Interplay between SARS-CoV-2 and the type I interferon response

A novel coronavirus outbreak of global health concern

(2020) Chen Wang et al.   LANCET

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

(2020) Timothy P. Sheahan et al.   Nature Communications

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

(2020) Jasper Fuk-Woo Chan et al.   Emerging Microbes & Infections

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

An Infectious cDNA Clone of SARS-CoV-2

(2020) Xuping Xie et al.   Cell Host & Microbe

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19

(2020) Hin Chu et al.   CLINICAL INFECTIOUS DISEASES

COVID ‐19: lambda interferon against viral load and hyperinflammation

(2020) Evangelos Andreakos et al.   EMBO Molecular Medicine

COVID-19 and emerging viral infections: The case for interferon lambda

(2020) Ludmila Prokunina-Olsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

(2020) Ivan Fan-Ngai Hung et al.   LANCET

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors

(2020) Matthew Hackbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-α2b Treatment for COVID-19

(2020) Qiong Zhou et al.   Frontiers in Immunology

Antiviral activities of type I interferons to SARS-CoV-2 infection

(2020) Emily Mantlo et al.   ANTIVIRAL RESEARCH

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Type III interferons disrupt the lung epithelial barrier upon viral recognition

(2020) Achille Broggi et al.   SCIENCE

Self-Awareness: Nucleic Acid–Driven Inflammation and the Type I Interferonopathies

(2019) Carolina Uggenti et al.   Annual Review of Immunology

Plasmacytoid Dendritic Cells: Development, Regulation, and Function

(2019) Boris Reizis   IMMUNITY

PKR: A Kinase to Remember

(2019) Shunit Gal-Ben-Ari et al.   Frontiers in Molecular Neuroscience

Antagonism of dsRNA-Induced Innate Immune Pathways by NS4a and NS4b Accessory Proteins during MERS Coronavirus Infection

(2019) Courtney E. Comar et al.   mBio

Plasmacytoid Dendritic Cells and Infected Cells Form an Interferogenic Synapse Required for Antiviral Responses

(2019) Sonia Assil et al.   Cell Host & Microbe

Ribavirin and Interferon Therapy for Critically Ill Patients with the Middle East Respiratory Syndrome: A multicenter observational study

(2019) Yaseen Arabi et al.   CLINICAL INFECTIOUS DISEASES

IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

(2019) Rudragouda Channappanavar et al.   JOURNAL OF CLINICAL INVESTIGATION

Interferon-Stimulated Genes: What Do They All Do?

(2019) John W. Schoggins   Annual Review of Virology

TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells

(2019) Ghizlane Maarifi et al.   Science Advances

Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion

(2019) Achille Broggi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stimulation of Innate Immunity by Host and Viral RNAs

(2019) Felix Streicher et al.   TRENDS IN IMMUNOLOGY

Novel host restriction factors implicated in HIV-1 replication

(2018) Dibya Ghimire et al.   JOURNAL OF GENERAL VIROLOGY

SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells

(2018) Chun-Feng Yu et al.   JOURNAL OF IMMUNOLOGY

An “Old” protein with a new story: Coronavirus endoribonuclease is important for evading host antiviral defenses

(2018) Xufang Deng et al.   VIROLOGY

Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses

(2018) Brian Webster et al.   eLife

Antiviral interferon response at single-cell resolution

(2018) Soheil Rastgou Talemi et al.   IMMUNOLOGICAL REVIEWS

Inhibition of Stress Granule Formation by Middle East Respiratory Syndrome Coronavirus 4a Accessory Protein Facilitates Viral Translation, Leading to Efficient Virus Replication

