G-Quadruplexes as pathogenic drivers in neurodegenerative disorders
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
G-Quadruplexes as pathogenic drivers in neurodegenerative disorders
Authors
Keywords
-
Journal
NUCLEIC ACIDS RESEARCH
Volume -, Issue -, Pages -
Publisher
Oxford University Press (OUP)
Online
2021-03-29
DOI
10.1093/nar/gkab164
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Prion protein transcription is auto-regulated through dynamic interactions with G-quadruplex motifs in its own promoter
- (2020) Prashant Pradhan et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Elevated methylation levels, reduced expression levels, and frequent contractions in a clinical cohort of C9orf72 expansion carriers
- (2020) Jazmyne L. Jackson et al. Molecular Neurodegeneration
- Molecular dissection of ALS‐linked TDP‐43 – involvement of the Gly‐rich domain in interaction with G‐quadruplex mRNA
- (2020) Akira Ishiguro et al. FEBS LETTERS
- eIF4G has intrinsic G-quadruplex binding activity that is required for tiRNA function
- (2020) Shawn M Lyons et al. NUCLEIC ACIDS RESEARCH
- R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation
- (2020) Chun-Ying Lee et al. Nature Communications
- Single-molecule fluorescence studies on cotranscriptional G-quadruplex formation coupled with R-loop formation
- (2020) Gunhyoung Lim et al. NUCLEIC ACIDS RESEARCH
- Replication of G Quadruplex DNA
- (2019) Leticia Koch Lerner et al. Genes
- Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies
- (2019) Ana Bajc Česnik et al. JOURNAL OF CELL SCIENCE
- FMRP - G-quadruplex mRNA - miR-125a interactions: Implications for miR-125a mediated translation regulation of PSD-95 mRNA
- (2019) Brett DeMarco et al. PLoS One
- Stress granules and neurodegeneration
- (2019) Benjamin Wolozin et al. NATURE REVIEWS NEUROSCIENCE
- TDP-43 as a potential biomarker for amyotrophic lateral sclerosis: a systematic review and meta-analysis
- (2018) Vivek Majumder et al. BMC Neurology
- Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis
- (2018) Tatyana A. Shelkovnikova et al. Molecular Neurodegeneration
- CpG Methylation Changes G-Quadruplex Structures Derived from Gene Promoters and Interaction with VEGF and SP1
- (2018) Kaori Tsukakoshi et al. MOLECULES
- Protein Phase Separation: A New Phase in Cell Biology
- (2018) Steven Boeynaems et al. TRENDS IN CELL BIOLOGY
- Characterizations of distinct parallel and antiparallel G-quadruplexes formed by two-repeat ALS and FTD related GGGGCC sequence
- (2018) Bo Zhou et al. Scientific Reports
- The molecular language of membraneless organelles
- (2018) Edward Gomes et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells
- (2018) Alessio De Magis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transcriptome-wide identification of transient RNA G-quadruplexes in human cells
- (2018) Sunny Y. Yang et al. Nature Communications
- Effects of G-quadruplex topology on translational inhibition by tRNA fragments in mammalian and plant systems in vitro
- (2017) Paulina Jackowiak et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- The effects of structure on pre-mRNA processing and stability
- (2017) Rachel Soemedi et al. METHODS
- Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing 1 mRNA 5′-UTR
- (2017) Damian S. McAninch et al. Molecular BioSystems
- Strong transcription blockage mediated by R-loop formation within a G-rich homopurine–homopyrimidine sequence localized in the vicinity of the promoter
- (2017) Boris P. Belotserkovskii et al. NUCLEIC ACIDS RESEARCH
- A G-quadruplex motif in an envelope gene promoter regulates transcription and virion secretion in HBV genotype B
- (2017) Banhi Biswas et al. NUCLEIC ACIDS RESEARCH
- Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease
- (2017) Tatsuo Mano et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs
- (2017) Shawn M. Lyons et al. Nature Communications
- ALS/FTD-Associated C9ORF72 Repeat RNA Promotes Phase Transitions In Vitro and in Cells
- (2017) Marta M. Fay et al. Cell Reports
- The Interplay between G-quadruplex and Transcription
- (2017) Nayun Kim CURRENT MEDICINAL CHEMISTRY
- Detection of DNA Methylation of G-Quadruplex and i-Motif-Forming Sequences by Measuring the Initial Elongation Efficiency of Polymerase Chain Reaction
- (2016) Wataru Yoshida et al. ANALYTICAL CHEMISTRY
- RNA G-Quadruplex Invasion and Translation Inhibition by Antisense γ-Peptide Nucleic Acid Oligomers
- (2016) Stanley N. Oyaghire et al. BIOCHEMISTRY
- There has been an awakening: Emerging mechanisms of C9orf72 mutations in FTD/ALS
- (2016) Aaron D. Gitler et al. BRAIN RESEARCH
- Recent advances in targeting the telomeric G-quadruplex DNA sequence with small molecules as a strategy for anticancer therapies
- (2016) Mohammad K Islam et al. Future Medicinal Chemistry
- TDP-43 binds and transports G-quadruplex-containing mRNAs into neurites for local translation
- (2016) Akira Ishiguro et al. GENES TO CELLS
- G-quadruplex structures mark human regulatory chromatin
- (2016) Robert Hänsel-Hertsch et al. NATURE GENETICS
- G-quadruplexes as novel cis-elements controlling transcription during embryonic development
- (2016) Aldana P. David et al. NUCLEIC ACIDS RESEARCH
- RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria
- (2016) J. U. Guo et al. SCIENCE
- Constitutive translation of human α-synuclein is mediated by the 5′-untranslated region
- (2016) Pelagia Koukouraki et al. Open Biology
- The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains
- (2016) Erin G Conlon et al. eLife
- Metal Cations in G-Quadruplex Folding and Stability
- (2016) Debmalya Bhattacharyya et al. Frontiers in Chemistry
- The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients
- (2015) Zhengrui Xi et al. ACTA NEUROPATHOLOGICA
- Relationships between putative G-quadruplex-forming sequences, RecQ helicases, and transcription
- (2015) John A. Smestad et al. BMC Medical Genetics
- Emerging role of RNA•DNA hybrids inC9orf72-linked neurodegeneration
- (2015) Jiou Wang et al. CELL CYCLE
- G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome
- (2015) Roberto Simone et al. FEBS LETTERS
- DNA Replication Dynamics of the GGGGCC Repeat of theC9orf72Gene
- (2015) Ryan Griffin Thys et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of Small Molecules for Up-Regulating the Translation of Antiamyloidogenic Secretase, a Disintegrin and Metalloproteinase 10 (ADAM10), by Binding to the G-Quadruplex-Forming Sequence in the 5′ Untranslated Region (UTR) of Its mRNA
- (2015) Jie Dai et al. JOURNAL OF MEDICINAL CHEMISTRY
- The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
- (2015) Ke Zhang et al. NATURE
- High-throughput sequencing of DNA G-quadruplex structures in the human genome
- (2015) Vicki S Chambers et al. NATURE BIOTECHNOLOGY
- R loops: new modulators of genome dynamics and function
- (2015) José M. Santos-Pereira et al. NATURE REVIEWS GENETICS
- Stabilization of the G-quadruplex at the VEGF IRES represses cap-independent translation
- (2015) Anne Cammas et al. RNA Biology
- DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice
- (2015) Elsa Suberbielle et al. Nature Communications
- Topology of a G-quadruplex DNA formed by C9orf72 hexanucleotide repeats associated with ALS and FTD
- (2015) Bo Zhou et al. Scientific Reports
- Amyloid Precursor Protein Translation Is Regulated by a 3’UTR Guanine Quadruplex
- (2015) Ezekiel Crenshaw et al. PLoS One
- FMRP interacts with G-quadruplex structures in the 3’-UTR of its dendritic target Shank1 mRNA
- (2015) Yang Zhang et al. RNA Biology
- Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier
- (2014) Jenny Russ et al. ACTA NEUROPATHOLOGICA
- C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD
- (2014) Elaine Y. Liu et al. ACTA NEUROPATHOLOGICA
- Liquid-Liquid Phase Separation in Biology
- (2014) Anthony A. Hyman et al. Annual Review of Cell and Developmental Biology
- RNA metabolism in the pathogenesis of Parkinson׳s disease
- (2014) Bingwei Lu et al. BRAIN RESEARCH
- R-loops induce repressive chromatin marks over mammalian gene terminators
- (2014) Konstantina Skourti-Stathaki et al. NATURE
- C9orf72 nucleotide repeat structures initiate molecular cascades of disease
- (2014) Aaron R. Haeusler et al. NATURE
- G-quadruplexes within prion mRNA: the missing link in prion disease?
