Host DDX Helicases as Possible SARS-CoV-2 Proviral Factors: A Structural Overview of Their Hijacking Through Multiple Viral Proteins

Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

(2020) Shuai Xia et al.   Cellular & Molecular Immunology

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense

(2020) Frances Taschuk et al.   Viruses-Basel

Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection

(2020) Junwen Luan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

SARS ‐CoV‐2 receptor ACE 2 and TMPRSS 2 are primarily expressed in bronchial transient secretory cells

(2020) Soeren Lukassen et al.   EMBO JOURNAL

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor

(2020) Annalaura Brai et al.   ACS Medicinal Chemistry Letters

A high ATP concentration enhances the cooperative translocation of the SARS coronavirus helicase nsP13 in the unwinding of duplex RNA

(2020) Kyoung-Jin Jang et al.   Scientific Reports

A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping

(2020) Maria Romano et al.   Cells

DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins

(2020) Annalaura Brai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Architecture and self‐assembly of the SARS‐CoV ‐2 nucleocapsid protein

(2020) Qiaozhen Ye et al.   PROTEIN SCIENCE

DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection

(2019) Annalaura Brai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis

(2019) Zhihui Jia et al.   NUCLEIC ACIDS RESEARCH

The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X

(2019) He Song et al.   Nature Communications

The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity

(2019) Natacha S. Ogando et al.   Frontiers in Microbiology

Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity

(2019) Steven M. Heaton et al.   Cells

Nucleocapsid protein recruitment to replication-transcription complexes plays a crucial role in coronaviral life cycle

(2019) Yingying Cong et al.   JOURNAL OF VIROLOGY

Knockdown of DEAD-box RNA helicase DDX5 selectively attenuates serine 311 phosphorylation of NF-κB p65 subunit and expression level of anti-apoptotic factor Bcl-2

(2019) Ken Tanaka et al.   CELLULAR SIGNALLING

RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis

(2019) Tri D. Ngo et al.   Cell Reports

DDX5 RNA Helicases: Emerging Roles in Viral Infection

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rossmann-Fold Methyltransferases: Taking a “β-Turn” around Their Cofactor, S-Adenosylmethionine

(2018) Bhanu Pratap Singh Chouhan et al.   BIOCHEMISTRY

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

(2017) François Ferron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

(DEAD)-box RNA helicase 3 modulates NF-κB signal pathway by controlling the phosphorylation of PP2A-C subunit

(2017) Xin Wang et al.   Oncotarget

Crystal structure of Middle East respiratory syndrome coronavirus helicase

(2017) Wei Hao et al.   PLoS Pathogens

Cellular RNA Helicase DDX1 Is Involved in Transmissible Gastroenteritis Virus nsp14-Induced Interferon-Beta Production

(2017) Yanrong Zhou et al.   Frontiers in Immunology

DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS

(2016) Lili Gu et al.   BIOCHEMICAL JOURNAL

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

(2016) Annalaura Brai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influenza A Virus Polymerase Recruits the RNA Helicase DDX19 to Promote the Nuclear Export of Viral mRNAs

(2016) Cédric Diot et al.   Scientific Reports

When core competence is not enough: functional interplay of the DEAD-box helicase core with ancillary domains and auxiliary factors in RNA binding and unwinding

(2015) Markus G. Rudolph et al.   BIOLOGICAL CHEMISTRY

Structure and Function of RNase AS: A Novel Virulence Factor From Mycobacterium tuberculosis

(2015) Maria Romano et al.   CURRENT MEDICINAL CHEMISTRY

Division of Labor in an Oligomer of the DEAD-Box RNA Helicase Ded1p

(2015) Andrea A. Putnam et al.   MOLECULAR CELL

Synergistic effects of ATP and RNA binding to human DEAD-box protein DDX1

(2015) Julian N. Kellner et al.   NUCLEIC ACIDS RESEARCH

Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complex

(2015) Yuanyuan Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What we know but do not understand about nidovirus helicases

(2015) Kathleen C. Lehmann et al.   VIRUS RESEARCH

Structure of the SPRY domain of the human RNA helicase DDX1, a putative interaction platform within a DEAD-box protein

(2015) Julian N. Kellner et al.   Acta Crystallographica Section F-Structural Biology Communications

RNA methyltransferases involved in 5′ cap biosynthesis

(2015) Magdalena Byszewska et al.   RNA Biology

Evaluation of SSYA10-001 as a Replication Inhibitor of Severe Acute Respiratory Syndrome, Mouse Hepatitis, and Middle East Respiratory Syndrome Coronaviruses

(2014) Adeyemi O. Adedeji et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The SARS coronavirus nucleocapsid protein – Forms and functions

(2014) Chung-ke Chang et al.   ANTIVIRAL RESEARCH

Nucleocapsid Phosphorylation and RNA Helicase DDX1 Recruitment Enables Coronavirus Transition from Discontinuous to Continuous Transcription

(2014) Chia-Hsin Wu et al.   Cell Host & Microbe

Sensing viral invasion by RIG-I like receptors

(2014) Ji-Seung Yoo et al.   CURRENT OPINION IN MICROBIOLOGY

CoronavirusNsp10, a Critical Co-factor for Activation of Multiple Replicative Enzymes

(2014) Mickaël Bouvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Function of RNase AS, a Polyadenylate-Specific Exoribonuclease Affecting Mycobacterial Virulence In Vivo

(2014) Maria Romano et al.   STRUCTURE

The Coronavirus Nucleocapsid Is a Multifunctional Protein

(2014) Ruth McBride et al.   Viruses-Basel

Distinct DDX DEAD-box RNA helicases cooperate to modulate the HIV-1 Rev function

(2013) Mariko Yasuda-Inoue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crystal structure-based exploration of the important role of Arg106 in the RNA-binding domain of human coronavirus OC43 nucleocapsid protein

(2013) I.-Jung Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structure-Function Analysis of Severe Acute Respiratory Syndrome Coronavirus RNA Cap Guanine-N7-Methyltransferase

(2013) Y. Chen et al.   JOURNAL OF VIROLOGY

The Cellular Interactome of the Coronavirus Infectious Bronchitis Virus Nucleocapsid Protein and Functional Implications for Virus Biology

(2013) E. Emmott et al.   JOURNAL OF VIROLOGY

Human DEAD Box Helicase 3 Couples I B Kinase   to Interferon Regulatory Factor 3 Activation

(2013) L. Gu et al.   MOLECULAR AND CELLULAR BIOLOGY

Transient Oligomerization of the SARS-CoV N Protein – Implication for Virus Ribonucleoprotein Packaging

(2013) Chung-ke Chang et al.   PLoS One

SARS-CoV nucleocapsid protein interacts with cellular pyruvate kinase protein and inhibits its activity

(2012) Wei-Yen Wei et al.   ARCHIVES OF VIROLOGY

RGG motif proteins: Modulators of mRNA functional states

(2012) Purusharth Rajyaguru et al.   CELL CYCLE

Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid protein

(2012) Yu-Sheng Lo et al.   FEBS LETTERS

Superfamily 2 helicases

(2012) Alicia et al.   Frontiers in Bioscience-Landmark

Mechanism of Nucleic Acid Unwinding by SARS-CoV Helicase

(2012) Adeyemi O. Adedeji et al.   PLoS One

RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex

(2012) M. Bouvet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity

(2012) Akshay A. D'Cruz et al.   PROTEIN SCIENCE

RNA helicases in infection and disease

(2012) Lenz Steimer et al.   RNA Biology

Structure and Dynamics of the Second CARD of Human RIG-I Provide Mechanistic Insights into Regulation of RIG-I Activation

(2012) Fabien Ferrage et al.   STRUCTURE

Tinkering with Translation: Protein Synthesis in Virus-Infected Cells

(2012) D. Walsh et al.   Cold Spring Harbor Perspectives in Biology

DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells

(2011) Zhiqiang Zhang et al.   IMMUNITY

The DEAD-box RNA helicase DDX3 interacts with DDX5, co-localizes with it in the cytoplasm during the G2/M phase of the cycle, and affects its shuttling during mRNP export

(2011) Yeo-Jin Choi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Conventional and unconventional mechanisms for capping viral mRNA

(2011) Etienne Decroly et al.   NATURE REVIEWS MICROBIOLOGY

From unwinding to clamping — the DEAD box RNA helicase family

(2011) Patrick Linder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Solution structures of DEAD-box RNA chaperones reveal conformational changes and nucleic acid tethering by a basic tail

