Journal
BIOMEDICINES
Volume 10, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines10030595
Keywords
chronic kidney disease; ferroptosis; fibrosis inflammation; nobiletin
Categories
Funding
- Ministry of Science and Technology of Taiwan [MOST 109-2314-B-039-043-MY3]
- China Medical University [CMU110-N-24]
Ask authors/readers for more resources
This study demonstrated the beneficial effects of Nobiletin in improving the progression of chronic kidney disease. Nobiletin was found to alleviate kidney fibrosis, oxidative stress, and inflammatory response. It may serve as a potential therapeutic candidate for the treatment of progressive chronic kidney disease.
Nobiletin (Nob), a critical active flavonoid of citrus fruits, has received attention for its superior physical functions, which have shown to improve the progression of diseases. Chronic kidney disease (CKD) is recognized as a global health problem, and its mortality and morbidity rates are worsened with an increased risk of accompanying disorders. In this study, we aimed to elucidate whether Nob treatment ameliorates kidney fibrosis and also to identify the potential signaling networks in a unilateral ureteral obstructive (UUO) mouse model, which was used to mimic the progression of CKD. Six-week-old C57BL/6J mice were orally treated with 50 mg/kg of Nob for 14 constitutive days after UUO surgery. We found that the administration of Nob diminished kidney fibrosis and the expression of EMT markers, ameliorated oxidative stress and ferroptosis-associated injury, and mitigated the inflammatory response in the kidneys of UUO mice. Our results suggested that Nob treatment has antiferroptosis, anti-inflammatory, and antifibrotic effects, improving the progression of CKD in UUO mice. Nob may serve as a potential therapeutic candidate for the improvement of progressive CKD in further studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available