Fangfang Wu, Xiangyang Xue
Summary: A novel prognostic signature for lung adenocarcinoma patients was identified in this study using data from the TCGA database. Patients in the high-risk group had significantly worse overall survival compared to the low-risk group. Gene set variation analysis indicated differences in the tumor microenvironment between the two groups may explain the variations in survival outcomes for LUAD patients.
Article
Medical Laboratory Technology
Yan Chen, Xiuxiu Zhang, Jinze Li, Min Zhou
Summary: The study integrated a machine-learning framework to identify LUAD-related lncRNA survival biomarkers, and discovered an eight-lncRNA signature including NPSR1-AS1, SATB2-AS1, LINC01090, etc., which contributes to predicting patient's prognosis risk and survival outcomes. Furthermore, parsing LUAD tumor immune infiltration and constructing the ceRNA network revealed the close association of these lncRNAs with immune cell infiltration and MHC molecule expression.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Multidisciplinary Sciences
Jingjing Cai, Chunyan Li, Hongsheng Li, Xiaoxiong Wang, Yongchun Zhou
Summary: Bioinformatics analysis of ferroptosis-related genes allowed the establishment of an effective signature for predicting prognosis in LUAD patients. The high-risk group showed significantly lower survival rates compared to the low-risk group, with risk score being an independent prognostic indicator.
Article
Cell Biology
Xin Yang, Minhui Mei, Jingze Yang, Jinlu Guo, Fan Du, Shi Liu
Summary: This study established a prognostic risk model for hepatocellular carcinoma (HCC) based on 17 ferroptosis-related long non-coding RNAs (lncRNAs). The model showed significant prognostic value for HCC and may serve as therapeutic targets associated with ferroptosis in clinical practice.
Article
Pharmacology & Pharmacy
Lingling Hong, Xuehai Wang, Weiming Cui, Fengxu Wang, Weiwei Shi, Shali Yu, Yonghua Luo, Lixin Zhong, Xinyuan Zhao
Summary: Ferroptosis-associated long non-coding RNA (FMRlncRNA) can be used as prognostic markers for lung adenocarcinoma. A risk model based on five ferroptosis-associated FMRlncRNAs was established, which showed good stability and predictive function. LINC01572 was identified as a novel ferroptosis suppressor in lung adenocarcinoma.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Lu Lu, Le-Ping Liu, Qiang-Qiang Zhao, Rong Gui, Qin-Yu Zhao
Summary: The highly heterogeneous malignancy, lung adenocarcinoma (LUAD), poses challenges for prognosis prediction. Ferroptosis, an iron-dependent cell death mechanism, plays a crucial role in tumor cell survival. Long non-coding RNAs (lncRNAs) are key regulators in LUAD development and are linked to ferroptosis, offering new targets for treatment and prognosis. By analyzing RNA sequencing data, a robust risk prediction model of 12 ferroptosis-related lncRNAs was constructed for LUAD, with functional enrichment analysis showing involvement in various cellular functions and signaling pathways, impacting immune status in different risk groups.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anmin Huang, Ting Li, Xueting Xie, Jinglin Xia
Summary: Long non-coding RNAs (lncRNAs) play important roles in various pathophysiological processes, including cancer, with frequent dysregulation in hepatocellular carcinoma (HCC). By combining ferroptosis, immunity, and lncRNA, potential biomarkers for clinical cancer therapy have been identified. The development of an immune- and ferroptosis-related lncRNA risk signature (IFLSig) using bioinformatics methods has shown association with prognosis in HCC patients.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Genetics & Heredity
Ziyuan Ren, Minghui Hu, Zhonglin Wang, Junpeng Ge, Xiaoyan Zhou, Guoming Zhang, Hongying Zheng
Summary: This study established a 15-gene prognostic signature based on ferroptosis-related genes for lung adenocarcinoma (LUAD) and validated its predictive ability, providing nomograms for clinical reference. Functional analysis revealed associations between ferroptosis and cell cycle, cell metabolism, and immune pathways. Pan-cancer analysis demonstrated the heterogeneity of these genes among different cancer types. Ten genes were identified as potential targets for further research, with KRAS and PGD suggested as novel immunotherapy biomarkers.
FRONTIERS IN GENETICS
(2021)