Role of Ferroptosis in Fibrotic Diseases

Exosomes derived from hepatitis B virus-infected hepatocytes promote liver fibrosis via miR-222/TFRC axis

(2022) Qidi Zhang et al.   CELL BIOLOGY AND TOXICOLOGY

An 8-ferroptosis-related genes signature from Bronchoalveolar Lavage Fluid for prognosis in patients with idiopathic pulmonary fibrosis

(2022) Yaowu He et al.   BMC Pulmonary Medicine

Fisetin Attenuates Doxorubicin-Induced Cardiomyopathy In Vivo and In Vitro by Inhibiting Ferroptosis Through SIRT1/Nrf2 Signaling Pathway Activation

(2022) Danlei Li et al.   Frontiers in Pharmacology

Iron-Dependent Mitochondrial Dysfunction Contributes to the Pathogenesis of Pulmonary Fibrosis

(2022) Mai Takahashi et al.   Frontiers in Pharmacology

Bioinformatics Analysis Identifies Potential Ferroptosis Key Genes in the Pathogenesis of Pulmonary Fibrosis

(2022) Jie He et al.   Frontiers in Genetics

Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling

(2022) Zhenzhou Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Salidroside inhibits doxorubicin-induced cardiomyopathy by modulating a ferroptosis-dependent pathway

(2022) Hang Chen et al.   PHYTOMEDICINE

Dexmedetomidine post-conditioning alleviates myocardial ischemia–reperfusion injury in rats by ferroptosis inhibition via SLC7A11/GPX4 axis activation

(2022) Peng Yu et al.   Human Cell

Nobiletin Alleviates Ferroptosis-Associated Renal Injury, Inflammation, and Fibrosis in a Unilateral Ureteral Obstruction Mouse Model

(2022) Yi-Hsin Lo et al.   Biomedicines

Ferroptosis, a new target for treatment of renal injury and fibrosis in a 5/6 nephrectomy-induced CKD rat model

(2022) Jingyu Wang et al.   Cell Death Discovery

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling

(2021) Li-Fei Luo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice

(2021) Xiaomeng Feng et al.   Frontiers in Endocrinology

Lipid Metabolism and Ferroptosis

(2021) Ji-Yoon Lee et al.   Biology-Basel

Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury

(2021) Kuo Du et al.   LIVER INTERNATIONAL

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

TRIM26 Induces Ferroptosis to Inhibit Hepatic Stellate Cell Activation and Mitigate Liver Fibrosis Through Mediating SLC7A11 Ubiquitination

(2021) Yiming Zhu et al.   Frontiers in Cell and Developmental Biology

circSnx12 Is Involved in Ferroptosis During Heart Failure by Targeting miR-224-5p

(2021) Haoyuan Zheng et al.   Frontiers in Cardiovascular Medicine

Dihydroartemisinin alleviates hepatic fibrosis through inducing ferroptosis in hepatic stellate cells

(2021) Zili Zhang et al.   BIOFACTORS

The SGLT-2 inhibitor empagliflozin improves myocardial strain, reduces cardiac fibrosis and pro-inflammatory cytokines in non-diabetic mice treated with doxorubicin

(2021) Vincenzo Quagliariello et al.   Cardiovascular Diabetology

SLC7A11/xCT Prevents Cardiac Hypertrophy by Inhibiting Ferroptosis

(2021) Xiyu Zhang et al.   CARDIOVASCULAR DRUGS AND THERAPY

Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis

(2021) Chang-Hsun Ho et al.   Evidence-based Complementary and Alternative Medicine

Etomidate Attenuates the Ferroptosis in Myocardial Ischemia/Reperfusion Rat Model Via Nrf2 Pathway

(2021) Zhenqian Lv et al.   SHOCK

Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis

(2021) Bo Zhang et al.   Cell Death & Disease

Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

(2021) Shintaro Ide et al.   eLife

Targeting Ferroptosis Attenuates Interstitial Inflammation and Kidney Fibrosis

(2021) Lu Zhou et al.   Kidney Diseases

Histone methyltransferase SETDB1 inhibits TGF-β-induced epithelial–mesenchymal transition in pulmonary fibrosis by regulating SNAI1 expression and the ferroptosis signaling pathway

(2021) Tiantian Liu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis

(2021) Haipeng Cheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF‐1α/SLC7A11 pathway

(2021) Siyu Yuan et al.   CELL PROLIFERATION

Tectorigenin protects against unilateral ureteral obstruction by inhibiting Smad3‐mediated ferroptosis and fibrosis

(2021) Jianchun Li et al.   PHYTOTHERAPY RESEARCH

Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis

(2021) Aimin Wu et al.   Redox Biology

N6-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells

(2021) Min Shen et al.   Redox Biology

Histochrome Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death

(2021) Ji-Won Hwang et al.   Antioxidants

Iron metabolism regulation of epithelial-mesenchymal transition in idiopathic pulmonary fibrosis

(2021) Yi Han et al.   Annals of Translational Medicine

Ferroptosis-Related Genes in Bronchoalveolar Lavage Fluid Serves as Prognostic Biomarkers for Idiopathic Pulmonary Fibrosis

(2021) Meng Li et al.   Frontiers in Medicine

Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis

(2021) Jiazhi Yi et al.   Cell Death Discovery

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling

(2020) Divya Venkatesh et al.   GENES & DEVELOPMENT

Critical role for iron accumulation in the pathogenesis of fibrotic lung disease

(2020) Md Khadem Ali et al.   JOURNAL OF PATHOLOGY

Aifm2, a NADH Oxidase, Supports Robust Glycolysis and Is Required for Cold- and Diet-Induced Thermogenesis

(2020) Hai P. Nguyen et al.   MOLECULAR CELL

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

Pretreatment with Roxadustat (FG-4592) Attenuates Folic Acid-Induced Kidney Injury through Antiferroptosis via Akt/GSK-3β/Nrf2 Pathway

(2020) Xue Li et al.   Oxidative Medicine and Cellular Longevity

Where ferroptosis inhibitors and paraquat detoxification mechanisms intersect, exploring possible treatment strategies

(2020) Niloofar Rashidipour et al.   TOXICOLOGY

lncRNA ZFAS1 promotes lung fibroblast-to-myofibroblast transition and ferroptosis via functioning as a ceRNA through miR-150-5p/SLC38A1 axis

(2020) Yanni Yang et al.   Aging-US

Hepatic Transferrin Plays a Role in Systemic Iron Homeostasis and Liver Ferroptosis

(2020) Yingying Yu et al.   BLOOD

Chrysophanol attenuates hepatitis B virus X protein-induced hepatic stellate cell fibrosis by regulating endoplasmic reticulum stress and ferroptosis

(2020) Chan-Yen Kuo et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload

(2020) Junyan Wang et al.   Cell Death & Disease

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

(2020) Tomonori Tadokoro et al.   JCI Insight

NEDD4L-mediated LTF protein degradation limits ferroptosis

(2020) Yuan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

(2020) Yilong Zou et al.   NATURE

Spectrum of Fibrotic Lung Diseases

(2020) Marlies Wijsenbeek et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting Ferroptosis: New Hope for As-Yet-Incurable Diseases

(2020) Marcus Conrad et al.   TRENDS IN MOLECULAR MEDICINE

The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells

(2020) Zili Zhang et al.   Redox Biology

Iron Metabolism in Ferroptosis

(2020) Xin Chen et al.   Frontiers in Cell and Developmental Biology

Oxidative Damage and Antioxidant Defense in Ferroptosis

(2020) Feimei Kuang et al.   Frontiers in Cell and Developmental Biology

The Metabolic Underpinnings of Ferroptosis

(2020) Jiashuo Zheng et al.   Cell Metabolism

Lipid Peroxidation, GSH Depletion, and SLC7A11 Inhibition are Common Causes of EMT and Ferroptosis in A549 Cells, but Different in Specific Mechanisms

(2020) Lulu Sun et al.   DNA AND CELL BIOLOGY

Fibrosis: from mechanisms to medicines

(2020) Neil C. Henderson et al.   NATURE

Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

(2020) Paolo Spagnolo et al.   PHARMACOLOGY & THERAPEUTICS

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Progress in Understanding and Treating Idiopathic Pulmonary Fibrosis

(2019) Jonathan A. Kropski et al.   Annual Review of Medicine

Radiation-Induced Lung Injury

(2019) Alexander N. Hanania et al.   CHEST

Lipid Peroxidation and GPX4 Inhibition Are Common Causes for Myofibroblast Differentiation and Ferroptosis

(2019) Yue Gong et al.   DNA AND CELL BIOLOGY

Ferroptosis inhibitor alleviates Radiation-induced lung fibrosis (RILF) via down-regulation of TGF-β1