(2011) A. L. Mallam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA helicases

(2011) Arnaz Ranji et al.   RNA Biology

Coronaviruses

(2011) Mark R. Denison et al.   RNA Biology

DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-β-inducing potential

(2010) Hiroyuki Oshiumi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Cellular RNA Helicase DDX1 Interacts with Coronavirus Nonstructural Protein 14 and Enhances Viral Replication

(2010) L. Xu et al.   JOURNAL OF VIROLOGY

An Interaction between the Nucleocapsid Protein and a Component of the Replicase-Transcriptase Complex Is Crucial for the Infectivity of Coronavirus Genomic RNA

(2010) K. R. Hurst et al.   JOURNAL OF VIROLOGY

Comparative Structural Analysis of Human DEAD-Box RNA Helicases

(2010) Patrick Schütz et al.   PLoS One

Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing

(2010) Lance D. Eckerle et al.   PLoS Pathogens

DEAD-box proteins as RNA helicases and chaperones

(2010) Inga Jarmoskaite et al.   Wiley Interdisciplinary Reviews-RNA

Cxcl16 interact with SARS-CoV N protein in and out cell

(2010) Yuan-peng Zhang et al.   VIROLOGICA SINICA

Interaction between SARS-CoV helicase and a multifunctional cellular protein (Ddx5) revealed by yeast and mammalian cell two-hybrid systems

(2009) Jin-Yan Chen et al.   ARCHIVES OF VIROLOGY

The mechanism of ATP-dependent RNA unwinding by DEAD box proteins

(2009) Manuel Hilbert et al.   BIOLOGICAL CHEMISTRY

Coronavirus Nucleocapsid Protein Facilitates Template Switching and Is Required for Efficient Transcription

(2009) S. Zuniga et al.   JOURNAL OF VIROLOGY

Structure of the Yeast DEAD Box Protein Mss116p Reveals Two Wedges that Crimp RNA

(2009) Mark Del Campo et al.   MOLECULAR CELL

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nucleocapsid protein of SARS-associated coronavirus inhibits B23 phosphorylation

(2008) Yingchun Zeng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential Inhibitory Activities and Stabilisation of DNA Aptamers against the SARS Coronavirus Helicase

(2008) Ka To Shum et al.   CHEMBIOCHEM

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response

(2008) Didier Soulat et al.   EMBO JOURNAL

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKɛ-mediated IRF activation

(2008) Martina Schröder et al.   EMBO JOURNAL

Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization

(2008) Tsui-Yi Peng et al.   FEBS Journal

Glycogen Synthase Kinase-3 Regulates the Phosphorylation of Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein and Viral Replication

(2008) Chia-Hsin Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Nucleocapsid Protein of Severe Acute Respiratory Syndrome Coronavirus Inhibits Cell Cytokinesis and Proliferation by Interacting with Translation Elongation Factor 1 

(2008) B. Zhou et al.   JOURNAL OF VIROLOGY

Multiple Nucleic Acid Binding Sites and Intrinsic Disorder of Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein: Implications for Ribonucleocapsid Protein Packaging

(2008) C.-K. Chang et al.   JOURNAL OF VIROLOGY

The M, E, and N Structural Proteins of the Severe Acute Respiratory Syndrome Coronavirus Are Required for Efficient Assembly, Trafficking, and Release of Virus-Like Particles

(2008) Y. L. Siu et al.   JOURNAL OF VIROLOGY

Cooperative binding of ATP and RNA induces a closed conformation in a DEAD box RNA helicase

(2008) B. Theissen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-Coronavirus Replication/Transcription Complexes Are Membrane-Protected and Need a Host Factor for Activity In Vitro

(2008) Martijn J. van Hemert et al.   PLoS Pathogens

Solution Structure of the C-terminal Dimerization Domain of SARS Coronavirus Nucleocapsid Protein Solved by the SAIL-NMR Method

(2007) Mitsuhiro Takeda et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of phosphorylation clusters in the biology of the coronavirus infectious bronchitis virus nucleocapsid protein

(2007) Kelly-Anne Spencer et al.   VIROLOGY