G-quadruplexes and helicases

Re-evaluation of G-quadruplex propensity with G4Hunter

(2016) Amina Bedrat et al.   NUCLEIC ACIDS RESEARCH

The Effect of DNA Sequence Directionality on G-Quadruplex Folding

(2015) Maja Marušič et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular mechanism of G-quadruplex unwinding helicase: sequential and repetitive unfolding of G-quadruplex by Pif1 helicase

(2015) Xi-Miao Hou et al.   BIOCHEMICAL JOURNAL

Relationships between putative G-quadruplex-forming sequences, RecQ helicases, and transcription

(2015) John A. Smestad et al.   BMC Medical Genetics

Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA

(2015) Jun Gao et al.   CHEMICAL COMMUNICATIONS

Recent Developments in G-Quadruplex Probes

(2015) Dik-Lung Ma et al.   CHEMISTRY & BIOLOGY

RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends

(2015) J. Audry et al.   EMBO JOURNAL

Borrowing Nuclear DNA Helicases to Protect Mitochondrial DNA

(2015) Lin Ding et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

G-quadruplexes Significantly Stimulate Pif1 Helicase-catalyzed Duplex DNA Unwinding

(2015) Xiao-Lei Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Distinct Triplex DNA Unwinding Activity of ChlR1 Helicase

(2015) Manhong Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Parallel Quadruplex DNA Is Bound Tightly but Unfolded Slowly by Pif1 Helicase

(2015) Alicia K. Byrd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

(2015) William C. Drosopoulos et al.   JOURNAL OF CELL BIOLOGY

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

DNA replication origin activation in space and time

(2015) Michalis Fragkos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATP-dependent G-quadruplex unfolding by Bloom helicase exhibits low processivity

(2015) Jagat B. Budhathoki et al.   NUCLEIC ACIDS RESEARCH

Direct evidence of mitochondrial G-quadruplex DNA by using fluorescent anti-cancer agents

(2015) Wei-Chun Huang et al.   NUCLEIC ACIDS RESEARCH

A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands

(2015) O. Mendoza et al.   NUCLEIC ACIDS RESEARCH

Guanine quadruplex structures localize to heterochromatin

(2015) Roland F. Hoffmann et al.   NUCLEIC ACIDS RESEARCH

Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway

(2015) Federica Calì et al.   NUCLEIC ACIDS RESEARCH

Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase

(2015) Michael C. Chen et al.   NUCLEIC ACIDS RESEARCH

BLM unfolds G-quadruplexes in different structural environments through different mechanisms

(2015) Wen-Qiang Wu et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

The tale of RNA G-quadruplex

(2015) Prachi Agarwala et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events

(2015) Deanna N. Edwards et al.   Nature Communications

Mutagenic consequences of a single G-quadruplex demonstrate mitotic inheritance of DNA replication fork barriers

(2015) Bennie Lemmens et al.   Nature Communications

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

(2015) Palaniraja Thandapani et al.   eLife

Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3’-Tail Sequences Are Sufficient for Tight and Complete Binding

(2015) Philip J. Smaldino et al.   PLoS One

Human RecQ Helicases in DNA Repair, Recombination, and Replication

(2014) Deborah L. Croteau et al.   Annual Review of Biochemistry

Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion

(2014) Xiao Ling Li et al.   CELL CYCLE

Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome

(2014) Sanjay Kumar Bharti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Existence and consequences of G-quadruplex structures in DNA

(2014) Pierre Murat et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

FANCJ promotes DNA synthesis through G-quadruplex structures

(2014) P. Castillo Bosch et al.   EMBO JOURNAL

G4 motifs affect origin positioning and efficiency in two vertebrate replicators

(2014) A.-L. Valton et al.   EMBO JOURNAL

DNA Sequences Proximal to Human Mitochondrial DNA Deletion Breakpoints Prevalent in Human Disease Form G-quadruplexes, a Class of DNA Structures Inefficiently Unwound by the Mitochondrial Replicative Twinkle Helicase

(2014) Sanjay Kumar Bharti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution structure of the RecQ C-terminal domain of human Bloom syndrome protein

(2014) Chin-Ju Park et al.   JOURNAL OF BIOMOLECULAR NMR

Diffusion of Human Replication Protein A along Single-Stranded DNA

(2014) Binh Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and Conformational Dynamics of a Stacked Dimeric G-Quadruplex Formed by the Human CEB1 Minisatellite

(2014) Michael Adrian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism and Manipulation of DNA:RNA Hybrid G-Quadruplex Formation in Transcription of G-Rich DNA