- (2014) René C.L. Olsthoorn NUCLEIC ACIDS RESEARCH
- Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability
- (2014) Kaalak Reddy et al. NUCLEIC ACIDS RESEARCH
- G-quadruplexes in viruses: function and potential therapeutic applications
- (2014) Mathieu Métifiot et al. NUCLEIC ACIDS RESEARCH
- G-Quadruplex Structures Formed by Expanded Hexanucleotide Repeat RNA and DNA from the Neurodegenerative Disease-Linked C9orf72 Gene Efficiently Sequester and Activate Heme
- (2014) Jason C. Grigg et al. PLoS One
- G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments
- (2014) Pavel Ivanov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- G quadruplex RNA structures in PSD-95 mRNA: potential regulators of miR-125a seed binding site accessibility
- (2014) Snezana Stefanovic et al. RNA
- Genome-Wide Profiling of Yeast DNA:RNA Hybrid Prone Sites with DRIP-Chip
- (2014) Yujia A. Chan et al. PLoS Genetics
- R-loops Associated with Triplet Repeat Expansions Promote Gene Silencing in Friedreich Ataxia and Fragile X Syndrome
- (2014) Matthias Groh et al. PLoS Genetics
- hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations
- (2013) Kohji Mori et al. ACTA NEUROPATHOLOGICA
- Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood
- (2013) Veronique V. Belzil et al. ACTA NEUROPATHOLOGICA
- Hypermethylation of the CpG Island Near the G4C2 Repeat in ALS with a C9orf72 Expansion
- (2013) Zhengrui Xi et al. AMERICAN JOURNAL OF HUMAN GENETICS
- The Disease-associated r(GGGGCC)nRepeat from theC9orf72Gene Forms Tract Length-dependent Uni- and Multimolecular RNA G-quadruplex Structures
- (2013) Kaalak Reddy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells
- (2013) Giulia Biffi et al. Nature Chemistry
- Quantitative visualization of DNA G-quadruplex structures in human cells
- (2013) Giulia Biffi et al. Nature Chemistry
- The translation of translational control by FMRP: therapeutic targets for FXS
- (2013) Jennifer C Darnell et al. NATURE NEUROSCIENCE
- Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS
- (2013) Peter E.A. Ash et al. NEURON
- Detection of G-quadruplex DNA in mammalian cells
- (2013) A. Henderson et al. NUCLEIC ACIDS RESEARCH
- Exploring mRNA 3′-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shortening
- (2013) Jean-Denis Beaudoin et al. NUCLEIC ACIDS RESEARCH
- The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS
- (2013) K. Mori et al. SCIENCE
- G-quadruplex structures are stable and detectable in human genomic DNA
- (2013) Enid Yi Ni Lam et al. Nature Communications
- The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis
- (2013) Yoshinori Nishimoto et al. Molecular Brain
- Stabilization of G-quadruplex DNA by C-5-methyl-cytosine in bcl-2 promoter: Implications for epigenetic regulation
- (2012) Jing Lin et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A G-Rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing
- (2012) Jean-François Fisette et al. JOURNAL OF NEUROCHEMISTRY
- R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters
- (2012) Paul A. Ginno et al. MOLECULAR CELL
- DNA secondary structures: stability and function of G-quadruplex structures
- (2012) Matthew L. Bochman et al. NATURE REVIEWS GENETICS
- 5'-UTR RNA G-quadruplexes: translation regulation and targeting
- (2012) A. Bugaut et al. NUCLEIC ACIDS RESEARCH
- C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes
- (2012) Pietro Fratta et al. Scientific Reports
- Transcription Arrest by a G Quadruplex Forming-Trinucleotide Repeat Sequence from the Human c-myb Gene
- (2011) Christopher Broxson et al. BIOCHEMISTRY
- G–quadruplex RNA structure as a signal for neurite mRNA targeting
- (2011) Murugan Subramanian et al. EMBO REPORTS
- Translational Repression of the Disintegrin and Metalloprotease ADAM10 by a Stable G-quadruplex Secondary Structure in Its 5′-Untranslated Region
- (2011) Sven Lammich et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation
- (2011) Pavel Ivanov et al. MOLECULAR CELL
- Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
- (2011) Shankar Balasubramanian et al. NATURE REVIEWS DRUG DISCOVERY
- Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
- (2011) Mariely DeJesus-Hernandez et al. NEURON
- A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
- (2011) Alan E. Renton et al. NEURON
- G-quadruplex nucleic acids and human disease
- (2010) Yuliang Wu et al. FEBS Journal
- Angiogenin-induced tRNA-derived Stress-induced RNAs Promote Stress-induced Stress Granule Assembly
- (2010) Mohamed M. Emara et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An RNA G-Quadruplex Is Essential for Cap-Independent Translation Initiation in Human VEGF IRES
- (2010) Mark J. Morris et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia
- (2010) Ian RA Mackenzie et al. LANCET NEUROLOGY
- hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies
- (2010) Eun Kyung Lee et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mechanisms and implications of transcription blockage by guanine-rich DNA sequences
- (2010) B. P. Belotserkovskii et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
- (2009) Nahum Sonenberg et al. CELL
- Identification and Characterization of Nucleolin as a c-mycG-quadruplex-binding Protein
- (2009) Verónica González et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct NMR Detection of Alkali Metal Ions Bound to G-Quadruplex DNA
- (2008) Ramsey Ida et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer
- (2008) Marie-Cécile Didiot et al. NUCLEIC ACIDS RESEARCH
- Stability and kinetics of G-quadruplex structures
- (2008) A. N. Lane et al. NUCLEIC ACIDS RESEARCH
- Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif
- (2008) A. Arora et al. RNA
- Genome-wide analysis reveals regulatory role of G4 DNA in gene transcription
- (2007) Z. Du et al. GENOME RESEARCH
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started