(2018) Keisuke Nakagawa et al.   JOURNAL OF VIROLOGY

Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages

(2018) Aaron F. Carlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells

(2018) Florian Wimmers et al.   Nature Communications

LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step

(2018) Katrina B. Mar et al.   Nature Communications

The defective component of viral populations

(2018) Veronica V Rezelj et al.   Current Opinion in Virology

Development of Pin1 inhibitors and their potential as therapeutic agents

(2018) Yusuke Nakatsu et al.   CURRENT MEDICINAL CHEMISTRY

Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance

(2018) Kalliopi Pervolaraki et al.   PLoS Pathogens

Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness

(2017) Ioanna E. Galani et al.   IMMUNITY

Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages

(2017) Xufang Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

(2017) Nikaïa Smith et al.   Nature Communications

DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes

(2017) Jennifer H. Lumb et al.   Cell Reports

Interferon-λs: Front-Line Guardians of Immunity and Homeostasis in the Respiratory Tract

(2017) Evangelos Andreakos et al.   Frontiers in Immunology

Type I Interferons as Regulators of Lung Inflammation

(2017) Spyridon Makris et al.   Frontiers in Immunology

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Cell-Cell Sensing of Viral Infection by Plasmacytoid Dendritic Cells

(2016) Brian Webster et al.   JOURNAL OF VIROLOGY

SARS and MERS: recent insights into emerging coronaviruses

(2016) Emmie de Wit et al.   NATURE REVIEWS MICROBIOLOGY

Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1

(2016) Qingzhan Zhang et al.   VIROLOGY

Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

(2016) Huib H. Rabouw et al.   PLoS Pathogens

Integration of PKR-dependent translation inhibition with innate immunity is required for a coordinated anti-viral response

(2015) Alexandre Dalet et al.   FEBS LETTERS

IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study

(2015) Sarah Shalhoub et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

(2015) Jasper Fuk-Woo Chan et al.   JOURNAL OF INFECTIOUS DISEASES

Disease-Promoting Effects of Type I Interferons in Viral, Bacterial, and Coinfections

(2015) Sophia Davidson et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

MDA5 Is Critical to Host Defense during Infection with Murine Coronavirus

(2015) Zachary B. Zalinger et al.   JOURNAL OF VIROLOGY

Single-cell analysis shows that paracrine signaling by first responder cells shapes the interferon-β response to viral infection

(2015) Sonali Patil et al.   Science Signaling

To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes

(2015) Melody M.H. Li et al.   TRENDS IN CELL BIOLOGY

Single-cell analysis shows that paracrine signaling by first responder cells shapes the interferon-β response to viral infection

(2015) Sonali Patil et al.   Science Signaling

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study

(2014) Jaffar A. Al-Tawfiq et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

SARS-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the MAVS/TRAF3/TRAF6 Signalosome

(2014) Chong-Shan Shi et al.   JOURNAL OF IMMUNOLOGY

Attenuation and Restoration of Severe Acute Respiratory Syndrome Coronavirus Mutant Lacking 2'-O-Methyltransferase Activity

(2014) V. D. Menachery et al.   JOURNAL OF VIROLOGY

Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study

(2014) Ali S Omrani et al.   LANCET INFECTIOUS DISEASES

Interferon induction of IFITM proteins promotes infection by human coronavirus OC43

(2014) X. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFITM Proteins Inhibit Entry Driven by the MERS-Coronavirus Spike Protein: Evidence for Cholesterol-Independent Mechanisms

(2014) Florian Wrensch et al.   Viruses-Basel

Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses

(2014) V. D. Menachery et al.   mBio

Sensing of Immature Particles Produced by Dengue Virus Infected Cells Induces an Antiviral Response by Plasmacytoid Dendritic Cells

(2014) Elodie Décembre et al.   PLoS Pathogens

IFITM-Family Proteins: The Cell's First Line of Antiviral Defense

(2014) Charles C. Bailey et al.   Annual Review of Virology

Enveloped Viruses Disable Innate Immune Responses in Dendritic Cells by Direct Activation of TAM Receptors

(2013) Suchita Bhattacharyya et al.   Cell Host & Microbe

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-  treatment

(2013) A. H. de Wilde et al.   JOURNAL OF GENERAL VIROLOGY

Tropism of and Innate Immune Responses to the Novel Human Betacoronavirus Lineage C Virus in Human Ex Vivo Respiratory Organ Cultures