(2019) Xuan Li et al.   Journal of Inflammation-London

Retrospective study of clinical features and prognosis of edaravone in the treatment of paraquat poisoning

(2019) Ren Yi et al.   MEDICINE

Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure

(2019) Xiaoqing Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting metabolic dysregulation for fibrosis therapy

(2019) Xiao Zhao et al.   NATURE REVIEWS DRUG DISCOVERY

RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells

(2019) Zili Zhang et al.   Autophagy

Role of ferroptosis in the process of acute radiation-induced lung injury in mice

(2019) Xuan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ESCRT-III–dependent membrane repair blocks ferroptosis

(2019) Enyong Dai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro

(2019) Takujiro Homma et al.   EXPERIMENTAL CELL RESEARCH

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

Shared and distinct mechanisms of fibrosis

(2019) Jörg H. W. Distler et al.   Nature Reviews Rheumatology

Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

(2019) Tae-Jun Park et al.   Cell Death & Disease

Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels

(2019) Yansheng Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress

(2019) Wenyuan Li et al.   DNA AND CELL BIOLOGY

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

(2018) Yuichi Baba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mechanisms of Renal Fibrosis

(2018) Benjamin D. Humphreys   Annual Review of Physiology

Magnesium isoglycyrrhizinate ameliorates liver fibrosis and hepatic stellate cell activation by regulating ferroptosis signaling pathway

(2018) Miao Sui et al.   BIOMEDICINE & PHARMACOTHERAPY

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Selenocysteine in mammalian thioredoxin reductase and application of ebselen as a therapeutic

(2018) Xiaoyuan Ren et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resolution of organ fibrosis

(2018) Joon-Il Jun et al.   JOURNAL OF CLINICAL INVESTIGATION

Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications

(2018) Ralf Weiskirchen et al.   MOLECULAR ASPECTS OF MEDICINE

Idiopathic Pulmonary Fibrosis

(2018) David J. Lederer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells

(2018) Zili Zhang et al.   Autophagy

Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities

(2018) Nikolaos G. Frangogiannis   MOLECULAR ASPECTS OF MEDICINE

Lipid storage and lipophagy regulates ferroptosis

(2018) Yuansong Bai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway

(2018) Zhaoyan Kong et al.   BIOMEDICINE & PHARMACOTHERAPY

P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation

(2018) Ling Wang et al.   IUBMB LIFE

Myocardial fibrosis: biomedical research from bench to bedside

(2017) Mariann Gyöngyösi et al.   EUROPEAN JOURNAL OF HEART FAILURE

Idiopathic pulmonary fibrosis

(2017) Luca Richeldi et al.   LANCET

Ferroptosis Inhibition: Mechanisms and Opportunities

(2017) Jose Pedro Friedmann Angeli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Idiopathic pulmonary fibrosis

(2017) Fernando J. Martinez et al.   Nature Reviews Disease Primers

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

(2015) M Hayano et al.   CELL DEATH AND DIFFERENTIATION

Fibrosis — A Common Pathway to Organ Injury and Failure

(2015) Don C. Rockey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis

(2015) Rui-Ming Liu et al.   Redox Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

The physiological functions of iron regulatory proteins in iron homeostasis - an update

(2014) De-Liang Zhang et al.   Frontiers in Pharmacology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Transforming growth factor β suppresses glutamate–cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model

(2012) Rui-Ming Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-β1-dependent mechanism

(2012) Marta R. Gorowiec et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

(2012) B. N. Chorley et al.   NUCLEIC ACIDS RESEARCH

Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress

(2011) Yasuhiro Terasaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Dietary flaxseed prevents radiation-induced oxidative lung damage, inflammation and fibrosis in a mouse model of thoracic radiation injury

(2010) James C Lee et al.   CANCER BIOLOGY & THERAPY

N-acetylcysteine inhibits alveolar epithelial-mesenchymal transition

(2009) V. M. Felton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Ferritin Heavy Chain–Mediated Iron Homeostasis and Subsequent Increased Reactive Oxygen Species Production Are Essential for Epithelial-Mesenchymal Transition

(2009) Ke-Hua Zhang et al.   CANCER RESEARCH

Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells

(2008) Aki Ogura et al.   CANCER LETTERS

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Paraquat Poisonings: Mechanisms of Lung Toxicity, Clinical Features, and Treatment

(2007) R. J. Dinis-Oliveira et al.   CRITICAL REVIEWS IN TOXICOLOGY