Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis

FGF21 facilitates autophagy in prostate cancer cells by inhibiting the PI3K–Akt–mTOR signaling pathway

(2021) Han Dai et al.   Cell Death & Disease

Inhibition of the ox-LDL-Induced Pyroptosis by FGF21 of Human Umbilical Vein Endothelial Cells Through the TET2-UQCRC1-ROS Pathway

(2020) Jiao-Jiao Chen et al.   DNA AND CELL BIOLOGY

Anaemia, iron homeostasis and pulmonary hypertension: a review

(2020) Thomas Sonnweber et al.   Internal and Emergency Medicine

Transmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signaling

(2020) Aimin Wu et al.   Cell Death & Disease

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis

(2020) Zhaolin Zeng et al.   EXPERIMENTAL CELL RESEARCH

Systematic review of the clinical outcomes of iron reduction in Hereditary Hemochromatosis

(2020) Anil Prabhu et al.   HEPATOLOGY

Ferroptosis: machinery and regulation

(2020) Xin Chen et al.   Autophagy

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

(2019) Shinya Tsurusaki et al.   Cell Death & Disease

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Reduced Oxidative Stress and Enhanced FGF21 Formation in Livers of Endurance-Exercised Rats with Diet-Induced NASH

(2019) Janin Henkel et al.   Nutrients

FGF21 attenuates pulmonary fibrogenesis through ameliorating oxidative stress in vivo and in vitro

(2018) Shengqi Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Heme oxygenase-1 mediates BAY 11–7085 induced ferroptosis

(2018) Ling-Chu Chang et al.   CANCER LETTERS

FGF21 induced by carbon monoxide mediates metabolic homeostasis via the PERK/ATF4 pathway

(2018) Yeonsoo Joe et al.   FASEB JOURNAL

Expression of Fibroblast Growth Factor 21 and β-Klotho Regulates Hepatic Fibrosis through the Nuclear Factor-κB and c-Jun N-Terminal Kinase Pathways

(2018) Kyong Joo Lee et al.   Gut and Liver

Involvement of cytosolic and mitochondrial iron in iron overload cardiomyopathy: an update

(2018) Richard Gordan et al.   HEART FAILURE REVIEWS

FGF21 Alleviates Hepatic Endoplasmic Reticulum Stress under Physiological Conditions

(2018) Ryuto MARUYAMA et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Fibroblast growth factor 21 is an early predictor of acute-on-chronic liver failure in critically ill patients with cirrhosis

(2018) Astrid Ruiz-Margáin et al.   LIVER TRANSPLANTATION

Fibroblast growth factor 21 in cardio-metabolic disorders: a systematic review and meta-analysis

(2018) Ishan Lakhani et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Hemochromatosis: pathophysiology, evaluation, and management of hepatic iron overload with a focus on MRI

(2018) Shmuel Golfeyz et al.   Expert Review of Gastroenterology & Hepatology

Fibroblast growth factor-21 protects against fibrosis in hypertensive heart disease

(2018) Gemma Ferrer-Curriu et al.   JOURNAL OF PATHOLOGY

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

The mechanisms of systemic iron homeostasis and etiology, diagnosis, and treatment of hereditary hemochromatosis

(2017) Hiroshi Kawabata   INTERNATIONAL JOURNAL OF HEMATOLOGY

Fibroblast growth factor 21 and its novel association with oxidative stress

(2017) Miguel Ángel Gómez-Sámano et al.   Redox Biology

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

(2017) Michael John Kerins et al.   ANTIOXIDANTS & REDOX SIGNALING

FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process

(2016) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Haemochromatosis

(2016) Lawrie W Powell et al.   LANCET

Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

(2015) Marian Valko et al.   ARCHIVES OF TOXICOLOGY

Fibroblast growth factor (FGF21) protects mouse liver against d-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways

(2015) Yinhang Yu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

(2015) Min-Young Kwon et al.   Oncotarget

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Mitogen-Activated Protein Kinase Phosphatase 3 (MKP-3)-Deficient Mice Are Resistant to Diet-Induced Obesity

(2014) B. Feng et al.   DIABETES

FGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizers

(2014) Y Leng et al.   MOLECULAR PSYCHIATRY

FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases

(2014) Kook Hwan Kim et al.   Diabetes & Metabolism Journal

Regulation of systemic iron homeostasis

(2013) Karin E. Finberg   CURRENT OPINION IN HEMATOLOGY

Systemic Iron Homeostasis

(2013) Tomas Ganz   PHYSIOLOGICAL REVIEWS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice

(2012) Zhuzhen Zhang et al.   HEPATOLOGY

Fibroblast Growth Factor 21 (FGF21) Inhibits Chondrocyte Function and Growth Hormone Action Directly at the Growth Plate

(2012) Shufang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-transferrin bound iron: A key role in iron overload and iron toxicity

(2011) Pierre Brissot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Upregulation of heme oxygenase-1 via PI3K/Akt and Nrf-2 signaling pathways mediates the anti-inflammatory activity of Schisandrin in Porphyromonas gingivalis LPS-stimulated macrophages

(2011) Sun Young Park et al.   IMMUNOLOGY LETTERS

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathology of Hepatic Iron Overload

(2011) Yves Deugnier et al.   SEMINARS IN LIVER DISEASE

Hereditary Hemochromatosis: Pathogenesis, Diagnosis, and Treatment

(2010) Antonello Pietrangelo   GASTROENTEROLOGY