(2014) Jia-yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD

(2014) Lucas T Gray et al.   Nature Chemical Biology

RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP

(2014) Jagat B. Budhathoki et al.   NUCLEIC ACIDS RESEARCH

A competitive formation of DNA:RNA hybrid G-quadruplex is responsible to the mitochondrial transcription termination at the DNA replication priming site

(2014) Ke-wei Zheng et al.   NUCLEIC ACIDS RESEARCH

Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs

(2014) Giang Huong Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures

(2014) Sujoy Chatterjee et al.   Nature Communications

Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system

(2014) Weiwei Wang et al.   eLife

RPA-Mediated Unfolding of Systematically Varying G-Quadruplex Structures

(2013) Sujay Ray et al.   BIOPHYSICAL JOURNAL

Fluorescent Probes for G-Quadruplex Structures

(2013) Balayeshwanth R. Vummidi et al.   CHEMBIOCHEM

Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

(2013) Weiqiang Lin et al.   EMBO JOURNAL

Binding of G-quadruplexes to the N-terminal Recognition Domain of the RNA Helicase Associated with AU-rich Element (RHAU)

(2013) Markus Meier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability

(2013) Sanjay Kumar Bharti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCJ couples replication past natural fork barriers with maintenance of chromatin structure

(2013) Rebekka A. Schwab et al.   JOURNAL OF CELL BIOLOGY

Pif1 family helicases suppress genome instability at G-quadruplex motifs

(2013) Katrin Paeschke et al.   NATURE

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Human Rev1 polymerase disrupts G-quadruplex DNA

(2013) S. Eddy et al.   NUCLEIC ACIDS RESEARCH

The RNA helicase RHAU (DHX36) suppresses expression of the transcription factor PITX1

(2013) E. P. Booy et al.   NUCLEIC ACIDS RESEARCH

Detection of G-quadruplex DNA in mammalian cells

(2013) A. Henderson et al.   NUCLEIC ACIDS RESEARCH

Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal–Hreidarsson syndrome

(2013) Zhong Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RTEL1 Is a Replisome-Associated Helicase That Promotes Telomere and Genome-Wide Replication

(2013) J.-B. Vannier et al.   SCIENCE

A Recessive Founder Mutation in Regulator of Telomere Elongation Helicase 1, RTEL1, Underlies Severe Immunodeficiency and Features of Hoyeraal Hreidarsson Syndrome

(2013) Bari J. Ballew et al.   PLoS Genetics

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

(2012) Jean-Baptiste Vannier et al.   CELL

Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences

(2012) Rama Rao Damerla et al.   CELL CYCLE

DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network

(2012) Kenneth K. Karanja et al.   CELL CYCLE

Luminescent G-quadruplex Probes

(2012) Dik-Lung Ma et al.   CURRENT PHARMACEUTICAL DESIGN

DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase

(2012) N. Sabouri et al.   GENES & DEVELOPMENT

The Q Motif of Fanconi Anemia Group J Protein (FANCJ) DNA Helicase Regulates Its Dimerization, DNA Binding, and DNA Repair Function

(2012) Yuliang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disease-causing missense mutations in human DNA helicase disorders

(2012) Avvaru N. Suhasini et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

(2012) Raphaël Rodriguez et al.   Nature Chemical Biology

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

Unraveling cell type–specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs

(2012) Emilie Besnard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial DNA deletions are associated with non-B DNA conformations

(2012) Joana Damas et al.   NUCLEIC ACIDS RESEARCH

The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary

(2012) E. P. Booy et al.   NUCLEIC ACIDS RESEARCH

G4LDB: a database for discovering and studying G-quadruplex ligands

(2012) Qian Li et al.   NUCLEIC ACIDS RESEARCH

5'-UTR RNA G-quadruplexes: translation regulation and targeting

(2012) A. Bugaut et al.   NUCLEIC ACIDS RESEARCH

Stimulation of Gross Chromosomal Rearrangements by the Human CEB1 and CEB25 Minisatellites in Saccharomyces cerevisiae Depends on G-Quadruplexes or Cdc13

(2012) Aurèle Piazza et al.   PLoS Genetics

G-quadruplexes in RNA biology

(2012) Stefania Millevoi et al.   Wiley Interdisciplinary Reviews-RNA

Superfamily I helicases as modular components of DNA-processing machines

(2011) Mark S. Dillingham   BIOCHEMICAL SOCIETY TRANSACTIONS

DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

(2011) Katrin Paeschke et al.   CELL

Iron–sulphur clusters in nucleic acid processing enzymes

(2011) Malcolm F White et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Human DHX9 helicase preferentially unwinds RNA-containing displacement loops (R-loops) and G-quadruplexes

