Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis

Anti-obesity effect of trans-cinnamic acid on HepG2 cells and HFD-fed mice

(2020) Zhenyu Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection

(2019) Hai Hu et al.   Frontiers in Immunology

Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases

(2019) Massimo Bortolotti et al.   Frontiers in Pharmacology

Apoptotic effects of hsian‐tsao ( Mesona procumbens Hemsley) on hepatic stellate cells mediated by reactive oxygen species and ERK, JNK, and caspase‐3 pathways

(2019) Yung‐Hsiang Yeh et al.   Food Science & Nutrition

Investigation of Biological Activities of Wild Bitter Melon (Momordica charantia Linn. Var. Abbreviata Ser.)

(2019) Thi My Hanh Pham et al.   Biomolecules

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

(2019) Lian-Jiu Su et al.   Oxidative Medicine and Cellular Longevity

TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019

(2019) Dewidar et al.   Cells

Understanding of ROS-Inducing Strategy in Anticancer Therapy

(2019) Su Ji Kim et al.   Oxidative Medicine and Cellular Longevity

Food components with antifibrotic activity and implications in prevention of liver disease

(2018) Minkyung Bae et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The Bioactive Extract of Pinnigorgia sp. Induces Apoptosis of Hepatic Stellate Cells via ROS-ERK/JNK-Caspase-3 Signaling

(2018) Liang-Mou Kuo et al.   Marine Drugs

The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice

(2018) Xi Li et al.   Frontiers in Pharmacology

Silybin Alleviates Hepatic Steatosis and Fibrosis in NASH Mice by Inhibiting Oxidative Stress and Involvement with the Nf-κB Pathway

(2018) Qiang Ou et al.   DIGESTIVE DISEASES AND SCIENCES

Enhancement of Silymarin Anti-fibrotic Effects by Complexation With Hydroxypropyl (HPBCD) and Randomly Methylated (RAMEB) β-Cyclodextrins in a Mouse Model of Liver Fibrosis

(2018) Sami Gharbia et al.   Frontiers in Pharmacology

Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells

(2018) Yan Jia et al.   Redox Biology

Hepatoprotective Role of Thymol in Drug-Induced Gastric Ulcer Model

(2018) Fatime Geyikoglu et al.   Annals of Hepatology

3,5-Diethoxy-3′-Hydroxyresveratrol (DEHR) Ameliorates Liver Fibrosis via Caveolin-1 Activation in Hepatic Stellate Cells and in a Mouse Model of Bile Duct Ligation Injury

(2018) Phil Lee et al.   MOLECULES

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway

(2018) Mao Mu et al.   Drug Design Development and Therapy

Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats

(2018) Yuxin Chen et al.   Biomed Research International

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

IL-32γ promotes integrin αvβ6 expression through the activation of NF-κB in HSCs

(2017) Hongcan Liu et al.   Experimental and Therapeutic Medicine

Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells

(2017) Daniel F. Hicks et al.   Scientific Reports

p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer

(2016) Angeles Duran et al.   CANCER CELL

Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress

(2016) Haitao Shi et al.   CLINICAL NUTRITION

Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells

(2016) Ying Hui Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wild Bitter Melon Leaf Extract Inhibits Porphyromonas gingivalis-Induced Inflammation: Identification of Active Compounds through Bioassay-Guided Isolation

(2016) Tzung-Hsun Tsai et al.   MOLECULES

Succinate causes α-SMA production through GPR91 activation in hepatic stellate cells

(2015) Ying Hui Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated fromMomordica charantiaVine

(2015) Jutamas Saengsai et al.   Evidence-based Complementary and Alternative Medicine

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis

(2015) Katrin Palumbo-Zerr et al.   NATURE MEDICINE

Epigallocatechin 3-Gallate Ameliorates Bile Duct Ligation Induced Liver Injury in Mice by Modulation of Mitochondrial Oxidative Stress and Inflammation

(2015) Kezhen Shen et al.   PLoS One

Inhibitory effects of wild bitter melon leaf extract on Propionibacterium acnes-induced skin inflammation in mice and cytokine production in vitro

(2015) Wen-Cheng Huang et al.   Food & Function

Fuzheng Huayu recipe alleviates hepatic fibrosis via inhibiting TNF-α induced hepatocyte apoptosis

(2014) Yan-yan Tao et al.   BMC Complementary and Alternative Medicine

Novel role of nuclear receptor rev-erbα in hepatic stellate cell activation: Potential therapeutic target for liver injury

(2014) Ting Li et al.   HEPATOLOGY

Momordica Charantia lectin exhibits antitumor activity towards hepatocellular carcinoma

(2014) Chris Zhiyi Zhang et al.   INVESTIGATIONAL NEW DRUGS

Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis

(2014) Fredrick J. Bohanon et al.   JOURNAL OF SURGICAL RESEARCH

Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/mTOR/p70S6K and TGFβ/Smad signalling pathways

(2014) Jie Li et al.   LIVER INTERNATIONAL

Protective Effect of Astaxanthin on Liver Fibrosis through Modulation of TGF-β1 Expression and Autophagy

(2014) Miao Shen et al.   MEDIATORS OF INFLAMMATION

Intracellular Glutathione Depletion by Oridonin Leads to Apoptosis in Hepatic Stellate Cells

(2014) Liang-Mou Kuo et al.   MOLECULES

Curcumin Protects against CCl4-Induced Liver Fibrosis in Rats by Inhibiting HIF-1α Through an ERK-Dependent Pathway

(2014) Yanling Zhao et al.   MOLECULES

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Bitter melon juice activates cellular energy sensor AMP-activated protein kinase causing apoptotic death of human pancreatic carcinoma cells

(2013) Manjinder Kaur et al.   CARCINOGENESIS

Cucurbitane Triterpenoid fromMomordica charantiaInduces Apoptosis and Autophagy in Breast Cancer Cells, in Part, through Peroxisome Proliferator-Activated ReceptorγActivation

(2013) Jing-Ru Weng et al.   Evidence-based Complementary and Alternative Medicine

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy

(2013) Virginia Hernández-Gea et al.   JOURNAL OF HEPATOLOGY

Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis

(2013) A. Wehr et al.   JOURNAL OF IMMUNOLOGY

Bitter Melon Extracts Enhance the Activity of Chemotherapeutic Agents Through the Modulation of Multiple Drug Resistance

(2013) Deep Kwatra et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Hepatic stellate cells hold the key to liver fibrosis

(2013) Katrina Ray   Nature Reviews Gastroenterology & Hepatology

Dietary Supplementation of Blueberry Juice Enhances Hepatic Expression of Metallothionein and Attenuates Liver Fibrosis in Rats

(2013) Yuping Wang et al.   PLoS One

Glutathione Efflux and Cell Death

(2012) Rodrigo Franco et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy fuels tissue fibrogenesis

(2012) Virginia Hernández-Gea et al.   Autophagy

Selective activation of Toll-like receptor 7 in activated hepatic stellate cells may modulate their profibrogenic phenotype

(2012) Ming-Huei Chou et al.   BIOCHEMICAL JOURNAL

The MAP30 protein from bitter gourd (Momordica charantia) seeds promotes apoptosis in liver cancer cells in vitro and in vivo

(2012) Evandro Fei Fang et al.   CANCER LETTERS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) extract and its bioactive components suppress Propionibacterium acnes-induced inflammation

(2012) Chin Hsu et al.   FOOD CHEMISTRY

Regulation of hepatic stellate cells by connective tissue growth factor

(2012) Guangcun Huang   Frontiers in Bioscience-Landmark

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

(2012) Juliane S. Troeger et al.   GASTROENTEROLOGY

Application of high-speed counter-current chromatography coupled with a reverse micelle solvent system to separate three proteins from Momordica charantia

(2012) Yingnan Li et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro-fibrogenic/anti-fibrogenic molecules balance

(2012) Luis Daniel Hernández-Ortega et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Protective effects of hydrogen sulfide on oxidative stress and fibrosis in hepatic stellate cells

(2012) HAI-NING FAN et al.   Molecular Medicine Reports

RNase MC2: a new Momordica charantia ribonuclease that induces apoptosis in breast cancer cells associated with activation of MAPKs and induction of caspase pathways

(2011) Evandro Fei Fang et al.   APOPTOSIS

Induction of G1 arrest and apoptosis in androgen-dependent human prostate cancer by Kuguacin J, a triterpenoid from Momordica charantia leaf

(2011) Pornsiri Pitchakarn et al.   CANCER LETTERS

A role for autophagy during hepatic stellate cell activation

(2011) Lien F.R. Thoen et al.   JOURNAL OF HEPATOLOGY

Kuguacin J isolated from Momordica charantia leaves inhibits P-glycoprotein (ABCB1)-mediated multidrug resistance

(2011) Pornsiri Pitchakarn et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Bitter Melon (Momordica charantia) Extract Inhibits Breast Cancer Cell Proliferation by Modulating Cell Cycle Regulatory Genes and Promotes Apoptosis

(2010) R. B. Ray et al.   CANCER RESEARCH

Thiol redox systems and protein kinases in hepatic stellate cell regulatory processes

(2010) Anna Maria Brunati et al.   FREE RADICAL RESEARCH

Liver X Receptor Signaling Is a Determinant of Stellate Cell Activation and Susceptibility to Fibrotic Liver Disease

(2010) Simon W. Beaven et al.   GASTROENTEROLOGY

Integrin expression and function in the response of primary culture hepatic stellate cells to connective tissue growth factor (CCN2)

(2010) Guangcun Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Evolving challenges in hepatic fibrosis

(2010) Scott L. Friedman   Nature Reviews Gastroenterology & Hepatology

Interleukin-1 participates in the progression from liver injury to fibrosis

(2009) Roben G. Gieling et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells

(2009) Su Dao Xiong et al.   INTERNATIONAL JOURNAL OF CANCER

Preface

(2008) Scott L. Friedman   Clinics in Liver Disease

Stellate Cell Contraction: Role, Regulation, and Potential Therapeutic Target

(2008) Russell K. Soon et al.   Clinics in Liver Disease

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Hepatic fibrosis—Overview

(2008) Scott L. Friedman   TOXICOLOGY