(2013) R. W. Y. Chan et al.   JOURNAL OF VIROLOGY

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin

(2013) Darryl Falzarano et al.   Scientific Reports

Inhibition of HIV-1 Particle Assembly by 2′,3′-Cyclic-Nucleotide 3′-Phosphodiesterase

(2012) Sam J. Wilson et al.   Cell Host & Microbe

The TIM and TAM Families of Phosphatidylserine Receptors Mediate Dengue Virus Entry

(2012) Laurent Meertens et al.   Cell Host & Microbe

PACSIN1 regulates the TLR7/9-mediated type I interferon response in plasmacytoid dendritic cells

(2012) Eiji Esashi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Severe Acute Respiratory Syndrome Coronavirus Protein nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation Initiation

(2012) K. G. Lokugamage et al.   JOURNAL OF VIROLOGY

Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response

(2012) Ulfert Rand et al.   Molecular Systems Biology

Plasmacytoid dendritic cells control T-cell response to chronic viral infection

(2012) L. Cervantes-Barragan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

dsRNA-Dependent Protein Kinase PKR and its Role in Stress, Signaling and HCV Infection

(2012) Stéphanie Dabo et al.   Viruses-Basel

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

(2011) John R. Teijaro et al.   CELL

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus

(2011) I-Chueh Huang et al.   PLoS Pathogens

Plasmacytoid Dendritic Cell Ablation Impacts Early Interferon Responses and Antiviral NK and CD8+ T Cell Accrual

(2010) Melissa Swiecki et al.   IMMUNITY

Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections

(2010) M. Mordstein et al.   JOURNAL OF VIROLOGY

Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases

(2010) M. A. Clementz et al.   JOURNAL OF VIROLOGY

Murine Coronavirus Induces Type I Interferon in Oligodendrocytes through Recognition by RIG-I and MDA5

(2010) J. Li et al.   JOURNAL OF VIROLOGY

SARS spike protein induces phenotypic conversion of human B cells to macrophage-like cells

(2010) Shu-Fen Chiang et al.   MOLECULAR IMMUNOLOGY

Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells

(2010) A. L. Blasius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3

(2010) M. Sasai et al.   SCIENCE

SARS-CoV nucleocapsid protein antagonizes IFN-β response by targeting initial step of IFN-β induction pathway, and its C-terminal region is critical for the antagonism

(2010) Xiaolu Lu et al.   VIRUS GENES

A Systems Immunology Approach to Plasmacytoid Dendritic Cell Function in Cytopathic Virus Infections

(2010) Gennady Bocharov et al.   PLoS Pathogens

In Vitro Reconstitution of SARS-Coronavirus mRNA Cap Methylation

(2010) Mickaël Bouvet et al.   PLoS Pathogens

Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex

(2009) Kam-Leung Siu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

(2009) Wei Cao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cellular Immune Responses to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection in Senescent BALB/c Mice: CD4+ T Cells Are Important in Control of SARS-CoV Infection

(2009) J. Chen et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF- B Signaling

(2009) M. Frieman et al.   JOURNAL OF VIROLOGY

Molecular Determinants for Subcellular Localization of the Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame 3b Protein

(2009) E. C. Freundt et al.   JOURNAL OF VIROLOGY

The SARS Coronavirus 3a Protein Causes Endoplasmic Reticulum Stress and Induces Ligand-Independent Downregulation of the Type 1 Interferon Receptor

(2009) Rinki Minakshi et al.   PLoS One

A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection

(2009) D. Marsolais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Murine Coronavirus Cell Type Dependent Interaction with the Type I Interferon Response

(2009) Kristine Rose et al.   Viruses-Basel

Epstein-Barr virus-encoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitro

(2008) J. D. O'Neil et al.   JOURNAL OF GENERAL VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

(2008) K. Narayanan et al.   JOURNAL OF VIROLOGY