(2011) Prasun Chakraborty et al.   DNA REPAIR

G-quadruplex-induced instability during leading-strand replication

(2011) Judith Lopes et al.   EMBO JOURNAL

Biochemical Characterization of Warsaw Breakage Syndrome Helicase

(2011) Yuliang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rudimentary G-quadruplex–based telomere capping in Saccharomyces cerevisiae

(2011) Jasmine S Smith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

G-quadruplex formation at the 3' end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase

(2011) Q. Wang et al.   NUCLEIC ACIDS RESEARCH

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

(2011) Peter Sarkies et al.   NUCLEIC ACIDS RESEARCH

G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA

(2011) Banabihari Giri et al.   NUCLEIC ACIDS RESEARCH

The DEAH-box RNA helicase RHAU binds an intramolecular RNA G‐quadruplex in TERC and associates with telomerase holoenzyme

(2011) Simon Lattmann et al.   NUCLEIC ACIDS RESEARCH

Yin Yang 1 contains G-quadruplex structures in its promoter and 5′-UTR and its expression is modulated by G4 resolvase 1

(2011) Weiwei Huang et al.   NUCLEIC ACIDS RESEARCH

Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

(2011) M. Aggarwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fanconi anemia and Bloom's syndrome crosstalk through FANCJ–BLM helicase interaction

(2011) Avvaru N. Suhasini et al.   TRENDS IN GENETICS

The RecQ DNA Helicases in DNA Repair

(2010) Kara A. Bernstein et al.   Annual Review of Genetics

Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity

(2010) Cyril M. Sanders   BIOCHEMICAL JOURNAL

Human DHX9 Helicase Unwinds Triple-Helical DNA Structures

(2010) Aklank Jain et al.   BIOCHEMISTRY

DNA Binding Induces Dimerization ofSaccharomyces cerevisiaePif1

(2010) Sergio Barranco-Medina et al.   BIOCHEMISTRY

Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes

(2010) Young-Hoon Kang et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

G-Quadruplex Hinders Translocation of BLM Helicase on DNA: A Real-Time Fluorescence Spectroscopic Unwinding Study and Comparison with Duplex Substrates

(2010) Jia-quan Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular analyses of DNA helicases involved in the replicational stress response

(2010) Yuliang Wu et al.   METHODS

The 5' Guanosine Tracts of Human Telomerase RNA Are Recognized by the G-Quadruplex Binding Domain of the RNA Helicase DHX36 and Function To Increase RNA Accumulation

(2010) A. N. Sexton et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU

(2010) Simon Lattmann et al.   NUCLEIC ACIDS RESEARCH

Fluorescence-based duplex–quadruplex competition test to screen for telomerase RNA quadruplex ligands

(2010) Laurent Lacroix et al.   NUCLEIC ACIDS RESEARCH

Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae

(2010) Aurèle Piazza et al.   NUCLEIC ACIDS RESEARCH

RNA helicases at work: binding and rearranging

(2010) Eckhard Jankowsky   TRENDS IN BIOCHEMICAL SCIENCES

G-Quadruplex DNA Sequences Are Evolutionarily Conserved and Associated with Distinct Genomic Features in Saccharomyces cerevisiae

(2010) John A. Capra et al.   PLoS Computational Biology

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Telomeric D-loops Containing 8-Oxo-2′-deoxyguanosine Are Preferred Substrates for Werner and Bloom Syndrome Helicases and Are Bound by POT1

(2009) Avik Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential

(2009) Jay E. Johnson et al.   NUCLEIC ACIDS RESEARCH

The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo

(2009) Cyril Ribeyre et al.   PLoS Genetics

Translocation and Unwinding Mechanisms of RNA and DNA Helicases

(2008) Anna Marie Pyle   Annual Review of Biophysics

Simian Virus 40 Large T-Antigen G-Quadruplex DNA Helicase Inhibition by G-Quadruplex DNA-Interactive Agents†

(2008) Bodin Tuesuwan et al.   BIOCHEMISTRY

Real-time Investigation of SV40 Large T-antigen Helicase Activity Using Surface Plasmon Resonance

(2008) Jason Plyler et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G4 Resolvase 1 Binds Both DNA and RNA Tetramolecular Quadruplex with High Affinity and Is the Major Source of Tetramolecular Quadruplex G4-DNA and G4-RNA Resolving Activity in HeLa Cell Lysates

(2008) Steven D. Creacy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY